PedAM

Pediatric Disease Annotations & Medicines


	alcohol abuse

Disease ID	1817
Disease	alcohol abuse
Definition	The use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice.
Synonym	aa - alcohol abuse abuse, alcohol alcohol abuse (disorder) alcohol abuse disorder alcohol abuse, unspecified alcohol abuse, unspecified drinking behavior alcohol abuse-unspec alcohol abuses drinking problem drinking problems dysfunctional alcohol use ethanol abuse ethanol abuse (finding) etoh abuse problem drinking
DOID	DOID:1574
UMLS	C0085762
SNOMED-CT	SNOMEDCT_US_2016_09_01:15167005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:79) C0023890 \| cirrhosis \| 16 C0023895 \| liver disease \| 13 C0030305 \| pancreatitis \| 12 C0023890 \| liver cirrhosis \| 10 C0011570 \| depression \| 8 C0003467 \| anxiety \| 8 C0019158 \| hepatitis \| 5 C0011847 \| diabetes \| 5 C0020538 \| hypertension \| 5 C0042373 \| vascular disease \| 4 C0001339 \| acute pancreatitis \| 4 C0036341 \| schizophrenia \| 3 C0497327 \| dementia \| 3 C0005586 \| bipolar disorder \| 3 C0004936 \| mental disorders \| 2 C0149521 \| chronic pancreatitis \| 2 C0019163 \| hepatitis b \| 2 C0029456 \| osteoporosis \| 2 C0948265 \| metabolic syndrome \| 2 C0039841 \| thiamine deficiency \| 2 C0023895 \| hepatopathy \| 2 C0003469 \| anxiety disorder \| 2 C0033975 \| psychosis \| 2 C0023895 \| hepatic disorders \| 2 C0037317 \| sleep disturbance \| 2 C0019151 \| hepatic encephalopathy \| 2 C0028754 \| obesity \| 2 C0023895 \| hepatic disease \| 2 C0004623 \| bacterial infection \| 2 C0040188 \| tic disorders \| 2 C0016412 \| folate deficiency \| 1 C0270549 \| generalized anxiety disorder \| 1 C0349464 \| wernicke-korsakoff syndrome \| 1 C0085580 \| essential hypertension \| 1 C0162429 \| nutritional deficiencies \| 1 C0040034 \| thrombocytopenia \| 1 C0031090 \| periodontal disease \| 1 C0376670 \| alcoholic pancreatitis \| 1 C0022116 \| ischaemia \| 1 C0023364 \| leptospirosis \| 1 C0033975 \| psychotic disorder \| 1 C0001957 \| delirium tremens \| 1 C0040425 \| tonsillitis \| 1 C0004134 \| ataxia \| 1 C0011849 \| diabetes mellitus \| 1 C0878544 \| cardiomyopathy \| 1 C0031212 \| personality disorders \| 1 C0018799 \| heart disease \| 1 C0149654 \| conduct disorder \| 1 C0023895 \| liver disorders \| 1 C0022658 \| renal disease \| 1 C0002395 \| alzheimer's disease \| 1 C0023895 \| liver disorder \| 1 C0018801 \| heart failure \| 1 C0030662 \| pathological gambling \| 1 C0003469 \| anxiety disorders \| 1 C0017152 \| gastritis \| 1 C0007222 \| cardiovascular disease \| 1 C0019196 \| hepatitis c \| 1 C0349464 \| korsakoff syndrome \| 1 C0032285 \| pneumonia \| 1 C0042769 \| virus infection \| 1 C0021053 \| immune dysfunction \| 1 C0028756 \| severe obesity \| 1 C0021390 \| inflammatory bowel disease \| 1 C0023895 \| liver diseases \| 1 C0004626 \| bacterial pneumonia \| 1 C0041696 \| major depression \| 1 C0001973 \| alcoholism \| 1 C0008350 \| gall stone \| 1 C0851578 \| sleep disorders \| 1 C0162429 \| malnutrition \| 1 C0023801 \| madelung's disease \| 1 C0019204 \| hepatocellular carcinoma \| 1 C0014544 \| epilepsy \| 1 C0007193 \| dilated cardiomyopathy \| 1 C0037317 \| sleep disturbances \| 1 C0014544 \| epileptic fits \| 1 C0020676 \| hypothyroidism \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:42) 125 \| ADH1B \| infer 126 \| ADH1C \| infer 127 \| ADH4 \| infer 216 \| ALDH1A1 \| infer 217 \| ALDH2 \| infer 348 \| APOE \| infer 847 \| CAT \| infer 1312 \| COMT \| infer 1394 \| CRHR1 \| infer 1571 \| CYP2E1 \| infer 1812 \| DRD1 \| infer 1813 \| DRD2 \| infer 1814 \| DRD3 \| infer 1815 \| DRD4 \| infer 2554 \| GABRA1 \| infer 2559 \| GABRA6 \| infer 2560 \| GABRB1 \| infer 2561 \| GABRB2 \| infer 2566 \| GABRG2 \| infer 2904 \| GRIN2B \| infer 2944 \| GSTM1 \| infer 3351 \| HTR1B \| infer 3356 \| HTR2A \| infer 3358 \| HTR2C \| infer 3361 \| HTR5A \| infer 3363 \| HTR7 \| infer 4128 \| MAOA \| infer 4852 \| NPY \| infer 1728 \| NQO1 \| infer 4835 \| NQO2 \| infer 4985 \| OPRD1 \| infer 4986 \| OPRK1 \| infer 4988 \| OPRM1 \| infer 5173 \| PDYN \| infer 6506 \| SLC1A2 \| infer 6531 \| SLC6A3 \| infer 6532 \| SLC6A4 \| infer 6622 \| SNCA \| infer 50833 \| TAS2R16 \| infer 5726 \| TAS2R38 \| infer 7124 \| TNF \| infer 7166 \| TPH1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:325) 100126791 \| EGOT \| DISEASES 1080 \| CFTR \| DISEASES 2554 \| GABRA1 \| DISEASES 50508 \| NOX3 \| DISEASES 55810 \| FOXJ2 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 1815 \| DRD4 \| DISEASES 51208 \| CLDN18 \| DISEASES 124 \| ADH1A \| DISEASES 5714 \| PSMD8 \| DISEASES 112755 \| STX1B \| DISEASES 2953 \| GSTT2 \| DISEASES 80339 \| PNPLA3 \| DISEASES 25828 \| TXN2 \| DISEASES 5173 \| PDYN \| DISEASES 10627 \| MYL12A \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 2222 \| FDFT1 \| DISEASES 1666 \| DECR1 \| DISEASES 83988 \| NCALD \| DISEASES 57030 \| SLC17A7 \| DISEASES 81576 \| CCDC130 \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 57817 \| HAMP \| DISEASES 6347 \| CCL2 \| DISEASES 6346 \| CCL1 \| DISEASES 6688 \| SPI1 \| DISEASES 9896 \| FIG4 \| DISEASES 1839 \| HBEGF \| DISEASES 9421 \| HAND1 \| DISEASES 338 \| APOB \| DISEASES 5967 \| REG1A \| DISEASES 4985 \| OPRD1 \| DISEASES 4317 \| MMP8 \| DISEASES 1958 \| EGR1 \| DISEASES 4852 \| NPY \| DISEASES 2166 \| FAAH \| DISEASES 2354 \| FOSB \| DISEASES 7389 \| UROD \| DISEASES 2678 \| GGT1 \| DISEASES 8484 \| GALR3 \| DISEASES 57053 \| CHRNA10 \| DISEASES 3630 \| INS \| DISEASES 3040 \| HBA2 \| DISEASES 348 \| APOE \| DISEASES 55821 \| ALLC \| DISEASES 1571 \| CYP2E1 \| DISEASES 113 \| ADCY7 \| DISEASES 8864 \| PER2 \| DISEASES 51540 \| SCLY \| DISEASES 1401 \| CRP \| DISEASES 10526 \| IPO8 \| DISEASES 10677 \| AVIL \| DISEASES 1593 \| CYP27A1 \| DISEASES 10643 \| IGF2BP3 \| DISEASES 3569 \| IL6 \| DISEASES 9177 \| HTR3B \| DISEASES 3074 \| HEXB \| DISEASES 6532 \| SLC6A4 \| DISEASES 217 \| ALDH2 \| DISEASES 1143 \| CHRNB4 \| DISEASES 23184 \| MESDC2 \| DISEASES 56052 \| ALG1 \| DISEASES 4969 \| OGN \| DISEASES 495 \| ATP4A \| DISEASES 5465 \| PPARA \| DISEASES 25939 \| SAMHD1 \| DISEASES 5595 \| MAPK3 \| DISEASES 2033 \| EP300 \| DISEASES 2906 \| GRIN2D \| DISEASES 3553 \| IL1B \| DISEASES 84708 \| LNX1 \| DISEASES 1001 \| CDH3 \| DISEASES 2557 \| GABRA4 \| DISEASES 5443 \| POMC \| DISEASES 5924 \| RASGRF2 \| DISEASES 127 \| ADH4 \| DISEASES 22937 \| SCAP \| DISEASES 4986 \| OPRK1 \| DISEASES 51083 \| GAL \| DISEASES 55749 \| CCAR1 \| DISEASES 56938 \| ARNTL2 \| DISEASES 51411 \| BIN2 \| DISEASES 64784 \| CRTC3 \| DISEASES 5373 \| PMM2 \| DISEASES 10351 \| ABCA8 \| DISEASES 432 \| ASGR1 \| DISEASES 7157 \| TP53 \| DISEASES 150094 \| SIK1 \| DISEASES 6531 \| SLC6A3 \| DISEASES 100996939 \| PYURF \| DISEASES 2561 \| GABRB2 \| DISEASES 3358 \| HTR2C \| DISEASES 1392 \| CRH \| DISEASES 3439 \| IFNA1 \| DISEASES 6291 \| SAA4 \| DISEASES 6506 \| SLC1A2 \| DISEASES 2904 \| GRIN2B \| DISEASES 7082 \| TJP1 \| DISEASES 5741 \| PTH \| DISEASES 10413 \| YAP1 \| DISEASES 3087 \| HHEX \| DISEASES 57630 \| SH3RF1 \| DISEASES 2890 \| GRIA1 \| DISEASES 10 \| NAT2 \| DISEASES 3361 \| HTR5A \| DISEASES 3763 \| KCNJ6 \| DISEASES 653689 \| GSTT2B \| DISEASES 1636 \| ACE \| DISEASES 7109 \| TRAPPC10 \| DISEASES 3060 \| HCRT \| DISEASES 27306 \| HPGDS \| DISEASES 2565 \| GABRG1 \| DISEASES 2560 \| GABRB1 \| DISEASES 886 \| CCKAR \| DISEASES 213 \| ALB \| DISEASES 8820 \| HESX1 \| DISEASES 7349 \| UCN \| DISEASES 128 \| ADH5 \| DISEASES 6690 \| SPINK1 \| DISEASES 9607 \| CARTPT \| DISEASES 143872 \| ARHGAP42 \| DISEASES 5267 \| SERPINA4 \| DISEASES 1138 \| CHRNA5 \| DISEASES 5368 \| PNOC \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 23440 \| OTP \| DISEASES 7200 \| TRH \| DISEASES 83660 \| TLN2 \| DISEASES 1140 \| CHRNB1 \| DISEASES 84342 \| COG8 \| DISEASES 9455 \| HOMER2 \| DISEASES 1816 \| DRD5 \| DISEASES 2915 \| GRM5 \| DISEASES 2353 \| FOS \| DISEASES 125 \| ADH1B \| DISEASES 255239 \| ANKK1 \| DISEASES 57099 \| AVEN \| DISEASES 200558 \| APLF \| DISEASES 2147 \| F2 \| DISEASES 5644 \| PRSS1 \| DISEASES 9575 \| CLOCK \| DISEASES 4023 \| LPL \| DISEASES 3265 \| HRAS \| DISEASES 6868 \| ADAM17 \| DISEASES 836 \| CASP3 \| DISEASES 7368 \| UGT8 \| DISEASES 3952 \| LEP \| DISEASES 55584 \| CHRNA9 \| DISEASES 55885 \| LMO3 \| DISEASES 1191 \| CLU \| DISEASES 1136 \| CHRNA3 \| DISEASES 3350 \| HTR1A \| DISEASES 1442 \| CSH1 \| DISEASES 9370 \| ADIPOQ \| DISEASES 51085 \| MLXIPL \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 9242 \| MSC \| DISEASES 200539 \| ANKRD23 \| DISEASES 6014 \| RIT2 \| DISEASES 79075 \| DSCC1 \| DISEASES 23212 \| RRS1 \| DISEASES 3039 \| HBA1 \| DISEASES 386724 \| AMIGO3 \| DISEASES 1555 \| CYP2B6 \| DISEASES 154865 \| IQUB \| DISEASES 1812 \| DRD1 \| DISEASES 121278 \| TPH2 \| DISEASES 29110 \| TBK1 \| DISEASES 64782 \| AEN \| DISEASES 2903 \| GRIN2A \| DISEASES 4887 \| NPY2R \| DISEASES 10810 \| WASF3 \| DISEASES 51738 \| GHRL \| DISEASES 342035 \| GLDN \| DISEASES 885 \| CCK \| DISEASES 4987 \| OPRL1 \| DISEASES 79658 \| ARHGAP10 \| DISEASES 1103 \| CHAT \| DISEASES 3988 \| LIPA \| DISEASES 57142 \| RTN4 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3363 \| HTR7 \| DISEASES 7360 \| UGP2 \| DISEASES 4889 \| NPY5R \| DISEASES 9639 \| ARHGEF10 \| DISEASES 4128 \| MAOA \| DISEASES 4208 \| MEF2C \| DISEASES 1395 \| CRHR2 \| DISEASES 113675 \| SDSL \| DISEASES 3720 \| JARID2 \| DISEASES 1508 \| CTSB \| DISEASES 7444 \| VRK2 \| DISEASES 3146 \| HMGB1 \| DISEASES 257101 \| ZNF683 \| DISEASES 8720 \| MBTPS1 \| DISEASES 6483 \| ST3GAL2 \| DISEASES 224 \| ALDH3A2 \| DISEASES 4205 \| MEF2A \| DISEASES 50618 \| ITSN2 \| DISEASES 100506658 \| OCLN \| DISEASES 3359 \| HTR3A \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 2555 \| GABRA2 \| DISEASES 781 \| CACNA2D1 \| DISEASES 2917 \| GRM7 \| DISEASES 7867 \| MAPKAPK3 \| DISEASES 841 \| CASP8 \| DISEASES 8936 \| WASF1 \| DISEASES 57016 \| AKR1B10 \| DISEASES 4151 \| MB \| DISEASES 4638 \| MYLK \| DISEASES 83666 \| PARP9 \| DISEASES 1002 \| CDH4 \| DISEASES 104 \| ADARB1 \| DISEASES 5646 \| PRSS3 \| DISEASES 1312 \| COMT \| DISEASES 4886 \| NPY1R \| DISEASES 10724 \| MGEA5 \| DISEASES 1813 \| DRD2 \| DISEASES 9937 \| DCLRE1A \| DISEASES 2913 \| GRM3 \| DISEASES 27350 \| APOBEC3C \| DISEASES 6000 \| RGS7 \| DISEASES 51022 \| GLRX2 \| DISEASES 336 \| APOA2 \| DISEASES 632 \| BGLAP \| DISEASES 4121 \| MAN1A1 \| DISEASES 79626 \| TNFAIP8L2 \| DISEASES 246269 \| LACE1 \| DISEASES 1268 \| CNR1 \| DISEASES 3351 \| HTR1B \| DISEASES 1137 \| CHRNA4 \| DISEASES 6658 \| SOX3 \| DISEASES 959 \| CD40LG \| DISEASES 7803 \| PTP4A1 \| DISEASES 55277 \| FGGY \| DISEASES 5146 \| PDE6C \| DISEASES 8471 \| IRS4 \| DISEASES 79717 \| PPCS \| DISEASES 80712 \| ESX1 \| DISEASES 27035 \| NOX1 \| DISEASES 129685 \| TAF8 \| DISEASES 2899 \| GRIK3 \| DISEASES 54577 \| UGT1A7 \| DISEASES 7099 \| TLR4 \| DISEASES 1269 \| CNR2 \| DISEASES 3376 \| IARS \| DISEASES 11330 \| CTRC \| DISEASES 6096 \| RORB \| DISEASES 1325 \| CORT \| DISEASES 219 \| ALDH1B1 \| DISEASES 83715 \| ESPN \| DISEASES 11332 \| ACOT7 \| DISEASES 4129 \| MAOB \| DISEASES 84912 \| SLC35B4 \| DISEASES 2563 \| GABRD \| DISEASES 1536 \| CYBB \| DISEASES 3356 \| HTR2A \| DISEASES 22944 \| KIN \| DISEASES 10455 \| ECI2 \| DISEASES 551 \| AVP \| DISEASES 114131 \| UCN3 \| DISEASES 6462 \| SHBG \| DISEASES 10087 \| COL4A3BP \| DISEASES 5412 \| UBL3 \| DISEASES 8777 \| MPDZ \| DISEASES 5268 \| SERPINB5 \| DISEASES 1814 \| DRD3 \| DISEASES 4336 \| MOBP \| DISEASES 9467 \| SH3BP5 \| DISEASES 2617 \| GARS \| DISEASES 1443 \| CSH2 \| DISEASES 1621 \| DBH \| DISEASES 130 \| ADH6 \| DISEASES 2875 \| GPT \| DISEASES 2912 \| GRM2 \| DISEASES 174 \| AFP \| DISEASES 27327 \| TNRC6A \| DISEASES 6489 \| ST8SIA1 \| DISEASES 23426 \| GRIP1 \| DISEASES 594857 \| NPS \| DISEASES 1394 \| CRHR1 \| DISEASES 221037 \| JMJD1C \| DISEASES 25780 \| RASGRP3 \| DISEASES 7122 \| CLDN5 \| DISEASES 1135 \| CHRNA2 \| DISEASES 728441 \| GGT2 \| DISEASES 164668 \| APOBEC3H \| DISEASES 7018 \| TF \| DISEASES 210 \| ALAD \| DISEASES 3267 \| AGFG1 \| DISEASES 2641 \| GCG \| DISEASES 1385 \| CREB1 \| DISEASES 6916 \| TBXAS1 \| DISEASES 389158 \| PLSCR5 \| DISEASES 4988 \| OPRM1 \| DISEASES 10163 \| WASF2 \| DISEASES 7124 \| TNF \| DISEASES 26054 \| SENP6 \| DISEASES 7086 \| TKT \| DISEASES 139728 \| PNCK \| DISEASES 2566 \| GABRG2 \| DISEASES 10015 \| PDCD6IP \| DISEASES 3586 \| IL10 \| DISEASES 627 \| BDNF \| DISEASES 3077 \| HFE \| DISEASES 131 \| ADH7 \| DISEASES 114907 \| FBXO32 \| DISEASES 23025 \| UNC13A \| DISEASES 5715 \| PSMD9 \| DISEASES 3684 \| ITGAM \| DISEASES 136541 \| PRSS58 \| DISEASES 64786 \| TBC1D15 \| DISEASES 8742 \| TNFSF12 \| DISEASES 391104 \| VHLL \| DISEASES 8677 \| STX10 \| DISEASES 284424 \| MIR7-3HG \| DISEASES 378805 \| LINC-PINT \| DISEASES
Locus	(Waiting for update.)

Disease ID	1817
Disease	alcohol abuse
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:65) HP:0001394 \| Hepatic cirrhosis \| 16 HP:0001733 \| Pancreatic inflammation \| 12 HP:0000716 \| Depression \| 8 HP:0000739 \| Anxiety \| 8 HP:0001397 \| Hepatic steatosis \| 7 HP:0012115 \| Liver inflammation \| 5 HP:0000822 \| Hypertension \| 5 HP:0000708 \| Behavioral problems \| 5 HP:0001735 \| Acute pancreatitis \| 4 HP:0100033 \| Tic disorder \| 3 HP:0007302 \| Bipolar disorder \| 3 HP:0001298 \| Encephalopathy \| 3 HP:0100753 \| Schizophrenia \| 3 HP:0000726 \| Dementia \| 3 HP:0002664 \| Neoplasia \| 3 HP:0002360 \| Sleep disturbance \| 2 HP:0012531 \| Pain \| 2 HP:0001513 \| Obesity \| 2 HP:0012075 \| Personality disorder \| 2 HP:0000718 \| Aggressive behaviour \| 2 HP:0006280 \| Chronic pancreas inflammation \| 2 HP:0000505 \| Poor vision \| 2 HP:0002480 \| Hepatic encephalopathy \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0000670 \| Dental caries \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0002591 \| Voracious appetite \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0003077 \| Hyperlipidemia \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0000734 \| Disinhibition \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0002529 \| Neuronal loss in central nervous system \| 1 HP:0001873 \| Low platelet count \| 1 HP:0000952 \| Yellow skin \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0000709 \| Psychosis \| 1 HP:0007185 \| Loss of consciousness \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001289 \| Confusion \| 1 HP:0000737 \| Irritability \| 1 HP:0100806 \| Sepsis \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0001644 \| Congestive cardiomyopathy \| 1 HP:0004395 \| Malnutrition \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0012393 \| Allergy \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0001251 \| Ataxia \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0001402 \| Hepatocellular carcinoma \| 1 HP:0002180 \| Neurodegeneration \| 1 HP:0001645 \| Sudden cardiac death \| 1 HP:0002354 \| Memory loss \| 1 HP:0100507 \| Folate deficiency \| 1 HP:0002090 \| Pneumonia \| 1 HP:0012664 \| Reduced ejection fraction \| 1 HP:0011110 \| Inflammation of tonsils \| 1 HP:0005263 \| Gastritis \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0000989 \| pruritis \| 1 HP:0030731 \| Carcinoma \| 1

Disease ID	1817
Disease	alcohol abuse
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:23)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1229984	21917409	10327	AKR1A1	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.001085767	2012	ADH1B	4	99318162	T	C
rs1229984	24553426	125	ADH1B	umls:C0085762	BeFree	We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.	0.025570413	2014	ADH1B	4	99318162	T	C
rs1229984	21917409	125	ADH1B	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.025570413	2012	ADH1B	4	99318162	T	C
rs1229984	21917409	217	ALDH2	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.027666003	2012	ADH1B	4	99318162	T	C
rs1229984	21917409	126	ADH1C	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.012649486	2012	ADH1B	4	99318162	T	C
rs1229984	24018899	125	ADH1B	umls:C0085762	BeFree	Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.	0.025570413	2013	ADH1B	4	99318162	T	C
rs17110747	24491795	121278	TPH2	umls:C0085762	BeFree	More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.	0.000271442	2014	TPH2	12	72032174	G	A
rs1800562	26164493	3077	HFE	umls:C0085762	BeFree	In Caucasians, C282Y HFE homozygotes are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, due to alcohol abuse or concurrent genetic modifiers that are now being identified.	0.000814326	2015	HFE	6	26092913	G	A
rs1800562	20542038	3077	HFE	umls:C0085762	BeFree	Unlike these rare instances, in white people, homozygotes for C282Y polymorphism in HFE are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, when these individuals abuse alcohol or from other unidentified modifying factors.	0.000814326	2010	HFE	6	26092913	G	A
rs2306073	22538398	56938	ARNTL2	umls:C0085762	BeFree	Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).	0.000542884	2012	ARNTL2;ARNTL2-AS1	12	27402904	C	T
rs4570625	24491795	121278	TPH2	umls:C0085762	BeFree	More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.	0.000271442	2014	TPH2	12	71938143	G	T
rs4964057	20554694	56938	ARNTL2	umls:C0085762	BeFree	ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013).	0.000542884	2010	ARNTL2	12	27363909	T	G
rs4964057	22538398	56938	ARNTL2	umls:C0085762	BeFree	Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).	0.000542884	2012	ARNTL2	12	27363909	T	G
rs671	21917409	10327	AKR1A1	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.001085767	2012	ALDH2	12	111803962	G	A
rs671	21917409	126	ADH1C	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.012649486	2012	ALDH2	12	111803962	G	A
rs671	21917409	217	ALDH2	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.027666003	2012	ALDH2	12	111803962	G	A
rs671	21917409	125	ADH1B	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.025570413	2012	ALDH2	12	111803962	G	A
rs698	21917409	217	ALDH2	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.027666003	2012	ADH1C	4	99339632	T	C,A
rs698	21917409	125	ADH1B	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.025570413	2012	ADH1C	4	99339632	T	C,A
rs698	21917409	10327	AKR1A1	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.001085767	2012	ADH1C	4	99339632	T	C,A
rs698	21917409	126	ADH1C	umls:C0085762	BeFree	Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).	0.012649486	2012	ADH1C	4	99339632	T	C,A
rs7958822	22538398	56938	ARNTL2	umls:C0085762	BeFree	Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).	0.000542884	2012	ARNTL2	12	27348173	G	A
rs7958822	20554694	56938	ARNTL2	umls:C0085762	BeFree	ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013).	0.000542884	2010	ARNTL2	12	27348173	G	A

GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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