PedAM
Pediatric Disease Annotations & Medicines
| acute leukemia | ||||
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:18) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1045642 | 21133625 | 5243 | ABCB1 | umls:C0085669 | BeFree | Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. | 0.007871814 | 2010 | ABCB1 | 7 | 87509329 | A | T,G |
| rs1048943 | 23056546 | 1543 | CYP1A1 | umls:C0085669 | BeFree | Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls. | 0.001085767 | 2012 | CYP1A1 | 15 | 74720644 | T | G,C,A |
| rs1137101 | 17072067 | 3953 | LEPR | umls:C0085669 | BeFree | The aim of the study was to evaluate bone marrow and peripheral blood leptin level and frequency of distribution of leptin receptor gene polymorphism Gln223Arg in children with acute leukemia. | 0.000542884 | 2006 | LEPR | 1 | 65592830 | A | G |
| rs1137101 | 17072067 | 3952 | LEP | umls:C0085669 | BeFree | The aim of the study was to evaluate bone marrow and peripheral blood leptin level and frequency of distribution of leptin receptor gene polymorphism Gln223Arg in children with acute leukemia. | 0.000542884 | 2006 | LEPR | 1 | 65592830 | A | G |
| rs121434592 | 18392055 | 207 | AKT1 | umls:C0085669 | BeFree | Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. | 0.001085767 | 2008 | AKT1 | 14 | 104780214 | C | T |
| rs121918464 | 21930766 | 5781 | PTPN11 | umls:C0085669 | BeFree | Thus, Ptpn11(E76K) mutation has non-lineage-specific effects on malignant transformation of hematopoietic cells and initiates acute leukemias at various stages of hematopoiesis. | 0.000814326 | 2011 | PTPN11 | 12 | 112450406 | G | A,C |
| rs13181 | 24486506 | 2068 | ERCC2 | umls:C0085669 | BeFree | The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis. | 0.000542884 | 2014 | ERCC2;KLC3 | 19 | 45351661 | T | A,G |
| rs1800566 | 22976839 | 5444 | PON1 | umls:C0085669 | BeFree | NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution. | 0.000271442 | 2012 | NQO1 | 16 | 69711242 | G | A |
| rs386602118 | 22652301 | 627 | BDNF | umls:C0085669 | BeFree | The BDNF Val66Met polymorphism may contribute to development of depressive symptomatology in patients undergoing stressful life events, such as diagnosis of acute leukemia and preparation for HSCT. | 0.000542884 | 2012 | NA | NA | NA | NA | NA |
| rs386626619 | 21421540 | 3717 | JAK2 | umls:C0085669 | BeFree | The transformation of MPNs into acute leukemia is by itself a very rare phenomenon, and so is the persistence of the JAK2(V617F) mutation after blast crisis. | 0.003528744 | 2011 | NA | NA | NA | NA | NA |
| rs386626619 | 21658659 | 3717 | JAK2 | umls:C0085669 | BeFree | JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia. | 0.003528744 | 2011 | NA | NA | NA | NA | NA |
| rs386626619 | 22818858 | 3717 | JAK2 | umls:C0085669 | BeFree | A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia. | 0.003528744 | 2012 | NA | NA | NA | NA | NA |
| rs397507444 | 17970089 | 4524 | MTHFR | umls:C0085669 | BeFree | The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population. | 0.005352893 | 2007 | MTHFR | 1 | 11794407 | T | G |
| rs662 | 22976839 | 5444 | PON1 | umls:C0085669 | BeFree | NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution. | 0.000271442 | 2012 | PON1 | 7 | 95308134 | T | C |
| rs77375493 | 21658659 | 3717 | JAK2 | umls:C0085669 | BeFree | JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia. | 0.003528744 | 2011 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs77375493 | 21421540 | 3717 | JAK2 | umls:C0085669 | BeFree | The transformation of MPNs into acute leukemia is by itself a very rare phenomenon, and so is the persistence of the JAK2(V617F) mutation after blast crisis. | 0.003528744 | 2011 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs77375493 | 22818858 | 3717 | JAK2 | umls:C0085669 | BeFree | A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia. | 0.003528744 | 2012 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs854560 | 22976839 | 5444 | PON1 | umls:C0085669 | BeFree | NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution. | 0.000271442 | 2012 | PON1 | 7 | 95316772 | A | C,G,N,T |
GWASdb Annotation(Total Genotypes:0) | |
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GWASdb Snp Trait(Total Genotypes:0) | |
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Mapped by lexical matching(Total Items:0) |
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Mapped by homologous gene(Total Items:0) |
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Chemical(Total Drugs:0) | |
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FDA approved drug and dosage information(Total Drugs:0) | |
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FDA labeling changes(Total Drugs:0) | |
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