PedAM
Pediatric Disease Annotations & Medicines
| adjustment disorder | ||||
| Disease ID | 1314 |
|---|---|
| Disease | adjustment disorder |
| Definition | Maladaptive reactions to identifiable psychosocial stressors occurring within a short time after onset of the stressor. They are manifested by either impairment in social or occupational functioning or by symptoms (depression, anxiety, etc.) that are in excess of a normal and expected reaction to the stressor. |
| Synonym | [x]adjustment disorders adjustment dis adjustment disorder (disorder) adjustment disorder, nos adjustment disorders adjustment disorders [disease/finding] brief situational non-psychotic disorder brief situational non-psychotic disorder, nos disorder, adjustment disorder, reactive disorders, adjustment disorders, reactive reactive dis reactive disorder reactive disorders |
| DOID | |
| UMLS | C0001546 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:7) C0003467 | anxiety | 17 C0011570 | depression | 5 C0003469 | anxiety disorders | 2 C0003469 | anxiety disorder | 2 C0002395 | alzheimer's dementia | 1 C0013415 | dysthymic disorder | 1 C0497327 | dementia | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:41) 374291 | NDUFS7 | DISEASES 4317 | MMP8 | DISEASES 7166 | TPH1 | DISEASES 51540 | SCLY | DISEASES 6532 | SLC6A4 | DISEASES 5934 | RBL2 | DISEASES 2033 | EP300 | DISEASES 2121 | EVC | DISEASES 64083 | GOLPH3 | DISEASES 4986 | OPRK1 | DISEASES 55749 | CCAR1 | DISEASES 3060 | HCRT | DISEASES 51072 | MEMO1 | DISEASES 5346 | PLIN1 | DISEASES 4054 | LTBP3 | DISEASES 5617 | PRL | DISEASES 51181 | DCXR | DISEASES 7200 | TRH | DISEASES 8625 | RFXANK | DISEASES 56945 | MRPS22 | DISEASES 3952 | LEP | DISEASES 10938 | EHD1 | DISEASES 5580 | PRKCD | DISEASES 3363 | HTR7 | DISEASES 2289 | FKBP5 | DISEASES 23294 | ANKS1A | DISEASES 4860 | PNP | DISEASES 2316 | FLNA | DISEASES 2048 | EPHB2 | DISEASES 8518 | IKBKAP | DISEASES 56243 | KIAA1217 | DISEASES 4129 | MAOB | DISEASES 3356 | HTR2A | DISEASES 2625 | GATA3 | DISEASES 8544 | PIR | DISEASES 51109 | RDH11 | DISEASES 9244 | CRLF1 | DISEASES 594857 | NPS | DISEASES 1394 | CRHR1 | DISEASES 8291 | DYSF | DISEASES 6949 | TCOF1 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1314 |
|---|---|
| Disease | adjustment disorder |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:8) HP:0000739 | Anxiety | 17 HP:0000716 | Depression | 5 HP:0000726 | Dementia | 1 HP:0000708 | Behavioral problems | 1 HP:0002883 | Rapid breathing | 1 HP:0001631 | Atria septal defect | 1 HP:0003418 | Back pain | 1 HP:0012075 | Personality disorder | 1 |
| Disease ID | 1314 |
|---|---|
| Disease | adjustment disorder |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:4) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs386626619 | 19605821 | 4597 | MVD | umls:C0001546 | BeFree | In this context, the distinctive role of a positive JAK2(V617F) mutation for the diagnosis of Ph- MPD was underscored, including entities with a low allele burden and the discrimination from reactive disorders (autoimmune myelofibrosis, reactive thrombocytosis). | 0.000271442 | 2009 | NA | NA | NA | NA | NA |
| rs386626619 | 19605821 | 3717 | JAK2 | umls:C0001546 | BeFree | In this context, the distinctive role of a positive JAK2(V617F) mutation for the diagnosis of Ph- MPD was underscored, including entities with a low allele burden and the discrimination from reactive disorders (autoimmune myelofibrosis, reactive thrombocytosis). | 0.000271442 | 2009 | NA | NA | NA | NA | NA |
| rs77375493 | 19605821 | 3717 | JAK2 | umls:C0001546 | BeFree | In this context, the distinctive role of a positive JAK2(V617F) mutation for the diagnosis of Ph- MPD was underscored, including entities with a low allele burden and the discrimination from reactive disorders (autoimmune myelofibrosis, reactive thrombocytosis). | 0.000271442 | 2009 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs77375493 | 19605821 | 4597 | MVD | umls:C0001546 | BeFree | In this context, the distinctive role of a positive JAK2(V617F) mutation for the diagnosis of Ph- MPD was underscored, including entities with a low allele burden and the discrimination from reactive disorders (autoimmune myelofibrosis, reactive thrombocytosis). | 0.000271442 | 2009 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0001546 | citalopram | D015283 | 59729-33-8 | adjustment disorders | MESH:D000275 | therapeutic | 12006908 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |