PedAM

Pediatric Disease Annotations & Medicines


	appendicitis

Disease ID	1220
Disease	appendicitis
Definition	Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.
Synonym	acute appendicitis appendicitis (disorder) appendicitis [disease/finding] appendicitis nos appendicitis nos (disorder) appendicitis, nos appendicitis, unqualified appendicitis, unqualified (disorder)
DOID	DOID:8337
UMLS	C0003615
MeSH	D001064
SNOMED-CT	SNOMEDCT_US_2016_09_01:74400008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:86) C0031154 \| peritonitis \| 36 C0019294 \| inguinal hernia \| 7 C0012813 \| diverticulitis \| 6 C0021843 \| intestinal obstruction \| 5 C0037280 \| infestation \| 4 C0021843 \| bowel obstruction \| 4 C0085693 \| acute appendicitis \| 3 C0021933 \| intussusception \| 3 C0023418 \| leukemia \| 3 C0085669 \| acute leukemia \| 3 C0003615 \| appendicitis \| 3 C0002766 \| analgesia \| 2 C0023798 \| lipoma \| 2 C0023470 \| myelocytic leukemia \| 2 C0040053 \| thrombosis \| 2 C0040046 \| thrombophlebitis \| 2 C0001175 \| acquired immunodeficiency syndrome \| 1 C0036117 \| salmonella infection \| 1 C0496779 \| appendiceal cancer \| 1 C0206674 \| villous adenoma \| 1 C0025037 \| meckel's diverticulum \| 1 C0024623 \| gastric cancer \| 1 C0025162 \| toxic megacolon \| 1 C0003125 \| anorexia nervosa \| 1 C0008311 \| cholangitis \| 1 C0011847 \| diabetes \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0018801 \| heart failure \| 1 C0036285 \| scarlet fever \| 1 C0034150 \| purpura \| 1 C0037856 \| testicular torsion \| 1 C0023487 \| acute promyelocytic leukemia \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0155773 \| portal vein thrombosis \| 1 C0036341 \| schizophrenia \| 1 C0001418 \| adenocarcinoma \| 1 C0019322 \| umbilical hernia \| 1 C0001261 \| actinomycosis \| 1 C1527336 \| sjogren's syndrome \| 1 C0020538 \| hypertension \| 1 C0158699 \| renal agenesis \| 1 C0003864 \| arthritis \| 1 C0001263 \| abdominal actinomycosis \| 1 C0566602 \| primary sclerosing cholangitis \| 1 C0023487 \| promyelocytic leukemia \| 1 C0003874 \| septic arthritis \| 1 C0018802 \| congestive heart failure \| 1 C0162529 \| ischemic colitis \| 1 C0020295 \| hydronephrosis \| 1 C1261473 \| sarcoma \| 1 C0376358 \| prostate cancer \| 1 C0086227 \| enterobius vermicularis infection \| 1 C0042769 \| virus infection \| 1 C0009319 \| colitis \| 1 C0085411 \| angiodysplasia \| 1 C2712893 \| swine flu \| 1 C0011849 \| diabetes mellitus \| 1 C0008313 \| sclerosing cholangitis \| 1 C0014175 \| endometriosis \| 1 C0242172 \| pelvic inflammatory disease \| 1 C0022661 \| end-stage renal disease \| 1 C0011991 \| diarrhoea \| 1 C0086227 \| enterobiasis \| 1 C0009324 \| ulcerative colitis \| 1 C0020541 \| portal hypertension \| 1 C0010346 \| crohn's disease \| 1 C0011854 \| type 1 diabetes \| 1 C0024205 \| lymphadenitis \| 1 C0008325 \| cholecystitis \| 1 C0152110 \| meralgia paresthetica \| 1 C0025469 \| mesenteric adenitis \| 1 C1258215 \| ileus \| 1 C0024110 \| lung abscess \| 1 C0022658 \| renal disease \| 1 C0024899 \| mastocytosis \| 1 C0036117 \| salmonella infect \| 1 C0036220 \| kaposi sarcoma \| 1 C0334121 \| inflammatory myofibroblastic tumor \| 1 C0021845 \| intestinal perforation \| 1 C0024299 \| lymphoma \| 1 C0027947 \| neutropenia \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0334634 \| mantle cell lymphoma \| 1 C0031069 \| familial mediterranean fever \| 1 C0001430 \| adenoma \| 1 C0020542 \| pulmonary hypertension \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) IFNG \| 3458 \| CTD_human IL10 \| 3586 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 929 \| CD14 \| infer 3553 \| IL1B \| infer 3569 \| IL6 \| infer 7099 \| TLR4 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:170) 3475 \| IFRD1 \| DISEASES 8935 \| SKAP2 \| DISEASES 11185 \| INMT \| DISEASES 9821 \| RB1CC1 \| DISEASES 6793 \| STK10 \| DISEASES 1113 \| CHGA \| DISEASES 3929 \| LBP \| DISEASES 10005 \| ACOT8 \| DISEASES 10857 \| PGRMC1 \| DISEASES 7076 \| TIMP1 \| DISEASES 10916 \| MAGED2 \| DISEASES 4210 \| MEFV \| DISEASES 1512 \| CTSH \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 9545 \| RAB3D \| DISEASES 10282 \| BET1 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 6346 \| CCL1 \| DISEASES 2026 \| ENO2 \| DISEASES 7291 \| TWIST1 \| DISEASES 3007 \| HIST1H1D \| DISEASES 22863 \| ATG14 \| DISEASES 1401 \| CRP \| DISEASES 4677 \| NARS \| DISEASES 3569 \| IL6 \| DISEASES 5004 \| ORM1 \| DISEASES 9982 \| FGFBP1 \| DISEASES 4673 \| NAP1L1 \| DISEASES 55567 \| DNAH3 \| DISEASES 11019 \| LIAS \| DISEASES 5289 \| PIK3C3 \| DISEASES 57509 \| MTUS1 \| DISEASES 11043 \| MID2 \| DISEASES 6855 \| SYP \| DISEASES 3553 \| IL1B \| DISEASES 9410 \| SNRNP40 \| DISEASES 8647 \| ABCB11 \| DISEASES 3299 \| HSF4 \| DISEASES 8626 \| TP63 \| DISEASES 25996 \| REXO2 \| DISEASES 23710 \| GABARAPL1 \| DISEASES 4060 \| LUM \| DISEASES 125972 \| CALR3 \| DISEASES 84651 \| SPINK7 \| DISEASES 55909 \| BIN3 \| DISEASES 3934 \| LCN2 \| DISEASES 498 \| ATP5A1 \| DISEASES 83734 \| ATG10 \| DISEASES 6695 \| SPOCK1 \| DISEASES 7345 \| UCHL1 \| DISEASES 23643 \| LY96 \| DISEASES 4838 \| NODAL \| DISEASES 3815 \| KIT \| DISEASES 5130 \| PCYT1A \| DISEASES 6006 \| RHCE \| DISEASES 5966 \| REL \| DISEASES 213 \| ALB \| DISEASES 7123 \| CLEC3B \| DISEASES 150159 \| SLC9B1 \| DISEASES 4724 \| NDUFS4 \| DISEASES 10915 \| TCERG1 \| DISEASES 23305 \| ACSL6 \| DISEASES 1672 \| DEFB1 \| DISEASES 115825 \| WDFY2 \| DISEASES 23588 \| KLHDC2 \| DISEASES 717 \| C2 \| DISEASES 64127 \| NOD2 \| DISEASES 116285 \| ACSM1 \| DISEASES 6356 \| CCL11 \| DISEASES 116844 \| LRG1 \| DISEASES 56246 \| MRAP \| DISEASES 646 \| BNC1 \| DISEASES 160065 \| PATE1 \| DISEASES 26145 \| IRF2BP1 \| DISEASES 948 \| CD36 \| DISEASES 197259 \| MLKL \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 8793 \| TNFRSF10D \| DISEASES 8557 \| TCAP \| DISEASES 10713 \| USP39 \| DISEASES 8636 \| SSNA1 \| DISEASES 10332 \| CLEC4M \| DISEASES 147912 \| SIX5 \| DISEASES 53347 \| UBASH3A \| DISEASES 64755 \| C16orf58 \| DISEASES 3579 \| CXCR2 \| DISEASES 414325 \| DEFB103A \| DISEASES 6863 \| TAC1 \| DISEASES 3996 \| LLGL1 \| DISEASES 5345 \| SERPINF2 \| DISEASES 10194 \| TSHZ1 \| DISEASES 55894 \| DEFB103B \| DISEASES 5241 \| PGR \| DISEASES 9622 \| KLK4 \| DISEASES 1668 \| DEFA3 \| DISEASES 6401 \| SELE \| DISEASES 55742 \| PARVA \| DISEASES 2152 \| F3 \| DISEASES 3146 \| HMGB1 \| DISEASES 5562 \| PRKAA1 \| DISEASES 51703 \| ACSL5 \| DISEASES 7405 \| UVRAG \| DISEASES 6288 \| SAA1 \| DISEASES 30849 \| PIK3R4 \| DISEASES 2526 \| FUT4 \| DISEASES 6364 \| CCL20 \| DISEASES 9464 \| HAND2 \| DISEASES 147409 \| DSG4 \| DISEASES 80274 \| SCUBE1 \| DISEASES 9706 \| ULK2 \| DISEASES 56259 \| CTNNBL1 \| DISEASES 4114 \| MAGEB3 \| DISEASES 359948 \| IRF2BP2 \| DISEASES 10090 \| UST \| DISEASES 6280 \| S100A9 \| DISEASES 262 \| AMD1 \| DISEASES 1755 \| DMBT1 \| DISEASES 2209 \| FCGR1A \| DISEASES 959 \| CD40LG \| DISEASES 10561 \| IFI44 \| DISEASES 81030 \| ZBP1 \| DISEASES 3434 \| IFIT1 \| DISEASES 3437 \| IFIT3 \| DISEASES 3433 \| IFIT2 \| DISEASES 4318 \| MMP9 \| DISEASES 23413 \| NCS1 \| DISEASES 1503 \| CTPS1 \| DISEASES 5453 \| POU3F1 \| DISEASES 26190 \| FBXW2 \| DISEASES 51230 \| PHF20 \| DISEASES 3055 \| HCK \| DISEASES 11330 \| CTRC \| DISEASES 1041 \| CDSN \| DISEASES 170302 \| ARX \| DISEASES 9912 \| ARHGAP44 \| DISEASES 3030 \| HADHA \| DISEASES 192668 \| CYS1 \| DISEASES 1667 \| DEFA1 \| DISEASES 728358 \| DEFA1B \| DISEASES 2524 \| FUT2 \| DISEASES 64423 \| INF2 \| DISEASES 3660 \| IRF2 \| DISEASES 2596 \| GAP43 \| DISEASES 51520 \| LARS \| DISEASES 3652 \| IPP \| DISEASES 10379 \| IRF9 \| DISEASES 9718 \| ECE2 \| DISEASES 4626 \| MYH8 \| DISEASES 10437 \| IFI30 \| DISEASES 57224 \| NHSL1 \| DISEASES 3430 \| IFI35 \| DISEASES 7124 \| TNF \| DISEASES 7866 \| IFRD2 \| DISEASES 6559 \| SLC12A3 \| DISEASES 3925 \| STMN1 \| DISEASES 3586 \| IL10 \| DISEASES 151871 \| DPPA2 \| DISEASES 6949 \| TCOF1 \| DISEASES 345611 \| IRGM \| DISEASES 503542 \| SPRN \| DISEASES 930 \| CD19 \| DISEASES 51271 \| UBAP1 \| DISEASES 9051 \| PSTPIP1 \| DISEASES 102723508 \| KANTR \| DISEASES 6080 \| SNORA73A \| DISEASES
Locus	(Waiting for update.)

Disease ID	1220
Disease	appendicitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:73) HP:0012531 \| Pain \| 36 HP:0002586 \| Peritonitis \| 35 HP:0002027 \| Abdominal pain \| 23 HP:0100790 \| Hernia \| 20 HP:0002566 \| Intestinal malrotation \| 19 HP:0005214 \| Bowel obstruction \| 9 HP:0001696 \| Situs inversus totalis \| 8 HP:0000023 \| Inguinal hernia \| 7 HP:0100806 \| Sepsis \| 7 HP:0001945 \| Fever \| 6 HP:0100541 \| Crural hernia \| 5 HP:0005211 \| Midgut malrotation \| 5 HP:0002488 \| Acute leukemias \| 3 HP:0001909 \| Leukemia \| 3 HP:0002576 \| Intussusception \| 3 HP:0002904 \| High blood bilirubin levels \| 3 HP:0002664 \| Neoplasia \| 3 HP:0100592 \| Peritoneal abscess \| 2 HP:0011899 \| Hyperfibrinogenemia \| 2 HP:0012032 \| Lipoma \| 2 HP:0100758 \| Gangrene \| 2 HP:0004418 \| Thrombophlebitis \| 2 HP:0100570 \| Carcinoid tumor \| 2 HP:0045073 \| Serositis \| 2 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0000822 \| Hypertension \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0001974 \| Leukocytosis \| 1 HP:0000126 \| Hydronephrosis \| 1 HP:0002013 \| Emesis \| 1 HP:0004320 \| Vaginal fistula \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0002063 \| Muscle rigidity \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0030157 \| Flank pain \| 1 HP:0002018 \| Nausea \| 1 HP:0000790 \| Hematuria \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0001289 \| Confusion \| 1 HP:0001369 \| Arthritis \| 1 HP:0002039 \| Anorexia \| 1 HP:0001537 \| Umbilical hernias \| 1 HP:0001944 \| Dehydration \| 1 HP:0002583 \| Colitis \| 1 HP:0030127 \| Endometriosis \| 1 HP:0004836 \| Acute promyelocytic leukemia \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0100495 \| Mastocytosis \| 1 HP:0030151 \| Cholangitis \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0003470 \| Inability to move \| 1 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0000104 \| Renal agenesis \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0001541 \| Ascites \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100813 \| Testicular torsion \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0100753 \| Schizophrenia \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0012281 \| Chylous ascites \| 1 HP:0100242 \| Sarcoma \| 1 HP:0002840 \| Lymphadenitis \| 1

Disease ID	1220
Disease	appendicitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:20) C0031154 \| peritonitis \| 35 C0019270 \| hernia \| 18 C0030193 \| pain \| 17 C0000727 \| acute abdomen \| 11 C0009450 \| infection \| 9 C0740577 \| acute abdominal pain \| 3 C0235329 \| small bowel obstruction \| 3 C1384353 \| parasitic infestation \| 2 C0017086 \| gangrene \| 2 C0034192 \| pylephlebitis \| 2 C0002766 \| analgesia \| 2 C0021311 \| infections \| 2 C0040046 \| thrombophlebitis \| 2 C0341402 \| rectal perforation \| 1 C0032320 \| pneumoperitoneum \| 1 C0003123 \| anorexia \| 1 C0036690 \| septicemia \| 1 C0025037 \| meckel's diverticulum \| 1 C0030201 \| postoperative pain \| 1 C1258215 \| ileus \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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