PedAM
Pediatric Disease Annotations & Medicines
| allergic asthma | ||||
| Disease ID | 1730 |
|---|---|
| Disease | allergic asthma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:14) HP:0002099 | Asthma | 15 HP:0012384 | Nasal inflammation | 8 HP:0003193 | Allergic rhinitis | 5 HP:0001880 | Eosinophilia | 4 HP:0012393 | Allergy | 3 HP:0001513 | Obesity | 3 HP:0003287 | Abnormality of mitochondrial metabolism | 2 HP:0000819 | Diabetes mellitus | 2 HP:0030828 | Wheezing | 2 HP:0002960 | Autoimmune condition | 1 HP:0011947 | Respiratory infection | 1 HP:0006528 | Chronic lung disease | 1 HP:0001047 | Atopic dermatitis | 1 HP:0002837 | Recurrent bronchitis | 1 |
| Disease ID | 1730 |
|---|---|
| Disease | allergic asthma |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0035455 | rhinitis | 8 C0014457 | eosinophilia | 4 C0001883 | airway obstruction | 1 C0085129 | bronchial hyperreactivity | 1 C0004096 | airway hyperreactivity | 1 C0042769 | viral infections | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:21) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs16947078 | 25056814 | 30009 | TBX21 | umls:C0155877 | BeFree | Polymorphisms rs4794067 and rs16947078 of TBX21 were found to be associated with acetylsalicylic acid-induced and allergic asthma, respectively. | 0.000542884 | 2014 | NA | 17 | 47748134 | A | G |
| rs2233407 | 20674643 | 4792 | NFKBIA | umls:C0155877 | BeFree | The IKBA rs2233407 A>T polymorphism may predispose individuals to the development of atopic asthma via regulation of IKBA gene expression at the transcriptional level. | 0.000542884 | 2010 | NFKBIA | 14 | 35405317 | T | A |
| rs2243250 | 22652416 | 3565 | IL4 | umls:C0155877 | BeFree | Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma. | 0.011596056 | 2012 | IL4 | 5 | 132673462 | C | T |
| rs2303063 | 15753894 | 11005 | SPINK5 | umls:C0155877 | BeFree | We investigated whether single nucleotide polymorphisms in SPINK5 (ie, -785 A/G, Asn368Ser, and Lys420Glu) are associated with asthma, atopic phenotypes, and atopic dermatitis in 200 families ascertained by a proband with asthma (nonaffected spouses served as a matched control population) and an independent set of 252 trios with asthma. | 0.000542884 | 2005 | SPINK5 | 5 | 148100464 | G | A |
| rs2303067 | 15753894 | 11005 | SPINK5 | umls:C0155877 | BeFree | We investigated whether single nucleotide polymorphisms in SPINK5 (ie, -785 A/G, Asn368Ser, and Lys420Glu) are associated with asthma, atopic phenotypes, and atopic dermatitis in 200 families ascertained by a proband with asthma (nonaffected spouses served as a matched control population) and an independent set of 252 trios with asthma. | 0.000542884 | 2005 | SPINK5 | 5 | 148101392 | A | G |
| rs2872507 | 22986918 | 94103 | ORMDL3 | umls:C0155877 | BeFree | Our results suggest that rs2872507 is associated with ORMDL3 gene expression and with ICS treatment response in children with atopic asthma. | 0.000814326 | 2012 | NA | 17 | 39884510 | G | A |
| rs3217304 | 18187694 | 3631 | INPP4A | umls:C0155877 | BeFree | Our genetic association studies of 21 human genes in 171 trios led to the identification of a biallelic repeat (rs3217304) in INPP4A, associated with atopic asthma (P = 0.009). | 0.000271442 | 2008 | INPP4A | 2 | 98544046 | CA | - |
| rs324011 | 24912007 | 6778 | STAT6 | umls:C0155877 | BeFree | Association of the STAT-6 rs324011 (C2892T) variant but not rs324015 (G2964A), with atopic asthma in a Saudi Arabian population. | 0.001085767 | 2014 | STAT6 | 12 | 57108399 | C | T |
| rs324015 | 24912007 | 6778 | STAT6 | umls:C0155877 | BeFree | Association of the STAT-6 rs324011 (C2892T) variant but not rs324015 (G2964A), with atopic asthma in a Saudi Arabian population. | 0.001085767 | 2014 | STAT6 | 12 | 57096317 | T | C |
| rs324015 | 24952213 | 6778 | STAT6 | umls:C0155877 | BeFree | In conclusion, our meta-analyses suggest that short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma, while rs324015 may have a protective effect on atopic asthma. | 0.001085767 | 2014 | STAT6 | 12 | 57096317 | T | C |
| rs386599440 | 24495860 | 2206 | MS4A2 | umls:C0155877 | BeFree | Data indicated that the MS4A2 gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians. | 0.000814326 | 2014 | NA | NA | NA | NA | NA |
| rs41347648 | 17558309 | 57105 | CYSLTR2 | umls:C0155877 | BeFree | In our earlier association study, the M201V variant of the cysteinyl-leukotriene 2 receptor gene (CysLT2), located at 13q14, was implicated in atopic asthma. | 0.000814326 | 2007 | CYSLTR2 | 13 | 48707418 | A | G |
| rs4523 | 12000493 | 6915 | TBXA2R | umls:C0155877 | BeFree | In conclusion, our results suggest that the T924C marker in the TBXA2R gene is associated, in Chinese children, with an increased susceptibility of developing atopic asthma. | 0.000542884 | 2002 | TBXA2R | 19 | 3595796 | A | G |
| rs4794067 | 25056814 | 30009 | TBX21 | umls:C0155877 | BeFree | Polymorphisms rs4794067 and rs16947078 of TBX21 were found to be associated with acetylsalicylic acid-induced and allergic asthma, respectively. | 0.000542884 | 2014 | TBX21 | 17 | 47731462 | T | C |
| rs4986790 | 15356557 | 7099 | TLR4 | umls:C0155877 | BeFree | Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polymorphism and independently with asthma, especially atopic asthma. | 0.000814326 | 2004 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 15356557 | 3586 | IL10 | umls:C0155877 | BeFree | Decreased LPS-induced IL-12(p70) and IL-10 responses were associated with the TLR4 (Asp299Gly) polymorphism and independently with asthma, especially atopic asthma. | 0.003257302 | 2004 | TLR4 | 9 | 117713024 | A | G |
| rs533116 | 22947041 | 11251 | PTGDR2 | umls:C0155877 | BeFree | The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. | 0.000271442 | 2012 | NA | 11 | 60860110 | C | T |
| rs55661460 | 11704807 | 3593 | IL12B | umls:C0155877 | BeFree | We screened for mutation in IL12B and found three novel (-4475-4insG, Glu186Asp and Ser226Asn) variants and one previously reported (1188A>C) variant in IL12B, and conducted transmission disequilibrium tests in families identified through children with atopic asthma or allergic rhinitis. | 0.001357209 | 2001 | IL12B | 5 | 159320326 | C | T |
| rs5743836 | 20038537 | 54106 | TLR9 | umls:C0155877 | BeFree | A well-documented single nucleotide polymorphism (SNP) within the TLR9 promoter (TLR9 -1237T/C), is associated with a variety of inflammatory disorders, including allergic asthma, inflammatory bowel disease, and atopy. | 0.000271442 | 2010 | TLR9 | 3 | 52226766 | A | G |
| rs7081735 | 18682798 | 5791 | PTPRE | umls:C0155877 | BeFree | The results suggest a protective association to allergic asthma for PTPRE rs7081735 in the SLSJ sample (p = 0.000463; corrected p = 0.0478). | 0.000271442 | 2008 | PTPRE | 10 | 127998792 | G | A |
| rs71802646 | 24952213 | 6778 | STAT6 | umls:C0155877 | BeFree | In conclusion, our meta-analyses suggest that short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma, while rs324015 may have a protective effect on atopic asthma. | 0.001085767 | 2014 | STAT6 | 12 | 57111290 | ACAC | - |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |