PedAM
Pediatric Disease Annotations & Medicines
| agoraphobia | ||||
| Disease ID | 1120 |
|---|---|
| Disease | agoraphobia |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:5) HP:0000739 | Anxiety | 4 HP:0000716 | Depression | 2 HP:0100785 | Insomnia | 1 HP:0007302 | Bipolar disorder | 1 HP:0001513 | Obesity | 1 |
| Disease ID | 1120 |
|---|---|
| Disease | agoraphobia |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:6) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs11724320 | 17948870 | 4852 | NPY | umls:C0001818 | BeFree | A synonymous (Gly-426-Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002-0.019). | 0.000271442 | 2008 | NPY1R;NPY5R | 4 | 163346771 | T | C |
| rs11946004 | 17948870 | 4852 | NPY | umls:C0001818 | BeFree | A synonymous (Gly-426-Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002-0.019). | 0.000271442 | 2008 | NPY5R | 4 | 163351551 | G | A,T |
| rs1718119 | 17197037 | 10645 | CAMKK2 | umls:C0001818 | BeFree | We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale. | 0.000271442 | 2007 | P2RX7;LOC105370032 | 12 | 121177300 | G | T,A |
| rs1718119 | 17197037 | 5027 | P2RX7 | umls:C0001818 | BeFree | We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale. | 0.000271442 | 2007 | P2RX7;LOC105370032 | 12 | 121177300 | G | T,A |
| rs3817190 | 17197037 | 10645 | CAMKK2 | umls:C0001818 | BeFree | We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale. | 0.000271442 | 2007 | CAMKK2 | 12 | 121274274 | T | A |
| rs3817190 | 17197037 | 5027 | P2RX7 | umls:C0001818 | BeFree | We found, however, a prominent association between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale. | 0.000271442 | 2007 | CAMKK2 | 12 | 121274274 | T | A |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:5) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0001818 | adinazolam | C039668 | 37115-32-5 | agoraphobia | MESH:D000379 | therapeutic | 2651489 | ||
| C0001818 | alprazolam | D000525 | 28981-97-7 | agoraphobia | MESH:D000379 | therapeutic | 2651489 | ||
| C0001818 | clozapine | D003024 | 5786-21-0 | agoraphobia | MESH:D000379 | therapeutic | 11230003 | ||
| C0001818 | imipramine | D007099 | 50-49-7 | agoraphobia | MESH:D000379 | therapeutic | 8098050 | ||
| C0001818 | levonorgestrel | D016912 | 797-63-7 | agoraphobia | MESH:D000379 | marker/mechanism | 8601550 | ||
FDA approved drug and dosage information(Total Drugs:2) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D000379 | mirena | levonorgestrel | 52MG | INTRAUTERINE DEVICE;INTRAUTERINE | Prescription | None | Yes | Yes |
| MESH:D000379 | levonorgestrel | levonorgestrel | 75MG/IMPLANT | IMPLANT;IMPLANTATION | Discontinued | None | No | No |
FDA labeling changes(Total Drugs:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D000379 | 1/10/2009 | mirena | levonorgestrel-releasing intrauterine system | Treatment of heavy menstrual bleeding for women using intrauterine contraception | New indication for the treatment of heavy menstrual bleeding for women who choose to use intrauterine contraception Use before menarche is not indicated | Labeling | - | P | - | - | Berlex | - | TRUE' |
| MESH:D000379 | 10/7/2009 | plan b one step | levonorgestrel | Emergency contraception - OTC in women 17 years and older; RX for women younger than age 17 years | New single dose 1.5 mg tablet New dosage regimen | Labeling | - | P | - | - | Duramed | - | FALSE' |