PedAM
Pediatric Disease Annotations & Medicines
| autistic disorder | ||||
| Disease ID | 194 |
|---|---|
| Disease | autistic disorder |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:12) HP:0003144 | Increased serum serotonin HP:0000750 | Late-onset speech development HP:0000721 | Lack of spontaneous play HP:0001249 | Mental retardation HP:0000728 | Impaired ability to form peer relationships HP:0001250 | Seizures HP:0000732 | Inflexible adherence to routines or rituals HP:0000733 | Repetitive movements HP:0000717 | Autism HP:0000758 | Impaired use of nonverbal behaviors HP:0000723 | Restricted behavior HP:0002353 | Abnormal EEG |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:14) HP:0000737 | Irritability | 22 HP:0001631 | Atria septal defect | 7 HP:0001249 | Mental retardation | 4 HP:0000718 | Aggressive behaviour | 3 HP:0000708 | Behavioral problems | 2 HP:0000739 | Anxiety | 2 HP:0000716 | Depression | 2 HP:0001250 | Seizures | 2 HP:0000717 | Autism | 2 HP:0000020 | Bladder incontinence | 1 HP:0002353 | Abnormal EEG | 1 HP:0002342 | Intellectual disability, moderate | 1 HP:0000729 | Pervasive developmental disorder | 1 HP:0030083 | Salt craving | 1 |
| Disease ID | 194 |
|---|---|
| Disease | autistic disorder |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:118) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10038113 | 19456320 | 1008 | CDH10 | umls:C0004352 | GAD | [A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.] | 0.124734064 | 2009 | NA | 5 | 25902233 | T | C |
| rs1042173 | 17999363 | 3690 | ITGB3 | umls:C0004352 | BeFree | Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family triads with autism and using sex of the proband as a PC, we found significant interaction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3. | 0.136816922 | 2007 | SLC6A4 | 17 | 30197993 | A | C |
| rs1042173 | 17999363 | 6532 | SLC6A4 | umls:C0004352 | BeFree | Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family triads with autism and using sex of the proband as a PC, we found significant interaction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3. | 0.267543009 | 2007 | SLC6A4 | 17 | 30197993 | A | C |
| rs10489525 | 24189344 | 7812 | CSDE1 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | CSDE1 | 1 | 114721064 | G | A |
| rs1051266 | 20468076 | 6573 | SLC19A1 | umls:C0004352 | BeFree | Subsequent log linear analysis of the RFC1 A80G genotype within family trios revealed that the maternal G allele was associated with a significant increase in risk of autism whereas the inherited genotype of the child was not. | 0.120271442 | 2010 | SLC19A1 | 21 | 45537880 | T | C |
| rs10513025 | 19812673 | 9037 | SEMA5A | umls:C0004352 | GAD | [We also demonstrated that expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene.] | 0.125905708 | 2009 | NA | 5 | 9623510 | T | C |
| rs10513025 | 19812673 | 50834 | TAS2R1 | umls:C0004352 | GAD | [Initial analysis did not yield genome-wide significant associations; however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 x 10(-7)).] | 0.002638474 | 2009 | NA | 5 | 9623510 | T | C |
| rs10513025 | 19812673 | 100113384 | SNORD123 | umls:C0004352 | GAD | [A genome-wide linkage and association scan reveals novel loci for autism.] | 0.002367032 | 2009 | NA | 5 | 9623510 | T | C |
| rs10513025 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | NA | 5 | 9623510 | T | C |
| rs11102800 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114498310 | C | T |
| rs11582563 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114416918 | G | A |
| rs11585926 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114431068 | T | C |
| rs11587400 | 24189344 | 643586 | PKMP1 | umls:C0004352 | GWASCAT | Common genetic variants on 1p13.2 associate with risk of autism. | 0.12 | 2013 | NA | 1 | 114537037 | C | T |
| rs11589568 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114453702 | T | C |
| rs121917893 | 20615874 | 7038 | TG | umls:C0004352 | BeFree | By incorporating the R451C mutation found in neuroligin (NLGN) and associated with autism and the thyroglobulin G2320R (G221R in NLGN) mutation responsible for congenital hypothyroidism into NLGN3, we show that mutations in the alpha/beta-hydrolase fold domain influence folding and biosynthetic processing of neuroligin3 as determined by in vitro susceptibility to proteases, glycosylation processing, turnover, and processing rates. | 0.000271442 | 2010 | NLGN3 | X | 71167508 | C | T |
| rs121917893 | 20615874 | 54413 | NLGN3 | umls:C0004352 | BeFree | By incorporating the R451C mutation found in neuroligin (NLGN) and associated with autism and the thyroglobulin G2320R (G221R in NLGN) mutation responsible for congenital hypothyroidism into NLGN3, we show that mutations in the alpha/beta-hydrolase fold domain influence folding and biosynthetic processing of neuroligin3 as determined by in vitro susceptibility to proteases, glycosylation processing, turnover, and processing rates. | 0.21806451 | 2010 | NLGN3 | X | 71167508 | C | T |
| rs121917893 | 15152050 | 54413 | NLGN3 | umls:C0004352 | BeFree | The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. | 0.21806451 | 2004 | NLGN3 | X | 71167508 | C | T |
| rs121918817 | 12610651 | 6323 | SCN1A | umls:C0004352 | BeFree | R542Q in SCN1A was observed in one autism family and had previously been identified in a patient with juvenile myoclonic epilepsy. | 0.000814326 | 2003 | SCN1A | 2 | 166045080 | C | T |
| rs13000344 | 21750575 | 5013 | OTX1 | umls:C0004352 | BeFree | Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts. | 0.000271442 | 2011 | NA | 2 | 63062599 | T | G |
| rs1340513 | 20410850 | 23081 | KDM4C | umls:C0004352 | BeFree | The strongest association was detected with rs1340513 in the JMJD2C gene at 9p24.1 (P=0.007; corrected P=0.011) that is the same SNP associated with infantile autism (P=0.0007) in the autism genome project consortium (2007). | 0.002638474 | 2010 | KDM4C | 9 | 6977633 | G | A |
| rs1340513 | 20410850 | 23081 | KDM4C | umls:C0004352 | GAD | [The strongest association was detected with rs1340513 in the JMJD2C gene at 9p24.1 (P=0.007; corrected P=0.011) that is the same SNP associated with infantile autism (P=0.0007) in the autism genome project consortium (2007).] | 0.002638474 | 2010 | KDM4C | 9 | 6977633 | G | A |
| rs144093574 | 19645625 | 57502 | NLGN4X | umls:C0004352 | BeFree | In the preliminary study of specific exons of NLGN3 and NLGN4 genes, we identified the p.K378R substitution (c.1597 A > G) in exon 5 of the NLGN4 gene in a patient who was found to have mild autism and normal IQ at 3 years of age. | 0.149161289 | 2009 | NLGN4X | X | 5903545 | T | C |
| rs144093574 | 19645625 | 54413 | NLGN3 | umls:C0004352 | BeFree | In the preliminary study of specific exons of NLGN3 and NLGN4 genes, we identified the p.K378R substitution (c.1597 A > G) in exon 5 of the NLGN4 gene in a patient who was found to have mild autism and normal IQ at 3 years of age. | 0.21806451 | 2009 | NLGN4X | X | 5903545 | T | C |
| rs167771 | 19058789 | 1814 | DRD3 | umls:C0004352 | GAD | [The DRD3 gene is related to stereotyped behavior, liability to side effects of antipsychotic medication, and movement disorders and may therefore have important clinical implications for ASD.] | 0.125276948 | 2009 | DRD3 | 3 | 114157428 | G | A |
| rs1801394 | 19440165 | 4552 | MTRR | umls:C0004352 | BeFree | MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. | 0.002638474 | 2009 | MTRR;FASTKD3 | 5 | 7870860 | A | G |
| rs1801394 | 19440165 | 4548 | MTR | umls:C0004352 | BeFree | A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods. | 0.003181358 | 2009 | MTRR;FASTKD3 | 5 | 7870860 | A | G |
| rs1801394 | 19440165 | 6470 | SHMT1 | umls:C0004352 | BeFree | MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. | 0.002638474 | 2009 | MTRR;FASTKD3 | 5 | 7870860 | A | G |
| rs1805087 | 19440165 | 4548 | MTR | umls:C0004352 | BeFree | A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods. | 0.003181358 | 2009 | MTR | 1 | 236885200 | A | G |
| rs1858830 | 19681062 | 4233 | MET | umls:C0004352 | GAD | [Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder.] | 0.140726728 | 2009 | MET | 7 | 116672385 | C | G |
| rs1858830 | 19681062 | 8731 | RNMT | umls:C0004352 | BeFree | Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. | 0.003800186 | 2009 | MET | 7 | 116672385 | C | G |
| rs1861972 | 16252243 | 2020 | EN2 | umls:C0004352 | BeFree | Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD). | 0.222007993 | 2005 | EN2 | 7 | 155461298 | G | A |
| rs1861972 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | EN2 | 7 | 155461298 | G | A |
| rs1861973 | 16252243 | 2020 | EN2 | umls:C0004352 | BeFree | Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchange (AGRE) demonstrated that two intronic SNPs, rs1861972 and rs1861973, in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with autism spectrum disorder (ASD). | 0.222007993 | 2005 | EN2 | 7 | 155461450 | T | C |
| rs187134574 | 21441247 | 6853 | SYN1 | umls:C0004352 | BeFree | Additional mutations in SYN1 (A51G, A550T and T567A) were found in 1.0 and 3.5% of French-Canadian individuals with autism and epilepsy, respectively. | 0.080814326 | 2011 | SYN1 | X | 47619577 | G | C |
| rs1877455 | 24189344 | 10286 | BCAS2 | umls:C0004352 | BeFree | Meta-analysis identified three single-nucleotide polymorphisms, rs936938 (P=4.49 × 10(-8)), non-synonymous rs6537835 (P=3.26 × 10(-8)) and rs1877455 (P=8.70 × 10(-8)), and related haplotypes, AMPD1-NRAS-CSDE1, TRIM33 and TRIM33-BCAS2, associated with autism; all were mapped to a previously reported linkage region (1p13.2) with autism. | 0.000271442 | 2013 | NA | 1 | 114556471 | C | T |
| rs1881084 | 20442744 | 414 | ARSD | umls:C0004352 | BeFree | Association analysis showed significant associations in MKL2 with ASD (rs756472, P=4.31 x 10(-5)) and between SND1 and strict autism (rs1881084, P=7.76 x 10(-5)) in the Finnish and Northern Dutch populations, respectively. | 0.009229024 | 2010 | SND1 | 7 | 127704626 | G | A |
| rs1979277 | 19440165 | 4552 | MTRR | umls:C0004352 | BeFree | MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. | 0.002638474 | 2009 | SHMT1 | 17 | 18328782 | G | A |
| rs1979277 | 19440165 | 6470 | SHMT1 | umls:C0004352 | BeFree | MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism. | 0.002638474 | 2009 | SHMT1 | 17 | 18328782 | G | A |
| rs1979277 | 19440165 | 4548 | MTR | umls:C0004352 | BeFree | A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods. | 0.003181358 | 2009 | SHMT1 | 17 | 18328782 | G | A |
| rs201551401 | 25977097 | 2861 | GPR37 | umls:C0004352 | BeFree | Autism deleterious mutated GPR37(R558Q) slightly interacts with MUPP1 and retains in ER, resulting in dendritic alteration. | 0.000271442 | 2015 | GPR37 | 7 | 124746694 | C | T |
| rs201551401 | 25977097 | 8777 | MPDZ | umls:C0004352 | BeFree | Autism deleterious mutated GPR37(R558Q) slightly interacts with MUPP1 and retains in ER, resulting in dendritic alteration. | 0.000271442 | 2015 | GPR37 | 7 | 124746694 | C | T |
| rs201765376 | 19440165 | 4548 | MTR | umls:C0004352 | BeFree | A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods. | 0.003181358 | 2009 | MTR | 1 | 236838504 | C | T |
| rs2018650 | 21750575 | 5013 | OTX1 | umls:C0004352 | BeFree | Similarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts. | 0.000271442 | 2011 | EHBP1;LOC100132215 | 2 | 63045589 | T | C |
| rs2073559 | 20554015 | 5649 | RELN | umls:C0004352 | BeFree | The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. | 0.152157082 | 2011 | RELN | 7 | 103678477 | C | T |
| rs2227281 | 17712621 | 1791 | DNTT | umls:C0004352 | BeFree | Therefore in the present study, we have performed genetic analysis of three markers of GluR6 (SNP1: rs2227281, SNP2: rs2227283, SNP3: rs2235076) for possible association with autism through population, and family-based (TDT and HHRR) approaches. | 0.001628651 | 2007 | GRIK2 | 6 | 102055321 | C | T |
| rs2227283 | 17712621 | 1791 | DNTT | umls:C0004352 | BeFree | Therefore in the present study, we have performed genetic analysis of three markers of GluR6 (SNP1: rs2227281, SNP2: rs2227283, SNP3: rs2235076) for possible association with autism through population, and family-based (TDT and HHRR) approaches. | 0.001628651 | 2007 | GRIK2 | 6 | 102055442 | G | A,T |
| rs2229864 | 20554015 | 5649 | RELN | umls:C0004352 | BeFree | The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. | 0.152157082 | 2011 | RELN | 7 | 103515258 | A | G |
| rs2235076 | 17712621 | 1791 | DNTT | umls:C0004352 | BeFree | Therefore in the present study, we have performed genetic analysis of three markers of GluR6 (SNP1: rs2227281, SNP2: rs2227283, SNP3: rs2235076) for possible association with autism through population, and family-based (TDT and HHRR) approaches. | 0.001628651 | 2007 | GRIK2 | 6 | 102068385 | G | A |
| rs2254298 | 22510359 | 5021 | OXTR | umls:C0004352 | BeFree | It is suggested that polymorphic variation at the oxytocin receptor gene (rs2254298) is associated with sociability, amygdala volume and differential risk for psychiatric conditions including autism, depression and anxiety disorder, depending on the quality of early environmental experiences. | 0.1459178 | 2012 | OXTR | 3 | 8760542 | G | A |
| rs2292813 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | SLC25A12;LOC105373738 | 2 | 171787719 | T | C |
| rs234715 | 21610500 | 1312 | COMT | umls:C0004352 | BeFree | Significant interaction effects were observed for maternal MTHFR 677 TT, CBS rs234715 GT + TT, and child COMT 472 AA genotypes, with greater risk for autism when mothers did not report taking prenatal vitamins periconceptionally (4.5 [1.4-14.6]; 2.6 [1.2-5.4]; and 7.2 [2.3-22.4], respectively). | 0.125276948 | 2011 | CBS | 21 | 43068285 | G | T |
| rs234715 | 21610500 | 102724560 | LOC102724560 | umls:C0004352 | BeFree | Significant interaction effects were observed for maternal MTHFR 677 TT, CBS rs234715 GT + TT, and child COMT 472 AA genotypes, with greater risk for autism when mothers did not report taking prenatal vitamins periconceptionally (4.5 [1.4-14.6]; 2.6 [1.2-5.4]; and 7.2 [2.3-22.4], respectively). | 0.000271442 | 2011 | CBS | 21 | 43068285 | G | T |
| rs2710102 | 21987501 | 26047 | CNTNAP2 | umls:C0004352 | BeFree | In the current study we investigated the functional effects of variants of CNTNAP2 associated with autism and language impairment (rs7794745 and rs2710102; presumed risk alleles T and C, respectively) in healthy individuals using functional magnetic resonance imaging (fMRI) during performance of a language task (n = 66). | 0.222712698 | 2011 | CNTNAP2 | 7 | 147877298 | A | G |
| rs2736654 | 21491613 | 2739 | GLO1 | umls:C0004352 | BeFree | Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism. | 0.126362715 | 2011 | NA | NA | NA | NA | NA |
| rs28364997 | 25313507 | 6531 | SLC6A3 | umls:C0004352 | BeFree | SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. | 0.007372538 | 2014 | SLC6A3 | 5 | 1403013 | G | A |
| rs28934906 | 17684768 | 4204 | MECP2 | umls:C0004352 | BeFree | Females with the p.R306C or p.T158M mutations in the MECP2 gene were more likely to have an initial diagnosis of autism, and the specific Rett syndrome symptoms were noted at a later age. | 0.156566165 | 2008 | MECP2 | X | 154031355 | G | A |
| rs28935468 | 17684768 | 4204 | MECP2 | umls:C0004352 | BeFree | Females with the p.R306C or p.T158M mutations in the MECP2 gene were more likely to have an initial diagnosis of autism, and the specific Rett syndrome symptoms were noted at a later age. | 0.156566165 | 2008 | MECP2 | X | 154030912 | G | A |
| rs35678 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | ATP2B2 | 3 | 10338239 | C | T |
| rs362691 | 20554015 | 5649 | RELN | umls:C0004352 | BeFree | The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. | 0.152157082 | 2011 | RELN | 7 | 103610714 | G | A,C |
| rs370911031 | 20479890 | 23413 | NCS1 | umls:C0004352 | BeFree | Mutations in IL1RAPL1 have recently been associated with autism spectrum disorders and a missense mutation (R102Q) on NCS-1 has been found in one individual with autism. | 0.000542884 | 2010 | NCS1 | 9 | 130219801 | G | A |
| rs370911031 | 18801879 | 23413 | NCS1 | umls:C0004352 | BeFree | The screening failed to identify non-synonymous variant in IL1RAPL2, whereas a rare missense (R102Q) in NCS-1/FREQ was identified in one autistic patient. | 0.000542884 | 2008 | NCS1 | 9 | 130219801 | G | A |
| rs370911031 | 20479890 | 11141 | IL1RAPL1 | umls:C0004352 | BeFree | Mutations in IL1RAPL1 have recently been associated with autism spectrum disorders and a missense mutation (R102Q) on NCS-1 has been found in one individual with autism. | 0.124267125 | 2010 | NCS1 | 9 | 130219801 | G | A |
| rs374903967 | 15967618 | 4152 | MBD1 | umls:C0004352 | BeFree | Although our findings could not confirm that the genes of this family are responsible for the etiology in the majority of autistic patients, the R269C mutation in the MBD1 gene may relate to autism. | 0.006263026 | 2005 | MBD1 | 18 | 50275233 | G | A |
| rs3802905 | 18270976 | 64221 | ROBO3 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124879688 | C | G |
| rs3802905 | 18270976 | 54538 | ROBO4 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124879688 | C | G |
| rs3809865 | 17999363 | 3690 | ITGB3 | umls:C0004352 | BeFree | Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family triads with autism and using sex of the proband as a PC, we found significant interaction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3. | 0.136816922 | 2007 | ITGB3;LOC102724508 | 17 | 47311220 | T | A |
| rs3809865 | 17999363 | 6532 | SLC6A4 | umls:C0004352 | BeFree | Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family triads with autism and using sex of the proband as a PC, we found significant interaction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3. | 0.267543009 | 2007 | ITGB3;LOC102724508 | 17 | 47311220 | T | A |
| rs3827735 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114510087 | C | A |
| rs386514057 | 20468076 | 6573 | SLC19A1 | umls:C0004352 | BeFree | Subsequent log linear analysis of the RFC1 A80G genotype within family trios revealed that the maternal G allele was associated with a significant increase in risk of autism whereas the inherited genotype of the child was not. | 0.120271442 | 2010 | NA | NA | NA | NA | NA |
| rs386572987 | 21491613 | 2739 | GLO1 | umls:C0004352 | BeFree | Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism. | 0.126362715 | 2011 | NA | NA | NA | NA | NA |
| rs3923890 | 18270976 | 64221 | ROBO3 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124870514 | A | T |
| rs3923890 | 18270976 | 54538 | ROBO4 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124870514 | A | T |
| rs397507444 | 19440165 | 4548 | MTR | umls:C0004352 | BeFree | A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods. | 0.003181358 | 2009 | MTHFR | 1 | 11794407 | T | G |
| rs397507444 | 19440165 | 4524 | MTHFR | umls:C0004352 | BeFree | MTHFR A1298C acts additively in increasing the risk for autism. | 0.130825337 | 2009 | MTHFR | 1 | 11794407 | T | G |
| rs397514680 | 21441247 | 6853 | SYN1 | umls:C0004352 | BeFree | Additional mutations in SYN1 (A51G, A550T and T567A) were found in 1.0 and 3.5% of French-Canadian individuals with autism and epilepsy, respectively. | 0.080814326 | 2011 | SYN1 | X | 47574336 | C | T,G |
| rs4141463 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | MACROD2 | 20 | 14766825 | T | C |
| rs4141463 | 20663923 | 140733 | MACROD2 | umls:C0004352 | GAD | [A genome-wide scan for common alleles affecting risk for autism.] | 0.242909916 | 2010 | MACROD2 | 20 | 14766825 | T | C |
| rs4141463 | 20663923 | 140733 | MACROD2 | umls:C0004352 | GWASCAT | A genome-wide scan for common alleles affecting risk for autism. | 0.242909916 | 2010 | MACROD2 | 20 | 14766825 | T | C |
| rs4141463 | 21656903 | 140733 | MACROD2 | umls:C0004352 | BeFree | The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. | 0.242909916 | 2011 | MACROD2 | 20 | 14766825 | T | C |
| rs4150167 | 22843504 | 9013 | TAF1C | umls:C0004352 | GWASCAT | Individual common variants exert weak effects on the risk for autism spectrum disorderspi. | 0.242367032 | 2012 | TAF1C | 16 | 84180078 | C | T |
| rs4307059 | 19404256 | 1008 | CDH10 | umls:C0004352 | GAD | [Common genetic variants on 5p14.1 associate with autism spectrum disorders.] | 0.124734064 | 2009 | NA | 5 | 25967594 | T | C |
| rs4307059 | 19404256 | 1007 | CDH9 | umls:C0004352 | GAD | [Common genetic variants on 5p14.1 associate with autism spectrum disorders.] | 0.122367032 | 2009 | NA | 5 | 25967594 | T | C |
| rs4307059 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | NA | 5 | 25967594 | T | C |
| rs4606490 | 18270976 | 64221 | ROBO3 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124872835 | C | T |
| rs4606490 | 18270976 | 54538 | ROBO4 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124872835 | C | T |
| rs4675502 | 22843504 | 117583 | PARD3B | umls:C0004352 | GWASCAT | Individual common variants exert weak effects on the risk for autism spectrum disorderspi. | 0.12 | 2012 | PARD3B | 2 | 205221447 | G | A |
| rs4746 | 21491613 | 2739 | GLO1 | umls:C0004352 | BeFree | Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism. | 0.126362715 | 2011 | GLO1 | 6 | 38682852 | T | G |
| rs6355 | 21183371 | 6532 | SLC6A4 | umls:C0004352 | BeFree | Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. | 0.267543009 | 2011 | SLC6A4 | 17 | 30221792 | C | G |
| rs6355 | 21183371 | 3918 | LAMC2 | umls:C0004352 | BeFree | Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. | 0.001085767 | 2011 | SLC6A4 | 17 | 30221792 | C | G |
| rs6355 | 21183371 | 1437 | CSF2 | umls:C0004352 | BeFree | Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. | 0.001085767 | 2011 | SLC6A4 | 17 | 30221792 | C | G |
| rs6537825 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33;LOC101928890 | 1 | 114405659 | A | G |
| rs6537825 | 24189344 | 101928890 | LOC101928890 | umls:C0004352 | GWASCAT | Common genetic variants on 1p13.2 associate with risk of autism. | 0.12 | 2013 | TRIM33;LOC101928890 | 1 | 114405659 | A | G |
| rs6537835 | 24189344 | 10286 | BCAS2 | umls:C0004352 | BeFree | Meta-analysis identified three single-nucleotide polymorphisms, rs936938 (P=4.49 × 10(-8)), non-synonymous rs6537835 (P=3.26 × 10(-8)) and rs1877455 (P=8.70 × 10(-8)), and related haplotypes, AMPD1-NRAS-CSDE1, TRIM33 and TRIM33-BCAS2, associated with autism; all were mapped to a previously reported linkage region (1p13.2) with autism. | 0.000271442 | 2013 | NA | 1 | 114566293 | G | A |
| rs6590109 | 18270976 | 54538 | ROBO4 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO4 | 11 | 124889152 | G | A |
| rs6590109 | 18270976 | 64221 | ROBO3 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO4 | 11 | 124889152 | G | A |
| rs662 | 16027737 | 5444 | PON1 | umls:C0004352 | BeFree | As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025). | 0.120271442 | 2005 | PON1 | 7 | 95308134 | T | C |
| rs6661053 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114496497 | T | C |
| rs6735330 | 21750575 | 7514 | XPO1 | umls:C0004352 | BeFree | In XPO1, rs6735330 was associated with autism in all four cohorts (P<0.05), being significant in ASD-CARC cohorts (P-value following false discovery rate correction for multiple testing (P(FDR))=1.29 × 10(-5)), the AGRE cohort (P(FDR)=0.0011) and the combined families (P(FDR)=2.34 × 10(-9)). | 0.000271442 | 2011 | XPO1 | 2 | 61504343 | G | A |
| rs6872664 | 22739633 | 8604 | SLC25A12 | umls:C0004352 | BeFree | We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene). | 0.139283643 | 2012 | PITX1;C5orf66 | 5 | 135031908 | C | T |
| rs6943555 | 21471458 | 26053 | AUTS2 | umls:C0004352 | GAD | [Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.] | 0.005081451 | 2011 | AUTS2 | 7 | 70341037 | T | A |
| rs69510130 | 21118708 | 1791 | DNTT | umls:C0004352 | BeFree | In TDT analysis, rs69510130 (p=0.027) showed nominal associations with autism; modest haplotype association was also observed. | 0.001628651 | 2011 | NA | NA | NA | NA | NA |
| rs7142002 | 20663923 | 5527 | PPP2R5C | umls:C0004352 | GAD | [A genome-wide scan for common alleles affecting risk for autism.] | 0.002367032 | 2010 | PPP2R5C | 14 | 101894408 | T | C |
| rs73598374 | 17340203 | 100 | ADA | umls:C0004352 | BeFree | Our findings suggest that the ADA G22A polymorphism plays a minimal role in susceptibility to autism in North American families. | 0.128544182 | 2008 | ADA | 20 | 44651586 | C | T |
| rs736707 | 20554015 | 5649 | RELN | umls:C0004352 | BeFree | The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. | 0.152157082 | 2011 | RELN;LOC101927870 | 7 | 103489956 | A | G |
| rs7511633 | 24189344 | 51592 | TRIM33 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | TRIM33 | 1 | 114456655 | G | A |
| rs756472 | 20442744 | 414 | ARSD | umls:C0004352 | BeFree | Association analysis showed significant associations in MKL2 with ASD (rs756472, P=4.31 x 10(-5)) and between SND1 and strict autism (rs1881084, P=7.76 x 10(-5)) in the Finnish and Northern Dutch populations, respectively. | 0.009229024 | 2010 | MKL2 | 16 | 14185624 | G | A |
| rs7794745 | 21987501 | 26047 | CNTNAP2 | umls:C0004352 | BeFree | In the current study we investigated the functional effects of variants of CNTNAP2 associated with autism and language impairment (rs7794745 and rs2710102; presumed risk alleles T and C, respectively) in healthy individuals using functional magnetic resonance imaging (fMRI) during performance of a language task (n = 66). | 0.222712698 | 2011 | CNTNAP2 | 7 | 146792514 | A | T |
| rs78692805 | 19607881 | 5080 | PAX6 | umls:C0004352 | BeFree | A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient. | 0.203452799 | 2009 | PAX6 | 11 | 31802709 | G | C |
| rs7925879 | 18270976 | 64221 | ROBO3 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124870795 | A | G |
| rs7925879 | 18270976 | 54538 | ROBO4 | umls:C0004352 | BeFree | Four SNPs of ROBO3 (rs3923890, P = 0.023; rs7925879, P = 0.017; rs4606490, P = 0.033; and rs3802905, P = 0.049) and a single SNP of ROBO4 (rs6590109, P = 0.009) showed associations with autism; the A/A genotype of rs3923890 showed lower ADI-R_A scores, which reflect social interaction. | 0.122638474 | 2008 | ROBO3 | 11 | 124870795 | A | G |
| rs79667838 | 18393381 | 2925 | GRPR | umls:C0004352 | BeFree | However, there is a potential role of C6S and L181F mutations on GRPR function, and possibly in the pathogenesis of the autistic disorders in the two patients. | 0.003452799 | 2008 | GRPR | X | 16150432 | C | T |
| rs797046134 | NA | 220 | ALDH1A3 | umls:C0004352 | CLINVAR | NA | 0.12 | NA | ALDH1A3 | 15 | 100914748 | T | C |
| rs797046135 | NA | 8456 | FOXN1 | umls:C0004352 | CLINVAR | NA | 0.12 | NA | FOXN1 | 17 | 28524525 | C | T |
| rs8453 | 24189344 | 7812 | CSDE1 | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120271442 | 2013 | NRAS;CSDE1 | 1 | 114716978 | G | T |
| rs8453 | 24189344 | 4893 | NRAS | umls:C0004352 | GWASCAT | Our study suggests TRIM33 and NRAS-CSDE1 as candidate genes for autism, and may provide a novel insight into the etiology of autism. | 0.120542884 | 2013 | NRAS;CSDE1 | 1 | 114716978 | G | T |
| rs854560 | 16027737 | 5444 | PON1 | umls:C0004352 | BeFree | As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025). | 0.120271442 | 2005 | PON1 | 7 | 95316772 | A | C,G,N,T |
| rs926938 | 24189344 | 270 | AMPD1 | umls:C0004352 | GWASCAT | Meta-analysis identified three single-nucleotide polymorphisms, rs936938 (P=4.49 × 10(-8)), non-synonymous rs6537835 (P=3.26 × 10(-8)) and rs1877455 (P=8.70 × 10(-8)), and related haplotypes, AMPD1-NRAS-CSDE1, TRIM33 and TRIM33-BCAS2, associated with autism; all were mapped to a previously reported linkage region (1p13.2) with autism. | 0.12 | 2013 | AMPD1 | 1 | 114697195 | A | G |
| rs936938 | 24189344 | 10286 | BCAS2 | umls:C0004352 | BeFree | Meta-analysis identified three single-nucleotide polymorphisms, rs936938 (P=4.49 × 10(-8)), non-synonymous rs6537835 (P=3.26 × 10(-8)) and rs1877455 (P=8.70 × 10(-8)), and related haplotypes, AMPD1-NRAS-CSDE1, TRIM33 and TRIM33-BCAS2, associated with autism; all were mapped to a previously reported linkage region (1p13.2) with autism. | 0.000271442 | 2013 | CXCR6;FYCO1 | 3 | 45939277 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:321) | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | POS | SNPID | REF | ALT | ORI_SNPID | PMID | P_VALUE | P_VALUE_TEXT | OR/BETA | CI95_TEXT | GWAS_INITIAL_SAMPLE_SIZE | SUB_POPULATION | SUPER_POPULATION | GWAS_TRAIT | HPO_ID | HPO_TERM | DO_ID | DO_TERM | MESH_ID | MESH_TERM | EFO_ID | EFO_TERM | DOLITE_TERM | RISK_ALLELE | PUBLICATION_TYPE | AA | GENE_SYMBOL | TYPE | REFGENE |
| 1 | 2390588 | rs10910078 | T | C | rs10910078 | 22412387 | 0.00000663 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | NA |
| 1 | 54216654 | rs761490 | C | G | rs761490 | 24047820 | 3.00E-05 | NA | 0.09 | [0.05-0.13] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs761490-C | NA | C | NA |
| 1 | 95151813 | rs841361 | C | T | rs841361 | 22843504 | 9.36E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 1 | 114948281 | rs6537825 | A | G | rs6537825 | 24189344 | 3.00E-08 | NA | 1.4 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs6537825-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 114959540 | rs11582563 | G | A | rs11582563 | 24189344 | 1.98E-07 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053; AGTTGT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11582563-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 114973690 | rs11585926 | T | C | rs11585926 | 24189344 | 1.98E-07 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053; AGTTGT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11585926-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 114996324 | rs11589568 | T | C | rs11589568 | 24189344 | 1.98E-07 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053; AGTTGT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11589568-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 114999277 | rs7511633 | G | A | rs7511633 | 24189344 | 1.98E-07 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053; AGTTGT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs7511633-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | A |
| 1 | 115039119 | rs6661053 | T | C | rs6661053 | 24189344 | 1.98E-07 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053; AGTTGT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs6661053-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115040932 | rs11102800 | C | T | rs11102800 | 24189344 | 5.82E-08 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053,rs11102800; AGTTGTC) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11102800-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 115052708 | rs3827735 | C | A | rs3827735 | 24189344 | 3.22E-05 | NA | 1.33 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs3827735-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115052708 | rs3827735 | C | A | rs3827735 | 24189344 | 6.39E-08 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053,rs11102800,rs3827735; AGTTGTCC) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs3827735-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115061584 | rs11102807 | A | G | rs11102807 | 24189344 | 4.06E-08 | (Haplotype: rs6537825,rs11582563,rs11585926,rs11589568,rs7511633,rs6661053,rs11102800,rs3827735,rs11102807; AGTTGTCCA) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11102807-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 115073876 | rs10858047 | T | C | rs10858047 | 24189344 | 2.23E-05 | NA | 1.05 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10858047-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 115079658 | rs11587400 | C | T | rs11587400 | 24189344 | 8.36E-08 | (Haplotype: rs10858047,rs11587400,rs1877455; TCT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs11587400-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115099092 | rs1877455 | C | T | rs1877455 | 24189344 | 6.72E-08 | (Haplotype: rs11587400,rs1877455; CT) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs1877455-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115099092 | rs1877455 | C | T | rs1877455 | 24189344 | 8.70E-08 | NA | 1.2 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs1877455-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115171649 | rs7539721 | C | T | rs7539721 | 24189344 | 2.39E-05 | NA | 1.09 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs7539721-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 115200808 | rs6537841 | A | G | rs6537841 | 24189344 | 2.04E-05 | NA | 1.15 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs6537841-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 115222434 | rs761755 | G | A | rs761755 | 24189344 | 2.55E-05 | NA | 1.15 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs761755-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 115239816 | rs926938 | A | G | rs926938 | 24189344 | 4.00E-08 | NA | 1.27 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs926938-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 115259599 | rs11558867 | G | GG,GT | rs8453 | 24189344 | 2.77E-08 | (Haplotype: rs926938,rs8453; AG) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs8453-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115259599 | rs8453 | G | T | rs8453 | 24189344 | 2.77E-08 | (Haplotype: rs926938,rs8453; AG) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs8453-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 1 | 115263685 | rs10489525 | G | A | rs10489525 | 24189344 | 5.51E-06 | NA | 1.11 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10489525-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 115263685 | rs10489525 | G | A | rs10489525 | 24189344 | 9.33E-08 | (Haplotype: rs926938,rs8453,rs10489525; AGG) | NA | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10489525-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 1 | 116525672 | rs12726299 | G | A | rs12726299 | 22843504 | 1.50E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 1 | 183616926 | rs1174657 | T | C | rs1174657 | 21182207 | 1.70E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 1 | 183617105 | rs1174658 | A | G | rs1174658 | 21182207 | 1.70E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 1 | 183668132 | rs6424904 | A | G | rs6424904 | 21182207 | 3.90E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 1 | 187057847 | rs10911998 | C | T | rs10911998 | 24189344 | 4.49E-05 | NA | 1.14 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10911998-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 1 | 206698249 | rs11118968 | G | A | rs11118968 | 22843504 | 2.45E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 1 | 227655222 | rs953537 | T | C | rs953537 | 21182207 | 1.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 1 | 229811989 | rs4925506 | C | T | rs4925506 | 22935194 | 2.95E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 1 | 233823925 | rs595191 | A | G | rs595191 | 21182207 | 2.50E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 1 | 236912286 | rs2297956 | G | A | rs2297956 | 19812673 | 4.99E-05 | NA | NA | NA | 1,553 affected offspring from 1,031 families | NOPOP(1553) | ALL(1553) | NOPOP(1553) | ALL(1553) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 2 | 31146497 | rs10205350 | G | T | rs10205350 | 22843504 | 3.94E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 2 | 127773880 | rs11899372 | G | T | rs11899372 | 22935194 | 1.86E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | G | NA |
| 2 | 152006025 | rs289932 | C | T | rs289932 | 22843504 | 5.42E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 2 | 152052326 | rs289858 | G | A | rs289858 | 22843504 | 2.81E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 2 | 166714081 | rs2304003 | T | C | rs2304003 | 24564958 | 9.00E-06 | (Age 17) | 0.14 | [0.081-0.199] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs2304003-T | NA | G | NA |
| 2 | 206086171 | rs4675502 | G | A | rs4675502 | 22843504 | 4.00E-07 | Strict, all | 1.28 | [1.16-1.41] | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 2 | 206694181 | rs10185592 | A | C | rs10185592 | 22843504 | 3.15E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 2 | 212439312 | rs1879532 | T | C,G | rs1879532 | 22843504 | 1.66E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 2 | 230518233 | rs6752370 | A | G | rs6752370 | 22843504 | 8.53E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 2 | 231034524 | rs6436915 | G | T | rs6436915 | 22412387 | 0.0000068 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | SP110 |
| 3 | 31175501 | rs7625163 | T | C | rs7625163 | 21182207 | 3.30E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 3 | 38882519 | rs4453791 | T | C | rs4453791 | 24564958 | 9.00E-09 | (Age 17) | 0.23 | [0.15-0.31] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4453791-C | NA | T | NA |
| 3 | 60289842 | rs10510837 | G | A | rs10510837 | 21182207 | 4.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 3 | 152611465 | rs7649494 | A | G | rs7649494 | 21182207 | 1.60E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 3 | 152613883 | rs2872090 | C | T | rs2872090 | 21182207 | 1.70E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 3 | 152630713 | rs10935907 | T | C | rs10935907 | 21182207 | 6.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 3 | 161821524 | rs1581057 | A | C | rs1581057 | 24564958 | 6.00E-06 | (Age 8) | 0.13 | [0.071-0.189] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1581057-C | NA | C | NA |
| 3 | 171227112 | rs2075360 | C | T | rs2075360 | 21182207 | 4.80E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 3 | 183523657 | rs263035 | A | G | rs263035 | 22843504 | 2.26E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 3 | 183525121 | rs263030 | A | G | rs263030 | 22843504 | 2.76E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 3 | 183527618 | rs263025 | T | C | rs263025 | 22843504 | 1.58E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 4 | 12099503 | rs1479278 | A | C | rs1479278 | 21182207 | 3.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 4 | 12099850 | rs1031097 | T | C | rs1031097 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 4 | 12144279 | rs17265093 | A | G | rs17265093 | 21182207 | 7.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 4 | 12144655 | rs17331012 | G | A | rs17331012 | 21182207 | 1.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 4 | 12174662 | rs11730805 | T | G | rs11730805 | 21182207 | 7.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 4 | 59844473 | rs11931812 | T | C | rs11931812 | 21182207 | 1.80E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 4 | 84841250 | rs17007739 | T | G | rs17007739 | 22843504 | 4.77E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 4 | 90059434 | rs6828137 | G | T | rs6828137 | 21182207 | 8.20E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 4 | 90073214 | rs756345 | G | A | rs756345 | 21182207 | 7.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 4 | 101904205 | rs2850611 | C | T | rs2850611 | 21182207 | 6.80E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 4 | 145111329 | rs3923603 | C | T | rs3923603 | 21182207 | 6.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 4 | 145123453 | rs4599356 | A | G | rs4599356 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 4 | 146849295 | rs12331851 | G | A | rs12331851 | 22843504 | 6.08E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 4 | 151101672 | rs11947645 | G | A | rs11947645 | 24133439 | 1.00E-06 | NA | 5.33 | [3.17-7.48] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11947645-A | NA | G | DCLK2 |
| 5 | 2109901 | rs6879627 | T | C | rs6879627 | 22843504 | 3.99E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 5 | 7914632 | rs16879418 | C | T | rs16879418 | 21182207 | 3.10E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 5 | 9623622 | rs10513025 | T | C | rs10513025 | 19812673 | 3.00E-07 | NA | 1.81 | NA | 1,553 affected offspring from 1,031 families | NOPOP(1553) | ALL(1553) | NOPOP(1553) | ALL(1553) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 11371305 | rs6891903 | A | G | rs6891903 | 22843504 | 7.80E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 5 | 23056410 | rs6879343 | C | T | rs6879343 | 21182207 | 4.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 25782399 | rs12521681 | G | A | rs12521681 | 19404256 | 9.81E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25797388 | rs443439 | G | A | rs443439 | 19404256 | 7.36E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25797453 | rs437316 | G | A | rs437316 | 19404256 | 7.50E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25798716 | rs438137 | C | A | rs438137 | 19404256 | 9.76E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25799092 | rs374014 | A | G | rs374014 | 19404256 | 6.97E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25801089 | rs10491401 | C | T | rs10491401 | 19404256 | 7.14E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25801289 | rs423116 | G | A | rs423116 | 19404256 | 5.30E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25801732 | rs2619940 | T | C | rs2619940 | 19404256 | 7.38E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25801771 | rs2619941 | G | A | rs2619941 | 19404256 | 6.75E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25801818 | rs2619942 | G | A | rs2619942 | 19404256 | 6.52E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25802828 | rs367519 | T | C | rs367519 | 19404256 | 6.01E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25840136 | rs11740209 | C | T | rs11740209 | 19404256 | 1.25E-06 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25840450 | rs10065041 | T | C | rs10065041 | 19404256 | 1.01E-06 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25841163 | rs409649 | A | G | rs409649 | 19404256 | 1.80E-07 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25867540 | rs922551 | A | G | rs922551 | 19404256 | 1.67E-07 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25869401 | rs12521157 | C | T | rs12521157 | 19404256 | 1.25E-07 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25870090 | rs1366465 | T | C | rs1366465 | 19404256 | 1.03E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25894398 | rs10058083 | G | A | rs10058083 | 19404256 | 3.15E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25896004 | rs4701511 | C | A | rs4701511 | 19404256 | 1.69E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25897556 | rs6894102 | T | C | rs6894102 | 19404256 | 2.87E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25898921 | rs7704909 | T | C | rs7704909 | 19404256 | 9.94E-10 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25899020 | rs1896731 | T | C | rs1896731 | 19404256 | 4.80E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25899414 | rs7705715 | T | C | rs7705715 | 19404256 | 2.04E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25900440 | rs13176113 | G | A | rs13176113 | 19404256 | 3.08E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25901098 | rs4701259 | A | G | rs4701259 | 19404256 | 2.63E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25901608 | rs17482975 | C | T | rs17482975 | 19404256 | 1.90E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25902342 | rs10038113 | T | C | rs10038113 | 19404256 | 7.36E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25902342 | rs10038113 | T | C | rs10038113 | 19456320 | 3.00E-06 | NA | 1.33 | [1.11-1.43] | 1,390 family members | NOPOP(1390) | ALL(1390) | NOPOP(1390) | ALL(1390) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10038113-T | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 25902368 | rs13187934 | C | T | rs13187934 | 19404256 | 2.29E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25909764 | rs11739167 | C | T | rs11739167 | 19404256 | 1.95E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25910929 | rs10942147 | G | A | rs10942147 | 19404256 | 1.59E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25911136 | rs9293194 | C | A | rs9293194 | 19404256 | 1.21E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25912113 | rs12521388 | G | A | rs12521388 | 19404256 | 1.52E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25915032 | rs7447989 | A | G | rs7447989 | 19404256 | 1.03E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25915652 | rs1346536 | A | G | rs1346536 | 19404256 | 2.42E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25919023 | rs12697669 | C | A | rs12697669 | 19404256 | 2.27E-06 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25920401 | rs12659830 | G | T | rs12659830 | 19404256 | 1.84E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25924228 | rs6452304 | T | C | rs6452304 | 19404256 | 3.28E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25924622 | rs6452305 | A | C | rs6452305 | 19404256 | 3.33E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25926366 | rs7380139 | A | G | rs7380139 | 19404256 | 2.38E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25928566 | rs6873221 | G | A | rs6873221 | 19404256 | 1.05E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25932607 | rs10063934 | G | A | rs10063934 | 19404256 | 1.66E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25934805 | rs12519594 | G | A | rs12519594 | 19404256 | 3.01E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25935070 | rs12187724 | A | C | rs12187724 | 19404256 | 1.55E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25944946 | rs6894838 | T | C | rs6894838 | 19404256 | 9.06E-07 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25946935 | rs10214380 | T | C | rs10214380 | 19404256 | 1.86E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25951561 | rs12518194 | A | G | rs12518194 | 19404256 | 1.07E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25955317 | rs4475231 | C | T | rs4475231 | 19404256 | 1.81E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25958905 | rs4701260 | G | A | rs4701260 | 19404256 | 6.79E-06 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25959546 | rs12187661 | C | T | rs12187661 | 19404256 | 1.59E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25967703 | rs4307059 | T | C | rs4307059 | 19404256 | 2.00E-10 | NA | 1.19 | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs4307059-T | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25969379 | rs6891206 | T | C | rs6891206 | 19404256 | 4.09E-08 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25971356 | rs13166776 | T | C | rs13166776 | 19404256 | 3.84E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 25972821 | rs4327572 | C | T | rs4327572 | 19404256 | 2.71E-09 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26046052 | rs6898772 | T | C | rs6898772 | 19404256 | 3.52E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26048424 | rs12516367 | T | C | rs12516367 | 19404256 | 3.45E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26057117 | rs12514304 | G | T | rs12514304 | 19404256 | 4.14E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26064803 | rs10072518 | C | T | rs10072518 | 19404256 | 1.29E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26065402 | rs7720426 | G | A | rs7720426 | 19404256 | 1.40E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26071476 | rs12173236 | C | T | rs12173236 | 19404256 | 1.37E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 26073238 | rs1330642 | C | T | rs1330642 | 19404256 | 3.51E-05 | NA | NA | NA | 3,101 family members; 1,204 cases; 6,491 controls | NOPOP(10796) | ALL(10796) | NOPOP(10796) | ALL(10796) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. |
| 5 | 65539847 | rs29456 | T | C | rs29456 | 22843504 | 1.23E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 5 | 67108133 | rs17317826 | T | G | rs17317826 | 21182207 | 6.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 67256569 | rs1366315 | T | C | rs1366315 | 21182207 | 1.80E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 67275356 | rs999826 | G | A | rs999826 | 21182207 | 8.50E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 76976039 | rs351871 | A | G | rs351871 | 22843504 | 3.82E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 79348759 | rs404375 | G | A | rs404375 | 21182207 | 8.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 97655286 | rs17165849 | G | T | rs17165849 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 5 | 97744026 | rs1378441 | C | A | rs1378441 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 5 | 97754900 | rs11241318 | G | T | rs11241318 | 21182207 | 1.30E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 97756382 | rs1455420 | T | G | rs1455420 | 21182207 | 3.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 97768486 | rs1563317 | A | G | rs1563317 | 21182207 | 1.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 5 | 97783046 | rs1037597 | T | C | rs1037597 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 5 | 97801476 | rs11954735 | G | A | rs11954735 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 97888736 | rs4703129 | C | A | rs4703129 | 21182207 | 1.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 5 | 108284342 | rs3797817 | A | G | rs3797817 | 22935194 | 0.000000028 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | A | FER |
| 5 | 162083518 | rs7711337 | G | A | rs7711337 | 22843504 | 8.00E-07 | Spectrum, all | 1.22 | [1.12-1.32] | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 5 | 174774285 | rs17064931 | A | G | rs17064931 | 21182207 | 6.70E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 6 | 1885972 | rs3800119 | C | T | rs3800119 | 22412387 | 0.00000928 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | GMDS |
| 6 | 1942538 | rs3800143 | T | C | rs3800143 | 22412387 | 0.00000412 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | GMDS |
| 6 | 20731524 | rs7741604 | A | C | rs7741604 | 22843504 | 8.81E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 6 | 23790115 | rs1408744 | A | G | rs1408744 | 22843504 | 8.06E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 6 | 29180721 | rs9257616 | G | A | rs9257616 | 24047820 | 3.00E-07 | NA | 0.09 | [0.058-0.128] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs9257616-G | NA | G | NA |
| 6 | 39124682 | rs9942541 | C | T | rs9942541 | 24564958 | 5.00E-06 | (Age 8) | 0.23 | [0.13-0.33] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs9942541-T | NA | C | NA |
| 6 | 113156392 | rs13215654 | A | G | rs13215654 | 21182207 | 2.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 6 | 113463252 | rs13218679 | C | T | rs13218679 | 21182207 | 7.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 6 | 113497065 | rs926730 | A | C | rs926730 | 21182207 | 3.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 6 | 113509151 | rs12154111 | C | T | rs12154111 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 6 | 113515814 | rs774568 | A | G | rs774568 | 21182207 | 9.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 6 | 113518365 | rs774564 | A | G | rs774564 | 21182207 | 6.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 6 | 113972290 | rs9387161 | C | T | rs9387161 | 21182207 | 1.10E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 6 | 146991045 | rs2226067 | A | G | rs2226067 | 21182207 | 4.40E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 6 | 160834515 | rs12194182 | T | C | rs12194182 | 22843504 | 8.86E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 6 | 167557034 | rs11575088 | C | A | rs11575088 | 24133439 | 3.00E-06 | NA | 1.62 | [0.94-2.30] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11575088-A | NA | C | NA |
| 6 | 167557199 | rs11575089 | G | A | rs11575089 | 24133439 | 3.41E-06 | Genotyped | 1.62 | [0.94-2.3] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11575089-A | NA | G | NA |
| 7 | 4031064 | rs17134117 | C | T | rs17134117 | 22935194 | 4.16E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T,C | SDK1 |
| 7 | 6434087 | rs836474 | G | T | rs836474 | 22843504 | 5.86E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 7 | 16780009 | rs7800565 | A | G | rs7800565 | 22843504 | 7.95E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 7 | 41123452 | rs12701862 | G | A | rs12701862 | 22843504 | 8.76E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 7 | 104420060 | rs4460308 | T | C | rs4460308 | 24564958 | 6.00E-06 | (Age 8) | 0.11 | [0.051-0.169] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4460308-C | NA | T | LHFPL3 |
| 7 | 120405335 | rs10239799 | C | T | rs10239799 | 22935194 | 4.89E-10 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 7 | 129723707 | rs10251765 | T | G | rs10251765 | 21182207 | 1.60E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 7 | 129738451 | rs17133163 | T | C | rs17133163 | 21182207 | 3.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 7 | 146122788 | rs1718101 | T | C | rs1718101 | 22843504 | 7.78E-09 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 7 | 146489606 | rs7794745 | A | T | rs7794745 | 18179894 | 1.74E-05 | Autism | NA | NA | 148 unspecified affected offspring; 292 individuals | NOPOP(440) | ALL(440) | NOPOP(440) | ALL(440) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 7 | 155677943 | rs7786445 | T | C | rs7786445 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 8 | 28531939 | rs240919 | T | C | rs240919 | 24189344 | 2.25E-05 | NA | 1.25 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs240919-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 8 | 72561742 | rs7834018 | C | T | rs7834018 | 22843504 | 8.00E-07 | Strict, EA | 1.56 | [1.30-1.89] | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 8 | 75487288 | rs1425761 | C | T | rs1425761 | 21182207 | 9.72E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 8 | 104553408 | rs2080610 | A | C | rs2080610 | 21182207 | 2.80E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 8 | 105307981 | rs1374520 | C | A | rs1374520 | 21182207 | 6.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 8 | 105310154 | rs1868011 | G | A | rs1868011 | 21182207 | 8.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 8 | 139413333 | rs2056412 | T | C | rs2056412 | 22935194 | 1.41E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | FAM135B |
| 9 | 16517953 | rs12115663 | C | A | rs12115663 | 24047820 | 3.60E-05 | NA | 0.11 | [0.06-0.16] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs12115663-C | NA | C | BNC2 |
| 9 | 74174742 | rs2309982 | A | G | rs2309982 | 21182207 | 3.70E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 9 | 80863088 | rs1929402 | G | A | rs1929402 | 21182207 | 3.50E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 9 | 110472296 | rs1411355 | C | T | rs1411355 | 21182207 | 4.30E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 9 | 116890163 | rs2839874 | C | G | rs2839874 | 24564958 | 6.00E-06 | (Age 8) | 0.13 | [0.071-0.189] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs2839874-C | NA | C | NA |
| 9 | 129402567 | rs12342373 | G | A | rs12342373 | 24564958 | 3.00E-06 | (Age 8) | 0.19 | [0.11-0.27] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs12342373-A | NA | A | LMX1B |
| 10 | 5424465 | rs10904487 | C | T | rs10904487 | 22843504 | 4.29E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 10 | 15391182 | rs4750628 | G | A | rs4750628 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 10 | 15393309 | rs10796285 | G | A | rs10796285 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 10 | 15395181 | rs11599615 | T | C | rs11599615 | 21182207 | 7.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 10 | 56301930 | rs1930165 | G | A | rs1930165 | 22843504 | 9.86E-08 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 10 | 104202729 | rs7086205 | C | T | rs7086205 | 24133439 | 3.67E-06 | Genotyped | 1.69 | [0.98-2.4] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs7086205-C | NA | C | NA |
| 10 | 104207799 | rs927821 | C | A | rs927821 | 24133439 | 3.00E-06 | NA | 1.7 | [0.99-2.42] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs927821-A | NA | T | NA |
| 10 | 108367728 | rs7910584 | C | A | rs7910584 | 22843504 | 7.14E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 10 | 109626066 | rs1834180 | G | A | rs1834180 | 24047820 | 5.00E-07 | NA | 0.1 | [0.060-0.134] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1834180-A | NA | A | NA |
| 10 | 117942634 | rs11197571 | A | G | rs11197571 | 21182207 | 3.30E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 10 | 119662092 | rs1936295 | T | C | rs1936295 | 22843504 | 6.64E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 10 | 129043310 | rs11819364 | A | C | rs11819364 | 24564958 | 9.00E-06 | (Age 17) | 0.32 | [0.18-0.46] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11819364-C | NA | A | DOCK1 |
| 11 | 17403639 | rs1557765 | T | C | rs1557765 | 24564958 | 7.00E-06 | (Age 8) | 0.12 | [0.061-0.179] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1557765-C | NA | G | NA |
| 11 | 20926256 | rs1429793 | G | T | rs1429793 | 22935194 | 1.76E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | NELL1 |
| 11 | 66662731 | rs7122539 | G | A | rs7122539 | 22843504 | 9.64E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 11 | 85671702 | rs618679 | A | C | rs618679 | 24189344 | 2.41E-05 | NA | 1.13 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs618679-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | G |
| 11 | 85672383 | rs2077815 | G | A | rs2077815 | 24189344 | 6.59E-05 | NA | 1.11 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs2077815-G | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | A |
| 11 | 85715736 | rs527162 | C | T | rs527162 | 24189344 | 3.30E-05 | NA | 1.11 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs527162-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | T |
| 11 | 85781322 | rs669556 | C | T | rs669556 | 24189344 | 2.39E-05 | NA | 1.12 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs669556-C | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | A |
| 11 | 106858675 | rs11211996 | T | C | rs11211996 | 22843504 | 4.29E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 11 | 106983728 | rs1895729 | G | A | rs1895729 | 22843504 | 1.32E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 11 | 107000535 | rs10749886 | G | A | rs10749886 | 22843504 | 4.05E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 11 | 114072875 | rs3782000 | C | T | rs3782000 | 22843504 | 1.84E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 11 | 131320070 | rs1550976 | T | C | rs1550976 | 21182207 | 2.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 11 | 131320070 | rs1550976 | T | C | rs1550976 | 21182207 | 3.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 11 | 131320190 | rs1448363 | T | C | rs1448363 | 21182207 | 2.30E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 12 | 32178900 | rs7316376 | G | A | rs7316376 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 12 | 32197877 | rs7136780 | G | T | rs7136780 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 12 | 77749549 | rs4761371 | C | T | rs4761371 | 22843504 | 3.91E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 12 | 97434220 | rs6538761 | A | C | rs6538761 | 24189344 | 2.00E-06 | NA | 1.24 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs6538761-A | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 12 | 98027691 | rs11109142 | C | G | rs11109142 | 24564958 | 4.00E-06 | (Age 8) | 0.31 | [0.17-0.45] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11109142-G | NA | C | NA |
| 12 | 107222515 | rs4964491 | G | A | rs4964491 | 24133439 | 5.79E-06 | Imputed | 1.43 | [0.81-2.04] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4964491-A | NA | G | RIC8B |
| 12 | 107225331 | rs10778511 | A | T | rs10778511 | 24133439 | 3.80E-06 | Imputed | 1.45 | [0.84-2.07] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs10778511-A | NA | A | RIC8B |
| 12 | 107229705 | rs10444533 | C | T | rs10444533 | 24133439 | 4.00E-06 | NA | 1.46 | [0.84-2.07] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs10444533-C | NA | C | RIC8B |
| 12 | 120403797 | rs10774538 | C | T | rs10774538 | 22935194 | 0.000792 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | NA |
| 12 | 125968344 | rs11058197 | G | A | rs11058197 | 21182207 | 2.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 12 | 126084363 | rs16919315 | C | T | rs16919315 | 22843504 | 5.12E-08 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 13 | 57438062 | rs7319121 | G | T | rs7319121 | 22412387 | 0.00000458 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 13 | 57439337 | rs7989726 | G | T | rs7989726 | 22412387 | 0.00000923 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 13 | 57453331 | rs9569548 | C | T | rs9569548 | 22412387 | 0.00000396 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 13 | 57457404 | rs9569549 | C | T | rs9569549 | 22412387 | 0.00000396 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | NA |
| 13 | 57489776 | rs6561901 | A | G | rs6561901 | 22412387 | 0.00000714 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | G | NA |
| 13 | 89164320 | rs519700 | T | C | rs519700 | 22843504 | 9.06E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 13 | 110067124 | rs9521354 | C | A | rs9521354 | 22935194 | 0.00062 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | A | NA |
| 13 | 110067182 | rs9521355 | T | C | rs9521355 | 22935194 | 0.000208 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | C | NA |
| 14 | 24041624 | rs11844366 | T | C | rs11844366 | 21182207 | 1.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 14 | 49437931 | rs2352908 | T | G | rs2352908 | 24047820 | 1.00E-06 | NA | 0.12 | [0.071-0.169] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs2352908-G | NA | T | NA |
| 14 | 64331423 | rs2150291 | T | C | rs2150291 | 22843504 | 2.83E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 14 | 74870518 | rs11625667 | G | A | rs11625667 | 24047820 | 1.70E-05 | NA | 0.08 | [0.04-0.11] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11625667-G | NA | G | NA |
| 14 | 82546542 | rs4078830 | G | A | rs4078830 | 21182207 | 1.10E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 14 | 95107973 | rs4905226 | C | T | rs4905226 | 24564958 | 4.00E-06 | (Age 8) | 0.13 | [0.071-0.189] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4905226-T | NA | C | NA |
| 14 | 102360745 | rs7142002 | T | C | rs7142002 | 20663923 | 3.00E-06 | Spc | 1.56 | [1.28-1.89] | 1,385 affected children from 1,369 families | NOPOP(1385) | ALL(1385) | NOPOP(1385) | ALL(1385) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 15 | 42615305 | rs12903690 | A | G | rs12903690 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 15 | 59160188 | rs173214 | A | G | rs173214 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 15 | 59167865 | rs1078001 | G | A | rs1078001 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 15 | 59174539 | rs7179456 | G | T | rs7179456 | 21182207 | 7.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 15 | 59195679 | rs12595482 | G | A | rs12595482 | 21182207 | 3.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 15 | 59199937 | rs17302045 | T | G | rs17302045 | 21182207 | 7.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 15 | 59203615 | rs10518992 | T | C | rs10518992 | 21182207 | 5.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 15 | 59212111 | rs3145 | G | A | rs3145 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 15 | 59218094 | rs4775101 | C | T | rs4775101 | 21182207 | 1.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 15 | 59249584 | rs8037673 | G | A | rs8037673 | 21182207 | 8.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 15 | 59296491 | rs1446240 | G | T | rs1446240 | 21182207 | 1.90E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 15 | 59428658 | rs4218 | C | G | rs4218 | 24047820 | 1.00E-07 | NA | 0.1 | [0.063-0.137] unit increase | 5,584 European ancestry children | European(5584) | ALL(5584) | EUR(5584) | ALL(5584) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4218-G | NA | G | MYO1E |
| 15 | 63467887 | rs17828380 | G | C | rs17828380 | 24564958 | 5.00E-06 | (Age 8) | 0.18 | [0.1-0.26] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs17828380-C | NA | G | NA |
| 16 | 5001380 | rs9635542 | A | G | rs9635542 | 22843504 | 3.27E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 16 | 11313051 | rs7199390 | A | T | rs7199390 | 24564958 | 2.00E-06 | (Age 8) | 0.19 | [0.11-0.27] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs7199390-T | NA | A | NA |
| 16 | 24128397 | rs198198 | T | A | rs198198 | 24133439 | 9.59E-06 | Imputed | 1.41 | [0.79-2.03] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs198198-A | NA | A | PRKCB |
| 16 | 49113163 | rs11859884 | A | G | rs11859884 | 24133439 | 2.67E-06 | Imputed | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11859884-A | NA | A | NA |
| 16 | 49113335 | rs1009302 | C | T | rs1009302 | 24133439 | 2.68E-06 | Imputed | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1009302-C | NA | A | NA |
| 16 | 49113477 | rs1009301 | T | G | rs1009301 | 24133439 | 2.68E-06 | Imputed | 1.63 | [0.95-2.31] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1009301-G | NA | A | NA |
| 16 | 49115353 | rs1420612 | G | T | rs1420612 | 24133439 | 2.72E-06 | Imputed | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1420612-G | NA | C | NA |
| 16 | 49115962 | rs10521175 | C | A | rs10521175 | 24133439 | 2.75E-06 | Imputed | 1.63 | [0.95-2.31] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs10521175-A | NA | C | NA |
| 16 | 49117411 | rs9635530 | A | C | rs9635530 | 24133439 | 2.54E-06 | Imputed | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs9635530-A | NA | A | NA |
| 16 | 49118099 | rs16946876 | T | C | rs16946876 | 24133439 | 2.54E-06 | Imputed | 1.64 | [0.96-2.32] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs16946876-C | NA | T | NA |
| 16 | 49119449 | rs16946880 | C | T | rs16946880 | 24133439 | 2.53E-06 | Imputed | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs16946880-C | NA | C | NA |
| 16 | 49119787 | rs16946881 | C | T | rs16946881 | 24133439 | 2.53E-06 | Imputed | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs16946881-C | NA | C | NA |
| 16 | 49121379 | rs4785276 | A | G | rs4785276 | 24133439 | 8.46E-06 | Imputed | 1.53 | [0.86-2.2] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4785276-A | NA | A | NA |
| 16 | 49122315 | rs11860027 | C | T | rs11860027 | 24133439 | 2.52E-06 | Imputed | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs11860027-C | NA | C | NA |
| 16 | 49122930 | rs7499215 | G | T | rs7499215 | 24133439 | 2.51E-06 | Genotyped | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs7499215-G | NA | G | NA |
| 16 | 49124038 | rs1345406 | A | C | rs1345406 | 24133439 | 2.69E-06 | Genotyped | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1345406-A | NA | G | NA |
| 16 | 49124128 | rs1345405 | A | G | rs1345405 | 24133439 | 2.69E-06 | Genotyped | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1345405-A | NA | T | NA |
| 16 | 49124169 | rs1345404 | A | G | rs1345404 | 24133439 | 2.69E-06 | Imputed | 1.63 | [0.95-2.31] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1345404-A | NA | T | NA |
| 16 | 49125344 | rs1362594 | C | G | rs1362594 | 24133439 | 4.09E-06 | Imputed | 1.65 | [0.95-2.35] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1362594-C | NA | G | NA |
| 16 | 49126988 | rs1861572 | T | A | rs1861572 | 24133439 | 2.67E-06 | Imputed | 1.64 | [0.96-2.31] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1861572-A | NA | T | NA |
| 16 | 49127550 | rs753858 | T | C | rs753858 | 24133439 | 2.66E-06 | Imputed | 1.64 | [0.96-2.31] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs753858-C | NA | T | NA |
| 16 | 49129088 | rs4785161 | C | A | rs4785161 | 24133439 | 2.66E-06 | Imputed | 1.64 | [0.96-2.31] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4785161-A | NA | C | NA |
| 16 | 49136065 | rs2883805 | G | T | rs2883805 | 24133439 | 2.59E-06 | Imputed | 1.64 | [0.96-2.32] unit decrease | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs2883805-G | NA | G | NA |
| 16 | 49142506 | rs16946931 | T | C | rs16946931 | 24133439 | 2.00E-06 | NA | 1.68 | [1-2.37] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs16946931-C | NA | T | NA |
| 16 | 54745268 | rs9928941 | A | G | rs9928941 | 21182207 | 2.40E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 16 | 55043667 | rs4622507 | T | C | rs4622507 | 24564958 | 2.00E-06 | (Age 17) | 0.15 | [0.091-0.209] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs4622507-C | NA | G | NA |
| 16 | 62672612 | rs288604 | G | A | rs288604 | 22843504 | 2.98E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 16 | 80964131 | rs12446053 | G | A | rs12446053 | 21182207 | 2.10E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 16 | 81070697 | rs2602431 | A | G | rs2602431 | 21182207 | 6.60E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 16 | 84213684 | rs4150167 | C | T | rs4150167 | 22843504 | 3.00E-07 | Spectrum, all | 1.96 | [1.52-2.56] | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 16 | 88967437 | rs533581 | T | C | rs533581 | 24133439 | 8.00E-06 | NA | 1.36 | [0.77-1.96] unit increase | 965 European ancestry young adults | European(965) | ALL(965) | EUR(965) | ALL(965) | Social autistic-like traits | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs533581-C | NA | C | CBFA2T3 |
| 17 | 125892 | rs7207517 | C | T | rs7207517 | 22843504 | 3.05E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 17 | 26131326 | rs2779251 | G | A | rs2779251 | 22935194 | 1.49E-08 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | G | NA |
| 17 | 46394050 | rs7218167 | G | A | rs7218167 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 17 | 59388010 | rs3902107 | G | A | rs3902107 | 21182207 | 5.10E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 17 | 59389420 | rs1034911 | A | G | rs1034911 | 21182207 | 1.50E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 17 | 71064226 | rs9302952 | A | C | rs9302952 | 22843504 | 4.04E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 17 | 75545954 | rs12947286 | C | T | rs12947286 | 22412387 | 0.0000068 | NA | NA | NA | 943 families | NOPOP(943) | ALL(943) | NOPOP(943) | ALL(943) | Autism spectrum disorders | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | NA | Research Support, Non-U.S. Gov't | T | LOC100507351 |
| 18 | 3183354 | rs10853291 | T | C | rs10853291 | 24189344 | 9.83E-06 | NA | 1.43 | NA | 275 Chinese ancestry cases; 550 Chinese ancestry controls from 275 trios; 136 Chinese ancestry cases; 984 Chinese ancestry controls | Chinese(1945) | ALL(1945) | ASN(1945) | ALL(1945) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | rs10853291-T | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Intramural | C |
| 18 | 5529675 | rs1539809 | C | T | rs1539809 | 24564958 | 2.00E-06 | (Age 17) | 0.33 | [0.19-0.47] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs1539809-T | NA | T | EPB41L3 |
| 18 | 7034946 | rs600695 | G | A | rs600695 | 22843504 | 3.58E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 18 | 35078682 | rs17750321 | C | A | rs17750321 | 24564958 | 5.00E-06 | (Age 8) | 0.3 | [0.18-0.42] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs17750321-A | NA | C | CELF4 |
| 18 | 36005511 | rs932026 | G | A | rs932026 | 22843504 | 1.47E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 18 | 47093864 | rs2000813 | C | T | rs2000813 | 22843504 | 2.62E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 18 | 47640008 | rs9954152 | A | C | rs9954152 | 21182207 | 1.60E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 18 | 47643188 | rs2457965 | C | A | rs2457965 | 21182207 | 9.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 18 | 72987489 | rs2581644 | T | C | rs2581644 | 21182207 | 4.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 19 | 38912764 | rs892055 | A | G | rs892055 | 21182207 | 5.00E-06 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 19 | 41851509 | rs4803455 | C | A | rs4803455 | 21182207 | 5.30E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 20 | 4973456 | rs6053022 | A | G | rs6053022 | 22843504 | 4.97E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 20 | 8865718 | rs3761168 | C | A | rs3761168 | 24564958 | 8.00E-08 | (Age 17) | 0.32 | [0.2-0.44] unit increase | Up to 5,628 European ancestry individuals | European(5628) | ALL(5628) | EUR(5628) | ALL(5628) | Social communication problems | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | NA | NA | NA | NA | Autistic disorder | rs3761168-A | NA | T | PLCB1 |
| 20 | 14747471 | rs4141463 | T | C | rs4141463 | 20663923 | 4.00E-08 | Str | 1.37 | [1.22-1.52] | 1,385 affected children from 1,369 families | NOPOP(1385) | ALL(1385) | NOPOP(1385) | ALL(1385) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | T |
| 20 | 14862972 | rs6110458 | C | T | rs6110458 | 22843504 | 1.81E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 20 | 14865156 | rs14135 | T | C | rs14135 | 22843504 | 1.78E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | A |
| 20 | 14867422 | rs1475531 | G | T | rs1475531 | 22843504 | 2.01E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 20 | 18885738 | rs742731 | G | A | rs742731 | 21182207 | 6.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 20 | 36650065 | rs6022419 | A | G | rs6022419 | 21182207 | 2.00E-05 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 21 | 17295733 | rs389270 | T | C | rs389270 | 21182207 | 7.00E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 21 | 39865150 | rs2836439 | C | T | rs2836439 | 22843504 | 6.64E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| 21 | 42892056 | rs6517673 | G | A | rs6517673 | 21182207 | 1.20E-04 | NA | NA | NA | 843 family members | NOPOP(843) | ALL(843) | NOPOP(843) | ALL(843) | Asperger disorder | HPOID:0000717 | Autism | DOID:0050432 | Asperger syndrome | D020817 | Asperger Syndrome | NA | NA | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | G |
| 22 | 27199237 | rs9608521 | C | T | rs9608521 | 22843504 | 7.62E-07 | NA | NA | NA | 1,419 European ancestry cases from 1416 families | European(1419) | ALL(1419) | EUR(1419) | ALL(1419) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | C |
| X | 4930801 | rs11798405 | A | G | rs11798405 | 22935194 | 0.000186 | NA | NA | NA | Up to 2,165 individuals of European, East Asian, South Asian and African American ancestries | South Asian,East Asian,European,African American(2165) | ALL(2165) | SAN,ASN,EUR,AFR(2165) | ALL(2165) | Autism | HPOID:0000717 | Autism | DOID:0060041 | autism spectrum disorder | D001321 | Autistic Disorder | EFOID:0003758 | autism | Autistic disorder | NA | Research Support, Non-U.S. Gov't | A | NA |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:31) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0004352 | acetaminophen | D000082 | 103-90-2 | autistic disorder | MESH:D001321 | marker/mechanism | 18445737 | ||
| C0004352 | s-adenosylmethionine | D012436 | 29908-03-0 | autistic disorder | MESH:D001321 | marker/mechanism | 16917939 | ||
| C0004352 | aripiprazole | D000068180 | - | autistic disorder | MESH:D001321 | therapeutic | 17069544 | ||
| C0004352 | buspirone | D002065 | 36505-84-7 | autistic disorder | MESH:D001321 | therapeutic | 18056831 | ||
| C0004352 | choline | D002794 | 62-49-7 | autistic disorder | MESH:D001321 | marker/mechanism | 16818868 | ||
| C0004352 | citalopram | D015283 | 59729-33-8 | autistic disorder | MESH:D001321 | therapeutic | 18775368 | ||
| C0004352 | clonidine | D003000 | 4205-90-7 | autistic disorder | MESH:D001321 | therapeutic | 1479049 | ||
| C0004352 | creatine | D003401 | 57-00-1 | autistic disorder | MESH:D001321 | marker/mechanism | 16818868 | ||
| C0004352 | cyproheptadine | D003533 | 129-03-3 | autistic disorder | MESH:D001321 | therapeutic | 15068403 | ||
| C0004352 | digoxin | D004077 | 20830-75-5 | autistic disorder | MESH:D001321 | marker/mechanism | 14585753 | ||
| C0004352 | fenfluramine | D005277 | 458-24-2 | autistic disorder | MESH:D001321 | therapeutic | 2606882 | ||
| C0004352 | fluoxetine | D005473 | 54910-89-3 | autistic disorder | MESH:D001321 | therapeutic | 15246500 | ||
| C0004352 | fluvoxamine | D016666 | 54739-18-3 | autistic disorder | MESH:D001321 | therapeutic | 12607287 | ||
| C0004352 | folic acid | D005492 | 59-30-3 | autistic disorder | MESH:D001321 | marker/mechanism | 21388746 | ||
| C0004352 | glutathione | D005978 | 70-18-8 | autistic disorder | MESH:D001321 | marker/mechanism | 16917939 | ||
| C0004352 | haloperidol | D006220 | 52-86-8 | autistic disorder | MESH:D001321 | therapeutic | 11476129 | ||
| C0004352 | leuprolide | D016729 | 53714-56-0 | autistic disorder | MESH:D001321 | therapeutic | 17187010 | ||
| C0004352 | methylphenidate | D008774 | 113-45-1 | autistic disorder | MESH:D001321 | therapeutic | 16919137 | ||
| C0004352 | mirtazapine | C035133 | - | autistic disorder | MESH:D001321 | therapeutic | 16648008 | ||
| C0004352 | norepinephrine | D009638 | 51-41-2 | autistic disorder | MESH:D001321 | marker/mechanism | 8570775 | ||
| C0004352 | olanzapine | C076029 | 132539-06-1 | autistic disorder | MESH:D001321 | therapeutic | 17069543 | ||
| C0004352 | oxytocin | D010121 | 50-56-6 | autistic disorder | MESH:D001321 | therapeutic | 16904652 | ||
| C0004352 | propranolol | D011433 | 525-66-6 | autistic disorder | MESH:D001321 | therapeutic | 18766980 | ||
| C0004352 | sapropterin | C003402 | - | autistic disorder | MESH:D001321 | therapeutic | 16160627 | ||
| C0004352 | sirolimus | D020123 | 53123-88-9 | autistic disorder | MESH:D001321 | therapeutic | 21115397 | ||
| C0004352 | spironolactone | D013148 | 1952/1/7 | autistic disorder | MESH:D001321 | therapeutic | 17150311 | ||
| C0004352 | succimer | D004113 | 304-55-2 | autistic disorder | MESH:D001321 | therapeutic | 17187010 | ||
| C0004352 | thalidomide | D013792 | 50-35-1 | autistic disorder | MESH:D001321 | marker/mechanism | 10360298 | ||
| C0004352 | valproic acid | D014635 | 99-66-1 | autistic disorder | MESH:D001321 | marker/mechanism | 11263692 | ||
| C0004352 | valproic acid | D014635 | 99-66-1 | autistic disorder | MESH:D001321 | therapeutic | 18775368 | ||
| C0004352 | ziprasidone | C092292 | 146939-27-7 | autistic disorder | MESH:D001321 | therapeutic | 18315450 | ||
FDA approved drug and dosage information(Total Drugs:30) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D001321 | remeron | mirtazapine | 15MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D001321 | rapamune | sirolimus | 1MG/ML | SOLUTION;ORAL | Prescription | None | Yes | Yes |
| MESH:D001321 | rapamune | sirolimus | 1MG | TABLET;ORAL | Prescription | AB | Yes | No |
| MESH:D001321 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
| MESH:D001321 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
| MESH:D001321 | daytrana | methylphenidate | 10MG/9HR (1.1MG/HR) | FILM, EXTENDED RELEASE;TRANSDERMAL | Prescription | None | Yes | No |
| MESH:D001321 | abilify | aripiprazole | 10MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D001321 | abilify | aripiprazole | 1MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | SOLUTION;ORAL | Discontinued | None | Yes | No |
| MESH:D001321 | abilify | aripiprazole | 10MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET, ORALLY DISINTEGRATING;ORAL | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 9.75MG/1.3ML (7.5MG/ML) | INJECTABLE;INTRAMUSCULAR | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 10MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D001321 | abilify | aripiprazole | 1MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | SOLUTION;ORAL | Discontinued | None | Yes | No |
| MESH:D001321 | abilify | aripiprazole | 10MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET, ORALLY DISINTEGRATING;ORAL | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 9.75MG/1.3ML (7.5MG/ML) | INJECTABLE;INTRAMUSCULAR | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 10MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D001321 | abilify | aripiprazole | 1MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | SOLUTION;ORAL | Discontinued | None | Yes | No |
| MESH:D001321 | abilify | aripiprazole | 10MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET, ORALLY DISINTEGRATING;ORAL | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 9.75MG/1.3ML (7.5MG/ML) | INJECTABLE;INTRAMUSCULAR | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 10MG | TABLET;ORAL | Prescription | AB | Yes | Yes |
| MESH:D001321 | abilify | aripiprazole | 1MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | SOLUTION;ORAL | Discontinued | None | Yes | No |
| MESH:D001321 | abilify | aripiprazole | 10MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons | TABLET, ORALLY DISINTEGRATING;ORAL | Discontinued | None | No | No |
| MESH:D001321 | abilify | aripiprazole | 9.75MG/1.3ML (7.5MG/ML) | INJECTABLE;INTRAMUSCULAR | Discontinued | None | No | No |
| MESH:D001321 | zyprexa | olanzapine | 2.5MG | TABLET;ORAL | Prescription | AB | Yes | No |
| MESH:D001321 | zyprexa | olanzapine | 10MG/VIAL | INJECTABLE;INTRAMUSCULAR | Prescription | AP | Yes | Yes |
| MESH:D001321 | zyprexa | olanzapine | 2.5MG | TABLET;ORAL | Prescription | AB | Yes | No |
| MESH:D001321 | zyprexa | olanzapine | 10MG/VIAL | INJECTABLE;INTRAMUSCULAR | Prescription | AP | Yes | Yes |
| MESH:D001321 | ofirmev | acetaminophen | 1GM/100ML (10MG/ML) | SOLUTION;IV (INFUSION) | Prescription | AP | Yes | Yes |
| MESH:D001321 | ofirmev | acetaminophen | 1GM/100ML (10MG/ML) | SOLUTION;IV (INFUSION) | Prescription | AP | Yes | Yes |
| MESH:D001321 | acetaminophen | acetaminophen | 650MG | SUPPOSITORY;RECTAL | Over-the-counter | None | Yes | Yes |
| MESH:D001321 | acetaminophen | acetaminophen | 650MG | SUPPOSITORY;RECTAL | Over-the-counter | None | Yes | Yes |
FDA labeling changes(Total Drugs:30) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D001321 | 12/1/2005 | remeron | mirtazapine | Major Depressive Disorder | Safety and effectiveness in the pediatric population have not been established FDA required boxed warning for all antidepressants: Suicidality in Children and Adolescents - Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of Remeron or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Remeron is not approved for use in pediatric patients. (See Warnings and Precautions: Pediatric Use) Pooled analyses of short-term (4 to 16 weeks) placebo-controlled trials of 9 antidepressant drugs (SSRIs and others) in children and adolescents with major depressive disorder (MDD), obsessive compulsive disorder (OCD), or other psychiatric disorders (a total of 24 trials involving over 4400 patients) have revealed a greater risk of adverse events representing suicidal thinking or behavior (suicidality) during the first few months of treatment in those receiving antidepressants. The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. No suicides occurred in these trials Two placebo-controlled trials in 258 pediatric patients with MDD have been conducted with Remeron and the data were not sufficient to support a claim for use in pediatric patients | Labeling | B | - | - | - | Organon | - | FALSE' |
| MESH:D001321 | 11/3/2005 | rapamune | sirolimus | Prophylaxis of organ rejection in patients undergoing renal transplants | Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric ( | Labeling | B | - | - | - | Wyeth | 11/17/2004 | FALSE' |
| MESH:D001321 | 11/3/2005 | rapamune | sirolimus | Prophylaxis of organ rejection in patients undergoing renal transplants | Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric ( | Labeling | B | - | - | - | Wyeth | 11/17/2004 | FALSE' |
| MESH:D001321 | 6/4/2006 | daytrana | methylphenidate | ADHD | Summary is pending | Labeling | - | P | - | - | Shire | - | FALSE' |
| MESH:D001321 | 12/14/2009 | daytrana | methylphenidate | Postmarketing safety study | Information added to Warnings and Adverse Reactions on skin reactions observed in a postmarketing dermal study in pediatric patients | Labeling | - | P | - | - | Shire | - | FALSE' |
| MESH:D001321 | 06/29/2010 | daytrana | methylphenidate | ADHD | Expanded pediatric indication to include adolescent patients ages13-17 years The most commonly reported adverse reactions in a trial in patients 13-17 years included appetite decreased, nausea, insomnia, weight decreased, dizziness, abdominal pain, and anorexia. The majority of patients had erythema at the application site Information on PK parameters, Adverse Event profile and clinical studies | Labeling | - | P | - | - | Shire | - | FALSE' |
| MESH:D001321 | 10/29/2007 | abilify | aripiprazole | Schizophrenia | Extended schizophrenia indication from adults to adolescents 1317 years Safety and effectiveness in pediatric patients with bipolar mania or agitation associated with schizophrenia or bipolar mania have not been established Efficacy for the maintenance treatment of schizophrenia in the pediatric population has not been evaluated In 6-week placebo controlled efficacy trial in patients 13 17 years with Schizophrenia 30 mg/day was not shown to be more efficacious than 10 mg/day Common adverse events observed were extrapyramidal disorder, somnolence, and tremor; these 3 AEs appear to have a possible dose response relationship Information on dose, AEs, clinical studies | Labeling | B | - | - | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 10/29/2007 | abilify | aripiprazole | Schizophrenia | Extended schizophrenia indication from adults to adolescents 1317 years Safety and effectiveness in pediatric patients with bipolar mania or agitation associated with schizophrenia or bipolar mania have not been established Efficacy for the maintenance treatment of schizophrenia in the pediatric population has not been evaluated In 6-week placebo controlled efficacy trial in patients 13 17 years with Schizophrenia 30 mg/day was not shown to be more efficacious than 10 mg/day Common adverse events observed were extrapyramidal disorder, somnolence, and tremor; these 3 AEs appear to have a possible dose response relationship Information on dose, AEs, clinical studies | Labeling | B | - | - | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 10/29/2007 | abilify | aripiprazole | Schizophrenia | Extended schizophrenia indication from adults to adolescents 1317 years Safety and effectiveness in pediatric patients with bipolar mania or agitation associated with schizophrenia or bipolar mania have not been established Efficacy for the maintenance treatment of schizophrenia in the pediatric population has not been evaluated In 6-week placebo controlled efficacy trial in patients 13 17 years with Schizophrenia 30 mg/day was not shown to be more efficacious than 10 mg/day Common adverse events observed were extrapyramidal disorder, somnolence, and tremor; these 3 AEs appear to have a possible dose response relationship Information on dose, AEs, clinical studies | Labeling | B | - | - | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 10/29/2007 | abilify | aripiprazole | Schizophrenia | Extended schizophrenia indication from adults to adolescents 1317 years Safety and effectiveness in pediatric patients with bipolar mania or agitation associated with schizophrenia or bipolar mania have not been established Efficacy for the maintenance treatment of schizophrenia in the pediatric population has not been evaluated In 6-week placebo controlled efficacy trial in patients 13 17 years with Schizophrenia 30 mg/day was not shown to be more efficacious than 10 mg/day Common adverse events observed were extrapyramidal disorder, somnolence, and tremor; these 3 AEs appear to have a possible dose response relationship Information on dose, AEs, clinical studies | Labeling | B | - | - | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 02/27/2008 | abilify | aripiprazole | Bipolar I Disorder | Extended treatment of acute Bipolar Disorder indication from adults to pediatrics 1017 years The efficacy for the maintenance treatment of Bipolar Disorder in the pediatric population has not been evaluated The recommended target dose in Bipolar Disorder is 10 mg/day. In the study of pediatric patients 10 17 years with Bipolar Mania, 4 common adverse reactions had a possible dose response relationship at 4 weeks; extrapyramidal disorder, somnolence, akathisia and salivary hypersecretion Information on dose, AEs, clinical studies | Labeling | - | - | B, P | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 02/27/2008 | abilify | aripiprazole | Bipolar I Disorder | Extended treatment of acute Bipolar Disorder indication from adults to pediatrics 1017 years The efficacy for the maintenance treatment of Bipolar Disorder in the pediatric population has not been evaluated The recommended target dose in Bipolar Disorder is 10 mg/day. In the study of pediatric patients 10 17 years with Bipolar Mania, 4 common adverse reactions had a possible dose response relationship at 4 weeks; extrapyramidal disorder, somnolence, akathisia and salivary hypersecretion Information on dose, AEs, clinical studies | Labeling | - | - | B, P | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 02/27/2008 | abilify | aripiprazole | Bipolar I Disorder | Extended treatment of acute Bipolar Disorder indication from adults to pediatrics 1017 years The efficacy for the maintenance treatment of Bipolar Disorder in the pediatric population has not been evaluated The recommended target dose in Bipolar Disorder is 10 mg/day. In the study of pediatric patients 10 17 years with Bipolar Mania, 4 common adverse reactions had a possible dose response relationship at 4 weeks; extrapyramidal disorder, somnolence, akathisia and salivary hypersecretion Information on dose, AEs, clinical studies | Labeling | - | - | B, P | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 02/27/2008 | abilify | aripiprazole | Bipolar I Disorder | Extended treatment of acute Bipolar Disorder indication from adults to pediatrics 1017 years The efficacy for the maintenance treatment of Bipolar Disorder in the pediatric population has not been evaluated The recommended target dose in Bipolar Disorder is 10 mg/day. In the study of pediatric patients 10 17 years with Bipolar Mania, 4 common adverse reactions had a possible dose response relationship at 4 weeks; extrapyramidal disorder, somnolence, akathisia and salivary hypersecretion Information on dose, AEs, clinical studies | Labeling | - | - | B, P | - | Otsuka | 11/14/2007 | FALSE' |
| MESH:D001321 | 11/19/2009 | abilify | aripiprazole | Irritability associated with autistic disorder | Safety and effectiveness in pediatric patients demonstrating irritability associated with autistic disorder were established in two placebo-controlled clinical trials in pediatric patients 6 - 17 years of age Most common adverse reactions observed in pediatric clinical trials in patients with autistic disorder included sedation, fatigue, vomiting, somnolence, tremor, pyrexia, drooling, decreased appetite, salivary hypersecretion, extrapyramidal disorder, and lethargy. Fatigue was a possible dose-response adverse reaction. Information on dosing, adverse reactions, and clinical studies | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 11/19/2009 | abilify | aripiprazole | Irritability associated with autistic disorder | Safety and effectiveness in pediatric patients demonstrating irritability associated with autistic disorder were established in two placebo-controlled clinical trials in pediatric patients 6 - 17 years of age Most common adverse reactions observed in pediatric clinical trials in patients with autistic disorder included sedation, fatigue, vomiting, somnolence, tremor, pyrexia, drooling, decreased appetite, salivary hypersecretion, extrapyramidal disorder, and lethargy. Fatigue was a possible dose-response adverse reaction. Information on dosing, adverse reactions, and clinical studies | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 11/19/2009 | abilify | aripiprazole | Irritability associated with autistic disorder | Safety and effectiveness in pediatric patients demonstrating irritability associated with autistic disorder were established in two placebo-controlled clinical trials in pediatric patients 6 - 17 years of age Most common adverse reactions observed in pediatric clinical trials in patients with autistic disorder included sedation, fatigue, vomiting, somnolence, tremor, pyrexia, drooling, decreased appetite, salivary hypersecretion, extrapyramidal disorder, and lethargy. Fatigue was a possible dose-response adverse reaction. Information on dosing, adverse reactions, and clinical studies | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 11/19/2009 | abilify | aripiprazole | Irritability associated with autistic disorder | Safety and effectiveness in pediatric patients demonstrating irritability associated with autistic disorder were established in two placebo-controlled clinical trials in pediatric patients 6 - 17 years of age Most common adverse reactions observed in pediatric clinical trials in patients with autistic disorder included sedation, fatigue, vomiting, somnolence, tremor, pyrexia, drooling, decreased appetite, salivary hypersecretion, extrapyramidal disorder, and lethargy. Fatigue was a possible dose-response adverse reaction. Information on dosing, adverse reactions, and clinical studies | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 9/6/2014 | abilify | aripiprazole | Maintenance treatment of irritability associated with autistic disorder | Efficacy for the maintenance treatment of irritability associated with autistic disorder was not established in a 12 week clinical trial in 85 pediatric patients 6-17 years Information on clinical trialPostmarketing study | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 9/6/2014 | abilify | aripiprazole | Maintenance treatment of irritability associated with autistic disorder | Efficacy for the maintenance treatment of irritability associated with autistic disorder was not established in a 12 week clinical trial in 85 pediatric patients 6-17 years Information on clinical trialPostmarketing study | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 9/6/2014 | abilify | aripiprazole | Maintenance treatment of irritability associated with autistic disorder | Efficacy for the maintenance treatment of irritability associated with autistic disorder was not established in a 12 week clinical trial in 85 pediatric patients 6-17 years Information on clinical trialPostmarketing study | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 9/6/2014 | abilify | aripiprazole | Maintenance treatment of irritability associated with autistic disorder | Efficacy for the maintenance treatment of irritability associated with autistic disorder was not established in a 12 week clinical trial in 85 pediatric patients 6-17 years Information on clinical trialPostmarketing study | Labeling | - | P | - | - | Otsuka | - | FALSE' |
| MESH:D001321 | 08/14/2008 | zyprexa | olanzapine | schizophrenia; bipolar disorder | Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg | - | B | - | - | - | Lilly | 10/1/2007 | FALSE' |
| MESH:D001321 | 08/14/2008 | zyprexa | olanzapine | schizophrenia; bipolar disorder | Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg | - | B | - | - | - | Lilly | 10/1/2007 | FALSE' |
| MESH:D001321 | 4/12/2009 | zyprexa | olanzapine | Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17 | Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies | Labeling | B | - | - | - | Lilly | 10/1/2007 | TRUE' |
| MESH:D001321 | 4/12/2009 | zyprexa | olanzapine | Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17 | Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies | Labeling | B | - | - | - | Lilly | 10/1/2007 | TRUE' |
| MESH:D001321 | 2/11/2010 | ofirmev | acetaminophen | Management of mild-to-moderate pain, for the management of moderate-to-severe pain with adjunctive opioid analgesics, and for the reduction of fever | The safety and effectiveness of Ofirmev for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of Ofirmev in adults. Additional safety and PK data was collected in 355 from premature neonates to adolescents. The effectiveness of Ofirmev for the treatment of acute pain and fever has not been studied in pediatric patients < 2 years of age.The PK exposure of Ofirmev observed in children and adolescents is similar to adults, but higher in neonates and infants. Dosing simulations from PK data in infants and neonates suggest that dose reductions of 33% in infants 1 month to < 2 years of age, and 50% in neonates up to 28 days, with a minimum dosing interval of 6 hours, will produce a PK exposure similar to that observed in children age 2 years and olderMost common adverse reactions in pediatric patients were nausea, vomiting, constipation, pruritus, agitation, and atelectasis.Information on dosing, clinical studies, adverse reactions and PK parametersNew dosage form and route of administration | Labeling | - | P | - | - | Cadence | - | FALSE' |
| MESH:D001321 | 01/27/2017 | ofirmev | acetaminophen | Treatmeny of pain and fever in pediatric patients birth to 2 years | Treatment of pain Efficacy was not demonstrated in pediatric patients younger than 2 years in a double-blind, placebo-controlled study of 198 pediatric patients younger than 2 years. Pediatric patients less than 2 years of age, including neonates from 28 to 40 weeks gestational age at birth, were randomized to receive opioid plus acetaminophen or opioid plus placebo. No difference in analgesic effect of intravenous acetaminophen, measured by assessment of reduced need for additional opioid treatment for pain control, was observed. Treatment of fever The safety and effectiveness for the treatment of fever in pediatric patients, including premature neonates born at 32 weeks or greater gestation is supported by adequate and well-controlled studies of Ofirmev in adults, clinical studies in 244 pediatric patients 2 years and older, and safety and pharmacokinetic data from 239 patients younger than 2 years including neonates 32 weeks or greater gestational age. Information on dosing, clinical trials. Postmarketing study. | Labeling | - | - | B,P | - | Mallinckrodt | 11/7/2016 | FALSE |
| MESH:D001321 | 2/11/2010 | ofirmev | acetaminophen | Management of mild-to-moderate pain, for the management of moderate-to-severe pain with adjunctive opioid analgesics, and for the reduction of fever | The safety and effectiveness of Ofirmev for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of Ofirmev in adults. Additional safety and PK data was collected in 355 from premature neonates to adolescents. The effectiveness of Ofirmev for the treatment of acute pain and fever has not been studied in pediatric patients < 2 years of age.The PK exposure of Ofirmev observed in children and adolescents is similar to adults, but higher in neonates and infants. Dosing simulations from PK data in infants and neonates suggest that dose reductions of 33% in infants 1 month to < 2 years of age, and 50% in neonates up to 28 days, with a minimum dosing interval of 6 hours, will produce a PK exposure similar to that observed in children age 2 years and olderMost common adverse reactions in pediatric patients were nausea, vomiting, constipation, pruritus, agitation, and atelectasis.Information on dosing, clinical studies, adverse reactions and PK parametersNew dosage form and route of administration | Labeling | - | P | - | - | Cadence | - | FALSE' |
| MESH:D001321 | 01/27/2017 | ofirmev | acetaminophen | Treatmeny of pain and fever in pediatric patients birth to 2 years | Treatment of pain Efficacy was not demonstrated in pediatric patients younger than 2 years in a double-blind, placebo-controlled study of 198 pediatric patients younger than 2 years. Pediatric patients less than 2 years of age, including neonates from 28 to 40 weeks gestational age at birth, were randomized to receive opioid plus acetaminophen or opioid plus placebo. No difference in analgesic effect of intravenous acetaminophen, measured by assessment of reduced need for additional opioid treatment for pain control, was observed. Treatment of fever The safety and effectiveness for the treatment of fever in pediatric patients, including premature neonates born at 32 weeks or greater gestation is supported by adequate and well-controlled studies of Ofirmev in adults, clinical studies in 244 pediatric patients 2 years and older, and safety and pharmacokinetic data from 239 patients younger than 2 years including neonates 32 weeks or greater gestational age. Information on dosing, clinical trials. Postmarketing study. | Labeling | - | - | B,P | - | Mallinckrodt | 11/7/2016 | FALSE |