PedAM

Pediatric Disease Annotations & Medicines


	arthritis, infectious

Disease ID	1085
Disease	arthritis, infectious
Definition	Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
Synonym	arthritis due to direct infection arthritis infect arthritis infectious arthritis pyogenic arthritis septic arthritis, infectious [disease/finding] arthritis, purulent arthritis, pyogenic arthritis, septic inf arthritis nos-unspec infect arthritis infection-associated arthritis infection-associated arthritis, nos infectious arthritis infective arthritis infective arthritis (disorder) infective arthritis [ambiguous] infective arthritis [dup] (disorder) infective arthritis nos infective arthritis nos (disorder) infective arthritis nos, of unspecified site infective arthritis nos, of unspecified site (disorder) infective arthritis or polyarthritis nos infective arthritis, nos pyarthrosis pyoarthrosis pyoarthrosis, nos pyogenic arthritis pyogenic arthritis (disorder) pyogenic arthritis nos pyogenic arthritis nos (disorder) pyogenic arthritis, nos septic arthritis septic arthrits unspecified infective arthritis unspecified infective arthritis, site unspecified
DOID	DOID:813
UMLS	C0003869
MeSH	D001170
SNOMED-CT	SNOMEDCT_US_2016_09_01:396234004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:33) C0029443 \| osteomyelitis \| 11 C0003873 \| rheumatoid arthritis \| 6 C0018099 \| gout \| 4 C0026934 \| mycoplasma \| 2 C0003864 \| arthritis \| 2 C1253936 \| joint effusion \| 2 C0014118 \| endocarditis \| 2 C1704275 \| pyomyositis \| 2 C0027813 \| neuritis \| 1 C0010346 \| crohn's disease \| 1 C0024198 \| lyme disease \| 1 C0004943 \| behcet's disease \| 1 C0553662 \| juvenile rheumatoid arthritis \| 1 C0270629 \| epidural abscess \| 1 C0011847 \| diabetes \| 1 C0039103 \| synovitis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0025289 \| meningitis \| 1 C0042769 \| virus infection \| 1 C0002895 \| sickle cell disease \| 1 C0032285 \| pneumonia \| 1 C0085652 \| pyoderma gangrenosum \| 1 C0003090 \| ankylosis \| 1 C0032285 \| pneumoniae \| 1 C0026764 \| multiple myeloma \| 1 C0409974 \| lupus erythematosus \| 1 C0011849 \| diabetes mellitus \| 1 C0021400 \| influenza \| 1 C0034212 \| pyoderma \| 1 C0027121 \| myositis \| 1 C0003874 \| septic arthritis \| 1 C0085669 \| acute leukemia \| 1 C0014121 \| bacterial endocarditis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) TNF \| 7124 \| CTD_human IFNG \| 3458 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1085
Disease	arthritis, infectious
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:30) HP:0002754 \| Bone infection \| 11 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0012531 \| Pain \| 5 HP:0001997 \| Gout \| 4 HP:0100584 \| Endocarditis \| 2 HP:0030838 \| Hip pain \| 2 HP:0001369 \| Arthritis \| 2 HP:0003095 \| Septic arthritis \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0000155 \| Oral ulcer \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002751 \| Kyphoscoliosis \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0000999 \| Pyoderma \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0002090 \| Pneumonia \| 1 HP:0000969 \| Dropsy \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0030839 \| Knee pain \| 1 HP:0100769 \| Synovitis \| 1 HP:0001945 \| Fever \| 1 HP:0010447 \| Fistula in ano \| 1 HP:0004976 \| Dislocations of the knees \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001287 \| Meningitis \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1

Disease ID	1085
Disease	arthritis, infectious
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0009450 \| infection \| 9 C1704275 \| pyomyositis \| 2 C1253936 \| joint effusion \| 2 C0311395 \| lameness \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0003869	amikacin	D000583	37517-28-5	arthritis, infectious	MESH:D001170	therapeutic	10223137
C0003869	chloramphenicol	D002701	56-75-7	arthritis, infectious	MESH:D001170	therapeutic	16611451
C0003869	ciprofloxacin	D002939	85721-33-1	arthritis, infectious	MESH:D001170	therapeutic	3555062
C0003869	indomethacin	D007213	53-86-1	arthritis, infectious	MESH:D001170	therapeutic	983356
C0003869	nafcillin	D009254	147-52-4	arthritis, infectious	MESH:D001170	therapeutic	7431181

FDA approved drug and dosage information(Total Drugs:2)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D001170	cipro	ciprofloxacin	400MG/40ML (10MG/ML)	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D001170	cipro	ciprofloxacin	250MG/5ML	FOR SUSPENSION;ORAL	Prescription	AB	Yes	No

FDA labeling changes(Total Drugs:2)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D001170	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'
MESH:D001170	03/25/2004	cipro	ciprofloxacin	Complicated UTI and pyelonephritis	Indicated for the treatment of complicated urinary tract infections (cUTIs) and pyelonephritis in pediatric patients 1 17 years of age Not drug of first choice due to increased adverse events compared to controls including events related to joints and/or surrounding tissues Information on PK and dose in pediatric patients 1 17 years of age The most frequent adverse events observed within 6 weeks of treatment initiation during the cUTI clinical trial were gastrointestinal 15% compared to 9% and musculoskeletal 9.3% compared to 6% in ciprofloxacin-treated compared to control-treated patients, respectively	Labeling	B	-	-	-	Bayer	12/18/2003	FALSE'

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