PedAM

Pediatric Disease Annotations & Medicines


	aspergillosis

Disease ID	433
Disease	aspergillosis
Definition	Infections with fungi of the genus ASPERGILLUS.
Synonym	[x]aspergillosis, unspecified [x]aspergillosis, unspecified (disorder) aspergillose aspergilloses aspergillosis (disorder) aspergillosis [disease/finding] aspergillosis, nos infection due to aspergillus
Orphanet	ORPHANET:1163
DOID	DOID:13564
UMLS	C0004030
MeSH	D001228
SNOMED-CT	SNOMEDCT_US_2016_09_01:65553006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:102) C0010674 \| cystic fibrosis \| 20 C0004096 \| asthma \| 15 C0376545 \| hematological malignancies \| 10 C0600260 \| obstructive pulmonary disease \| 10 C0024115 \| pulmonary disease \| 10 C0024117 \| chronic obstructive pulmonary disease \| 10 C0376545 \| hematologic malignancies \| 8 C0023418 \| leukemia \| 8 C0018203 \| chronic granulomatous disease \| 8 C0242379 \| lung cancer \| 7 C0027947 \| neutropenia \| 7 C0024141 \| systemic lupus erythematosus \| 4 C0023470 \| myeloid leukaemia \| 4 C0023467 \| acute myeloid leukaemia \| 4 C0021400 \| influenza \| 4 C0032285 \| pneumonia \| 4 C0409974 \| lupus erythematosus \| 4 C0085669 \| acute leukemia \| 3 C0376545 \| hematologic malignancy \| 3 C0023470 \| myelogenous leukemia \| 2 C0023470 \| myeloid leukemia \| 2 C0023467 \| acute myelogenous leukemia \| 2 C0026718 \| mucormycosis \| 2 C0023448 \| lymphocytic leukemia \| 2 C0011847 \| diabetes \| 2 C0026946 \| fungal infection \| 2 C0036202 \| sarcoidosis \| 2 C0004623 \| bacterial infection \| 2 C0023467 \| acute myeloid leukemia \| 2 C0023418 \| leukaemia \| 2 C0006267 \| bronchiectasis \| 2 C0009324 \| ulcerative colitis \| 2 C0041296 \| tuberculosis \| 2 C0376545 \| hematological malignancy \| 1 C0006840 \| candidiasis \| 1 C0007134 \| renal cell carcinoma \| 1 C0024115 \| lung disease \| 1 C0026470 \| monoclonal gammopathy of undetermined significance \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0041956 \| ureteral obstruction \| 1 C0002874 \| aplastic anemia \| 1 C0035204 \| respiratory diseases \| 1 C0026975 \| myelitis \| 1 C0024115 \| pulmonary diseases \| 1 C0026764 \| myeloma \| 1 C0034069 \| pulmonary fibrosis \| 1 C0003864 \| arthritis \| 1 C0002871 \| anemia \| 1 C0600260 \| obstructive pulmonary diseases \| 1 C0011633 \| dermatomyositis \| 1 C0023890 \| cirrhosis \| 1 C0013502 \| hydatid disease \| 1 C0024299 \| lymphoma \| 1 C0026946 \| fungal infections \| 1 C0035204 \| respiratory disease \| 1 C0242770 \| cryptogenic organizing pneumonia \| 1 C0008370 \| cholestasis \| 1 C0018799 \| heart disease \| 1 C0042384 \| vasculitis \| 1 C0038218 \| acute severe asthma \| 1 C0019158 \| hepatitis \| 1 C0023895 \| liver disease \| 1 C0024530 \| malaria \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0178879 \| obstructive uropathy \| 1 C0019187 \| alcoholic hepatitis \| 1 C0039590 \| testicular cancer \| 1 C0004623 \| bacterial infections \| 1 C0023890 \| liver cirrhosis \| 1 C0948187 \| tracheomalacia \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0013990 \| emphysema \| 1 C0009319 \| colitis \| 1 C0684249 \| lung carcinoma \| 1 C0024117 \| chronic obstructive pulmonary disease (copd) \| 1 C0007121 \| bronchogenic carcinoma \| 1 C0004031 \| allergic bronchopulmonary aspergillosis \| 1 C0042075 \| uropathy \| 1 C0023343 \| leprosy \| 1 C0001824 \| agranulocytosis \| 1 C0032285 \| pneumonitis \| 1 C0037199 \| sinusitis \| 1 C0004096 \| bronchial asthma \| 1 C1136085 \| monoclonal gammopathy \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0042769 \| virus infection \| 1 C0001261 \| actinomycosis \| 1 C0403529 \| goodpasture's syndrome \| 1 C0034072 \| pulmonary heart disease \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0684249 \| carcinoma of lung \| 1 C0019618 \| histiocytosis \| 1 C0024110 \| lung abscess \| 1 C0026764 \| multiple myeloma \| 1 C0019829 \| hodgkin lymphoma \| 1 C0023449 \| acute lymphocytic leukemia \| 1 C0023530 \| leucopenia \| 1 C0022398 \| hyper-ige syndrome \| 1 C1527311 \| brain swelling \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 64581 \| CLEC7A \| infer 7096 \| TLR1 \| infer 7099 \| TLR4 \| infer 10333 \| TLR6 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:193) 1080 \| CFTR \| DISEASES 1595 \| CYP51A1 \| DISEASES 3566 \| IL4R \| DISEASES 2191 \| FAP \| DISEASES 22798 \| LAMB4 \| DISEASES 5603 \| MAPK13 \| DISEASES 64841 \| GNPNAT1 \| DISEASES 55734 \| ZFP64 \| DISEASES 479 \| ATP12A \| DISEASES 10204 \| NUTF2 \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 2222 \| FDFT1 \| DISEASES 1666 \| DECR1 \| DISEASES 973 \| CD79A \| DISEASES 10567 \| RABAC1 \| DISEASES 2639 \| GCDH \| DISEASES 3912 \| LAMB1 \| DISEASES 6369 \| CCL24 \| DISEASES 6348 \| CCL3 \| DISEASES 8288 \| EPX \| DISEASES 1440 \| CSF3 \| DISEASES 6347 \| CCL2 \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 51561 \| IL23A \| DISEASES 3458 \| IFNG \| DISEASES 3111 \| HLA-DOA \| DISEASES 4224 \| MEP1A \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 27241 \| BBS9 \| DISEASES 54210 \| TREM1 \| DISEASES 1236 \| CCR7 \| DISEASES 1773 \| DNASE1 \| DISEASES 57418 \| WDR18 \| DISEASES 2161 \| F12 \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 5375 \| PMP2 \| DISEASES 3656 \| IRAK2 \| DISEASES 967 \| CD63 \| DISEASES 3569 \| IL6 \| DISEASES 5082 \| PDCL \| DISEASES 7097 \| TLR2 \| DISEASES 1559 \| CYP2C9 \| DISEASES 9360 \| PPIG \| DISEASES 6307 \| MSMO1 \| DISEASES 114294 \| LACTB \| DISEASES 4591 \| TRIM37 \| DISEASES 495 \| ATP4A \| DISEASES 7305 \| TYROBP \| DISEASES 23523 \| CABIN1 \| DISEASES 3553 \| IL1B \| DISEASES 1991 \| ELANE \| DISEASES 79968 \| WDR76 \| DISEASES 3589 \| IL11 \| DISEASES 5423 \| POLB \| DISEASES 6713 \| SQLE \| DISEASES 3700 \| ITIH4 \| DISEASES 3687 \| ITGAX \| DISEASES 80816 \| ASXL3 \| DISEASES 805 \| CALM2 \| DISEASES 5921 \| RASA1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 2206 \| MS4A2 \| DISEASES 3606 \| IL18 \| DISEASES 7292 \| TNFSF4 \| DISEASES 10413 \| YAP1 \| DISEASES 27163 \| NAAA \| DISEASES 7547 \| ZIC3 \| DISEASES 909 \| CD1A \| DISEASES 27020 \| NPTN \| DISEASES 808 \| CALM3 \| DISEASES 2220 \| FCN2 \| DISEASES 6352 \| CCL5 \| DISEASES 8320 \| EOMES \| DISEASES 213 \| ALB \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 5267 \| SERPINA4 \| DISEASES 55720 \| TSR1 \| DISEASES 6037 \| RNASE3 \| DISEASES 51523 \| CXXC5 \| DISEASES 64581 \| CLEC7A \| DISEASES 260434 \| PYDC1 \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 10963 \| STIP1 \| DISEASES 57521 \| RPTOR \| DISEASES 8028 \| MLLT10 \| DISEASES 9986 \| RCE1 \| DISEASES 947 \| CD34 \| DISEASES 8815 \| BANF1 \| DISEASES 5431 \| POLR2B \| DISEASES 5257 \| PHKB \| DISEASES 30835 \| CD209 \| DISEASES 23541 \| SEC14L2 \| DISEASES 3579 \| CXCR2 \| DISEASES 10726 \| NUDC \| DISEASES 149233 \| IL23R \| DISEASES 148266 \| ZNF569 \| DISEASES 2318 \| FLNC \| DISEASES 11016 \| ATF7 \| DISEASES 151056 \| PLB1 \| DISEASES 942 \| CD86 \| DISEASES 3916 \| LAMP1 \| DISEASES 59307 \| SIGIRR \| DISEASES 3320 \| HSP90AA1 \| DISEASES 1576 \| CYP3A4 \| DISEASES 23583 \| SMUG1 \| DISEASES 10755 \| GIPC1 \| DISEASES 3605 \| IL17A \| DISEASES 53827 \| FXYD5 \| DISEASES 3767 \| KCNJ11 \| DISEASES 1861 \| TOR1A \| DISEASES 3240 \| HP \| DISEASES 55124 \| PIWIL2 \| DISEASES 246778 \| IL27 \| DISEASES 801 \| CALM1 \| DISEASES 987 \| LRBA \| DISEASES 5169 \| ENPP3 \| DISEASES 51530 \| ZC3HC1 \| DISEASES 6364 \| CCL20 \| DISEASES 54106 \| TLR9 \| DISEASES 4519 \| MT-CYB \| DISEASES 7096 \| TLR1 \| DISEASES 7044 \| LEFTY2 \| DISEASES 1118 \| CHIT1 \| DISEASES 163486 \| DENND1B \| DISEASES 4688 \| NCF2 \| DISEASES 84504 \| NKX6-2 \| DISEASES 914 \| CD2 \| DISEASES 959 \| CD40LG \| DISEASES 1557 \| CYP2C19 \| DISEASES 64318 \| NOC3L \| DISEASES 64170 \| CARD9 \| DISEASES 2219 \| FCN1 \| DISEASES 6441 \| SFTPD \| DISEASES 729238 \| SFTPA2 \| DISEASES 5255 \| PHKA1 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 1043 \| CD52 \| DISEASES 26279 \| PLA2G2D \| DISEASES 5322 \| PLA2G5 \| DISEASES 6850 \| SYK \| DISEASES 7133 \| TNFRSF1B \| DISEASES 160897 \| GPR180 \| DISEASES 369 \| ARAF \| DISEASES 54206 \| ERRFI1 \| DISEASES 3604 \| TNFRSF9 \| DISEASES 1536 \| CYBB \| DISEASES 9308 \| CD83 \| DISEASES 5251 \| PHEX \| DISEASES 54790 \| TET2 \| DISEASES 4267 \| CD99 \| DISEASES 10333 \| TLR6 \| DISEASES 93978 \| CLEC6A \| DISEASES 7306 \| TYRP1 \| DISEASES 974 \| CD79B \| DISEASES 196410 \| METTL7B \| DISEASES 27297 \| CRCP \| DISEASES 9701 \| PPP6R2 \| DISEASES 2919 \| CXCL1 \| DISEASES 10521 \| DDX17 \| DISEASES 1394 \| CRHR1 \| DISEASES 1363 \| CPE \| DISEASES 201456 \| FBXO15 \| DISEASES 7124 \| TNF \| DISEASES 8605 \| PLA2G4C \| DISEASES 4615 \| MYD88 \| DISEASES 3920 \| LAMP2 \| DISEASES 5578 \| PRKCA \| DISEASES 3586 \| IL10 \| DISEASES 10046 \| MAMLD1 \| DISEASES 51071 \| DERA \| DISEASES 5164 \| PDK2 \| DISEASES 131870 \| NUDT16 \| DISEASES 51428 \| DDX41 \| DISEASES 5238 \| PGM3 \| DISEASES 22928 \| SEPHS2 \| DISEASES 2920 \| CXCL2 \| DISEASES 727897 \| MUC5B \| DISEASES 55733 \| HHAT \| DISEASES 83695 \| RHNO1 \| DISEASES 3684 \| ITGAM \| DISEASES 6510 \| SLC1A5 \| DISEASES 8825 \| LIN7A \| DISEASES 5726 \| TAS2R38 \| DISEASES 387521 \| TMEM189 \| DISEASES 7409 \| VAV1 \| DISEASES 283902 \| HCCAT5 \| DISEASES
Locus	(Waiting for update.)

Disease ID	433
Disease	aspergillosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:66) HP:0002099 \| Asthma \| 15 HP:0006510 \| Chronic obstructive pulmonary disease \| 10 HP:0001909 \| Leukemia \| 8 HP:0001875 \| Neutropenia \| 6 HP:0002664 \| Neoplasia \| 5 HP:0001399 \| Liver failure \| 4 HP:0002725 \| Systemic lupus erythematosus \| 4 HP:0004808 \| Acute myelogenous leukemia \| 4 HP:0012735 \| Coughing \| 3 HP:0002488 \| Acute leukemias \| 3 HP:0002090 \| Pneumonia \| 3 HP:0100632 \| Pulmonary sequestration \| 3 HP:0030731 \| Carcinoma \| 3 HP:0002105 \| Hemoptysis \| 3 HP:0100570 \| Carcinoid tumor \| 2 HP:0006721 \| Acute lymphocytic leukemia \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0012324 \| Myeloid leukemia \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0002110 \| Bronchiectasis \| 2 HP:0001945 \| Fever \| 2 HP:0002202 \| Pleural effusion \| 2 HP:0006528 \| Chronic lung disease \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0012653 \| Acute severe asthma \| 1 HP:0012234 \| Agranulocytosis \| 1 HP:0005945 \| Laryngeal obstruction \| 1 HP:0002113 \| Pulmonary infiltrates \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0002779 \| Tracheomalacia \| 1 HP:0011945 \| Cryptogenic organizing pneumonia \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0006698 \| Ventricular aneurysm \| 1 HP:0001396 \| Cholestasis \| 1 HP:0100626 \| Chronic hepatic failure \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0001903 \| Anemia \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0001681 \| Angina pectoris \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0002789 \| Increased respiratory rate or depth of breathing \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0009733 \| Glioma \| 1 HP:0002094 \| Dyspnea \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0002633 \| Vasculitis \| 1 HP:0200036 \| Skin nodule \| 1 HP:0007824 \| Total ophthalmoplegia \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0000752 \| Hyperactive behavior \| 1 HP:0002665 \| Lymphoma \| 1 HP:0002583 \| Colitis \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0002410 \| Aqueductal stenosis \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001369 \| Arthritis \| 1 HP:0006000 \| Ureteral obstruction \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001394 \| Hepatic cirrhosis \| 1

Disease ID	433
Disease	aspergillosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:26) C2707258 \| infections C2364133 \| infection C1963154 \| renal failure C1739376 \| orbital apex syndrome C1546533 \| abscess C1510428 \| cerebral abscess C1298681 \| oxalosis C0748159 \| pulmonary involvement C0333040 \| fungus ball C0302148 \| thrombus C0265149 \| purulent pericarditis C0264265 \| nasal necrosis C0259737 \| adiaspiromycosis C0241950 \| bowel infarction C0238790 \| bone destruction C0238036 \| bronchocentric granulomatosis C0149711 \| hilar adenopathy C0030486 \| paraplegia C0029132 \| optic neuropathy C0029089 \| ophthalmoplegia C0028992 \| omphalitis C0025289 \| meningitis C0024894 \| mastitis C0019655 \| histoplasmosis C0019079 \| haemoptysis C0014556 \| psychomotor seizure
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0009450 \| infection \| 14 C0021311 \| infections \| 3 C0333040 \| fungus ball \| 2 C1739376 \| orbital apex syndrome \| 1 C0748159 \| pulmonary involvement \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0004030	anidulafungin	C102786	-	aspergillosis	MESH:D001228	therapeutic	19029327
C0004030	caspofungin	C105417	-	aspergillosis	MESH:D001228	therapeutic	18835682
C0004030	clotrimazole	D003022	23593-75-1	aspergillosis	MESH:D001228	therapeutic	26387063
C0004030	fluconazole	D015725	86386-73-4	aspergillosis	MESH:D001228	therapeutic	18486603
C0004030	liposomal amphotericin b	C068538	-	aspergillosis	MESH:D001228	therapeutic	12001285
C0004030	voriconazole	D065819	-	aspergillosis	MESH:D001228	therapeutic	15642862

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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