All Snps(Total Genotypes:89) |
|---|
| snpId |
pubmedId |
geneId |
geneSymbol |
diseaseId |
sourceId |
sentence |
score |
Year |
geneSymbol_dbSNP |
CHROMOSOME |
POS |
REF |
ALT |
| rs1079196 | 22628180 | 2272 | FHIT | umls:C0003469 | BeFree | Suggestive association (P = 8 × 10(-8)) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. | 0.000271442 | 2012 | FHIT | 3 | 59821052 | G | A |
| rs10893268 | 25390645 | 390275 | OR8A1 | umls:C0003469 | GWASCAT | Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | 0.12 | 2014 | OR8A1 | 11 | 124568716 | C | T |
| rs110402 | 23274505 | 1394 | CRHR1 | umls:C0003469 | BeFree | We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). | 0.122985861 | 2013 | CRHR1;MGC57346-CRHR1 | 17 | 45802681 | G | A |
| rs1133503 | 24473444 | 79694 | MANEA | umls:C0003469 | BeFree | We used a multi-stage association study approach starting with four psychiatric disorders to show an association between a MANEA single-nucleotide polymorphism (SNP; rs1133503) and anxiety disorders. | 0.000271442 | 2013 | MANEA | 6 | 95606712 | C | T |
| rs1202184 | 20859246 | 5243 | ABCB1 | umls:C0003469 | BeFree | The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety. | 0.000271442 | 2011 | ABCB1 | 7 | 87584585 | C | T |
| rs12454712 | 20122683 | 5074 | PAWR | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000271442 | 2010 | BCL2 | 18 | 63178651 | T | C |
| rs12454712 | 20122683 | 596 | BCL2 | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000542884 | 2010 | BCL2 | 18 | 63178651 | T | C |
| rs1799971 | 15584875 | 4988 | OPRM1 | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.001085767 | 2004 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 15584875 | 125 | ADH1B | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.000814326 | 2004 | OPRM1 | 6 | 154039662 | A | G |
| rs1799971 | 15584875 | 1312 | COMT | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.016948948 | 2004 | OPRM1 | 6 | 154039662 | A | G |
| rs1800955 | 24100617 | 6532 | SLC6A4 | umls:C0003469 | BeFree | No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively. | 0.264310656 | 2014 | DRD4 | 11 | 636784 | T | C |
| rs1800955 | 24100617 | 1815 | DRD4 | umls:C0003469 | BeFree | No clear consensus on the role of any individual gene variant in personality modulation emerged, although SLC6A4 haplotypes and the DRD4 rs1800955 promoter variant seemed to be more reliably related to anxiety and impulsivity-related traits, respectively. | 0.001900093 | 2014 | DRD4 | 11 | 636784 | T | C |
| rs1922242 | 20859246 | 5243 | ABCB1 | umls:C0003469 | BeFree | The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety. | 0.000271442 | 2011 | ABCB1 | 7 | 87544351 | A | T |
| rs2020936 | 19541292 | 6532 | SLC6A4 | umls:C0003469 | BeFree | We found evidence for association (p = .0062, after accounting for multiple testing) for SLC6A4 SNPs rs6354 and rs2020936 (positioned in a different linkage disequilibrium [LD] block about 15.5 kb from 5HTTLPR) with anxiety and/or depression and neuroticism, with the strongest association for recurrent depression with onset in young adulthood (odds ratio = 1.55, 95% confidence interval = 1.16-2.06). | 0.264310656 | 2009 | SLC6A4 | 17 | 30223796 | G | A |
| rs2180619 | 24152087 | 6532 | SLC6A4 | umls:C0003469 | BeFree | The alleles of the rs2180619 are A > G; the G allele has been associated with addiction and high levels of anxiety (when the G allele interacts with the SS genotype of the 5-HTTLPR gene). | 0.264310656 | 2013 | CNR1 | 6 | 88168233 | G | A |
| rs2180619 | 19725030 | 6532 | SLC6A4 | umls:C0003469 | BeFree | The risk of high anxiety scores on BSI-Anx was 4.6-fold greater in homozygous 'GG' rs2180619 in combination with homozygous 'SS' 5-HTTLPR (P = 0.0005) compared to other genotypes. | 0.264310656 | 2009 | CNR1 | 6 | 88168233 | G | A |
| rs2234693 | 22901010 | 2099 | ESR1 | umls:C0003469 | BeFree | It appears unlikely that the common ESR1 variants rs2234693 and rs9340799 are associated with moderate depressive symptoms in women; however, there is some evidence that indicates a significant association with more severe depressive symptoms, major depressive disorder and anxiety. | 0.001357209 | 2012 | ESR1 | 6 | 151842200 | T | C |
| rs2254298 | 20708845 | 5021 | OXTR | umls:C0003469 | BeFree | Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. | 0.001085767 | 2011 | OXTR | 3 | 8760542 | G | A |
| rs2254298 | 22510359 | 5021 | OXTR | umls:C0003469 | BeFree | It is suggested that polymorphic variation at the oxytocin receptor gene (rs2254298) is associated with sociability, amygdala volume and differential risk for psychiatric conditions including autism, depression and anxiety disorder, depending on the quality of early environmental experiences. | 0.001085767 | 2012 | OXTR | 3 | 8760542 | G | A |
| rs2463107 | 20122683 | 596 | BCL2 | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000542884 | 2010 | NA | 12 | 79699537 | A | C |
| rs2463107 | 20122683 | 5074 | PAWR | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000271442 | 2010 | NA | 12 | 79699537 | A | C |
| rs25531 | 17375136 | 6532 | SLC6A4 | umls:C0003469 | BeFree | Subgroups based on the age of OCD onset, gender, familiality, factor analysis-derived symptom dimensions, or comorbidity with other psychiatric disorders failed to identify SLC6A4- or BDNF-associated phenotypes, with one exception of overall number of comorbid anxiety disorders being significantly associated with 5-HTTLPR/rs25531. | 0.264310656 | 2007 | SLC6A4;LOC105371720 | 17 | 30237328 | T | C |
| rs25531 | 21453464 | 6532 | SLC6A4 | umls:C0003469 | BeFree | The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. | 0.264310656 | 2011 | SLC6A4;LOC105371720 | 17 | 30237328 | T | C |
| rs324420 | 26036940 | 2166 | FAAH | umls:C0003469 | BeFree | The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions. | 0.000814326 | 2015 | FAAH | 1 | 46405089 | C | A |
| rs324981 | 24331455 | 594857 | NPS | umls:C0003469 | BeFree | Neuropeptide S is involved in anxiety and arousal modulation, and the functional polymorphism Asn107Ile (rs324981, A > T) of the neuropeptide S receptor gene (NPSR1) is associated with panic disorder and anxiety/fear-related traits. | 0.123528744 | 2015 | NPSR1;NPSR1-AS1 | 7 | 34778501 | A | T |
| rs324981 | 23466585 | 387129 | NPSR1 | umls:C0003469 | BeFree | Initial human studies indicate that the T-allele of the functional NPSR gene (NPSR1) polymorphism (rs324981), which increases NPS potency at NPSR, is associated with anxiety-related phenotypes. | 0.003257302 | 2013 | NPSR1;NPSR1-AS1 | 7 | 34778501 | A | T |
| rs324981 | 23466585 | 594857 | NPS | umls:C0003469 | BeFree | Initial human studies indicate that the T-allele of the functional NPSR gene (NPSR1) polymorphism (rs324981), which increases NPS potency at NPSR, is associated with anxiety-related phenotypes. | 0.123528744 | 2013 | NPSR1;NPSR1-AS1 | 7 | 34778501 | A | T |
| rs324981 | 21525857 | 387129 | NPSR1 | umls:C0003469 | BeFree | Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. | 0.003257302 | 2011 | NPSR1;NPSR1-AS1 | 7 | 34778501 | A | T |
| rs33939927 | 25127457 | 120892 | LRRK2 | umls:C0003469 | BeFree | Depressive symptoms were detected in 31.8% of R1441G-PD and 25% of i-PD patients and anxiety symptoms were evident in 4.5% and 15%, respectively, but the differences were not significant. | 0.000271442 | 2014 | LRRK2 | 12 | 40310434 | C | G,T |
| rs3761422 | 20520601 | 134 | ADORA1 | umls:C0003469 | BeFree | Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache. | 0.002638474 | 2010 | ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A | 22 | 24430704 | T | C |
| rs3761422 | 20520601 | 135 | ADORA2A | umls:C0003469 | BeFree | Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache. | 0.125081451 | 2010 | ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A | 22 | 24430704 | T | C |
| rs3812047 | 24324616 | 55558 | PLXNA3 | umls:C0003469 | BeFree | A significant sex-gene interaction was also observed since the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. | 0.000271442 | 2013 | GDNF | 5 | 37835296 | C | T |
| rs386602118 | 24021960 | 1978 | EIF4EBP1 | umls:C0003469 | BeFree | Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 19088493 | 627 | BDNF | umls:C0003469 | BeFree | Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. | 0.014039032 | 2008 | NA | NA | NA | NA | NA |
| rs386602118 | 24021960 | 3485 | IGFBP2 | umls:C0003469 | BeFree | Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 17392738 | 6531 | SLC6A3 | umls:C0003469 | BeFree | Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. | 0.123724241 | 2007 | NA | NA | NA | NA | NA |
| rs386602118 | 15913870 | 627 | BDNF | umls:C0003469 | BeFree | Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. | 0.014039032 | 2005 | NA | NA | NA | NA | NA |
| rs386602118 | 25618300 | 627 | BDNF | umls:C0003469 | BeFree | Patients with depressive or anxiety disorders and with available BDNF Val(66)Met polymorphism data (N=1271) were selected from Netherlands Study of Depression and Anxiety (NESDA). | 0.014039032 | 2014 | NA | NA | NA | NA | NA |
| rs386602118 | 20213725 | 627 | BDNF | umls:C0003469 | BeFree | A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. | 0.014039032 | 2010 | NA | NA | NA | NA | NA |
| rs386602118 | 24021960 | 474257 | BP2 | umls:C0003469 | BeFree | Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 24021960 | 1748 | DLX4 | umls:C0003469 | BeFree | Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 23221871 | 627 | BDNF | umls:C0003469 | BeFree | Gender-specific effects of brain-derived neurotrophic factor Val66Met polymorphism and childhood maltreatment on anxiety. | 0.014039032 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 21097659 | 627 | BDNF | umls:C0003469 | BeFree | In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. | 0.014039032 | 2011 | NA | NA | NA | NA | NA |
| rs386602118 | 19582565 | 1312 | COMT | umls:C0003469 | BeFree | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. | 0.016948948 | 2009 | NA | NA | NA | NA | NA |
| rs386602118 | 24021960 | 474256 | BP1 | umls:C0003469 | BeFree | Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 19923862 | 627 | BDNF | umls:C0003469 | BeFree | There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). | 0.014039032 | 2010 | NA | NA | NA | NA | NA |
| rs386602118 | 21097659 | 255239 | ANKK1 | umls:C0003469 | BeFree | In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. | 0.000271442 | 2011 | NA | NA | NA | NA | NA |
| rs4245146 | 20122683 | 596 | BCL2 | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000542884 | 2010 | DRD2 | 11 | 113447251 | T | C |
| rs4245146 | 20122683 | 5074 | PAWR | umls:C0003469 | BeFree | BCL2 rs12454712 (p = .0029) and DRD2 rs4245146 (p = .0010) showed evidence for association to generalized anxiety disorder, whereas rs2463107 (p = .0064) in PAWR and rs4245146 (p = .0029) in DRD2 showed evidence for association to the pooled group of all anxiety disorders. | 0.000271442 | 2010 | DRD2 | 11 | 113447251 | T | C |
| rs4570625 | 25455586 | 121278 | TPH2 | umls:C0003469 | BeFree | A functional variation in the TPH2 gene (G-703T, rs4570625) has been found to affect anxiety-related personality; however, information is very limited regarding the five factor model (FFM) personality traits. | 0.003800186 | 2014 | TPH2 | 12 | 71938143 | G | T |
| rs4680 | 17079080 | 6531 | SLC6A3 | umls:C0003469 | BeFree | The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria. | 0.123724241 | 2006 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 19582565 | 1312 | COMT | umls:C0003469 | BeFree | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. | 0.016948948 | 2009 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 24300663 | 1312 | COMT | umls:C0003469 | BeFree | Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis. | 0.016948948 | 2014 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 22387174 | 1312 | COMT | umls:C0003469 | BeFree | The present results provide further support for a-potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes and may aid in further clarifying the differential role of COMT genotype driven dopaminergic tonus in the processing of emotionally salient stimuli. | 0.016948948 | 2012 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 18729643 | 1312 | COMT | umls:C0003469 | BeFree | A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals. | 0.016948948 | 2008 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 17079080 | 6532 | SLC6A4 | umls:C0003469 | BeFree | The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria. | 0.264310656 | 2006 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 25238960 | 1312 | COMT | umls:C0003469 | BeFree | We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment (N=97 females: 24 Val/Val, 51 Val/Met, and 22 Met/Met). | 0.016948948 | 2014 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 19944409 | 1312 | COMT | umls:C0003469 | BeFree | The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. | 0.016948948 | 2010 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 25722948 | 1312 | COMT | umls:C0003469 | BeFree | We also found a significant interaction effect of COMT met alleles (β = -32.5 SE 14.1, P = 0.021). in patients genotyped for COMT val158met (N = 87) specifically COMT × conscientiousness (β = 0.73 SE 0.26, P = 0.0042) and COMT × anxiety (β = -0.42 SE 0.16, P = 0.0078) interaction effects. | 0.016948948 | 2014 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 18578865 | 1312 | COMT | umls:C0003469 | BeFree | Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT). | 0.016948948 | 2008 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 25598522 | 1312 | COMT | umls:C0003469 | BeFree | Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its genetic variation is thought to contribute to the interindividual variability in pain perception and anxiety regulation, whether or not migraine and COMT val(158) met genotype have an interactive effect in the key brain area related to maladaptive stress, the hippocampus, is still poorly understood. | 0.016948948 | 2015 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 17079080 | 1813 | DRD2 | umls:C0003469 | BeFree | The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria. | 0.125895776 | 2006 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 23475824 | 1312 | COMT | umls:C0003469 | BeFree | A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. | 0.016948948 | 2013 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 23025981 | 1312 | COMT | umls:C0003469 | BeFree | This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. | 0.016948948 | 2012 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 15584875 | 1312 | COMT | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.016948948 | 2004 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 17504250 | 1312 | COMT | umls:C0003469 | BeFree | COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adolescence: results from the Victorian Adolescent Health Cohort Study. | 0.016948948 | 2007 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 15584875 | 125 | ADH1B | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.000814326 | 2004 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 24118915 | 1312 | COMT | umls:C0003469 | BeFree | The interaction of early life experiences with COMT val158met affects anxiety sensitivity. | 0.016948948 | 2013 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 19398820 | 1312 | COMT | umls:C0003469 | BeFree | The data here are consistent with previous work delineating the different symptom subtypes of OCD, also with previous work suggesting that the Met/Met (L/L) genotype of the COMT Val158Met polymorphism may be associated with anxiety symptoms, as well as with previous work suggesting that dopaminergic genes may be particularly important in early-onset OCD. | 0.016948948 | 2008 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 15900225 | 1312 | COMT | umls:C0003469 | BeFree | Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health. | 0.016948948 | 2005 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 15584875 | 4988 | OPRM1 | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.001085767 | 2004 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 17146014 | 1312 | COMT | umls:C0003469 | BeFree | Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. | 0.016948948 | 2006 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 22745815 | 1312 | COMT | umls:C0003469 | BeFree | Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. | 0.016948948 | 2012 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 15450911 | 1312 | COMT | umls:C0003469 | BeFree | Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity. | 0.016948948 | 2004 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4680 | 17805313 | 1312 | COMT | umls:C0003469 | BeFree | Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness and magnitude; eg the functional Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls. | 0.016948948 | 2008 | COMT;MIR4761 | 22 | 19963748 | G | A |
| rs4692589 | 25390645 | 9848 | MFAP3L | umls:C0003469 | GWASCAT | Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. | 0.12 | 2014 | MFAP3L | 4 | 170014094 | A | G |
| rs5751876 | 22012471 | 135 | ADORA2A | umls:C0003469 | BeFree | Thus, in the present double-blind, placebo-controlled study we attempted to paradigmatically investigate a multi-level pathogenetic model of anxiety by testing the effect of 300 mg caffeine citrate as an antagonist at the adenosine A2A receptor vs placebo on the emotion-potentiated (unpleasant, neutral, and pleasant International Affective Picture System pictures) startle reflex in 110 healthy individuals (male=56, female=54) stratified for the adenosine A2A receptor (ADORA2A) 1976T>C polymorphism (rs5751876). | 0.125081451 | 2012 | ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A | 22 | 24441333 | T | C |
| rs6295 | 22222329 | 3350 | HTR1A | umls:C0003469 | BeFree | C allele of 5-HT1A C-1019G polymorphism might be an independent risk factor for anxiety disorders in temporal lobe epilepsy. | 0.007871814 | 2012 | HTR1A | 5 | 63962738 | C | G |
| rs6318 | 24770757 | 3358 | HTR2C | umls:C0003469 | BeFree | Associations between 5-HTR2A -1438A/G and 5-HTR2C Cys23Ser polymorphisms and depression and its severity were studied in CHD patients with consideration for the trigger factors, pathogenetic characteristics of CHD, and personal anxiety. | 0.083724241 | 2014 | HTR2C;LOC105373313 | X | 114731326 | C | G |
| rs6330 | 23772677 | 4803 | NGF | umls:C0003469 | BeFree | Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. | 0.000271442 | 2013 | NGF | 1 | 115286692 | G | A |
| rs6354 | 19541292 | 6532 | SLC6A4 | umls:C0003469 | BeFree | We found evidence for association (p = .0062, after accounting for multiple testing) for SLC6A4 SNPs rs6354 and rs2020936 (positioned in a different linkage disequilibrium [LD] block about 15.5 kb from 5HTTLPR) with anxiety and/or depression and neuroticism, with the strongest association for recurrent depression with onset in young adulthood (odds ratio = 1.55, 95% confidence interval = 1.16-2.06). | 0.264310656 | 2009 | SLC6A4 | 17 | 30222880 | G | T |
| rs63750579 | 25349165 | 351 | APP | umls:C0003469 | BeFree | Dutch APP(E693Q) transgenic mice accumulate oligomeric Aβ as they age, as well as Aβ oligomer-dose-dependent anxiety and impaired novel object recognition (NOR). | 0.121357209 | 2014 | APP | 21 | 25891856 | C | T,G |
| rs7209436 | 23274505 | 1394 | CRHR1 | umls:C0003469 | BeFree | We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). | 0.122985861 | 2013 | CRHR1;MGC57346-CRHR1 | 17 | 45792776 | C | T |
| rs75012854 | 15584875 | 125 | ADH1B | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.000814326 | 2004 | COMT;MIR4761 | 22 | 19962641 | A | G |
| rs75012854 | 15584875 | 4988 | OPRM1 | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.001085767 | 2004 | COMT;MIR4761 | 22 | 19962641 | A | G |
| rs75012854 | 15584875 | 1312 | COMT | umls:C0003469 | BeFree | Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse. | 0.016948948 | 2004 | COMT;MIR4761 | 22 | 19962641 | A | G |
| rs7997012 | 22006095 | 3356 | HTR2A | umls:C0003469 | BeFree | We show for the first time a pharmacogenetic effect of the HTR2A rs7997012 variant in anxiety disorders, suggesting that pharmacogenetic effects cross diagnostic categories. | 0.004538567 | 2013 | HTR2A | 13 | 46837850 | A | G |
| rs8192506 | 16904689 | 1622 | DBI | umls:C0003469 | BeFree | Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. | 0.000814326 | 2007 | DBI | 2 | 119372265 | A | G |
| rs9340799 | 22901010 | 2099 | ESR1 | umls:C0003469 | BeFree | It appears unlikely that the common ESR1 variants rs2234693 and rs9340799 are associated with moderate depressive symptoms in women; however, there is some evidence that indicates a significant association with more severe depressive symptoms, major depressive disorder and anxiety. | 0.001357209 | 2012 | ESR1 | 6 | 151842246 | A | G |
