PedAM

Pediatric Disease Annotations & Medicines


	allergic bronchopulmonary aspergillosis

Disease ID	45
Disease	allergic bronchopulmonary aspergillosis
Definition	Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Synonym	abpa abpa - allergic bronchopulmonary aspergillosis allergic aspergilloses, bronchopulmonary allergic aspergillosis, bronchopulmonary allergic bronchopulm asperg allergic bronchopulmonary aspergilloses allergic bronchopulmonary aspergillosis (abpa) allergic bronchopulmonary aspergillosis (disorder) allergic lung reaction to the fungus aspergillus alrgc brncpul asprglosis asperg allergic bronchopulm asperg bronchopulm allergic aspergilloses, allergic bronchopulmonary aspergilloses, bronchopulmonary allergic aspergillosis, allergic bronchopulmonary aspergillosis, allergic bronchopulmonary [disease/finding] aspergillosis, bronchopulmonary allergic bronchopulm asperg allergic bronchopulmonary allergic aspergilloses bronchopulmonary allergic aspergillosis bronchopulmonary aspergilloses, allergic bronchopulmonary aspergillosis, allergic
Orphanet	ORPHANET:1164
OMIM	OMIM:102565
DOID	DOID:13166
ICD10	ICD10CM:B44.81
UMLS	C0004031
MeSH	D001229
SNOMED-CT	SNOMEDCT_US_2016_09_01:37981002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:13) C0010674 \| cystic fibrosis \| 21 C0004096 \| asthma \| 15 C0024115 \| pulmonary disease \| 2 C0600260 \| obstructive pulmonary disease \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0006267 \| bronchiectasis \| 2 C0024115 \| lung disease \| 1 C0038218 \| acute severe asthma \| 1 C0003864 \| arthritis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0242379 \| lung cancer \| 1 C0004030 \| aspergillosis \| 1 C0004096 \| bronchial asthma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) FLNC \| 2318 \| OMIM
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:59) 1080 \| CFTR \| DISEASES 3566 \| IL4R \| DISEASES 5603 \| MAPK13 \| DISEASES 10204 \| NUTF2 \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 2222 \| FDFT1 \| DISEASES 973 \| CD79A \| DISEASES 8288 \| EPX \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 3111 \| HLA-DOA \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 56920 \| SEMA3G \| DISEASES 1773 \| DNASE1 \| DISEASES 967 \| CD63 \| DISEASES 5082 \| PDCL \| DISEASES 3687 \| ITGAX \| DISEASES 8795 \| TNFRSF10B \| DISEASES 2206 \| MS4A2 \| DISEASES 7292 \| TNFSF4 \| DISEASES 27020 \| NPTN \| DISEASES 6352 \| CCL5 \| DISEASES 1437 \| CSF2 \| DISEASES 5267 \| SERPINA4 \| DISEASES 6037 \| RNASE3 \| DISEASES 64581 \| CLEC7A \| DISEASES 3596 \| IL13 \| DISEASES 9986 \| RCE1 \| DISEASES 8815 \| BANF1 \| DISEASES 23541 \| SEC14L2 \| DISEASES 1237 \| CCR8 \| DISEASES 2318 \| FLNC \| DISEASES 1576 \| CYP3A4 \| DISEASES 5269 \| SERPINB6 \| DISEASES 5132 \| PDC \| DISEASES 1861 \| TOR1A \| DISEASES 55124 \| PIWIL2 \| DISEASES 5169 \| ENPP3 \| DISEASES 1118 \| CHIT1 \| DISEASES 959 \| CD40LG \| DISEASES 6441 \| SFTPD \| DISEASES 729238 \| SFTPA2 \| DISEASES 4153 \| MBL2 \| DISEASES 26279 \| PLA2G2D \| DISEASES 5322 \| PLA2G5 \| DISEASES 54206 \| ERRFI1 \| DISEASES 1993 \| ELAVL2 \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 1363 \| CPE \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 653509 \| SFTPA1 \| DISEASES 8605 \| PLA2G4C \| DISEASES 3586 \| IL10 \| DISEASES 55733 \| HHAT \| DISEASES 83695 \| RHNO1 \| DISEASES 1232 \| CCR3 \| DISEASES 387521 \| TMEM189 \| DISEASES
Locus	(Waiting for update.)

Disease ID	45
Disease	allergic bronchopulmonary aspergillosis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:14) HP:0012735 \| Cough HP:0002097 \| Emphysema HP:0002109 \| Abnormality of the bronchi HP:0001824 \| Weight loss HP:0002110 \| Bronchiectasis HP:0002092 \| Pulmonary arterial hypertension HP:0002120 \| Cerebral cortical atrophy HP:0001231 \| Abnormality of the fingernails HP:0002715 \| Abnormality of the immune system HP:0001879 \| Abnormality of eosinophils HP:0002093 \| Respiratory insufficiency HP:0002105 \| Hemoptysis HP:0011134 \| Low-grade fever HP:0002099 \| Asthma
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0002099 \| Asthma \| 15 HP:0002110 \| Bronchiectasis \| 2 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0012653 \| Acute severe asthma \| 1 HP:0012735 \| Coughing \| 1 HP:0001369 \| Arthritis \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0001370 \| Rheumatoid arthritis \| 1

Disease ID	45
Disease	allergic bronchopulmonary aspergillosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:18) C2364133 \| infection C2240374 \| eosinophilia C2073625 \| pleural effusion C1827192 \| allergic fungal sinusitis C0878544 \| cardiomyopathy C0746982 \| obstructive disease C0342269 \| steroid-induced diabetes C0340076 \| pulmonary eosinophilia C0333040 \| fungus ball C0276651 \| aspergilloma C0238132 \| bronchopleural fistula C0235896 \| pulmonary infiltration C0149781 \| spontaneous pneumothorax C0149711 \| hilar adenopathy C0022521 \| kartagener's syndrome C0010674 \| cystic fibrosis C0006267 \| bronchiectasis C0004096 \| asthma
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0010674 \| cystic fibrosis \| 21 C0004096 \| asthma \| 15 C0006267 \| bronchiectasis \| 2 C0276651 \| aspergilloma \| 2 C0032227 \| pleural effusion \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743836	18275280	54106	TLR9	umls:C0004031	BeFree	Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =.	0.005362824	2008	TLR9	3	52226766	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002092	Pulmonary hypertension	MP:0000231	hypertension;HP:0004370	Abnormality of temperature regulation

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002093	Respiratory insufficiency	MP:0011250	abdominal situs ambiguus;HP:0002092	Pulmonary hypertension

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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