PedAM

Pediatric Disease Annotations & Medicines


	allergic contact dermatitis

Disease ID	858
Disease	allergic contact dermatitis
Definition	A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
Synonym	acd - allergic contact dermatitis allergic contact dermatitides allergic contact dermatitis (disorder) allergic eczematous dermatitides allergic eczematous dermatitis contact allergic dermatitis contact dermatitides, allergic contact dermatitis, allergic dermatitides, allergic contact dermatitides, allergic eczematous dermatitis contact allergic dermatitis, allergic contact dermatitis, allergic contact [disease/finding] dermatitis, allergic eczematous dermatitis, contact, allergic eczematous dermatitides, allergic eczematous dermatitis, allergic
DOID	DOID:3042
UMLS	C0162820
MeSH	D017449
SNOMED-CT	SNOMEDCT_US_2016_09_01:238575004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0011603 \| dermatitis \| 4 C0011615 \| atopic dermatitis \| 2 C0011616 \| contact dermatitis \| 2 C0042384 \| vasculitis \| 1 C0024236 \| lymphoedema \| 1 C0037274 \| dermatoses \| 1 C1527383 \| morphea \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0013595 \| eczema \| 1 C0011570 \| depression \| 1 C0042109 \| urticaria \| 1 C0033860 \| psoriasis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:65) TNF \| 7124 \| CTD_human BCL2 \| 596 \| CTD_human CASP8 \| 841 \| CTD_human IFNG \| 3458 \| CTD_human CXCL2 \| 2920 \| CTD_human PLAT \| 5327 \| CTD_human BMP6 \| 654 \| CTD_human SOCS1 \| 8651 \| CTD_human SOCS2 \| 8835 \| CTD_human SLC2A3 \| 6515 \| CTD_human ST6GAL1 \| 6480 \| CTD_human SPP1 \| 6696 \| CTD_human IPCEF1 \| 26034 \| CTD_human NFE2L2 \| 4780 \| CTD_human NAMPT \| 10135 \| CTD_human SELE \| 6401 \| CTD_human SAT1 \| 6303 \| CTD_human IL2RA \| 3559 \| CTD_human CIDEC \| 63924 \| CTD_human IL1A \| 3552 \| CTD_human FYB \| 2533 \| CTD_human IL10 \| 3586 \| CTD_human CD36 \| 948 \| CTD_human CCR2 \| 729230 \| CTD_human MXD1 \| 4084 \| CTD_human IL2 \| 3558 \| CTD_human SLC7A5 \| 8140 \| CTD_human NUMA1 \| 4926 \| CTD_human STAC \| 6769 \| CTD_human ITGAM \| 3684 \| CTD_human CYP1A1 \| 1543 \| CTD_human UPP1 \| 7378 \| CTD_human CD3D \| 915 \| CTD_human NINJ1 \| 4814 \| CTD_human IL4 \| 3565 \| CTD_human IL5 \| 3567 \| CTD_human CNTN3 \| 5067 \| CTD_human IFI30 \| 10437 \| CTD_human MEOX1 \| 4222 \| CTD_human CCL19 \| 6363 \| CTD_human MRC1 \| 4360 \| CTD_human RGS1 \| 5996 \| CTD_human F13A1 \| 2162 \| CTD_human TMSB10 \| 9168 \| CTD_human CISH \| 1154 \| CTD_human CTSC \| 1075 \| CTD_human ASRGL1 \| 80150 \| CTD_human RAB32 \| 10981 \| CTD_human PRDX4 \| 10549 \| CTD_human TLR7 \| 51284 \| CTD_human QPCT \| 25797 \| CTD_human IL32 \| 9235 \| CTD_human PIM1 \| 5292 \| CTD_human EMB \| 133418 \| CTD_human PHLDA1 \| 22822 \| CTD_human ETS2 \| 2114 \| CTD_human ABCA6 \| 23460 \| CTD_human CREM \| 1390 \| CTD_human HSD11B1 \| 3290 \| CTD_human IGSF6 \| 10261 \| CTD_human TNFAIP6 \| 7130 \| CTD_human KMO \| 8564 \| CTD_human CALCRL \| 10203 \| CTD_human FCGR3B \| 2215 \| CTD_human FGL2 \| 10875 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 2312 \| FLG \| infer 10 \| NAT2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:196) 9817 \| KEAP1 \| DISEASES 30009 \| TBX21 \| DISEASES 25776 \| CBY1 \| DISEASES 3162 \| HMOX1 \| DISEASES 479 \| ATP12A \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 366 \| AQP9 \| DISEASES 29124 \| LGALS13 \| DISEASES 3982 \| LIM2 \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 6404 \| SELPLG \| DISEASES 3458 \| IFNG \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 3554 \| IL1R1 \| DISEASES 566 \| AZU1 \| DISEASES 6402 \| SELL \| DISEASES 51426 \| POLK \| DISEASES 27189 \| IL17C \| DISEASES 3659 \| IRF1 \| DISEASES 6939 \| TCF15 \| DISEASES 8698 \| S1PR4 \| DISEASES 1236 \| CCR7 \| DISEASES 29108 \| PYCARD \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 10912 \| GADD45G \| DISEASES 6117 \| RPA1 \| DISEASES 59340 \| HRH4 \| DISEASES 5279 \| PIGC \| DISEASES 3569 \| IL6 \| DISEASES 26525 \| IL36RN \| DISEASES 23392 \| KIAA0368 \| DISEASES 5004 \| ORM1 \| DISEASES 6366 \| CCL21 \| DISEASES 10850 \| CCL27 \| DISEASES 2766 \| GMPR \| DISEASES 7097 \| TLR2 \| DISEASES 10068 \| IL18BP \| DISEASES 23531 \| MMD \| DISEASES 8989 \| TRPA1 \| DISEASES 6521 \| SLC4A1 \| DISEASES 495 \| ATP4A \| DISEASES 5465 \| PPARA \| DISEASES 443 \| ASPA \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 943 \| TNFRSF8 \| DISEASES 941 \| CD80 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 9175 \| MAP3K13 \| DISEASES 6897 \| TARS \| DISEASES 51083 \| GAL \| DISEASES 3067 \| HDC \| DISEASES 3687 \| ITGAX \| DISEASES 5141 \| PDE4A \| DISEASES 3578 \| IL9 \| DISEASES 56832 \| IFNK \| DISEASES 196743 \| PAOX \| DISEASES 2206 \| MS4A2 \| DISEASES 3606 \| IL18 \| DISEASES 64422 \| ATG3 \| DISEASES 27342 \| RABGEF1 \| DISEASES 5304 \| PIP \| DISEASES 9437 \| NCR1 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 7412 \| VCAM1 \| DISEASES 132954 \| PDCL2 \| DISEASES 8320 \| EOMES \| DISEASES 152185 \| SPICE1 \| DISEASES 213 \| ALB \| DISEASES 7047 \| TGM4 \| DISEASES 1230 \| CCR1 \| DISEASES 1437 \| CSF2 \| DISEASES 51084 \| CRYL1 \| DISEASES 26253 \| CLEC4E \| DISEASES 915 \| CD3D \| DISEASES 94235 \| GNG8 \| DISEASES 4597 \| MVD \| DISEASES 719 \| C3AR1 \| DISEASES 5729 \| PTGDR \| DISEASES 6869 \| TACR1 \| DISEASES 1673 \| DEFB4A \| DISEASES 1493 \| CTLA4 \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 6373 \| CXCL11 \| DISEASES 624 \| BDKRB2 \| DISEASES 2733 \| GLE1 \| DISEASES 1212 \| CLTB \| DISEASES 116512 \| MRGPRD \| DISEASES 131450 \| CD200R1 \| DISEASES 2529 \| FUT7 \| DISEASES 4684 \| NCAM1 \| DISEASES 80381 \| CD276 \| DISEASES 6863 \| TAC1 \| DISEASES 940 \| CD28 \| DISEASES 1237 \| CCR8 \| DISEASES 6097 \| RORC \| DISEASES 3563 \| IL3RA \| DISEASES 9021 \| SOCS3 \| DISEASES 2192 \| FBLN1 \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 2826 \| CCR10 \| DISEASES 151888 \| BTLA \| DISEASES 353144 \| LCE3C \| DISEASES 10076 \| PTPRU \| DISEASES 353143 \| LCE3B \| DISEASES 114548 \| NLRP3 \| DISEASES 112744 \| IL17F \| DISEASES 10626 \| TRIM16 \| DISEASES 85480 \| TSLP \| DISEASES 3605 \| IL17A \| DISEASES 728 \| C5AR1 \| DISEASES 85301 \| COL27A1 \| DISEASES 3683 \| ITGAL \| DISEASES 64919 \| BCL11B \| DISEASES 51592 \| TRIM33 \| DISEASES 2114 \| ETS2 \| DISEASES 104 \| ADARB1 \| DISEASES 6772 \| STAT1 \| DISEASES 10367 \| MICU1 \| DISEASES 4283 \| CXCL9 \| DISEASES 56670 \| SUCNR1 \| DISEASES 5362 \| PLXNA2 \| DISEASES 7432 \| VIP \| DISEASES 51696 \| HECA \| DISEASES 913 \| CD1E \| DISEASES 912 \| CD1D \| DISEASES 6280 \| S100A9 \| DISEASES 3713 \| IVL \| DISEASES 2312 \| FLG \| DISEASES 914 \| CD2 \| DISEASES 965 \| CD58 \| DISEASES 3738 \| KCNA3 \| DISEASES 2730 \| GCLM \| DISEASES 680 \| BRS3 \| DISEASES 64170 \| CARD9 \| DISEASES 27069 \| GHITM \| DISEASES 958 \| CD40 \| DISEASES 6865 \| TACR2 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 5322 \| PLA2G5 \| DISEASES 23013 \| SPEN \| DISEASES 50943 \| FOXP3 \| DISEASES 386653 \| IL31 \| DISEASES 9308 \| CD83 \| DISEASES 7293 \| TNFRSF4 \| DISEASES 2625 \| GATA3 \| DISEASES 10549 \| PRDX4 \| DISEASES 9247 \| GCM2 \| DISEASES 1543 \| CYP1A1 \| DISEASES 9350 \| CER1 \| DISEASES 90865 \| IL33 \| DISEASES 29126 \| CD274 \| DISEASES 3903 \| LAIR1 \| DISEASES 65057 \| ACD \| DISEASES 6696 \| SPP1 \| DISEASES 4901 \| NRL \| DISEASES 3269 \| HRH1 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 594857 \| NPS \| DISEASES 7442 \| TRPV1 \| DISEASES 2199 \| FBLN2 \| DISEASES 50489 \| CD207 \| DISEASES 1638 \| DCT \| DISEASES 5005 \| ORM2 \| DISEASES 55683 \| KANSL3 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 4615 \| MYD88 \| DISEASES 1154 \| CISH \| DISEASES 116 \| ADCYAP1 \| DISEASES 3586 \| IL10 \| DISEASES 4753 \| NELL2 \| DISEASES 58494 \| JAM2 \| DISEASES 6949 \| TCOF1 \| DISEASES 100289462 \| DEFB4B \| DISEASES 2920 \| CXCL2 \| DISEASES 56413 \| LTB4R2 \| DISEASES 6188 \| RPS3 \| DISEASES 55350 \| VNN3 \| DISEASES 1232 \| CCR3 \| DISEASES 9 \| NAT1 \| DISEASES 7955 \| RNF217-AS1 \| DISEASES 692084 \| SNORD13 \| DISEASES 26802 \| SNORD47 \| DISEASES
Locus	(Waiting for update.)

Disease ID	858
Disease	allergic contact dermatitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:11) HP:0012393 \| Allergy \| 3 HP:0001047 \| Atopic dermatitis \| 2 HP:0002633 \| Vasculitis \| 1 HP:0000716 \| Depression \| 1 HP:0000964 \| Eczema \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0001019 \| Exfoliative dermititis \| 1 HP:0001025 \| Hives \| 1 HP:0003765 \| Psoriasis \| 1 HP:0001880 \| Eosinophilia \| 1

Disease ID	858
Disease	allergic contact dermatitis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0549297 \| ear swelling \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:2)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
2	64364632	rs6733160	T	C	rs6733160	23921680	7.00E-06	2-fold positive reaction cases	9.28	NA	up to 24 Korean ancestry cases; 52 Korean ancestry controls	Korean(76)	ALL(76)	ASN(76)	ALL(76)	Allergic dermatitis (nickel)	HPOID:0011123	Inflammatory abnormality of the skin	DOID:3042	allergic contact dermatitis	NA	NA	NA	NA	Dermatitis	rs6733160-C	NA	C	PELI1
12	96057184	rs2367563	A	G	rs2367563	23921680	4.00E-06	NA	5.92	NA	up to 24 Korean ancestry cases; 52 Korean ancestry controls	Korean(76)	ALL(76)	ASN(76)	ALL(76)	Allergic dermatitis (nickel)	HPOID:0011123	Inflammatory abnormality of the skin	DOID:3042	allergic contact dermatitis	NA	NA	NA	NA	Dermatitis	rs2367563-A	NA	T	NTN4

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0162820	amcinonide	C012716	-	dermatitis, allergic contact	MESH:D017449	marker/mechanism	10894975
C0162820	aspartame	D001218	22839-47-0	dermatitis, allergic contact	MESH:D017449	marker/mechanism	14996049
C0162820	baclofen	D001418	1134-47-0	dermatitis, allergic contact	MESH:D017449	therapeutic	20201957
C0162820	betamethasone	D001623	378-44-9	dermatitis, allergic contact	MESH:D017449	therapeutic	11692113
C0162820	clonidine	D003000	4205-90-7	dermatitis, allergic contact	MESH:D017449	marker/mechanism	6599488
C0162820	diflorasone	C014477	-	dermatitis, allergic contact	MESH:D017449	therapeutic	12956900
C0162820	framycetin	D005601	119-04-0	dermatitis, allergic contact	MESH:D017449	marker/mechanism	18383004
C0162820	oxytetracycline	D010118	79-57-2	dermatitis, allergic contact	MESH:D017449	marker/mechanism	8462297
C0162820	phenylephrine	D010656	59-42-7	dermatitis, allergic contact	MESH:D017449	marker/mechanism	18383004
C0162820	tacrolimus	D016559	109581-93-3	dermatitis, allergic contact	MESH:D017449	therapeutic	11692113

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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