PedAM

Pediatric Disease Annotations & Medicines


	aphthous stomatitis

Disease ID	1294
Disease	aphthous stomatitis
Definition	A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
Synonym	(oral aphthae) or (mouth ulcer) (oral aphthae) or (mouth ulcer) (disorder) aphtha aphtha (morphologic abnormality) aphthae aphthous oral ulcers aphthous stomatitides aphthous ulcer aphthous ulcer of mouth aphthous ulcer of mouth (disorder) aphthous ulceration aphthous ulceration (disorder) aphthous ulcerations aphthous ulcers canker sore canker sores canker sores oral cankers sores oral aphthae oral aphthae (disorder) oral aphthae (disorder) [ambiguous] oral aphthae nos oral aphthae nos (disorder) oral aphthae, nos oral aphthous ulcer oral aphthous ulcer (disorder) oral aphthous ulcer [ambiguous] oral aphthous ulcers oral canker sores sore, canker sores, canker stomatitides, aphthous stomatitis aphhnous stomatitis aphthous stomatitis, aphthous stomatitis, aphthous [disease/finding] ulcer aphthous oral ulcer, aphthous ulcerative stomatitis ulcerative stomatitis nos ulcers, aphthous
DOID	DOID:9663 DOID:9673
UMLS	C0038363
MeSH	D013281
SNOMED-CT	SNOMEDCT_US_2016_09_01:426965005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:16) C0015974 \| periodic fever \| 13 C0007570 \| celiac disease \| 3 C0021831 \| bowel disease \| 2 C0021390 \| inflammatory bowel disease \| 2 C0004943 \| behcet's disease \| 2 C0021390 \| inflammatory bowel diseases \| 2 C0038362 \| stomatitis \| 1 C0039103 \| synovitis \| 1 C0004943 \| behcet's syndrome \| 1 C0033246 \| proctitis \| 1 C0031069 \| familial mediterranean fever \| 1 C0024523 \| malabsorption \| 1 C0010346 \| crohn's disease \| 1 C0013295 \| duodenal ulcer \| 1 C0011570 \| depression \| 1 C0017574 \| gingivitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) 3586 \| IL10 \| infer 3592 \| IL12A \| infer 6532 \| SLC6A4 \| infer 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 3123 \| HLA-DRB1 \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 3569 \| IL6 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:102) 7132 \| TNFRSF1A \| DISEASES 2191 \| FAP \| DISEASES 9552 \| SPAG7 \| DISEASES 1511 \| CTSG \| DISEASES 1723 \| DHODH \| DISEASES 4210 \| MEFV \| DISEASES 973 \| CD79A \| DISEASES 973 \| CD79A \| DISEASES 7087 \| ICAM5 \| DISEASES 5444 \| PON1 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 3558 \| IL2 \| DISEASES 4598 \| MVK \| DISEASES 3565 \| IL4 \| DISEASES 116444 \| GRIN3B \| DISEASES 4317 \| MMP8 \| DISEASES 6431 \| SRSF6 \| DISEASES 718 \| C3 \| DISEASES 968 \| CD68 \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 27348 \| TOR1B \| DISEASES 971 \| CD72 \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 6532 \| SLC6A4 \| DISEASES 4025 \| LPO \| DISEASES 81671 \| VMP1 \| DISEASES 671 \| BPI \| DISEASES 23523 \| CABIN1 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 735 \| C9 \| DISEASES 8626 \| TP63 \| DISEASES 10512 \| SEMA3C \| DISEASES 121260 \| SLC15A4 \| DISEASES 7157 \| TP53 \| DISEASES 3439 \| IFNA1 \| DISEASES 3606 \| IL18 \| DISEASES 6317 \| SERPINB3 \| DISEASES 4900 \| NRGN \| DISEASES 3460 \| IFNGR2 \| DISEASES 1234 \| CCR5 \| DISEASES 213 \| ALB \| DISEASES 4589 \| MUC7 \| DISEASES 3627 \| CXCL10 \| DISEASES 56246 \| MRAP \| DISEASES 4327 \| MMP19 \| DISEASES 713 \| C1QB \| DISEASES 53347 \| UBASH3A \| DISEASES 10318 \| TNIP1 \| DISEASES 10456 \| HAX1 \| DISEASES 277 \| AMY1B \| DISEASES 926 \| CD8B \| DISEASES 6401 \| SELE \| DISEASES 114548 \| NLRP3 \| DISEASES 391 \| RHOG \| DISEASES 3329 \| HSPD1 \| DISEASES 3198 \| HOXA1 \| DISEASES 3605 \| IL17A \| DISEASES 3516 \| RBPJ \| DISEASES 1861 \| TOR1A \| DISEASES 2475 \| MTOR \| DISEASES 7096 \| TLR1 \| DISEASES 7052 \| TGM2 \| DISEASES 6993 \| DYNLT1 \| DISEASES 3459 \| IFNGR1 \| DISEASES 9447 \| AIM2 \| DISEASES 6283 \| S100A12 \| DISEASES 2209 \| FCGR1A \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 1301 \| COL11A1 \| DISEASES 959 \| CD40LG \| DISEASES 6572 \| SLC18A3 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 4958 \| OMD \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 1041 \| CDSN \| DISEASES 3105 \| HLA-A \| DISEASES 7056 \| THBD \| DISEASES 94027 \| CGB7 \| DISEASES 285440 \| CYP4V2 \| DISEASES 285440 \| CYP4V2 \| DISEASES 51109 \| RDH11 \| DISEASES 3811 \| KIR3DL1 \| DISEASES 22900 \| CARD8 \| DISEASES 51466 \| EVL \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 3803 \| KIR2DL2 \| DISEASES 25780 \| RASGRP3 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 94115 \| CGB8 \| DISEASES 3586 \| IL10 \| DISEASES 9051 \| PSTPIP1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1294
Disease	aphthous stomatitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0001945 \| Fever \| 14 HP:0012531 \| Pain \| 4 HP:0002608 \| Celiac disease \| 2 HP:0002664 \| Neoplasia \| 2 HP:0002024 \| Intestinal malabsorption \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0010280 \| Stomatitis \| 1 HP:0002155 \| Increased triglycerides \| 1 HP:0003781 \| Oversalivation \| 1 HP:0010783 \| Erythema \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0100769 \| Synovitis \| 1 HP:0000230 \| Inflamed gums \| 1 HP:0000716 \| Depression \| 1 HP:0002588 \| Duodenal ulcer \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0100699 \| Scarring \| 1

Disease ID	1294
Disease	aphthous stomatitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0015974 \| periodic fever \| 13 C0030193 \| pain \| 4

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0038363	colchicine	D003078	64-86-8	stomatitis, aphthous	MESH:D013281	therapeutic	2566048
C0038363	cyclosporine	D016572	59865-13-3	stomatitis, aphthous	MESH:D013281	therapeutic	2566048
C0038363	methotrexate	D008727	1959/5/2	stomatitis, aphthous	MESH:D013281	marker/mechanism	4243752
C0038363	sirolimus	D020123	53123-88-9	stomatitis, aphthous	MESH:D013281	marker/mechanism	18339148
C0038363	tacrolimus	D016559	109581-93-3	stomatitis, aphthous	MESH:D013281	marker/mechanism	18339148
C0038363	thalidomide	D013792	50-35-1	stomatitis, aphthous	MESH:D013281	therapeutic	15694139

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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