PedAM

Pediatric Disease Annotations & Medicines


	acute t cell leukemia

Disease ID	882
Disease	acute t cell leukemia
Definition	A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.
Synonym	acute t cell lymphoblastic leukemia acute t cell lymphocytic leukemia acute t-cell leukemia acute t-cell leukemias acute t-cell lymphoblastic leukaemia acute t-cell lymphoblastic leukemia acute t-cell lymphocytic leukemia acute t-lymphocytic leukemia acute t-lymphocytic leukemias cortical t all leukemia, acute t-cell leukemia, acute t-lymphocytic leukemia, lymphoblastic, acute, t cell leukemia, lymphoblastic, acute, t-cell leukemia, lymphocytic, acute t cell leukemia, lymphocytic, acute, t-cell leukemia, t-cell, acute leukemias, acute t-cell leukemias, acute t-lymphocytic lymphoblastic leukemia, acute, t cell lymphoblastic leukemia, acute, t-cell lymphocytic leukemia acute bt lymphocytic leukemia, t cell, acute lymphocytic leukemia, t-cell, acute pre t-all pre-t all precursor t cell lymphoblastic leukemia precursor t cell lymphoblastic leukemia lymphoma precursor t cell lymphoblastic lymphoma precursor t-cell lymphoblastic leukaemia precursor t-cell lymphoblastic leukemia precursor t-cell lymphoblastic leukemia (morphologic abnormality) precursor t-cell lymphoblastic leukemia-lymphoma precursor t-cell lymphoblastic leukemia-lymphoma [disease/finding] precursor t-lymphoblastic leukemia precursor t-lymphoblastic leukemia (t-cell all) pro-t all t acute lymphoblastic leukemia t cell leukemia, acute t lymphocytic leukemia, acute t-cell acute lymphoblastic leukaemia t-cell acute lymphoblastic leukemia t-cell acute lymphoblastic leukemia (disorder) t-cell acute lymphoblastic leukemias t-cell acute lymphocytic leukemia t-cell all t-cell leukemia, acute t-cell leukemias, acute t-cell type acute leukemia t-lymphocytic leukemia, acute t-lymphocytic leukemias, acute
DOID	DOID:5603
UMLS	C1961099
MeSH	D054218
SNOMED-CT	SNOMEDCT_US_2016_09_01:277575008
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:18) LMO1 \| 4004 \| CTD_human ABCG2 \| 9429 \| CTD_human NOTCH1 \| 4851 \| CTD_human BCL11B \| 64919 \| CTD_human BCL10 \| 8915 \| CLINVAR TAL1 \| 6886 \| CTD_human TLX1 \| 3195 \| CTD_human BAX \| 581 \| CLINVAR MYB \| 4602 \| CTD_human MTOR \| 2475 \| CTD_human PTPN2 \| 5771 \| CTD_human RPL10 \| 6134 \| CTD_human PHF6 \| 84295 \| CTD_human IL7R \| 3575 \| CTD_human LMO2 \| 4005 \| CTD_human RPL5 \| 6125 \| CTD_human CNOT3 \| 4849 \| CTD_human FBXW7 \| 55294 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 207 \| AKT1 \| infer 55294 \| FBXW7 \| infer 4851 \| NOTCH1 \| infer 5290 \| PIK3CA \| infer 5728 \| PTEN \| infer 7157 \| TP53 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:92) 23409 \| SIRT4 \| DISEASES 79444 \| BIRC7 \| DISEASES 10627 \| MYL12A \| DISEASES 3202 \| HOXA5 \| DISEASES 3558 \| IL2 \| DISEASES 3554 \| IL1R1 \| DISEASES 103910 \| MYL12B \| DISEASES 5335 \| PLCG1 \| DISEASES 7538 \| ZFP36 \| DISEASES 22933 \| SIRT2 \| DISEASES 7166 \| TPH1 \| DISEASES 2488 \| FSHB \| DISEASES 53 \| ACP2 \| DISEASES 5156 \| PDGFRA \| DISEASES 4005 \| LMO2 \| DISEASES 4001 \| LMNB1 \| DISEASES 8312 \| AXIN1 \| DISEASES 943 \| TNFRSF8 \| DISEASES 51176 \| LEF1 \| DISEASES 207 \| AKT1 \| DISEASES 8915 \| BCL10 \| DISEASES 10398 \| MYL9 \| DISEASES 80224 \| NUBPL \| DISEASES 55294 \| FBXW7 \| DISEASES 7070 \| THY1 \| DISEASES 308 \| ANXA5 \| DISEASES 3562 \| IL3 \| DISEASES 6240 \| RRM1 \| DISEASES 613 \| BCR \| DISEASES 7543 \| ZFX \| DISEASES 9079 \| LDB2 \| DISEASES 57521 \| RPTOR \| DISEASES 54205 \| CYCS \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 924 \| CD7 \| DISEASES 8837 \| CFLAR \| DISEASES 1464 \| CSPG4 \| DISEASES 57381 \| RHOJ \| DISEASES 10892 \| MALT1 \| DISEASES 5932 \| RBBP8 \| DISEASES 977 \| CD151 \| DISEASES 4772 \| NFATC1 \| DISEASES 51547 \| SIRT7 \| DISEASES 81608 \| FIP1L1 \| DISEASES 51548 \| SIRT6 \| DISEASES 3932 \| LCK \| DISEASES 50615 \| IL21R \| DISEASES 4004 \| LMO1 \| DISEASES 4602 \| MYB \| DISEASES 921 \| CD5 \| DISEASES 3205 \| HOXA9 \| DISEASES 5154 \| PDGFA \| DISEASES 2534 \| FYN \| DISEASES 3981 \| LIG4 \| DISEASES 253260 \| RICTOR \| DISEASES 1612 \| DAPK1 \| DISEASES 841 \| CASP8 \| DISEASES 6693 \| SPN \| DISEASES 5599 \| MAPK8 \| DISEASES 4311 \| MME \| DISEASES 10367 \| MICU1 \| DISEASES 5406 \| PNLIP \| DISEASES 840 \| CASP7 \| DISEASES 914 \| CD2 \| DISEASES 4893 \| NRAS \| DISEASES 8945 \| BTRC \| DISEASES 3195 \| TLX1 \| DISEASES 2959 \| GTF2B \| DISEASES 8543 \| LMO4 \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 896 \| CCND3 \| DISEASES 2268 \| FGR \| DISEASES 1676 \| DFFA \| DISEASES 26586 \| CKAP2 \| DISEASES 1677 \| DFFB \| DISEASES 23408 \| SIRT5 \| DISEASES 2683 \| B4GALT1 \| DISEASES 4267 \| CD99 \| DISEASES 23410 \| SIRT3 \| DISEASES 238 \| ALK \| DISEASES 7187 \| TRAF3 \| DISEASES 347734 \| SLC35B2 \| DISEASES 84433 \| CARD11 \| DISEASES 4626 \| MYH8 \| DISEASES 8861 \| LDB1 \| DISEASES 56616 \| DIABLO \| DISEASES 5087 \| PBX1 \| DISEASES 10043 \| TOM1 \| DISEASES 3939 \| LDHA \| DISEASES 3292 \| HSD17B1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	882
Disease	acute t cell leukemia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	(Waiting for update.)

Disease ID	882
Disease	acute t cell leukemia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1805794	25746326	7298	TYMS	umls:C1961099	BeFree	Among the investigated polymorphisms and mutations, NBN Glu185Gln significantly decreased susceptibility to B-cell ALL (p=0.037), while TYMS 3R allele decreased susceptibility to T-cell ALL (p=0.011).	0.000271442	2015	NBN	8	89978251	C	G
rs1805794	25746326	4683	NBN	umls:C1961099	BeFree	Among the investigated polymorphisms and mutations, NBN Glu185Gln significantly decreased susceptibility to B-cell ALL (p=0.037), while TYMS 3R allele decreased susceptibility to T-cell ALL (p=0.011).	0.000271442	2015	NBN	8	89978251	C	G
rs387906351	NA	8915	BCL10	umls:C1961099	CLINVAR	NA	0.120271442	NA	BCL10	1	85270827	-	T
rs398122513	NA	581	BAX	umls:C1961099	CLINVAR	NA	0.120271442	NA	BAX	19	48955799	G	A
rs398122842	NA	581	BAX	umls:C1961099	CLINVAR	NA	0.120271442	NA	BAX	19	48955715	GGGGGGG	-

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:8)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C1961099	cyclophosphamide	D003520	50-18-0	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	20167372
C1961099	cyclosporine	D016572	59865-13-3	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	3865016
C1961099	methotrexate	D008727	1959/5/2	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	16831976
C1961099	nelarabine	C104457	-	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	16831976
C1961099	pegaspargase	C042705	-	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	20167372
C1961099	sirolimus	D020123	53123-88-9	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	19246562
C1961099	thiotepa	D013852	52-24-4	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	8711459
C1961099	vincristine	D014750	-	precursor t-cell lymphoblastic leukemia-lymphoma	MESH:D054218	therapeutic	12426685

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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