PedAM

Pediatric Disease Annotations & Medicines


	atrioventricular block

Disease ID	889
Disease	atrioventricular block
Definition	Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
Synonym	atriovent block nos atrioventricular block (disorder) atrioventricular block (nos) atrioventricular block [disease/finding] atrioventricular block by ecg finding atrioventricular block by ekg finding atrioventricular block nos atrioventricular block nos (disorder) atrioventricular block unspecified atrioventricular block unspecified (disorder) atrioventricular block, nos atrioventricular block, unspecified atrioventricular blocks atrioventricular conduction block atrioventricular conduction blocks atrioventricular heart block av block av block (nos) av block, nos av blocks av heart block avb - atrioventricular block block, av blocks, av conduction block, atrioventricular conduction blocks, atrioventricular heart block atrioventricular
DOID	DOID:0050820
UMLS	C0004245
MeSH	D054537
SNOMED-CT	SNOMEDCT_US_2016_09_01:233917008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:41) C0027051 \| myocardial infarct \| 8 C0878544 \| cardiomyopathy \| 8 C0018801 \| heart failure \| 8 C0027051 \| myocardial infarction \| 8 C0007193 \| dilated cardiomyopathy \| 4 C0027059 \| myocarditis \| 3 C0036202 \| sarcoidosis \| 3 C0392077 \| cardiac sarcoidosis \| 3 C0040127 \| thyroid storm \| 2 C0018801 \| cardiac failure \| 2 C0264793 \| idiopathic dilated cardiomyopathy \| 2 C0023976 \| long qt syndrome \| 2 C0006384 \| bundle branch block \| 2 C0024299 \| lymphoma \| 2 C0037052 \| sick sinus syndrome \| 2 C0085615 \| right bundle branch block \| 1 C0002736 \| amyotrophic lateral sclerosis \| 1 C0007194 \| hypertrophic cardiomyopathy \| 1 C0342208 \| multinodular goiter \| 1 C0009319 \| colitis \| 1 C0003507 \| aortic valve stenosis \| 1 C0018023 \| nodular goiter \| 1 C0745140 \| hyperthyroid \| 1 C0155686 \| acute myocarditis \| 1 C0079731 \| b-cell lymphoma \| 1 C0340305 \| inferior myocardial infarction \| 1 C0026269 \| mitral stenosis \| 1 C0013264 \| duchenne muscular dystrophy \| 1 C0040156 \| thyrotoxicosis \| 1 C0268547 \| argininosuccinic aciduria \| 1 C0014547 \| partial epilepsy \| 1 C0042769 \| virus infection \| 1 C0023267 \| leiomyoma \| 1 C0027051 \| myocardial infarction (mi) \| 1 C0003507 \| aortic stenosis \| 1 C0040961 \| tricuspid regurgitation \| 1 C0085615 \| right bundle-branch block \| 1 C0155626 \| acute myocardial infarction \| 1 C1332850 \| primary cardiac lymphoma \| 1 C0033975 \| psychosis \| 1 C0040046 \| thrombophlebitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) GNAI2 \| 2771 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:176) 3784 \| KCNQ1 \| DISEASES 350 \| APOH \| DISEASES 5327 \| PLAT \| DISEASES 3912 \| LAMB1 \| DISEASES 79176 \| FBXL15 \| DISEASES 1410 \| CRYAB \| DISEASES 1594 \| CYP27B1 \| DISEASES 55856 \| ACOT13 \| DISEASES 3764 \| KCNJ8 \| DISEASES 84329 \| HVCN1 \| DISEASES 55154 \| MSTO1 \| DISEASES 9002 \| F2RL3 \| DISEASES 54795 \| TRPM4 \| DISEASES 6737 \| TRIM21 \| DISEASES 7014 \| TERF2 \| DISEASES 1401 \| CRP \| DISEASES 2230 \| FDX1 \| DISEASES 6741 \| SSB \| DISEASES 845 \| CASQ2 \| DISEASES 10021 \| HCN4 \| DISEASES 3757 \| KCNH2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 22858 \| ICK \| DISEASES 390 \| RND3 \| DISEASES 2121 \| EVC \| DISEASES 3371 \| TNC \| DISEASES 644 \| BLVRA \| DISEASES 8048 \| CSRP3 \| DISEASES 3746 \| KCNC1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 775 \| CACNA1C \| DISEASES 51411 \| BIN2 \| DISEASES 2702 \| GJA5 \| DISEASES 805 \| CALM2 \| DISEASES 319100 \| TAAR6 \| DISEASES 4851 \| NOTCH1 \| DISEASES 138151 \| NACC2 \| DISEASES 23082 \| PPRC1 \| DISEASES 5805 \| PTS \| DISEASES 2697 \| GJA1 \| DISEASES 10225 \| CD96 \| DISEASES 118611 \| C10orf90 \| DISEASES 4838 \| NODAL \| DISEASES 51422 \| PRKAG2 \| DISEASES 776 \| CACNA1D \| DISEASES 909 \| CD1A \| DISEASES 9992 \| KCNE2 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 3046 \| HBE1 \| DISEASES 3760 \| KCNJ3 \| DISEASES 2921 \| CXCL3 \| DISEASES 150921 \| TCF23 \| DISEASES 23305 \| ACSL6 \| DISEASES 9265 \| CYTH3 \| DISEASES 6901 \| TAZ \| DISEASES 6236 \| RRAD \| DISEASES 9640 \| ZNF592 \| DISEASES 80150 \| ASRGL1 \| DISEASES 116285 \| ACSM1 \| DISEASES 56246 \| MRAP \| DISEASES 134 \| ADORA1 \| DISEASES 5340 \| PLG \| DISEASES 171389 \| NLRP6 \| DISEASES 6910 \| TBX5 \| DISEASES 8884 \| SLC5A6 \| DISEASES 26512 \| INTS6 \| DISEASES 10290 \| SPEG \| DISEASES 11007 \| CCDC85B \| DISEASES 11238 \| CA5B \| DISEASES 3752 \| KCND3 \| DISEASES 137814 \| NKX2-6 \| DISEASES 811 \| CALR \| DISEASES 54802 \| TRIT1 \| DISEASES 78987 \| CRELD1 \| DISEASES 6330 \| SCN4B \| DISEASES 5932 \| RBBP8 \| DISEASES 1482 \| NKX2-5 \| DISEASES 3739 \| KCNA4 \| DISEASES 6331 \| SCN5A \| DISEASES 10052 \| GJC1 \| DISEASES 3751 \| KCND2 \| DISEASES 2626 \| GATA4 \| DISEASES 93974 \| ATPIF1 \| DISEASES 3753 \| KCNE1 \| DISEASES 3363 \| HTR7 \| DISEASES 23583 \| SMUG1 \| DISEASES 51337 \| THEM6 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 6614 \| SIGLEC1 \| DISEASES 7137 \| TNNI3 \| DISEASES 859 \| CAV3 \| DISEASES 9536 \| PTGES \| DISEASES 7874 \| USP7 \| DISEASES 1861 \| TOR1A \| DISEASES 1760 \| DMPK \| DISEASES 309 \| ANXA6 \| DISEASES 51703 \| ACSL5 \| DISEASES 801 \| CALM1 \| DISEASES 1121 \| CHM \| DISEASES 26151 \| NAT9 \| DISEASES 84665 \| MYPN \| DISEASES 8913 \| CACNA1G \| DISEASES 147409 \| DSG4 \| DISEASES 3360 \| HTR4 \| DISEASES 1756 \| DMD \| DISEASES 4537 \| MT-ND3 \| DISEASES 7179 \| TPTE \| DISEASES 6262 \| RYR2 \| DISEASES 88 \| ACTN2 \| DISEASES 5867 \| RAB4A \| DISEASES 7044 \| LEFTY2 \| DISEASES 7139 \| TNNT2 \| DISEASES 6738 \| TROVE2 \| DISEASES 4000 \| LMNA \| DISEASES 55974 \| SLC50A1 \| DISEASES 10654 \| PMVK \| DISEASES 153 \| ADRB1 \| DISEASES 4803 \| NGF \| DISEASES 2010 \| EMD \| DISEASES 959 \| CD40LG \| DISEASES 7803 \| PTP4A1 \| DISEASES 10964 \| IFI44L \| DISEASES 26027 \| ACOT11 \| DISEASES 8879 \| SGPL1 \| DISEASES 80312 \| TET1 \| DISEASES 84890 \| ADO \| DISEASES 26548 \| ITGB1BP2 \| DISEASES 3376 \| IARS \| DISEASES 1041 \| CDSN \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 29968 \| PSAT1 \| DISEASES 5293 \| PIK3CD \| DISEASES 8718 \| TNFRSF25 \| DISEASES 11332 \| ACOT7 \| DISEASES 388591 \| RNF207 \| DISEASES 3980 \| LIG3 \| DISEASES 5422 \| POLA1 \| DISEASES 1906 \| EDN1 \| DISEASES 3456 \| IFNB1 \| DISEASES 6019 \| RLN2 \| DISEASES 91543 \| RSAD2 \| DISEASES 440163 \| RNASE13 \| DISEASES 9467 \| SH3BP5 \| DISEASES 7021 \| TFAP2B \| DISEASES 347734 \| SLC35B2 \| DISEASES 65057 \| ACD \| DISEASES 7784 \| ZP3 \| DISEASES 83478 \| ARHGAP24 \| DISEASES 1837 \| DTNA \| DISEASES 284403 \| WDR62 \| DISEASES 6295 \| SAG \| DISEASES 2641 \| GCG \| DISEASES 3112 \| HLA-DOB \| DISEASES 2086 \| ERV3-1 \| DISEASES 6635 \| SNRPE \| DISEASES 5817 \| PVR \| DISEASES 3920 \| LAMP2 \| DISEASES 54475 \| NLE1 \| DISEASES 3712 \| IVD \| DISEASES 56244 \| BTNL2 \| DISEASES 30819 \| KCNIP2 \| DISEASES 51428 \| DDX41 \| DISEASES 493869 \| GPX8 \| DISEASES 9788 \| MTSS1 \| DISEASES 8972 \| MGAM \| DISEASES 8914 \| TIMELESS \| DISEASES 7732 \| RNF112 \| DISEASES 84033 \| OBSCN \| DISEASES 6625 \| SNRNP70 \| DISEASES 102723508 \| KANTR \| DISEASES 378938 \| MALAT1 \| DISEASES 4567 \| MT-TL1 \| DISEASES 103752588 \| PACERR \| DISEASES 6080 \| SNORA73A \| DISEASES
Locus	(Waiting for update.)

Disease ID	889
Disease	atrioventricular block
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:52) HP:0001635 \| Congestive heart failure \| 10 HP:0001662 \| Bradycardia \| 10 HP:0001638 \| Cardiomyopathy \| 7 HP:0001279 \| Syncope \| 7 HP:0011675 \| Arrhythmias \| 6 HP:0001649 \| Tachycardia \| 5 HP:0001644 \| Congestive cardiomyopathy \| 4 HP:0012819 \| Myocarditis \| 3 HP:0011710 \| Bundle-branch block \| 3 HP:0001658 \| Myocardial infarction \| 3 HP:0002665 \| Lymphoma \| 2 HP:0011712 \| Right bundle-branch block \| 2 HP:0011704 \| Sick sinus syndrome \| 2 HP:0004756 \| Ventricular tachycardia \| 2 HP:0012248 \| Lengthened PR interval on EKG \| 2 HP:0001664 \| Torsade de pointes \| 2 HP:0004755 \| Supraventricular tachycardia \| 2 HP:0005110 \| Atrial fibrillation \| 2 HP:0007354 \| Amyotrophic lateral sclerosis \| 1 HP:0012722 \| Heart block \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0004309 \| Pre-excitation syndrome \| 1 HP:0100785 \| Insomnia \| 1 HP:0005987 \| Multinodular goiter \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0001688 \| Sinus bradycardia \| 1 HP:0011540 \| Congenitally corrected transposition of the great arteries \| 1 HP:0004418 \| Thrombophlebitis \| 1 HP:0004935 \| Pulmonary atresia \| 1 HP:0005180 \| Tricuspid insufficiency \| 1 HP:0200128 \| Biventricular hypertrophy \| 1 HP:0002583 \| Colitis \| 1 HP:0001627 \| Congenital heart defects \| 1 HP:0001718 \| Mitral stenosis \| 1 HP:0001639 \| Hypertrophic cardiomyopathy \| 1 HP:0001669 \| Transposition of the great arteries \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0001709 \| Complete heart block \| 1 HP:0012592 \| Albuminuria \| 1 HP:0005994 \| Nodular goiter \| 1 HP:0004325 \| Low body weight \| 1 HP:0001657 \| Prolonged QT interval \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0000709 \| Psychosis \| 1 HP:0004754 \| Permanent atrial fibrillation \| 1 HP:0001250 \| Seizures \| 1 HP:0004757 \| Paroxysmal atrial fibrillation \| 1 HP:0004749 \| Atrial flutter \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0011703 \| Sinus tach \| 1

Disease ID	889
Disease	atrioventricular block
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0039070 \| syncope \| 7 C0039231 \| tachycardia \| 5 C0232197 \| fibrillation \| 3

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs120074189	20487114	3784	KCNQ1	umls:C0004245	BeFree	This case is the first report of fetal 2:1 AV block with KCNQ1 mutation (T587M) and unmasked maternal QT prolongation in the postpartum period.	0.002909916	2010	KCNQ1	11	2778003	C	T
rs120074192	17467630	3784	KCNQ1	umls:C0004245	BeFree	Human KCNQ1 S140G mutation is associated with atrioventricular blocks.	0.002909916	2007	KCNQ1	11	2527959	A	G
rs121913003	14991347	1674	DES	umls:C0004245	BeFree	We have previously characterized a de novo desmin R406W mutation in a patient of European origin with early onset muscle weakness in the lower extremities and atrioventricular conduction block requiring a permanent pacemaker.	0.001357209	2004	DES	2	219421532	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:51)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0004245	adenosine triphosphate	D000255	56-65-5	atrioventricular block	MESH:D054537	marker/mechanism	12381087
C0004245	amitriptyline	D000639	50-48-6	atrioventricular block	MESH:D054537	marker/mechanism	11089775
C0004245	arsenic trioxide	C006632	1327-53-3	atrioventricular block	MESH:D054537	marker/mechanism	10392399
C0004245	atenolol	D001262	29122-68-7	atrioventricular block	MESH:D054537	marker/mechanism	11229299
C0004245	atropine	D001285	51-55-8	atrioventricular block	MESH:D054537	marker/mechanism	2778956
C0004245	atropine	D001285	51-55-8	atrioventricular block	MESH:D054537	therapeutic	17711430
C0004245	bupivacaine	D002045	2180-92-9	atrioventricular block	MESH:D054537	marker/mechanism	18282259
C0004245	caffeine	D002110	1958/8/2	atrioventricular block	MESH:D054537	marker/mechanism	10337936
C0004245	carbachol	D002217	-	atrioventricular block	MESH:D054537	marker/mechanism	17277016
C0004245	carbamazepine	D002220	298-46-4	atrioventricular block	MESH:D054537	marker/mechanism	1148068
C0004245	carteolol	D002354	51781-06-7	atrioventricular block	MESH:D054537	marker/mechanism	12571398
C0004245	cladribine	D017338	4291-63-8	atrioventricular block	MESH:D054537	marker/mechanism	15561348
C0004245	chloroquine	D002738	1954/5/7	atrioventricular block	MESH:D054537	marker/mechanism	10381062
C0004245	chlorpromazine	D002746	50-53-3	atrioventricular block	MESH:D054537	marker/mechanism	1011369
C0004245	cimetidine	D002927	51481-61-9	atrioventricular block	MESH:D054537	marker/mechanism	2880057
C0004245	cisapride	D020117	81098-60-4	atrioventricular block	MESH:D054537	marker/mechanism	12595600
C0004245	clonidine	D003000	4205-90-7	atrioventricular block	MESH:D054537	marker/mechanism	3341873
C0004245	cyclophosphamide	D003520	50-18-0	atrioventricular block	MESH:D054537	marker/mechanism	17223814
C0004245	dapsone	D003622	80-08-0	atrioventricular block	MESH:D054537	marker/mechanism	19583683
C0004245	diatrizoate	D003973	117-96-4	atrioventricular block	MESH:D054537	marker/mechanism	3057857
C0004245	digoxin	D004077	20830-75-5	atrioventricular block	MESH:D054537	marker/mechanism	15334025
C0004245	diltiazem	D004110	42399-41-7	atrioventricular block	MESH:D054537	marker/mechanism	15234417
C0004245	disopyramide	D004206	3737/9/5	atrioventricular block	MESH:D054537	marker/mechanism	3970790
C0004245	doxapram	D004315	309-29-5	atrioventricular block	MESH:D054537	marker/mechanism	9672531
C0004245	enflurane	D004737	13838-16-9	atrioventricular block	MESH:D054537	marker/mechanism	3605739
C0004245	epirubicin	D015251	56420-45-2	atrioventricular block	MESH:D054537	marker/mechanism	17223814
C0004245	erythromycin	D004917	114-07-8	atrioventricular block	MESH:D054537	marker/mechanism	11724091
C0004245	etomidate	D005045	33125-97-2	atrioventricular block	MESH:D054537	marker/mechanism	18210663
C0004245	fluorouracil	D005472	51-21-8	atrioventricular block	MESH:D054537	marker/mechanism	8253323
C0004245	fosphenytoin	C043114	93390-81-9	atrioventricular block	MESH:D054537	marker/mechanism	16434340
C0004245	imipramine	D007099	50-49-7	atrioventricular block	MESH:D054537	marker/mechanism	1119616
C0004245	labetalol	D007741	36894-69-6	atrioventricular block	MESH:D054537	marker/mechanism	6476508
C0004245	lidocaine	D008012	137-58-6	atrioventricular block	MESH:D054537	marker/mechanism	18282259
C0004245	mefloquine	D015767	53230-10-7	atrioventricular block	MESH:D054537	marker/mechanism	20058779
C0004245	metoprolol	D008790	37350-58-6	atrioventricular block	MESH:D054537	marker/mechanism	18452693
C0004245	morphine	D009020	57-27-2	atrioventricular block	MESH:D054537	marker/mechanism	2446361
C0004245	nicotine	D009538	-	atrioventricular block	MESH:D054537	marker/mechanism	1259687
C0004245	octreotide	D015282	83150-76-9	atrioventricular block	MESH:D054537	marker/mechanism	14742361
C0004245	omeprazole	D009853	73590-58-6	atrioventricular block	MESH:D054537	marker/mechanism	12773066
C0004245	paclitaxel	D017239	-	atrioventricular block	MESH:D054537	marker/mechanism	17223814
C0004245	pentobarbital	D010424	76-74-4	atrioventricular block	MESH:D054537	marker/mechanism	3590213
C0004245	phenylpropanolamine	D010665	14838-15-4	atrioventricular block	MESH:D054537	marker/mechanism	3989943
C0004245	phenytoin	D010672	57-41-0	atrioventricular block	MESH:D054537	marker/mechanism	10407528
C0004245	pilocarpine	D010862	92-13-7	atrioventricular block	MESH:D054537	marker/mechanism	3785930
C0004245	propranolol	D011433	525-66-6	atrioventricular block	MESH:D054537	marker/mechanism	1879988
C0004245	propranolol	D011433	525-66-6	atrioventricular block	MESH:D054537	therapeutic	2444941
C0004245	quinine	D011803	130-95-0	atrioventricular block	MESH:D054537	marker/mechanism	3800084
C0004245	sotalol	D013015	3930-20-9	atrioventricular block	MESH:D054537	marker/mechanism	7162978
C0004245	thalidomide	D013792	50-35-1	atrioventricular block	MESH:D054537	marker/mechanism	16773277
C0004245	timolol	D013999	26839-75-8	atrioventricular block	MESH:D054537	marker/mechanism	10439680
C0004245	tretinoin	D014212	302-79-4	atrioventricular block	MESH:D054537	marker/mechanism	16447716

FDA approved drug and dosage information(Total Drugs:4)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D054537	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D054537	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D054537	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes
MESH:D054537	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes

FDA labeling changes(Total Drugs:4)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D054537	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D054537	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'
MESH:D054537	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D054537	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'