PedAM

Pediatric Disease Annotations & Medicines


	anaplastic large cell lymphoma

Disease ID	620
Disease	anaplastic large cell lymphoma
Definition	A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.
Synonym	(ki-1+) lymphoma alcl anaplastic large cell lymphoma (alcl) cd30+ anaplastic large cell lymphoma, cd30+ anaplastic large cell lymphoma, t cell and null cell type anaplastic large cell lymphoma, t cell and null cell type (morphologic abnormality) anaplastic large-cell lymphoma anaplastic large-cell lymphomas cd 030 positive anaplastic large cell lymphoma cd30 positive anaplastic large cell lymphoma cd30+ anaplastic large cell lymphoma cd30+ anaplastic large-cell lymphoma cd30-positive anaplastic large-cell lymphoma ki 1 lymphoma ki-1 lymphoma ki-1 lymphomas ki-1+ alcl ki-1+ anaplastic large cell lymphoma large cell (ki-1+) lymphoma large cell (ki-1+) lymphoma [obs] large cell anaplastic lymphoma large cell anaplastic lymphoma (disorder) large-cell lymphoma, anaplastic large-cell lymphomas, anaplastic lymphoma large cell ki 01 lymphoma, anaplastic large cell lymphoma, anaplastic large-cell lymphoma, ki-1 lymphoma, large-cell, anaplastic lymphoma, large-cell, anaplastic [disease/finding] lymphoma, large-cell, ki-1 lymphomas, anaplastic large-cell lymphomas, ki-1 systemic anaplastic large cell lymphoma systemic anaplastic large-cell lymphoma
Orphanet	ORPHANET:98841
DOID	DOID:0050744
UMLS	C0206180
MeSH	D017728
SNOMED-CT	SNOMEDCT_US_2016_09_01:277637000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:22) C0024299 \| lymphoma \| 9 C0024291 \| hemophagocytic lymphohistiocytosis \| 3 C0026986 \| myelodysplastic syndrome \| 2 C0023448 \| lymphocytic leukemia \| 2 C0023434 \| chronic lymphocytic leukemia \| 2 C0011603 \| dermatitis \| 2 C0343084 \| capillary leak syndrome \| 1 C0030805 \| bullous pemphigoid \| 1 C0079731 \| b-cell lymphoma \| 1 C0079731 \| b-cell lymphomas \| 1 C0030805 \| pemphigoid \| 1 C0079419 \| li-fraumeni syndrome \| 1 C0013990 \| emphysema \| 1 C0003873 \| rheumatoid arthritis \| 1 C0085113 \| neurofibromatosis \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0027121 \| myositis \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0011608 \| dermatitis herpetiformis \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0011615 \| atopic dermatitis \| 1 C0553662 \| juvenile arthritis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) STAT3 \| 6774 \| CTD_human TWIST1 \| 7291 \| CTD_human HSP90AA1 \| 3320 \| CTD_human ALK \| 238 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:185) 933 \| CD22 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 602 \| BCL3 \| DISEASES 6480 \| ST6GAL1 \| DISEASES 30009 \| TBX21 \| DISEASES 3560 \| IL2RB \| DISEASES 3002 \| GZMB \| DISEASES 6361 \| CCL17 \| DISEASES 5971 \| RELB \| DISEASES 973 \| CD79A \| DISEASES 944 \| TNFSF8 \| DISEASES 1440 \| CSF3 \| DISEASES 6198 \| RPS6KB1 \| DISEASES 595 \| CCND1 \| DISEASES 969 \| CD69 \| DISEASES 1027 \| CDKN1B \| DISEASES 604 \| BCL6 \| DISEASES 3398 \| ID2 \| DISEASES 471 \| ATIC \| DISEASES 10342 \| TFG \| DISEASES 1271 \| CNTFR \| DISEASES 3223 \| HOXC6 \| DISEASES 3581 \| IL9R \| DISEASES 1026 \| CDKN1A \| DISEASES 968 \| CD68 \| DISEASES 3958 \| LGALS3 \| DISEASES 6382 \| SDC1 \| DISEASES 5156 \| PDGFRA \| DISEASES 7111 \| TMOD1 \| DISEASES 8737 \| RIPK1 \| DISEASES 347733 \| TUBB2B \| DISEASES 894 \| CCND2 \| DISEASES 5159 \| PDGFRB \| DISEASES 904 \| CCNT1 \| DISEASES 945 \| CD33 \| DISEASES 84662 \| GLIS2 \| DISEASES 5595 \| MAPK3 \| DISEASES 5588 \| PRKCQ \| DISEASES 90 \| ACVR1 \| DISEASES 4058 \| LTK \| DISEASES 943 \| TNFRSF8 \| DISEASES 60482 \| SLC5A7 \| DISEASES 6774 \| STAT3 \| DISEASES 7535 \| ZAP70 \| DISEASES 51176 \| LEF1 \| DISEASES 51265 \| CDKL3 \| DISEASES 256076 \| COL6A5 \| DISEASES 29999 \| FSCN3 \| DISEASES 939 \| CD27 \| DISEASES 58488 \| PCTP \| DISEASES 1213 \| CLTC \| DISEASES 7157 \| TP53 \| DISEASES 207 \| AKT1 \| DISEASES 58985 \| IL22RA1 \| DISEASES 8915 \| BCL10 \| DISEASES 3578 \| IL9 \| DISEASES 9046 \| DOK2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 2838 \| GPR15 \| DISEASES 7345 \| UCHL1 \| DISEASES 1436 \| CSF1R \| DISEASES 10563 \| CXCL13 \| DISEASES 3815 \| KIT \| DISEASES 11189 \| CELF3 \| DISEASES 55687 \| TRMU \| DISEASES 6777 \| STAT5B \| DISEASES 6154 \| RPL26 \| DISEASES 9965 \| FGF19 \| DISEASES 5966 \| REL \| DISEASES 308 \| ANXA5 \| DISEASES 4869 \| NPM1 \| DISEASES 25798 \| BRI3 \| DISEASES 60686 \| C14orf93 \| DISEASES 290 \| ANPEP \| DISEASES 1642 \| DDB1 \| DISEASES 8772 \| FADD \| DISEASES 92483 \| LDHAL6B \| DISEASES 598 \| BCL2L1 \| DISEASES 10648 \| SCGB1D1 \| DISEASES 3726 \| JUNB \| DISEASES 5481 \| PPID \| DISEASES 1051 \| CEBPB \| DISEASES 27087 \| B3GAT1 \| DISEASES 3265 \| HRAS \| DISEASES 836 \| CASP3 \| DISEASES 924 \| CD7 \| DISEASES 8837 \| CFLAR \| DISEASES 64236 \| PDLIM2 \| DISEASES 666 \| BOK \| DISEASES 1191 \| CLU \| DISEASES 23075 \| SWAP70 \| DISEASES 57381 \| RHOJ \| DISEASES 4233 \| MET \| DISEASES 4684 \| NCAM1 \| DISEASES 27436 \| EML4 \| DISEASES 57674 \| RNF213 \| DISEASES 3200 \| HOXA3 \| DISEASES 1237 \| CCR8 \| DISEASES 4772 \| NFATC1 \| DISEASES 50616 \| IL22 \| DISEASES 9021 \| SOCS3 \| DISEASES 55967 \| NDUFA12 \| DISEASES 1937 \| EEF1G \| DISEASES 7127 \| TNFAIP2 \| DISEASES 3320 \| HSP90AA1 \| DISEASES 3932 \| LCK \| DISEASES 8631 \| SKAP1 \| DISEASES 23583 \| SMUG1 \| DISEASES 1235 \| CCR6 \| DISEASES 1447 \| CSN2 \| DISEASES 6776 \| STAT5A \| DISEASES 921 \| CD5 \| DISEASES 7171 \| TPM4 \| DISEASES 56940 \| DUSP22 \| DISEASES 355 \| FAS \| DISEASES 9260 \| PDLIM7 \| DISEASES 5905 \| RANGAP1 \| DISEASES 219844 \| HYLS1 \| DISEASES 5079 \| PAX5 \| DISEASES 51530 \| ZC3HC1 \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 7037 \| TFRC \| DISEASES 6693 \| SPN \| DISEASES 4478 \| MSN \| DISEASES 4311 \| MME \| DISEASES 1456 \| CSNK1G3 \| DISEASES 9267 \| CYTH1 \| DISEASES 2475 \| MTOR \| DISEASES 4283 \| CXCL9 \| DISEASES 163882 \| CNST \| DISEASES 3664 \| IRF6 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 93273 \| LEMD1 \| DISEASES 5788 \| PTPRC \| DISEASES 51696 \| HECA \| DISEASES 4580 \| MTX1 \| DISEASES 6098 \| ROS1 \| DISEASES 7170 \| TPM3 \| DISEASES 4170 \| MCL1 \| DISEASES 639 \| PRDM1 \| DISEASES 5406 \| PNLIP \| DISEASES 914 \| CD2 \| DISEASES 4791 \| NFKB2 \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 958 \| CD40 \| DISEASES 896 \| CCND3 \| DISEASES 2833 \| CXCR3 \| DISEASES 7185 \| TRAF1 \| DISEASES 1043 \| CD52 \| DISEASES 6850 \| SYK \| DISEASES 4609 \| MYC \| DISEASES 2782 \| GNB1 \| DISEASES 5111 \| PCNA \| DISEASES 7293 \| TNFRSF4 \| DISEASES 5272 \| SERPINB9 \| DISEASES 3662 \| IRF4 \| DISEASES 29126 \| CD274 \| DISEASES 6624 \| FSCN1 \| DISEASES 238 \| ALK \| DISEASES 8812 \| CCNK \| DISEASES 7187 \| TRAF3 \| DISEASES 4291 \| MLF1 \| DISEASES 11190 \| CEP250 \| DISEASES 1663 \| DDX11 \| DISEASES 3718 \| JAK3 \| DISEASES 3702 \| ITK \| DISEASES 7124 \| TNF \| DISEASES 7072 \| TIA1 \| DISEASES 1373 \| CPS1 \| DISEASES 22807 \| IKZF2 \| DISEASES 8635 \| RNASET2 \| DISEASES 345778 \| MTX3 \| DISEASES 2053 \| EPHX2 \| DISEASES 5452 \| POU2F2 \| DISEASES 29068 \| ZBTB44 \| DISEASES 930 \| CD19 \| DISEASES 4857 \| NOVA1 \| DISEASES 1232 \| CCR3 \| DISEASES 8218 \| CLTCL1 \| DISEASES 7409 \| VAV1 \| DISEASES 100507254 \| LINC01013 \| DISEASES 692111 \| SNORD71 \| DISEASES
Locus	(Waiting for update.)

Disease ID	620
Disease	anaplastic large cell lymphoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0002665 \| Lymphoma \| 9 HP:0005550 \| Chronic lymphatic leukemia \| 2 HP:0002863 \| Myelodysplastic syndrome \| 2 HP:0100614 \| Muscle inflammation \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001482 \| Subcutaneous nodule \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0002664 \| Neoplasia \| 1 HP:0030731 \| Carcinoma \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0002835 \| Aspiration \| 1

Disease ID	620
Disease	anaplastic large cell lymphoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C1608408 \| malignant transformation C1282609 \| granulocytosis C0302314 \| xanthelasma C0029132 \| optic neuropathy C0010823 \| cytomegalovirus infection
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0206180	crizotinib	C551994	-	lymphoma, large-cell, anaplastic	MESH:D017728	therapeutic	21345110
C0206180	methotrexate	D008727	1959/5/2	lymphoma, large-cell, anaplastic	MESH:D017728	therapeutic	17519458

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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