PedAM

Pediatric Disease Annotations & Medicines


	angina pectoris

Disease ID	1354
Disease	angina pectoris
Definition	The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Synonym	angina angina (disorder) angina pain angina pectoris (disorder) angina pectoris (disorder) [ambiguous] angina pectoris [disease/finding] angina pectoris nos angina pectoris nos (disorder) angina pectoris, nos angina, cardiac angina, nos anginal pain anginal syndrome anginas angor pectoris ap - angina pectoris cardiac angina chest pain - cardiac ischaemic chest pain ischaemic chest pain (disorder) ischaemic heart disease - angina ischemic chest pain ischemic chest pain (finding) ischemic heart disease - angina pain angina pectoris angina stenocardia stenocardia (disorder) stenocardias
UMLS	C0002962
MeSH	D000787
SNOMED-CT	SNOMEDCT_US_2016_09_01:194828000;SNOMEDCT_US_2016_09_01:225566008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:53) C0002965 \| unstable angina pectoris \| 14 C0002965 \| unstable angina \| 14 C0010068 \| coronary artery disease \| 12 C0020538 \| hypertension \| 10 C0004153 \| atherosclerosis \| 6 C0011847 \| diabetes \| 6 C0022116 \| ischemia \| 5 C0027051 \| myocardial infarct \| 5 C0027051 \| myocardial infarction \| 5 C0010054 \| coronary atherosclerosis \| 4 C0042373 \| vascular disease \| 4 C0151744 \| myocardial ischemia \| 3 C0007222 \| cardiovascular disease \| 3 C0022116 \| ischaemia \| 3 C0010073 \| coronary artery spasm \| 3 C0155626 \| acute myocardial infarction \| 3 C0018801 \| heart failure \| 3 C0018799 \| heart disease \| 2 C0151744 \| myocardial ischaemia \| 2 C0003850 \| arteriosclerosis \| 2 C0022658 \| nephropathy \| 2 C0042373 \| vascular diseases \| 2 C0010068 \| coronary disease \| 2 C0011849 \| diabetes mellitus \| 2 C0006267 \| bronchiectasis \| 2 C0007102 \| colon cancer \| 1 C0029408 \| osteoarthritis \| 1 C0020456 \| hyperglycemia \| 1 C0011570 \| depression \| 1 C0034150 \| purpura \| 1 C0010073 \| coronary spasm \| 1 C0040156 \| thyrotoxicosis \| 1 C1442837 \| myocardial necrosis \| 1 C0852949 \| arterial disease \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0007222 \| cardiovascular diseases \| 1 C0278553 \| recurrent colon cancer \| 1 C0151744 \| ischaemic heart disease \| 1 C1135191 \| systolic heart failure \| 1 C0018916 \| hemangioma \| 1 C0038531 \| subclavian steal syndrome \| 1 C0878544 \| cardiomyopathy \| 1 C0948265 \| metabolic syndrome \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0264683 \| coronary atheroma \| 1 C0004030 \| aspergillosis \| 1 C0020542 \| pulmonary hypertension \| 1 C0040053 \| thrombus \| 1 C0002726 \| amyloidosis \| 1 C0018824 \| valvular heart disease \| 1 C0398625 \| protein c deficiency \| 1 C0040053 \| thrombosis \| 1 C0020443 \| hypercholesterolaemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) AVP \| 551 \| CTD_human PLAU \| 5328 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) 1361 \| CPB2 \| infer 1535 \| CYBA \| infer 2243 \| FGA \| infer 2244 \| FGB \| infer 2811 \| GP1BA \| infer 3675 \| ITGA3 \| infer 4314 \| MMP3 \| infer 4318 \| MMP9 \| infer 7941 \| PLA2G7 \| infer 5444 \| PON1 \| infer 6872 \| TAF1 \| infer 217 \| ALDH2 \| infer 348 \| APOE \| infer 3383 \| ICAM1 \| infer 3569 \| IL6 \| infer 5175 \| PECAM1 \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1354
Disease	angina pectoris
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:37) HP:0001677 \| Coronary artery disease \| 14 HP:0012531 \| Pain \| 10 HP:0000822 \| Hypertension \| 10 HP:0002621 \| Atherosclerosis \| 6 HP:0100749 \| Thoracic pain \| 6 HP:0001297 \| Cerebral vascular events \| 4 HP:0001658 \| Myocardial infarction \| 4 HP:0004929 \| Coronary artherosclerosis \| 4 HP:0001635 \| Congestive heart failure \| 3 HP:0002110 \| Bronchiectasis \| 2 HP:0011675 \| Arrhythmias \| 2 HP:0005110 \| Atrial fibrillation \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0000112 \| Nephropathy \| 2 HP:0002094 \| Dyspnea \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0002634 \| Arteriosclerosis \| 2 HP:0011641 \| Coronary artery fistula \| 2 HP:0002092 \| Pulmonary artery hypertension \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0005132 \| Pericardial constriction \| 1 HP:0000979 \| Purpura \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0001028 \| Strawberry mark \| 1 HP:0001974 \| Leukocytosis \| 1 HP:0003003 \| Colon cancer \| 1 HP:0004754 \| Permanent atrial fibrillation \| 1 HP:0000716 \| Depression \| 1 HP:0003074 \| High blood glucose \| 1 HP:0011673 \| Cardiac hemangioma \| 1 HP:0001662 \| Bradycardia \| 1 HP:0001268 \| Mental deterioration \| 1 HP:0002153 \| Elevated serum potassium levels \| 1 HP:0001700 \| Myocardial necrosis \| 1 HP:0005543 \| Reduced protein C activity \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0011034 \| Amyloid disease \| 1

Disease ID	1354
Disease	angina pectoris
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:22) C0010068 \| coronary artery disease \| 12 C0020538 \| hypertension \| 10 C0030193 \| pain \| 10 C0011847 \| diabetes \| 6 C0008031 \| chest pain \| 6 C0022116 \| ischemia \| 5 C0010054 \| coronary atherosclerosis \| 4 C0037763 \| spasm \| 4 C0018801 \| heart failure \| 3 C0151744 \| myocardial ischemia \| 3 C0022116 \| ischaemia \| 3 C0856169 \| endothelial dysfunction \| 2 C0010068 \| coronary disease \| 2 C0013404 \| dyspnea \| 2 C0005750 \| stasis syndrome \| 1 C0242339 \| dyslipidemia \| 1 C0010073 \| coronary spasm \| 1 C0011570 \| depression \| 1 C0422833 \| ent symptoms \| 1 C0040053 \| thrombus \| 1 C1839611 \| n syndrome \| 1 C0542052 \| coronary insufficiency \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:47)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0002962	amiloride	D000584	2609-46-3	angina pectoris	MESH:D000787	therapeutic	8062500
C0002962	amitriptyline	D000639	50-48-6	angina pectoris	MESH:D000787	therapeutic	9591892
C0002962	amlodipine	D017311	88150-42-9	angina pectoris	MESH:D000787	therapeutic	10932030
C0002962	atenolol	D001262	29122-68-7	angina pectoris	MESH:D000787	therapeutic	101223
C0002962	atropine	D001285	51-55-8	angina pectoris	MESH:D000787	therapeutic	6305298
C0002962	betaxolol	D015784	63659-18-7	angina pectoris	MESH:D000787	therapeutic	14559135
C0002962	bisoprolol	D017298	66722-44-9	angina pectoris	MESH:D000787	therapeutic	2439788
C0002962	bleomycin	D001761	11056-06-7	angina pectoris	MESH:D000787	marker/mechanism	2456930
C0002962	celecoxib	D000068579	-	angina pectoris	MESH:D000787	marker/mechanism	16681880
C0002962	cyclophosphamide	D003520	50-18-0	angina pectoris	MESH:D000787	marker/mechanism	18849242
C0002962	diatrizoate	D003973	117-96-4	angina pectoris	MESH:D000787	marker/mechanism	9408613
C0002962	cisplatin	D002945	15663-27-1	angina pectoris	MESH:D000787	marker/mechanism	10397083
C0002962	diclofenac	D004008	15307-86-5	angina pectoris	MESH:D000787	marker/mechanism	9220183
C0002962	digoxin	D004077	20830-75-5	angina pectoris	MESH:D000787	therapeutic	2912410
C0002962	dihydroergotamine	D004087	511-12-6	angina pectoris	MESH:D000787	marker/mechanism	8308831
C0002962	diltiazem	D004110	42399-41-7	angina pectoris	MESH:D000787	therapeutic	10027656
C0002962	fluorouracil	D005472	51-21-8	angina pectoris	MESH:D000787	marker/mechanism	12402434
C0002962	leucovorin	D002955	1958/5/9	angina pectoris	MESH:D000787	marker/mechanism	15668828
C0002962	indomethacin	D007213	53-86-1	angina pectoris	MESH:D000787	marker/mechanism	9220183
C0002962	isradipine	D017275	75695-93-1	angina pectoris	MESH:D000787	marker/mechanism	11002857
C0002962	isradipine	D017275	75695-93-1	angina pectoris	MESH:D000787	therapeutic	1703598
C0002962	labetalol	D007741	36894-69-6	angina pectoris	MESH:D000787	therapeutic	2908732
C0002962	leuprolide	D016729	53714-56-0	angina pectoris	MESH:D000787	marker/mechanism	8030717
C0002962	metoprolol	D008790	37350-58-6	angina pectoris	MESH:D000787	therapeutic	21112460
C0002962	mifepristone	D015735	84371-65-3	angina pectoris	MESH:D000787	marker/mechanism	11187221
C0002962	nelfinavir	D019888	159989-64-7	angina pectoris	MESH:D000787	marker/mechanism	18025881
C0002962	nisoldipine	D015737	63675-72-9	angina pectoris	MESH:D000787	therapeutic	11720635
C0002962	nitric oxide	D009569	10102-43-9	angina pectoris	MESH:D000787	therapeutic	1686696
C0002962	phenylephrine	D010656	59-42-7	angina pectoris	MESH:D000787	marker/mechanism	10389447
C0002962	prazosin	D011224	19216-56-9	angina pectoris	MESH:D000787	marker/mechanism	472855
C0002962	propranolol	D011433	525-66-6	angina pectoris	MESH:D000787	marker/mechanism	12113709
C0002962	propranolol	D011433	525-66-6	angina pectoris	MESH:D000787	therapeutic	101223
C0002962	epoprostenol	D011464	35121-78-9	angina pectoris	MESH:D000787	therapeutic	2433921
C0002962	ramipril	D017257	87333-19-5	angina pectoris	MESH:D000787	therapeutic	10732883
C0002962	ranolazine	D000069458	-	angina pectoris	MESH:D000787	therapeutic	11975803
C0002962	rosiglitazone	C089730	-	angina pectoris	MESH:D000787	marker/mechanism	19591532
C0002962	sotalol	D013015	3930-20-9	angina pectoris	MESH:D000787	marker/mechanism	7171401
C0002962	sotalol	D013015	3930-20-9	angina pectoris	MESH:D000787	therapeutic	1360557
C0002962	dextrothyroxine	D003918	51-49-0	angina pectoris	MESH:D000787	marker/mechanism	5818672
C0002962	ticlopidine	D013988	55142-85-3	angina pectoris	MESH:D000787	therapeutic	19309387
C0002962	timolol	D013999	26839-75-8	angina pectoris	MESH:D000787	therapeutic	2508936
C0002962	vinblastine	D014747	865-21-4	angina pectoris	MESH:D000787	marker/mechanism	2456930
C0002962	vincristine	D014750	-	angina pectoris	MESH:D000787	marker/mechanism	11724093
C0002962	vindesine	D014751	53643-48-4	angina pectoris	MESH:D000787	marker/mechanism	3948198
C0002962	vinorelbine	C030852	71486-22-1	angina pectoris	MESH:D000787	marker/mechanism	10731757
C0002962	vitamin e	D014810	1406-18-4	angina pectoris	MESH:D000787	marker/mechanism	15562867
C0002962	vitamin e	D014810	1406-18-4	angina pectoris	MESH:D000787	therapeutic	9822095

FDA approved drug and dosage information(Total Drugs:3)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D000787	celebrex	celecoxib	100MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D000787	celebrex	celecoxib	100MG	CAPSULE;ORAL	Prescription	None	No	No
MESH:D000787	inomax	nitric oxide	100PPM Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	GAS;INHALATION	Discontinued	None	Yes	No

FDA labeling changes(Total Drugs:3)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D000787	12/15/2006	celebrex	celecoxib	Relief of the signs and symptoms of juvenile rheumatoid arthritis (JRA)	New indication in 2 years and older Has not been studied in patients < 2 years, in patients with body weight < 10 kg, or in patients with active systemic features Celecoxib should be used only with caution in patients with systemic onset JRA due to the risk for serious adverse reactions including the risk of disseminated intravascular coagulation The long-term cardiovascular toxicity in children has not been evaluated; it is unknown if the long-term risk may be similar to that seen in adults New 50 mg capsule developed Information on adding contents of a capsule to applesauce. for patients with difficulty swallowing capsules Information on dose, clinical studies, PK parameters, AEs	Labeling	B	-	-	-	Pfizer	08/23/2006	FALSE'
MESH:D000787	12/15/2006	celebrex	celecoxib	Relief of the signs and symptoms of juvenile rheumatoid arthritis (JRA)	New indication in 2 years and older Has not been studied in patients < 2 years, in patients with body weight < 10 kg, or in patients with active systemic features Celecoxib should be used only with caution in patients with systemic onset JRA due to the risk for serious adverse reactions including the risk of disseminated intravascular coagulation The long-term cardiovascular toxicity in children has not been evaluated; it is unknown if the long-term risk may be similar to that seen in adults New 50 mg capsule developed Information on adding contents of a capsule to applesauce. for patients with difficulty swallowing capsules Information on dose, clinical studies, PK parameters, AEs	Labeling	B	-	-	-	Pfizer	08/23/2006	FALSE'
MESH:D000787	12/21/2010	inomax	nitric oxide	Prevention of bronchopulmonary dysplasia	INOmax is not indicated for prevention of BPD in preterm neonates d 34 weeks gestational age.Efficacy for the prevention of BPD in preterm infants was not established in three ldouble-blind, placebo-controlled clinical trials in a total of 2,149 preterm infants Information on clinical trials, adverse reaction	Labeling	B	-	-	-	INO Therapeutics	2/11/2010	FALSE'