PedAM
Pediatric Disease Annotations & Medicines
| anemia, megaloblastic | ||||
| Disease ID | 1136 |
|---|---|
| Disease | anemia, megaloblastic |
| Definition | A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS. |
| Synonym | [x]megaloblastic anaemia nos [x]megaloblastic anemia nos [x]megaloblastic anemia nos (disorder) anaemia - megaloblastic anaemia megaloblastic anemia - megaloblastic anemia megaloblastic anemia, megaloblastic [disease/finding] anemias, megaloblastic megaloblastic megaloblastic anaemia megaloblastic anaemia nos megaloblastic anaemia nos (disorder) megaloblastic anemia megaloblastic anemia (disorder) megaloblastic anemia nos megaloblastic anemia nos (disorder) megaloblastic anemia, nos megaloblastic anemias |
| DOID | |
| UMLS | C0002888 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:22) C0016412 | folate deficiency | 6 C0030312 | pancytopenia | 6 C0002871 | anemia | 5 C0042847 | vitamin b12 deficiency | 4 C0042847 | vitamin b12 defic | 4 C0002871 | anaemia | 3 C0042847 | cobalamin deficiency | 3 C0002871 | anemias | 1 C0011570 | depression | 1 C0024523 | malabsorption | 1 C0024530 | malaria | 1 C0002886 | macrocytic anemia | 1 C0020456 | hyperglycemia | 1 C0085110 | severe combined immunodefic | 1 C0598608 | hyperhomocysteinemia | 1 C0024291 | haemophagocytic lymphohistiocytosis | 1 C0002892 | pernicious anaemia | 1 C0162429 | nutritional deficiencies | 1 C0085110 | severe combined immunodeficiency | 1 C0442874 | neuropathy | 1 C0162316 | iron deficiency anaemia | 1 C0153121 | mixed malaria | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:6) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1136 |
|---|---|
| Disease | anemia, megaloblastic |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:18) HP:0001903 | Anemia | 8 HP:0100507 | Folate deficiency | 6 HP:0001876 | Low blood cell count | 6 HP:0100502 | Vitamin B12 deficiency | 4 HP:0001945 | Fever | 2 HP:0001643 | Persistent ductus arteriosus | 1 HP:0000716 | Depression | 1 HP:0002721 | Immunodeficiency | 1 HP:0001981 | Schistocytosis | 1 HP:0001972 | Macrocytic anemia | 1 HP:0003074 | High blood glucose | 1 HP:0000738 | Sensory hallucination | 1 HP:0012132 | Erythroid hyperplasia | 1 HP:0001270 | Motor retardation | 1 HP:0004430 | Severe combined immunodeficiency | 1 HP:0005387 | Combined immunodeficiency | 1 HP:0001263 | Developmental retardation | 1 HP:0002024 | Intestinal malabsorption | 1 |
| Disease ID | 1136 |
|---|---|
| Disease | anemia, megaloblastic |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:14) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0002888 | chlorambucil | D002699 | 305-03-3 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 15656036 | ||
| C0002888 | chloroquine | D002738 | 1954/5/7 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 18057166 | ||
| C0002888 | colchicine | D003078 | 64-86-8 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 15656036 | ||
| C0002888 | cyclophosphamide | D003520 | 50-18-0 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 15656036 | ||
| C0002888 | fluorouracil | D005472 | 51-21-8 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 11129139 | ||
| C0002888 | folic acid | D005492 | 59-30-3 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 14227437 | ||
| C0002888 | folic acid | D005492 | 59-30-3 | anemia, megaloblastic | MESH:D000749 | therapeutic | 16353713 | ||
| C0002888 | leucovorin | D002955 | 1958/5/9 | anemia, megaloblastic | MESH:D000749 | therapeutic | 21310276 | ||
| C0002888 | metformin | D008687 | 657-24-9 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 12772378 | ||
| C0002888 | methotrexate | D008727 | 1959/5/2 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 10458822 | ||
| C0002888 | phenytoin | D010672 | 57-41-0 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 1147459 | ||
| C0002888 | pyrazinamide | D011718 | 98-96-4 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 4731775 | ||
| C0002888 | pyrimethamine | D011739 | 58-14-0 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 1256293 | ||
| C0002888 | triamterene | D014223 | 396-01-0 | anemia, megaloblastic | MESH:D000749 | marker/mechanism | 16187172 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |