PedAM

Pediatric Disease Annotations & Medicines


	anaplastic oligodendroglioma

Disease ID	968
Disease	anaplastic oligodendroglioma
Definition	An anaplastic oligodendroglioma in which there is insufficient information on the IDH genes and 1p/19q codeletion status.
Synonym	anaplastic oligodendroglioma, nos anaplastic oligodendroglioma, not otherwise specified anaplastic oligodendrogliomas malignant oligodendroglioma oligodendroglioma, anaplastic oligodendroglioma, anaplastic (morphologic abnormality) oligodendroglioma, anaplastic, malignant oligodendroglioma, malignant oligodendrogliomas, anaplastic undifferentiated oligodendroglioma who grade iii oligodendroglial neoplasm who grade iii oligodendroglial tumor
Orphanet	ORPHANET:251630
DOID	DOID:7154
UMLS	C0334590
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:6) C0206716 \| ganglioglioma \| 3 C0003864 \| arthritis \| 1 C0555198 \| malignant glioma \| 1 C0030312 \| pancytopenia \| 1 C0555198 \| malignant gliomas \| 1 C0003872 \| psoriatic arthritis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) IDH2 \| 3418 \| ORPHANET POT1 \| 25913 \| ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	Symbol \| Locus(Total Locus:2) IDH2 \| 15q26.1 POT1 \| 7q31.33

Disease ID	968
Disease	anaplastic oligodendroglioma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:2) HP:0001876 \| Low blood cell count \| 1 HP:0001369 \| Arthritis \| 1

Disease ID	968
Disease	anaplastic oligodendroglioma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:1) C0153690 \| bony metastases
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:12)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11133391	24135790	9575	CLOCK	umls:C0334590	BeFree	The variant allele for CLOCK rs11133391 under a recessive model increased risk of oligodendroglioma (OR 2.41; 95 % CI 1.31-4.42; p = 0.005), though not other glioma subtypes (p for heterogeneity = 0.0033).	0.000271442	2013	CLOCK	4	55501788	T	C
rs113488022	22568401	673	BRAF	umls:C0334590	BeFree	A BRAF(V600E) mutation was also detected in one oligodendroglioma, and a BRAF(A598V) in one diffuse astrocytoma.	0.000814326	2012	BRAF	7	140753336	A	T,G,C
rs118101777	25277207	3418	IDH2	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.122442977	2015	IDH2	15	90087472	C	T
rs118101777	25277207	3417	IDH1	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.006786047	2015	IDH2	15	90087472	C	T
rs121913500	25277207	3417	IDH1	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.006786047	2015	IDH1	2	208248388	C	T
rs121913500	22385787	3417	IDH1	umls:C0334590	BeFree	The mutation analysis performed on the latter case with DNA separately sampled from the oligodendroglioma- like area and the astrocytoma-like area detected IDH1 G395A in both areas.	0.006786047	2012	IDH1	2	208248388	C	T
rs121913500	23934175	3417	IDH1	umls:C0334590	BeFree	We evaluated nuclear cMYC protein levels and IDH1 (R132H) by immunohistochemistry in patients with oligodendroglioma/oligoastrocytomas (n = 20), astrocytomas (grade II) (n = 19), anaplastic astrocytomas (n = 21) or glioblastomas (n = 111).	0.006786047	2013	IDH1	2	208248388	C	T
rs121913500	25277207	3418	IDH2	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.122442977	2015	IDH1	2	208248388	C	T
rs121913500	23527265	3417	IDH1	umls:C0334590	BeFree	This glioma xenograft is the first to display a pure oligodendroglioma histology and expression of R132H.	0.006786047	2013	IDH1	2	208248388	C	T
rs121913503	25277207	3418	IDH2	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.122442977	2015	IDH2	15	90088606	C	T
rs121913503	25277207	3417	IDH1	umls:C0334590	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.006786047	2015	IDH2	15	90088606	C	T
rs5953210	25389533	4128	MAOA	umls:C0334590	BeFree	Moreover, we determined that MAO-A single nucleotide polymorphism variants are significantly linked with oral and pharyngeal cancer patients in comparison to OPMDs patients [rs5953210 risk G-allele, odds ratio = 1.76; 95% confidence interval = 1.02-3.01].	0.000271442	2014	MAOA	X	43654798	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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