PedAM

Pediatric Disease Annotations & Medicines


	astigmatism

Disease ID	667
Disease	astigmatism
Definition	Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed)
Synonym	astigmatism (disorder) astigmatism [disease/finding] astigmatism nos astigmatism nos (disorder) astigmatism, nos astigmatism, unspecified unspecified astigmatism unspecified astigmatism (disorder)
OMIM	OMIM:603047
DOID	DOID:11782
UMLS	C0004106
MeSH	D001251
SNOMED-CT	SNOMEDCT_US_2016_09_01:82649003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:23) C0086543 \| cataract \| 25 C0027092 \| myopia \| 23 C0022578 \| keratoconus \| 9 C0020490 \| hyperopia \| 7 C0002418 \| amblyopia \| 5 C0034951 \| refractive error \| 5 C0086543 \| cataracts \| 3 C0038379 \| strabismus \| 2 C0003081 \| anisometropia \| 2 C0017601 \| glaucoma \| 2 C0155135 \| corneal ectasia \| 2 C0035309 \| retinopathy \| 1 C0456909 \| vision loss \| 1 C0035334 \| retinitis pigmentosa \| 1 C0036416 \| scleritis \| 1 C0015310 \| exotropia \| 1 C0005745 \| ptosis \| 1 C0034951 \| refractive errors \| 1 C0700501 \| congenital nystagmus \| 1 C0036646 \| senile cataract \| 1 C0035333 \| retinitis \| 1 C0010043 \| corneal ulcer \| 1 C0014877 \| esotropia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 10008 \| KCNE3 \| infer 5156 \| PDGFRA \| infer 5334 \| PLCL1 \| infer 51450 \| PRRX2 \| infer 442108 \| RPL22P13 \| infer 8801 \| SUCLG2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:186) 401237 \| CASC15 \| DISEASES 3691 \| ITGB4 \| DISEASES 9552 \| SPAG7 \| DISEASES 1652 \| DDT \| DISEASES 11151 \| CORO1A \| DISEASES 51285 \| RASL12 \| DISEASES 2137 \| EXTL3 \| DISEASES 23554 \| TSPAN12 \| DISEASES 26574 \| AATF \| DISEASES 1075 \| CTSC \| DISEASES 2916 \| GRM6 \| DISEASES 5534 \| PPP3R1 \| DISEASES 25806 \| VAX2 \| DISEASES 7291 \| TWIST1 \| DISEASES 6626 \| SNRPA \| DISEASES 59269 \| HIVEP3 \| DISEASES 92797 \| HELB \| DISEASES 5300 \| PIN1 \| DISEASES 64428 \| NARFL \| DISEASES 3859 \| KRT12 \| DISEASES 3866 \| KRT15 \| DISEASES 5156 \| PDGFRA \| DISEASES 8739 \| HRK \| DISEASES 4836 \| NMT1 \| DISEASES 640 \| BLK \| DISEASES 84171 \| LOXL4 \| DISEASES 4016 \| LOXL1 \| DISEASES 84662 \| GLIS2 \| DISEASES 6558 \| SLC12A2 \| DISEASES 25939 \| SAMHD1 \| DISEASES 2901 \| GRIK5 \| DISEASES 10133 \| OPTN \| DISEASES 4924 \| NUCB1 \| DISEASES 9424 \| KCNK6 \| DISEASES 55717 \| WDR11 \| DISEASES 7301 \| TYRO3 \| DISEASES 55850 \| USE1 \| DISEASES 23095 \| KIF1B \| DISEASES 84695 \| LOXL3 \| DISEASES 8452 \| CUL3 \| DISEASES 10686 \| CLDN16 \| DISEASES 11107 \| PRDM5 \| DISEASES 10923 \| SUB1 \| DISEASES 4986 \| OPRK1 \| DISEASES 25793 \| FBXO7 \| DISEASES 11081 \| KERA \| DISEASES 50511 \| SYCP3 \| DISEASES 2588 \| GALNS \| DISEASES 54507 \| ADAMTSL4 \| DISEASES 3782 \| KCNN3 \| DISEASES 2206 \| MS4A2 \| DISEASES 740 \| MRPL49 \| DISEASES 26353 \| HSPB8 \| DISEASES 25836 \| NIPBL \| DISEASES 1562 \| CYP2C18 \| DISEASES 9530 \| BAG4 \| DISEASES 1013 \| CDH15 \| DISEASES 4681 \| NBL1 \| DISEASES 79190 \| IRX6 \| DISEASES 1409 \| CRYAA \| DISEASES 563 \| AZGP1 \| DISEASES 149461 \| CLDN19 \| DISEASES 84315 \| MON1A \| DISEASES 51752 \| ERAP1 \| DISEASES 168667 \| BMPER \| DISEASES 401 \| PHOX2A \| DISEASES 90167 \| FRMD7 \| DISEASES 282974 \| STK32C \| DISEASES 55832 \| CAND1 \| DISEASES 2562 \| GABRB3 \| DISEASES 26585 \| GREM1 \| DISEASES 558 \| AXL \| DISEASES 50964 \| SOST \| DISEASES 55872 \| PBK \| DISEASES 25928 \| SOSTDC1 \| DISEASES 84342 \| COG8 \| DISEASES 1296 \| COL8A2 \| DISEASES 1816 \| DRD5 \| DISEASES 65125 \| WNK1 \| DISEASES 9495 \| AKAP5 \| DISEASES 582 \| BBS1 \| DISEASES 55620 \| STAP2 \| DISEASES 64388 \| GREM2 \| DISEASES 58492 \| ZNF77 \| DISEASES 6764 \| ST5 \| DISEASES 205 \| AK4 \| DISEASES 199699 \| DAND5 \| DISEASES 8243 \| SMC1A \| DISEASES 3909 \| LAMA3 \| DISEASES 161882 \| ZFPM1 \| DISEASES 4166 \| CHST6 \| DISEASES 286753 \| TUSC5 \| DISEASES 1538 \| CYLC1 \| DISEASES 79191 \| IRX3 \| DISEASES 29940 \| DSE \| DISEASES 222546 \| RFX6 \| DISEASES 3751 \| KCND2 \| DISEASES 153571 \| C5orf38 \| DISEASES 3932 \| LCK \| DISEASES 4521 \| NUDT1 \| DISEASES 5313 \| PKLR \| DISEASES 60506 \| NYX \| DISEASES 2804 \| GOLGB1 \| DISEASES 259307 \| IL4I1 \| DISEASES 388228 \| SBK1 \| DISEASES 124454 \| EARS2 \| DISEASES 224 \| ALDH3A2 \| DISEASES 6890 \| TAP1 \| DISEASES 204 \| AK2 \| DISEASES 2331 \| FMOD \| DISEASES 4010 \| LMX1B \| DISEASES 10142 \| AKAP9 \| DISEASES 51256 \| TBC1D7 \| DISEASES 157680 \| VPS13B \| DISEASES 56980 \| PRDM10 \| DISEASES 7456 \| WIPF1 \| DISEASES 93034 \| NT5C1B \| DISEASES 22909 \| FAN1 \| DISEASES 55605 \| KIF21A \| DISEASES 6905 \| TBCE \| DISEASES 10090 \| UST \| DISEASES 1660 \| DHX9 \| DISEASES 1805 \| DPT \| DISEASES 5451 \| POU2F1 \| DISEASES 910 \| CD1B \| DISEASES 3645 \| INSRR \| DISEASES 6232 \| RPS27 \| DISEASES 2316 \| FLNA \| DISEASES 5309 \| PITX3 \| DISEASES 286257 \| C9orf142 \| DISEASES 51727 \| CMPK1 \| DISEASES 6491 \| STIL \| DISEASES 27069 \| GHITM \| DISEASES 7075 \| TIE1 \| DISEASES 656 \| BMP8B \| DISEASES 27286 \| SRPX2 \| DISEASES 203 \| AK1 \| DISEASES 6865 \| TACR2 \| DISEASES 2245 \| FGD1 \| DISEASES 10919 \| EHMT2 \| DISEASES 778 \| CACNA1F \| DISEASES 30813 \| VSX1 \| DISEASES 1325 \| CORT \| DISEASES 2512 \| FTL \| DISEASES 64421 \| DCLRE1C \| DISEASES 6103 \| RPGR \| DISEASES 646480 \| FABP9 \| DISEASES 444 \| ASPH \| DISEASES 51334 \| PRR16 \| DISEASES 3853 \| KRT6A \| DISEASES 9350 \| CER1 \| DISEASES 6453 \| ITSN1 \| DISEASES 50808 \| AK3 \| DISEASES 114899 \| C1QTNF3 \| DISEASES 56953 \| NT5M \| DISEASES 238 \| ALK \| DISEASES 4017 \| LOXL2 \| DISEASES 2524 \| FUT2 \| DISEASES 64115 \| C10orf54 \| DISEASES 4145 \| MATK \| DISEASES 6046 \| BRD2 \| DISEASES 7227 \| TRPS1 \| DISEASES 6235 \| RPS29 \| DISEASES 4901 \| NRL \| DISEASES 10581 \| IFITM2 \| DISEASES 57708 \| MIER1 \| DISEASES 4148 \| MATN3 \| DISEASES 9378 \| NRXN1 \| DISEASES 55777 \| MBD5 \| DISEASES 6399 \| TRAPPC2 \| DISEASES 6222 \| RPS18 \| DISEASES 1029 \| CDKN2A \| DISEASES 2900 \| GRIK4 \| DISEASES 197320 \| ZNF778 \| DISEASES 2263 \| FGFR2 \| DISEASES 7045 \| TGFBI \| DISEASES 342538 \| NACA2 \| DISEASES 3347 \| HTN3 \| DISEASES 8322 \| FZD4 \| DISEASES 7694 \| ZNF135 \| DISEASES 3292 \| HSD17B1 \| DISEASES 54938 \| SARS2 \| DISEASES 57000 \| GSN-AS1 \| DISEASES 102723508 \| KANTR \| DISEASES 26770 \| SNORD79 \| DISEASES 25826 \| SNORD82 \| DISEASES
Locus	(Waiting for update.)

Disease ID	667
Disease	astigmatism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:32) HP:0000518 \| Cataract \| 27 HP:0000545 \| Near sightedness \| 23 HP:0000563 \| Conical cornea \| 9 HP:0000540 \| Hypermetropia \| 7 HP:0000646 \| Wandering eyes \| 5 HP:0012393 \| Allergy \| 3 HP:0007663 \| Central visual loss \| 3 HP:0011003 \| High myopia \| 3 HP:0000572 \| Visual loss \| 3 HP:0000519 \| Cataracts, lenticular, bilateral \| 2 HP:0000486 \| Squint eyes \| 2 HP:0000501 \| Glaucoma \| 2 HP:0001259 \| Coma \| 2 HP:0001059 \| Pterygium \| 2 HP:0012803 \| Anisometropia \| 2 HP:0100689 \| Decreased corneal thickness \| 2 HP:0001065 \| Purplish striae \| 1 HP:0006934 \| Congenital nystagmus \| 1 HP:0001491 \| Congenital fibrosis of the extraocular muscles \| 1 HP:0011225 \| Epiblepharon \| 1 HP:0100532 \| Scleritis \| 1 HP:0012804 \| Corneal ulceration \| 1 HP:0000622 \| Blurred vision \| 1 HP:0000577 \| Exotropia \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0000510 \| Retinitis pigmentosa \| 1 HP:0000508 \| Drooping upper eyelid \| 1 HP:0000565 \| Inward turning of one or both eyes \| 1 HP:0100699 \| Scarring \| 1 HP:0001087 \| Childhood glaucoma \| 1 HP:0009737 \| Lisch nodules \| 1 HP:0000505 \| Poor vision \| 1

Disease ID	667
Disease	astigmatism
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0027092 \| myopia \| 23 C0034951 \| refractive error \| 4 C0003081 \| anisometropia \| 2 C0034951 \| refractive errors \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10189905	22144915	5334	PLCL1	umls:C0004106	GAD	[Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.]	0.002367032	2011	NA	2	198814386	T	G
rs2270676	22144915	10008	KCNE3	umls:C0004106	GAD	[Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.]	0.002367032	2011	KCNE3	11	74457366	A	G
rs6758183	22144915	57624	NYAP2	umls:C0004106	GAD	[Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.]	0.002367032	2011	NA	2	226136270	G	A
rs6792584	22144915	8801	SUCLG2	umls:C0004106	GAD	[Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.]	0.002367032	2011	SUCLG2	3	67480964	G	A
rs7677751	22144915	5156	PDGFRA	umls:C0004106	GAD	[Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.]	0.002367032	2011	PDGFRA	4	54258293	C	T
rs7866070	20585627	51450	PRRX2	umls:C0004106	GAD	[Web-based, participant-driven studies yield novel genetic associations for common traits.]	0.002367032	2010	PRRX2	9	129681820	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:33)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	28262409	rs4409675	A	T	rs4409675	23322567	2.00E-06	NA	0.06	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs4409675-T	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
1	175715606	rs17312292	G	C	rs17312292	23322567	7.00E-06	NA	0.88	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs17312292-C	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
2	71133014	rs3771395	G	A	rs3771395	23322567	2.00E-07	NA	0.08	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs3771395-G	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
2	137768702	rs979976	A	C	rs979976	23761726	8.00E-06	NA	0.13	[0.075-0.193] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs979976-A	Research Support, Non-U.S. Gov't	A	THSD7B
2	137769420	rs2116538	G	A	rs2116538	23761726	1.63E-05	NA	0.15	[0.08-0.21] unit decrease	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs2116538-A	Research Support, Non-U.S. Gov't	G	THSD7B
2	199679110	rs10189905	T	G	rs10189905	22144915	6.00E-07	NA	1.32	[1.18-1.46]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	NA	Meta-Analysis	Research Support, Non-U.S. Gov't
2	227000986	rs6758183	G	A	rs6758183	22144915	3.00E-06	NA	1.39	[1.21-1.57]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs6758183-A	Meta-Analysis	Research Support, Non-U.S. Gov't
3	65326882	rs6764388	T	C	rs6764388	23322567	6.00E-06	NA	0.05	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs6764388-T	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
3	67531388	rs6792584	G	A	rs6792584	22144915	5.00E-06	NA	1.24	[1.14-1.34]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs6792584-G	Meta-Analysis	Research Support, Non-U.S. Gov't
3	109462400	rs1164064	G	A	rs1164064	23761726	2.00E-06	NA	0.13	[0.079-0.189] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs1164064-A	Research Support, Non-U.S. Gov't	G	NA
3	156336555	rs7651778	C	T	rs7651778	23761726	5.00E-06	NA	0.13	[0.071-0.181] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs7651778-C	Research Support, Non-U.S. Gov't	C	NA
4	55087581	rs17084051	C	A	rs17084051	22144915	2.00E-06	NA	1.21	[1.13-1.29]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs17084051-A	Meta-Analysis	Research Support, Non-U.S. Gov't
4	55124460	rs7677751	C	T	rs7677751	22144915	8.00E-09	NA	1.26	[1.18-1.34]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs7677751-T	Meta-Analysis	Research Support, Non-U.S. Gov't
4	120187611	rs11098499	C	T	rs11098499	23322567	9.00E-06	NA	0.05	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs11098499-C	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
5	13798559	rs795544	A	C	rs795544	23322567	1.00E-06	NA	0.06	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	NA	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
5	32975490	rs10079889	A	G	rs10079889	23761726	1.38E-05	NA	0.14	[0.08-0.21] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs10079889-A	Research Support, Non-U.S. Gov't	G	NA
6	67248410	rs9445732	G	T	rs9445732	23322567	2.00E-06	NA	1.28	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs9445732-G	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
6	169820381	rs438465	T	C	rs438465	23761726	7.00E-06	NA	0.17	[0.097-0.249] unit decrease	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs438465-C	Research Support, Non-U.S. Gov't	C	NA
7	155837295	rs10226930	T	C	rs10226930	23322567	8.00E-07	NA	1.38	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs10226930-C	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
8	15197417	rs12676170	A	G	rs12676170	23322567	8.00E-06	NA	0.05	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs12676170-A	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
9	16970809	rs4961511	G	T	rs4961511	23322567	9.00E-06	NA	0.05	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs4961511-G	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
10	10388195	rs7092703	C	T	rs7092703	23322567	3.00E-06	NA	0.05	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs7092703-C	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
10	60318897	rs1658442	G	A	rs1658442	23322567	3.00E-06	NA	0.06	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs1658442-A	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
11	74168411	rs2270676	A	G	rs2270676	22144915	5.00E-06	NA	1.29	[1.17-1.41]	1,231 Chinese ancestry cases; 785 Chinese ancestry controls; 1,018 Malaysian ancestry cases; 1,220 Malaysian ancestry controls	Malaysian(2238)	Chinese(2016)	ALL(4254)	ASN(4254)	ALL(4254)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs2270676-G	Meta-Analysis	Research Support, Non-U.S. Gov't
11	96023214	rs485842	C	T	rs485842	23322567	2.00E-06	NA	0.06	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs485842-A	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
12	32097360	rs1151008	G	T	rs1151008	23761726	1.00E-06	NA	0.14	[0.085-0.203] unit decrease	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs1151008-G	Research Support, Non-U.S. Gov't	G	NA
13	76249103	rs11841001	G	A	rs11841001	23761726	4.00E-06	NA	0.21	[0.12-0.30] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs11841001-A	Research Support, Non-U.S. Gov't	G	LMO7
14	101539384	rs7147503	C	T	rs7147503	23322567	5.00E-06	NA	0.05	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs7147503-C	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
15	101721892	rs12593811	T	C	rs12593811	23322567	7.00E-06	NA	0.23	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs12593811-T	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
16	17739692	rs12445126	G	A	rs12445126	23322567	2.00E-06	NA	0.09	[NA] unit decrease	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs12445126-G	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
16	80305551	rs11859036	C	A	rs11859036	23761726	7.00E-06	NA	0.13	[0.071-0.185] unit increase	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs11859036-A	Research Support, Non-U.S. Gov't	C	NA
16	86485131	rs11644988	G	A	rs11644988	23322567	2.00E-06	NA	0.13	[NA] unit increase	22,100 European ancestry individuals	European(22100)	ALL(22100)	EUR(22100)	ALL(22100)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs11644988-G	Twin Study	Research Support, N.I.H., Extramural	Meta-Analysis
19	30088393	rs4805442	A	G	rs4805442	23761726	1.18E-05	NA	0.17	[0.09-0.24] unit decrease	2,784 European ancestry individuals	European(2784)	ALL(2784)	EUR(2784)	ALL(2784)	Corneal astigmatism	HPOID:0000483	Astigmatism	DOID:10124	corneal disease	D001251	Astigmatism	EFOID:0004222	astigmatism	Corneal disease	rs4805442-A	Research Support, Non-U.S. Gov't	G	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0004106	valproic acid	D014635	99-66-1	astigmatism	MESH:D001251	marker/mechanism	11986102

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)