PedAM
Pediatric Disease Annotations & Medicines
| anca-associated vasculitis | ||||
| Disease ID | 994 |
|---|---|
| Disease | anca-associated vasculitis |
| Definition | Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls. |
| Synonym | anca associated vasculitides anca associated vasculitis anca-associated vasculitide anca-associated vasculitides anti neutrophil cytoplasmic antibody associated vasculitis anti-neutrophil cytoplasmic antibody-associated vasculitis anti-neutrophil cytoplasmic antibody-associated vasculitis [disease/finding] pauci immune vasculitis pauci-immune vasculitides pauci-immune vasculitis vasculitide, anca-associated vasculitides, anca-associated vasculitides, pauci-immune vasculitis, anca-associated vasculitis, pauci-immune |
| Orphanet | |
| UMLS | C2717865 |
| MeSH | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:41) C0017658 | glomerulonephritis | 4 C0022658 | renal disease | 3 C0403416 | crescentic glomerulonephritis | 2 C0029882 | otitis media | 2 C0042384 | vasculitis | 2 C0036421 | systemic sclerosis | 2 C0027697 | nephritis | 1 C0442874 | neuropathy | 1 C0007688 | central retinal artery occlusion | 1 C0042373 | vascular disease | 1 C0024299 | lymphoma | 1 C0014118 | endocarditis | 1 C0017665 | membranous glomerulonephritis | 1 C0409974 | lupus erythematosus | 1 C0035302 | retinal artery occlusion | 1 C0025289 | meningitis | 1 C0042373 | vascular diseases | 1 C0221239 | rapidly progressive glomerulonephritis | 1 C0027707 | interstitial nephritis | 1 C0008728 | churg-strauss syndrome | 1 C0021345 | infectious mononucleosis | 1 C0206062 | interstitial lung disease | 1 C0041349 | tubulointerstitial nephritis | 1 C0085436 | cryptococcal meningitis | 1 C0948265 | metabolic syndrome | 1 C1527336 | sjogren's syndrome | 1 C0035078 | kidney failure | 1 C0015397 | eye disease | 1 C0022661 | end-stage renal disease | 1 C0035078 | renal failure | 1 C0027947 | neutropenia | 1 C0031117 | peripheral neuropathy | 1 C0079731 | b-cell lymphoma | 1 C0021345 | mononucleosis | 1 C0017665 | membranous nephropathy | 1 C0019163 | hepatitis b | 1 C0024141 | systemic lupus erythematosus | 1 C0024115 | lung disease | 1 C0021400 | influenza | 1 C0034069 | pulmonary fibrosis | 1 C0019158 | hepatitis | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 994 |
|---|---|
| Disease | anca-associated vasculitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:25) HP:0000099 | Glomerular nephritis | 4 HP:0008653 | Crescentic glomerulonephritis | 2 HP:0012378 | Fatigue | 2 HP:0000388 | Otitis media | 2 HP:0012578 | Membranous glomerulonephritis | 2 HP:0002633 | Vasculitis | 2 HP:0002725 | Systemic lupus erythematosus | 1 HP:0001945 | Fever | 1 HP:0000123 | Nephritis | 1 HP:0002206 | Pulmonary fibrosis | 1 HP:0001875 | Neutropenia | 1 HP:0001287 | Meningitis | 1 HP:0012115 | Liver inflammation | 1 HP:0001709 | Complete heart block | 1 HP:0001298 | Encephalopathy | 1 HP:0001970 | Interstitial nephritis | 1 HP:0012722 | Heart block | 1 HP:0009830 | Peripheral neuritis | 1 HP:0003774 | End-stage renal failure | 1 HP:0001907 | Thromboembolic disease | 1 HP:0100584 | Endocarditis | 1 HP:0012531 | Pain | 1 HP:0006530 | Interstitial lung disease | 1 HP:0030830 | Crackles | 1 HP:0000083 | Renal insufficiency | 1 |
| Disease ID | 994 |
|---|---|
| Disease | anca-associated vasculitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:7) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs2476601 | 22237046 | 26191 | PTPN22 | umls:C2717865 | BeFree | PTPN22 R620W polymorphism in the ANCA-associated vasculitides. | 0.002909916 | 2012 | PTPN22;AP4B1-AS1 | 1 | 113834946 | A | G |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:5) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C2717865 | allopurinol | D000493 | 315-30-0 | anti-neutrophil cytoplasmic antibody-associated vasculitis | MESH:D056648 | marker/mechanism | 10693882 | ||
| C2717865 | carbimazole | D002231 | 22232-54-8 | anti-neutrophil cytoplasmic antibody-associated vasculitis | MESH:D056648 | marker/mechanism | 19263707 | ||
| C2717865 | cyclophosphamide | D003520 | 50-18-0 | anti-neutrophil cytoplasmic antibody-associated vasculitis | MESH:D056648 | therapeutic | 16188901 | ||
| C2717865 | phenytoin | D010672 | 57-41-0 | anti-neutrophil cytoplasmic antibody-associated vasculitis | MESH:D056648 | marker/mechanism | 8671794 | ||
| C2717865 | propylthiouracil | D011441 | 51-52-5 | anti-neutrophil cytoplasmic antibody-associated vasculitis | MESH:D056648 | marker/mechanism | 10025935 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |