PedAM

Pediatric Disease Annotations & Medicines


	anorexia nervosa

Disease ID	531
Disease	anorexia nervosa
Definition	An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
Synonym	an - anorexia nervosa anorexia mentalis anorexia nervosa (disorder) anorexia nervosa [disease/finding] anorexia nervosas anorexia, nervosa nervosa, anorexia nervosas, anorexia
DOID	DOID:8689
UMLS	C0003125
MeSH	D000856
SNOMED-CT	SNOMEDCT_US_2016_09_01:56882008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:86) C0162429 \| malnourished \| 12 C0013473 \| eating disorder \| 11 C0002453 \| amenorrhea \| 6 C0003467 \| anxiety \| 6 C0162429 \| malnutrition \| 5 C0029456 \| osteoporosis \| 5 C0006370 \| bulimia \| 3 C0002871 \| anemia \| 2 C0005940 \| bone disease \| 2 C0679466 \| cognitive deficits \| 2 C0162429 \| undernutrition \| 2 C0032326 \| pneumothorax \| 2 C0030305 \| pancreatitis \| 2 C0013473 \| eating disorders \| 2 C0002020 \| alexithymia \| 2 C0011570 \| depression \| 2 C0027051 \| myocardial infarct \| 2 C2267227 \| bulimia nervosa \| 2 C0027051 \| myocardial infarction \| 2 C0035078 \| renal failure \| 1 C0022116 \| ischemia \| 1 C0003615 \| appendicitis \| 1 C0022735 \| klinefelter syndrome \| 1 C0003469 \| anxiety disorder \| 1 C0007222 \| cardiovascular disorders \| 1 C0001627 \| congenital adrenal hyperplasia \| 1 C0013990 \| emphysema \| 1 C0042373 \| vascular disorder \| 1 C0007104 \| female breast cancer \| 1 C0206734 \| hemangioblastoma \| 1 C0006625 \| cachexia \| 1 C0020598 \| hypoglycemia \| 1 C0019158 \| hepatitis \| 1 C0034888 \| rectal prolapse \| 1 C0011854 \| type 1 diabetes \| 1 C0878544 \| cardiomyopathy \| 1 C0162429 \| underfed \| 1 C0001197 \| acrodermatitis \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0017178 \| gastrointestinal disorder \| 1 C0221036 \| acrodermatitis enteropathica \| 1 C0598639 \| hypercortisolemia \| 1 C0003469 \| anxiety disorders \| 1 C0001339 \| acute pancreatitis \| 1 C0038353 \| gastric dilatation \| 1 C0018802 \| congestive heart failure \| 1 C0007177 \| cardiac tamponade \| 1 C0010346 \| crohn's disease \| 1 C0043121 \| wernicke's encephalopathy \| 1 C0031154 \| peritonitis \| 1 C0017178 \| gastrointestinal disorders \| 1 C0034063 \| pulmonary edema \| 1 C0442874 \| neuropathy \| 1 C0042373 \| vascular disease \| 1 C0031117 \| peripheral neuropathy \| 1 C0014848 \| achalasia \| 1 C0033975 \| psychosis \| 1 C0008350 \| gallstones \| 1 C0006012 \| borderline personality disorder \| 1 C0022658 \| nephropathy \| 1 C0011847 \| diabetes \| 1 C0038828 \| superior mesenteric artery syndrome \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0006142 \| breast cancer \| 1 C0086588 \| marasmus \| 1 C0236792 \| asperger syndrome \| 1 C0007570 \| celiac disease \| 1 C0018801 \| heart failure \| 1 C0020617 \| hypoglycemic coma \| 1 C0238033 \| male breast cancer \| 1 C0042373 \| vascular disorders \| 1 C0004763 \| barrett's esophagus \| 1 C0042769 \| virus infection \| 1 C0025202 \| melanoma \| 1 C0011849 \| diabetes mellitus \| 1 C1258215 \| ileus \| 1 C0020459 \| hyperinsulinaemia \| 1 C0020459 \| hyperinsulinemia \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0699893 \| non-melanoma skin cancer \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0028756 \| morbid obesity \| 1 C1621895 \| adrenal hyperplasia \| 1 C0038436 \| posttraumatic stress disorder \| 1 C0155626 \| acute myocardial infarction \| 1 C0023530 \| leukopenia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) HTR2A \| 3356 \| CTD_human BDNF \| 627 \| CTD_human SOX2-OT \| 347689 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:42) 181 \| AGRP \| infer 9472 \| AKAP6 \| infer 421 \| ARVCF \| infer 627 \| BDNF \| infer 1268 \| CNR1 \| infer 1312 \| COMT \| infer 1813 \| DRD2 \| infer 1814 \| DRD3 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 2119 \| ETV5 \| infer 2166 \| FAAH \| infer 728215 \| FAM155A \| infer 79068 \| FTO \| infer 51738 \| GHRL \| infer 132789 \| GNPDA2 \| infer 3352 \| HTR1D \| infer 3356 \| HTR2A \| infer 3777 \| KCNK3 \| infer 3782 \| KCNN3 \| infer 79047 \| KCTD15 \| infer 4036 \| LRP2 \| infer 4160 \| MC4R \| infer 11343 \| MGLL \| infer 23788 \| MTCH2 \| infer 27163 \| NAAA \| infer 257194 \| NEGR1 \| infer 22854 \| NTNG1 \| infer 4985 \| OPRD1 \| infer 128756 \| RPL15P1 \| infer 25970 \| SH2B1 \| infer 6530 \| SLC6A2 \| infer 6532 \| SLC6A4 \| infer 23635 \| SSBP2 \| infer 129787 \| TMEM18 \| infer 7124 \| TNF \| infer 7126 \| TNFAIP1 \| infer 7351 \| UCP2 \| infer 7352 \| UCP3 \| infer 9686 \| VGLL4 \| infer 219578 \| ZNF804B \| infer 128153 \| SPATA17 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:208) 100130776 \| AGAP2-AS1 \| DISEASES 2101 \| ESRRA \| DISEASES 1815 \| DRD4 \| DISEASES 80863 \| PRRT1 \| DISEASES 10454 \| TAB1 \| DISEASES 5173 \| PDYN \| DISEASES 5020 \| OXT \| DISEASES 6530 \| SLC6A2 \| DISEASES 30844 \| EHD4 \| DISEASES 56729 \| RETN \| DISEASES 6822 \| SULT2A1 \| DISEASES 26291 \| FGF21 \| DISEASES 51200 \| CPA4 \| DISEASES 10135 \| NAMPT \| DISEASES 5539 \| PPY \| DISEASES 2690 \| GHR \| DISEASES 1007 \| CDH9 \| DISEASES 2908 \| NR3C1 \| DISEASES 338 \| APOB \| DISEASES 83444 \| INO80B \| DISEASES 3485 \| IGFBP2 \| DISEASES 4985 \| OPRD1 \| DISEASES 7276 \| TTR \| DISEASES 9519 \| TBPL1 \| DISEASES 2691 \| GHRH \| DISEASES 8600 \| TNFSF11 \| DISEASES 3375 \| IAPP \| DISEASES 80218 \| NAA50 \| DISEASES 2693 \| GHSR \| DISEASES 4852 \| NPY \| DISEASES 1271 \| CNTFR \| DISEASES 2166 \| FAAH \| DISEASES 4159 \| MC3R \| DISEASES 3630 \| INS \| DISEASES 1890 \| TYMP \| DISEASES 83854 \| ANGPTL6 \| DISEASES 51540 \| SCLY \| DISEASES 6117 \| RPA1 \| DISEASES 1401 \| CRP \| DISEASES 80896 \| NPL \| DISEASES 1593 \| CYP27A1 \| DISEASES 79074 \| C2orf49 \| DISEASES 3569 \| IL6 \| DISEASES 9177 \| HTR3B \| DISEASES 51103 \| NDUFAF1 \| DISEASES 6532 \| SLC6A4 \| DISEASES 2901 \| GRIK5 \| DISEASES 421 \| ARVCF \| DISEASES 3553 \| IL1B \| DISEASES 7301 \| TYRO3 \| DISEASES 2892 \| GRIA3 \| DISEASES 5443 \| POMC \| DISEASES 80321 \| CEP70 \| DISEASES 10512 \| SEMA3C \| DISEASES 51083 \| GAL \| DISEASES 5286 \| PIK3C2A \| DISEASES 3782 \| KCNN3 \| DISEASES 5972 \| REN \| DISEASES 3484 \| IGFBP1 \| DISEASES 3358 \| HTR2C \| DISEASES 6570 \| SLC18A1 \| DISEASES 2796 \| GNRH1 \| DISEASES 1392 \| CRH \| DISEASES 4915 \| NTRK2 \| DISEASES 53942 \| CNTN5 \| DISEASES 9472 \| AKAP6 \| DISEASES 5741 \| PTH \| DISEASES 3192 \| HNRNPU \| DISEASES 6750 \| SST \| DISEASES 10417 \| SPON2 \| DISEASES 181 \| AGRP \| DISEASES 3060 \| HCRT \| DISEASES 81570 \| CLPB \| DISEASES 213 \| ALB \| DISEASES 1359 \| CPA3 \| DISEASES 7349 \| UCN \| DISEASES 4982 \| TNFRSF11B \| DISEASES 136242 \| PRSS37 \| DISEASES 11067 \| C10orf10 \| DISEASES 552 \| AVPR1A \| DISEASES 4160 \| MC4R \| DISEASES 4909 \| NTF4 \| DISEASES 50964 \| SOST \| DISEASES 4054 \| LTBP3 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 7200 \| TRH \| DISEASES 11280 \| SCN11A \| DISEASES 55790 \| CSGALNACT1 \| DISEASES 57493 \| HEG1 \| DISEASES 7351 \| UCP2 \| DISEASES 3952 \| LEP \| DISEASES 2688 \| GH1 \| DISEASES 3352 \| HTR1D \| DISEASES 619373 \| MBOAT4 \| DISEASES 3350 \| HTR1A \| DISEASES 9370 \| ADIPOQ \| DISEASES 119682 \| OR51L1 \| DISEASES 6181 \| RPLP2 \| DISEASES 1879 \| EBF1 \| DISEASES 55600 \| ITLN1 \| DISEASES 7352 \| UCP3 \| DISEASES 5021 \| OXTR \| DISEASES 8227 \| AKAP17A \| DISEASES 2863 \| GPR39 \| DISEASES 284359 \| IZUMO1 \| DISEASES 121278 \| TPH2 \| DISEASES 219578 \| ZNF804B \| DISEASES 3953 \| LEPR \| DISEASES 277 \| AMY1B \| DISEASES 1675 \| CFD \| DISEASES 91624 \| NEXN \| DISEASES 353288 \| KRT26 \| DISEASES 51738 \| GHRL \| DISEASES 885 \| CCK \| DISEASES 57142 \| RTN4 \| DISEASES 3363 \| HTR7 \| DISEASES 4889 \| NPY5R \| DISEASES 8788 \| DLK1 \| DISEASES 4128 \| MAOA \| DISEASES 1395 \| CRHR2 \| DISEASES 51094 \| ADIPOR1 \| DISEASES 27255 \| CNTN6 \| DISEASES 145264 \| SERPINA12 \| DISEASES 55179 \| FAIM \| DISEASES 866 \| SERPINA6 \| DISEASES 2100 \| ESR2 \| DISEASES 10950 \| BTG3 \| DISEASES 10617 \| STAMBP \| DISEASES 347148 \| QRFP \| DISEASES 2879 \| GPX4 \| DISEASES 50618 \| ITSN2 \| DISEASES 4983 \| OPHN1 \| DISEASES 3359 \| HTR3A \| DISEASES 2695 \| GIP \| DISEASES 93034 \| NT5C1B \| DISEASES 127343 \| DMBX1 \| DISEASES 5697 \| PYY \| DISEASES 1312 \| COMT \| DISEASES 4860 \| PNP \| DISEASES 1813 \| DRD2 \| DISEASES 128153 \| SPATA17 \| DISEASES 343035 \| RD3 \| DISEASES 3664 \| IRF6 \| DISEASES 3814 \| KISS1 \| DISEASES 7432 \| VIP \| DISEASES 632 \| BGLAP \| DISEASES 253738 \| EBF3 \| DISEASES 8732 \| RNGTT \| DISEASES 1268 \| CNR1 \| DISEASES 3351 \| HTR1B \| DISEASES 22854 \| NTNG1 \| DISEASES 278 \| AMY1C \| DISEASES 276 \| AMY1A \| DISEASES 988 \| CDC5L \| DISEASES 129685 \| TAF8 \| DISEASES 252995 \| FNDC5 \| DISEASES 2170 \| FABP3 \| DISEASES 7321 \| UBE2D1 \| DISEASES 6048 \| RNF5 \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 114798 \| SLITRK1 \| DISEASES 3356 \| HTR2A \| DISEASES 56261 \| GPCPD1 \| DISEASES 5080 \| PAX6 \| DISEASES 9365 \| KL \| DISEASES 551 \| AVP \| DISEASES 119679 \| OR52J3 \| DISEASES 401667 \| OR51A2 \| DISEASES 401666 \| OR51A4 \| DISEASES 8544 \| PIR \| DISEASES 6462 \| SHBG \| DISEASES 3486 \| IGFBP3 \| DISEASES 293 \| SLC25A6 \| DISEASES 51761 \| ATP8A2 \| DISEASES 1814 \| DRD3 \| DISEASES 5901 \| RAN \| DISEASES 9244 \| CRLF1 \| DISEASES 55188 \| RIC8B \| DISEASES 145270 \| PRIMA1 \| DISEASES 84628 \| NTNG2 \| DISEASES 6152 \| RPL24 \| DISEASES 152330 \| CNTN4 \| DISEASES 594857 \| NPS \| DISEASES 1394 \| CRHR1 \| DISEASES 7018 \| TF \| DISEASES 79843 \| FAM124B \| DISEASES 22891 \| ZNF365 \| DISEASES 176 \| ACAN \| DISEASES 2641 \| GCG \| DISEASES 3481 \| IGF2 \| DISEASES 94122 \| SYTL5 \| DISEASES 7124 \| TNF \| DISEASES 65065 \| NBEAL1 \| DISEASES 9686 \| VGLL4 \| DISEASES 55074 \| OXR1 \| DISEASES 79897 \| RPP21 \| DISEASES 627 \| BDNF \| DISEASES 3483 \| IGFALS \| DISEASES 64641 \| EBF2 \| DISEASES 2053 \| EPHX2 \| DISEASES 4925 \| NUCB2 \| DISEASES 64426 \| SUDS3 \| DISEASES 5726 \| TAS2R38 \| DISEASES 23601 \| CLEC5A \| DISEASES 64493 \| LINC00235 \| DISEASES 347689 \| SOX2-OT \| DISEASES
Locus	(Waiting for update.)

Disease ID	531
Disease	anorexia nervosa
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:87) HP:0000141 \| Abnormal absence of menstruation \| 6 HP:0000739 \| Anxiety \| 6 HP:0004395 \| Malnutrition \| 5 HP:0000939 \| Osteoporosis \| 5 HP:0001824 \| Weight loss \| 4 HP:0100543 \| Cognitive deficits \| 4 HP:0000752 \| Hyperactive behavior \| 4 HP:0004325 \| Low body weight \| 3 HP:0002015 \| Swallowing difficulty \| 3 HP:0100739 \| Binge and purge \| 3 HP:0000708 \| Behavioral problems \| 2 HP:0002107 \| Collapsed lung \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0011675 \| Arrhythmias \| 2 HP:0001259 \| Coma \| 2 HP:0000716 \| Depression \| 2 HP:0200136 \| Oral-pharyngeal dysphagia \| 2 HP:0001410 \| Decreased liver function \| 2 HP:0001733 \| Pancreatic inflammation \| 2 HP:0012531 \| Pain \| 2 HP:0002013 \| Emesis \| 2 HP:0001662 \| Bradycardia \| 2 HP:0001903 \| Anemia \| 2 HP:0000112 \| Nephropathy \| 1 HP:0001882 \| Decreased blood leukocyte number \| 1 HP:0002035 \| Rectal prolapse \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0008258 \| Congenital adrenal hyperplasia \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0012076 \| Borderline personality disorder \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0100580 \| Barrett's esophagus \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0001325 \| Coma caused by low blood sugar \| 1 HP:0001250 \| Seizures \| 1 HP:0001941 \| acidemia \| 1 HP:0002861 \| Melanoma \| 1 HP:0000969 \| Dropsy \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0000711 \| Restlessness \| 1 HP:0012075 \| Personality disorder \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0010797 \| Hemangioblastoma \| 1 HP:0010677 \| Enuresis nocturna \| 1 HP:0008770 \| Obsessive-compulsive trait \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0002148 \| Hypophosphataemia \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0000805 \| Enuresis \| 1 HP:0000842 \| Elevated insulin level \| 1 HP:0001664 \| Torsade de pointes \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0000858 \| Menstrual irregularity \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0002918 \| High blood magnesium levels \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0000786 \| Primary amenorrhea \| 1 HP:0003281 \| Increased ferritin \| 1 HP:0001631 \| Atria septal defect \| 1 HP:0000709 \| Psychosis \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0001081 \| Gallstones \| 1 HP:0010783 \| Erythema \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0002608 \| Celiac disease \| 1 HP:0005972 \| Respiratory acidosis \| 1 HP:0004326 \| Cachexia \| 1 HP:0002900 \| Hypokalemia \| 1 HP:0001944 \| Dehydration \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0002647 \| Aortic dissection \| 1 HP:0008221 \| Enlarged adrenal glands \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0000572 \| Visual loss \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0002586 \| Peritonitis \| 1 HP:0100962 \| Shyness \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0002575 \| Tracheoesophageal fistula \| 1 HP:0002571 \| Achalasia \| 1

Disease ID	531
Disease	anorexia nervosa
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:44) C0013473 \| eating disorder \| 9 C0003467 \| anxiety \| 6 C0002453 \| amenorrhea \| 6 C0029456 \| osteoporosis \| 5 C0815110 \| perfectionism \| 5 C0162429 \| malnutrition \| 5 C0871381 \| social cognition \| 3 C0277787 \| stigma \| 3 C0175696 \| g syndrome \| 3 C0006370 \| bulimia \| 3 C0860549 \| refeeding syndrome \| 3 C0013473 \| eating disorders \| 2 C0311276 \| severe malnutrition \| 2 C0679466 \| cognitive deficits \| 2 C0042963 \| vomiting \| 2 C0032326 \| pneumothorax \| 2 C0011570 \| depression \| 2 C0002020 \| alexithymia \| 2 C0006625 \| cachexia \| 1 C0020672 \| hypothermia \| 1 C0878544 \| cardiomyopathy \| 1 C0221036 \| acrodermatitis enteropathica \| 1 C1393529 \| vascular complications \| 1 C0231303 \| distress \| 1 C0018801 \| heart failure \| 1 C0020625 \| hyponatremia \| 1 C0033975 \| psychosis \| 1 C0276651 \| aspergilloma \| 1 C0341862 \| hypothalamic amenorrhea \| 1 C1258215 \| ileus \| 1 C0162429 \| undernutrition \| 1 C0013990 \| emphysema \| 1 C0023530 \| leukopenia \| 1 C0032320 \| pneumoperitoneum \| 1 C0020598 \| hypoglycemia \| 1 C0001339 \| acute pancreatitis \| 1 C0038828 \| superior mesenteric artery syndrome \| 1 C0003469 \| anxiety disorders \| 1 C0020617 \| hypoglycemic coma \| 1 C0038353 \| gastric dilatation \| 1 C0020459 \| hyperinsulinemia \| 1 C0007222 \| cardiovascular disorders \| 1 C0031117 \| peripheral neuropathy \| 1 C1839611 \| n syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:53)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10070190	23337130	1007	CDH9	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	5	26866262	G	A
rs10070190	23337130	10215	OLIG2	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	5	26866262	G	A
rs10070190	23337130	2892	GRIA3	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	5	26866262	G	A
rs1042571	24831852	181	AGRP	umls:C0003125	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.011539974	2014	POMC	2	25161018	G	A
rs1042571	24831852	4915	NTRK2	umls:C0003125	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.005634266	2014	POMC	2	25161018	G	A
rs10494067	21079607	22854	NTNG1	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	NTNG1	1	107288236	A	C
rs1074815	23337130	2892	GRIA3	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	NA	NA	NA	NA
rs1074815	23337130	10215	OLIG2	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	NA	NA	NA	NA
rs1074815	23337130	1007	CDH9	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	NA	NA	NA	NA
rs11179027	23337130	121278	TPH2	umls:C0003125	BeFree	In addition, rs3825885 (NTRK3, p = 9 × 10(-4)) was identified as an AN risk variant, and rs11179027 (TPH2, p = 2 × 10(-3)) as an OCD marker.	0.000814326	2012	TPH2	12	71983532	G	C
rs11179027	23337130	4916	NTRK3	umls:C0003125	BeFree	In addition, rs3825885 (NTRK3, p = 9 × 10(-4)) was identified as an AN risk variant, and rs11179027 (TPH2, p = 2 × 10(-3)) as an OCD marker.	0.000271442	2012	TPH2	12	71983532	G	C
rs1176744	19741568	9177	HTR3B	umls:C0003125	BeFree	In the pilot study, we found the coding HTR3B variant, p.Y129S, (rs1176744, P = 0.004, odds ratio = 2.06) to be associated with the restrictive subtype of AN.	0.000271442	2009	HTR3B	11	113932306	A	C
rs11783752	23337130	10215	OLIG2	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	8	20192013	G	A
rs11783752	23337130	2892	GRIA3	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	8	20192013	G	A
rs11783752	23337130	1007	CDH9	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	NA	8	20192013	G	A
rs13338499	24831852	181	AGRP	umls:C0003125	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.011539974	2014	LOC101927837	16	67486220	A	G
rs13338499	24831852	4915	NTRK2	umls:C0003125	BeFree	AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).	0.005634266	2014	LOC101927837	16	67486220	A	G
rs1473473	23239044	121278	TPH2	umls:C0003125	BeFree	TPH2 (tryptophan hydroxylase 2) SNP rs1473473 was previously associated with anorexia nervosa and EDs characterized by SV.	0.000814326	2012	TPH2	12	72010598	C	T
rs2048332	19680270	128153	SPATA17	umls:C0003125	GAD	[Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers.]	0.002367032	2009	LOC105372922	1	217936424	T	C
rs2295193	24106242	2099	ESR1	umls:C0003125	BeFree	Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: new data and meta-analysis.	0.003452799	2013	SYNE1	6	152131959	G	A
rs2383378	21079607	9472	AKAP6	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	AKAP6	14	32813264	C	A
rs2834070	23337130	1007	CDH9	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	LOC105372784	21	33015144	G	T
rs2834070	23337130	10215	OLIG2	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	LOC105372784	21	33015144	G	T
rs2834070	23337130	2892	GRIA3	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	LOC105372784	21	33015144	G	T
rs3825885	23337130	121278	TPH2	umls:C0003125	BeFree	In addition, rs3825885 (NTRK3, p = 9 × 10(-4)) was identified as an AN risk variant, and rs11179027 (TPH2, p = 2 × 10(-3)) as an OCD marker.	0.000814326	2012	NTRK3	15	88059610	T	C
rs3825885	23337130	4916	NTRK3	umls:C0003125	BeFree	In addition, rs3825885 (NTRK3, p = 9 × 10(-4)) was identified as an AN risk variant, and rs11179027 (TPH2, p = 2 × 10(-3)) as an OCD marker.	0.000271442	2012	NTRK3	15	88059610	T	C
rs386596687	16362631	2693	GHSR	umls:C0003125	BeFree	Therefore, the CC type of GHSR gene polymorphism (171T/C) is a risk factor for BN, but not for AN.	0.002638474	2006	NA	NA	NA	NA	NA
rs386602118	17435670	627	BDNF	umls:C0003125	BeFree	Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosa.	0.144251591	2007	NA	NA	NA	NA	NA
rs386602118	22127997	627	BDNF	umls:C0003125	BeFree	No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese.	0.144251591	2012	NA	NA	NA	NA	NA
rs386602118	15115760	627	BDNF	umls:C0003125	BeFree	We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.	0.144251591	2004	NA	NA	NA	NA	NA
rs410644	21079607	23635	SSBP2	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	NA	5	81791715	G	T
rs4680	14681918	1312	COMT	umls:C0003125	BeFree	Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa.	0.012082858	2004	COMT;MIR4761	22	19963748	G	A
rs4825476	23337130	2892	GRIA3	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	GRIA3	X	123307628	G	A
rs4825476	23337130	10215	OLIG2	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	GRIA3	X	123307628	G	A
rs4825476	23337130	1007	CDH9	umls:C0003125	BeFree	Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.	0.000271442	2012	GRIA3	X	123307628	G	A
rs5030980	15927146	181	AGRP	umls:C0003125	BeFree	Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.	0.011539974	2005	AGRP;ATP6V0D1;LOC101927837	16	67483042	C	T
rs533123	21079607	3352	HTR1D	umls:C0003125	BeFree	We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically.	0.005905708	2011	OPRD1	1	28814643	G	A
rs533123	21079607	4985	OPRD1	umls:C0003125	BeFree	We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically.	0.005905708	2011	OPRD1	1	28814643	G	A
rs6590474	19680270	4548	MTR	umls:C0003125	BeFree	The association analysis for MS-SNP haplotypes detected a statistically significant association (permutation P-value=0.00003) of the A-4-G-T haplotype that comprised four SNP/MS markers (rs6590474-D11S0268i-rs737582-rs7947224) on the 11q22 locus with AN.	0.000271442	2009	CNTN5	11	99982441	A	C
rs6782029	21079607	9686	VGLL4	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	VGLL4	3	11634315	T	C
rs6959888	21079607	219578	ZNF804B	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	ZNF804B	7	88967071	A	G
rs696217	16472909	51738	GHRL	umls:C0003125	BeFree	No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa.	0.016531667	2006	GHRL;GHRLOS	3	10289773	G	T
rs737582	19680270	4548	MTR	umls:C0003125	BeFree	The association analysis for MS-SNP haplotypes detected a statistically significant association (permutation P-value=0.00003) of the A-4-G-T haplotype that comprised four SNP/MS markers (rs6590474-D11S0268i-rs737582-rs7947224) on the 11q22 locus with AN.	0.000271442	2009	CNTN5	11	99992669	G	A
rs747302	23775054	1815	DRD4	umls:C0003125	BeFree	The DRD4 C-616G and DAT1 VNTR polymorphisms correlated with several psychopathological features in patients with AN.	0.00408156	2014	DRD4	11	636689	G	A,C
rs747302	23775054	6531	SLC6A3	umls:C0003125	BeFree	The DRD4 C-616G and DAT1 VNTR polymorphisms correlated with several psychopathological features in patients with AN.	0.000542884	2014	DRD4	11	636689	G	A,C
rs747302	23775054	55885	LMO3	umls:C0003125	BeFree	The DRD4 C-616G and DAT1 VNTR polymorphisms correlated with several psychopathological features in patients with AN.	0.000271442	2014	DRD4	11	636689	G	A,C
rs7532266	21079607	3352	HTR1D	umls:C0003125	BeFree	We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically.	0.005905708	2011	NA	1	23225130	A	C
rs7532266	21079607	4985	OPRD1	umls:C0003125	BeFree	We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically.	0.005905708	2011	NA	1	23225130	A	C
rs7947224	19680270	4548	MTR	umls:C0003125	BeFree	The association analysis for MS-SNP haplotypes detected a statistically significant association (permutation P-value=0.00003) of the A-4-G-T haplotype that comprised four SNP/MS markers (rs6590474-D11S0268i-rs737582-rs7947224) on the 11q22 locus with AN.	0.000271442	2009	CNTN5	11	100002678	T	C
rs830998	21079607	4036	LRP2	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	LRP2	2	169276576	A	C
rs957788	21079607	728215	FAM155A	umls:C0003125	GAD	[, our study suggests that both common SNPs and rare CNVs may confer genetic risk to AN.]	0.002367032	2011	FAM155A	13	107604872	T	C
rs9839776	24514567	347689	SOX2-OT	umls:C0003125	GWASCAT	A genome-wide association study of anorexia nervosa.	0.12	2013	SOX2-OT	3	181593779	C	T
rs9939609	22797368	79068	FTO	umls:C0003125	BeFree	Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa.	0.000542884	2012	FTO	16	53786615	T	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:63)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	19206334	rs28441017	G	A	rs28441017	23568457	9.00E-06	NA	0.09	[0.049-0.123] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs28441017-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	25469913	rs2064251	G	A	rs2064251	21079607	9.72E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	32668428	rs6425793	A	G	rs6425793	23568457	9.63E-06	NA	0.07	[0.036-0.096] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs6425793-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	68491995	rs12069862	G	A	rs12069862	23568457	5.42E-04	NA	0.11	[0.046-0.174] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs12069862-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	79227956	rs1937020	C	T	rs1937020	23568457	4.00E-06	NA	0.04	[0.023-0.059] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1937020-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
1	107830858	rs10494067	A	C	rs10494067	21079607	6.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C,A
1	180130723	rs55946907	C	T	rs55946907	23568457	9.00E-06	NA	0.07	[0.037-0.095] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs55946907-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	74761539	rs17010021	T	A	rs17010021	23568457	1.00E-05	NA	0.11	[0.057-0.153] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs17010021-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	80915114	rs1370339	C	T	rs1370339	24514567	5.68E-05	NA	1.1	[1.05-1.15]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1370339-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
2	170133086	rs830998	A	C	rs830998	21079607	9.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
2	223353446	rs17496827	A	C	rs17496827	23568457	7.00E-06	NA	0.04	[0.024-0.06] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs17496827-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
2	225308978	rs1523921	T	C	rs1523921	24514567	5.95E-05	NA	1.13	[1.06-1.20]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1523921-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	11675789	rs6782029	T	C	rs6782029	21079607	9.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
3	12038264	rs2618405	C	A	rs2618405	24514567	2.03E-05	NA	1.15	[1.08-1.23]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs2618405-C	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	130730517	rs13076493	C	T	rs13076493	23568457	3.34E-05	NA	0.04	[0.023-0.063] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs13076493-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
3	181311567	rs9839776	C	T	rs9839776	24514567	3.00E-07	NA	1.16	[1.10-1.23]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs9839776-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
4	5887440	rs3774895	A	T	rs3774895	23568457	2.00E-05	NA	0.04	[0.02-0.052] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs3774895-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
4	102048076	rs17030795	A	G	rs17030795	24514567	6.00E-06	NA	1.15	[1.08-1.22]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs17030795-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	163057016	rs17042030	G	A	rs17042030	21079607	1.15E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A,G
5	26723783	rs4479806	C	A	rs4479806	21079607	8.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
5	81074655	rs457008	C	T	rs457008	21079607	6.96E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C,T
5	81087534	rs410644	G	T	rs410644	21079607	7.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	94148538	rs469339	G	A	rs469339	23568457	3.00E-06	NA	0.14	[0.083-0.205] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs469339-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
5	118474109	rs4895185	A	G	rs4895185	23568457	1.69E-04	NA	0.03	[0.015-0.051] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs4895185-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	12193432	rs114945094	G	A	rs114945094	23568457	4.00E-06	NA	0.14	[0.078-0.192] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs114945094-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	41295903	rs11765463	G	A	rs11765463	21079607	1.30E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	88596385	rs6959888	A	G	rs6959888	21079607	2.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
7	106686448	rs2395833	G	T	rs2395833	24514567	5.62E-05	NA	1.1	[1.05-1.15]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs2395833-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
7	138817240	rs7798474	T	G	rs7798474	23568457	6.90E-05	NA	0.04	[0.019-0.059] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs7798474-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	141505087	rs145241704	T	G	rs145241704	23568457	2.00E-07	NA	0.14	[0.09-0.196] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs145241704-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	141589278	rs1285957	T	C	rs1285957	23568457	1.00E-06	NA	0.06	[0.032-0.08] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1285957-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
7	146934096	rs6943628	G	A	rs6943628	24514567	9.38E-05	NA	1.16	[1.08-1.25]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs6943628-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
8	19540262	rs11204064	A	G	rs11204064	24514567	1.57E-05	NA	1.12	[1.06-1.18]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs11204064-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
8	86101451	rs4150880	T	A	rs4150880	23568457	1.70E-05	NA	0.04	[0.025-0.065] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs4150880-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
8	96504472	rs77742018	A	G	rs77742018	23568457	4.00E-06	NA	0.12	[0.068-0.166] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs77742018-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
9	23874047	rs512089	A	C	rs512089	21079607	1.98E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	12702569	rs75263140	A	G	rs75263140	23568457	6.00E-06	NA	0.17	[0.098-0.246] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs75263140-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	77298609	rs2043090	A	G	rs2043090	23568457	3.00E-06	NA	0.12	[0.068-0.17] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs2043090-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	87694292	rs76765968	T	C	rs76765968	23568457	2.00E-06	NA	0.06	[0.037-0.091] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs76765968-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	88407055	rs2803546	G	A	rs2803546	23568457	2.79E-04	NA	0.03	[0.016-0.052] unit increase	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs2803546-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	102772283	rs11190790	A	C	rs11190790	23568457	2.02E-04	NA	0.03	[0.014-0.05] unit increase	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs11190790-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
10	124422108	rs2421031	T	C	rs2421031	23568457	4.62E-04	NA	0.05	[0.02-0.076] unit increase	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs2421031-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
11	129910584	rs3808986	C	A	rs3808986	21079607	1.38E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	49905713	rs7975712	T	C	rs7975712	21079607	1.68E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	49924637	rs11169058	C	T	rs11169058	21079607	1.44E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	49927148	rs12296440	G	A	rs12296440	21079607	1.24E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	49931585	rs11169063	T	C	rs11169063	21079607	1.92E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	50064928	rs7963954	A	G	rs7963954	21079607	1.39E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
13	24535988	rs1886797	T	C	rs1886797	24514567	2.18E-05	NA	1.13	[1.07-1.20]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1886797-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
13	64572127	rs9539891	C	T	rs9539891	24514567	5.88E-05	NA	1.12	[1.06-1.19]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs9539891-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	85549736	rs9531686	T	G	rs9531686	23568457	9.00E-06	NA	0.04	[0.022-0.054] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs9531686-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
13	108257220	rs957788	T	C	rs957788	21079607	8.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
14	33282470	rs2383378	C	A	rs2383378	21079607	6.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
14	33305020	rs12894779	G	A	rs12894779	21079607	1.54E-05	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
15	80166597	rs1113983	C	A	rs1113983	23568457	1.30E-04	NA	0.03	[0.015-0.051] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs1113983-C	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	29690904	rs9933310	A	G	rs9933310	23568457	3.30E-05	NA	0.04	[0.023-0.063] unit increase	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs9933310-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
16	79186886	rs8050187	T	C	rs8050187	23568457	7.00E-06	NA	0.04	[0.024-0.064] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs8050187-T	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
18	73050334	rs62090893	G	A	rs62090893	23568457	3.00E-07	NA	0.09	[0.052-0.118] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs62090893-G	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
19	11789015	rs206863	A	G	rs206863	24514567	6.47E-05	NA	1.16	[1.08-1.24]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs206863-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
20	18079131	rs17725255	T	C	rs17725255	21079607	2.00E-06	NA	NA	NA	1,033 European ancestry cases; 3,773 European ancestry pediatric controls	European(4806)	ALL(4806)	EUR(4806)	ALL(4806)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	22335508	rs10482915	G	A	rs10482915	24514567	3.96E-05	NA	1.19	[1.10-1.30]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs10482915-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
X	37999652	rs56156506	A	T	rs56156506	23568457	1.00E-06	NA	0.05	[0.031-0.075] unit decrease	237 female cases; 2,287 female controls	NOPOP(2524)	ALL(2524)	NOPOP(2524)	ALL(2524)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs56156506-A	Twin Study	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't
X	107692305	rs5929098	C	T	rs5929098	24514567	8.37E-05	NA	1.14	[1.07-1.21]	2,907 European ancestry cases; 14,860 European ancestry controls	European(17767)	ALL(17767)	EUR(17767)	ALL(17767)	Anorexia nervosa	HPOID:0002039	Anorexia	DOID:8689	anorexia nervosa	D000856	Anorexia Nervosa	NA	NA	Anorexia nervosa	rs5929098-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0003125	olanzapine	C076029	132539-06-1	anorexia nervosa	MESH:D000856	therapeutic	12616591

FDA approved drug and dosage information(Total Drugs:4)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D000856	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D000856	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes
MESH:D000856	zyprexa	olanzapine	2.5MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D000856	zyprexa	olanzapine	10MG/VIAL	INJECTABLE;INTRAMUSCULAR	Prescription	AP	Yes	Yes

FDA labeling changes(Total Drugs:4)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D000856	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D000856	08/14/2008	zyprexa	olanzapine	schizophrenia; bipolar disorder	Safety and effectiveness have not been established for patients less than 18 years of age In an analysis of placebo-controlled olanzapine monotherapy studies of adolescent patients, including those with schizophrenia or bipolar disorder, olanzapine was associated with: oHyperglycemia - a statistically significantly greater mean change in fasting glucose levels compared to placebo oHyperlipidemia statistically significant increases compared to placebo in fasting triglycerides, fasting total cholesterol and fasting LDL cholesterol oWeight gain olanzapine treated patients gained an average of 4.6 kg, compared to an average of 0.3 kg in placebo-treated patients with a median exposure of 3 weeks; Average weight gain during long-term therapy was 7.4 kg	-	B	-	-	-	Lilly	10/1/2007	FALSE'
MESH:D000856	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'
MESH:D000856	4/12/2009	zyprexa	olanzapine	Treatment of manic or mixed episodes of bipolar I disorder and schizophrenia in adolescents ages 13-17	Extended schizophrenia and manic or mixed episodes of bipolar I disorder indications from adults to adolescents 1317 years of age Safety and effectiveness in children < 13 years of age have not been established Recommended starting dose for adolescents is lower than that for adults Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic transaminase levels Information on dosing, adverse reactions, pharmacokinetics, clinical studies	Labeling	B	-	-	-	Lilly	10/1/2007	TRUE'