PedAM

Pediatric Disease Annotations & Medicines


	arachnoiditis

Disease ID	438
Disease	arachnoiditis
Definition	Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)
Synonym	arachnitis arachnoid membrane inflamm arachnoid membrane inflammation arachnoid membrane inflammations arachnoiditides arachnoiditis (disorder) arachnoiditis [disease/finding] arachnoiditis, nos inflamm arachnoid membrane inflammation, arachnoid membrane inflammations, arachnoid membrane other meningitis nos other meningitis nos &/or arachnoiditis other meningitis nos &/or arachnoiditis (disorder)
Orphanet	ORPHANET:137817
DOID	DOID:12156
UMLS	C0003708
MeSH	D001100
SNOMED-CT	SNOMEDCT_US_2016_09_01:8217007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:16) C0039144 \| syringomyelia \| 7 C0038013 \| ankylosing spondylitis \| 2 C0041296 \| tuberculosis \| 2 C0078981 \| arachnoid cyst \| 2 C0020255 \| hydrocephalus \| 2 C0038012 \| spondylitis \| 2 C0392548 \| cauda equina syndrome \| 2 C0041318 \| tubercular meningitis \| 1 C0038019 \| spondylosis \| 1 C0078981 \| arachnoid cysts \| 1 C0037928 \| myelopathy \| 1 C0019655 \| histoplasmosis \| 1 C0021874 \| intracranial abscess \| 1 C0026975 \| myelitis \| 1 C0030486 \| paraplegia \| 1 C0025289 \| meningitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:27) 84245 \| MRI1 \| DISEASES 4353 \| MPO \| DISEASES 10342 \| TFG \| DISEASES 3110 \| MNX1 \| DISEASES 3299 \| HSF4 \| DISEASES 80725 \| SRCIN1 \| DISEASES 5443 \| POMC \| DISEASES 2495 \| FTH1 \| DISEASES 4851 \| NOTCH1 \| DISEASES 654 \| BMP6 \| DISEASES 84315 \| MON1A \| DISEASES 8557 \| TCAP \| DISEASES 6863 \| TAC1 \| DISEASES 3309 \| HSPA5 \| DISEASES 4512 \| MT-CO1 \| DISEASES 4535 \| MT-ND1 \| DISEASES 284486 \| THEM5 \| DISEASES 3303 \| HSPA1A \| DISEASES 6354 \| CCL7 \| DISEASES 361 \| AQP4 \| DISEASES 9244 \| CRLF1 \| DISEASES 6164 \| RPL34 \| DISEASES 2919 \| CXCL1 \| DISEASES 5817 \| PVR \| DISEASES 100506742 \| CASP12 \| DISEASES 83857 \| TMTC1 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	438
Disease	arachnoiditis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:15) HP:0002829 \| Arthralgia HP:0000504 \| Abnormality of vision HP:0001287 \| Meningitis HP:0002076 \| Migraine HP:0000360 \| Tinnitus HP:0001324 \| Muscle weakness HP:0002839 \| Urinary bladder sphincter dysfunction HP:0012378 \| Fatigue HP:0000763 \| Sensory neuropathy HP:0000238 \| Hydrocephalus HP:0003401 \| Paresthesia HP:0001265 \| Hyporeflexia HP:0000478 \| Abnormality of the eye HP:0000365 \| Hearing impairment HP:0000970 \| Anhidrosis
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0003396 \| Syringomyelia \| 7 HP:0100775 \| Dural ectasia \| 2 HP:0100702 \| Arachnoid cyst \| 2 HP:0000238 \| Nonsyndromal hydrocephalus \| 2 HP:0001382 \| Hyperextensible joints \| 1 HP:0005864 \| Pseudoarthroses \| 1 HP:0003287 \| Abnormality of mitochondrial metabolism \| 1 HP:0002196 \| Myelopathy \| 1 HP:0001287 \| Meningitis \| 1 HP:0012532 \| Chronic pain \| 1 HP:0012531 \| Pain \| 1 HP:0010550 \| Paraplegia \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0002344 \| Progressive neurologic deterioration \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1

Disease ID	438
Disease	arachnoiditis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2598155 \| pain C2096314 \| facial pain C1962958 \| hematoma C1389102 \| spinal cord atrophy C0260662 \| hearing disorders C0149645 \| cervical myelopathy C0039145 \| syringomyelia C0009451 \| communicating hydrocephalus
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0039144 \| syringomyelia \| 7 C0030193 \| pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0003708	melphalan	D008558	148-82-3	arachnoiditis	MESH:D001100	marker/mechanism	8043096
C0003708	methotrexate	D008727	1959/5/2	arachnoiditis	MESH:D001100	marker/mechanism	14561622

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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