PedAM

Pediatric Disease Annotations & Medicines


	acute kidney tubular necrosis

Disease ID	1272
Disease	acute kidney tubular necrosis
Definition	Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
Synonym	acute necrosis tubular acute renal failure with tubular necrosis acute renal tubular necrosis acute tubular necrosis acute tubular necrosis (disorder) acute tubular necrosis, nos acute tubule necrosis atn - acute tubular necrosis kidney tubular necrosis, acute kidney tubular necrosis, acute [disease/finding] lower nephron nephroses lower nephron nephrosis nephron nephroses, lower nephron nephrosis, lower nephroses, lower nephron nephrosis lower nephron nephrosis, lower nephron renal tubular necrosis tubular necrosis acute tubulorrhexis
DOID	DOID:12556
UMLS	C0022672
MeSH	D007683
SNOMED-CT	SNOMEDCT_US_2016_09_01:35455006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:23) C0035078 \| renal failure \| 21 C0022660 \| acute renal failure \| 9 C0022116 \| ischemia \| 3 C0027697 \| nephritis \| 3 C0024530 \| malaria \| 2 C0041349 \| tubulointerstitial nephritis \| 2 C0022658 \| kidney disease \| 2 C0027707 \| interstitial nephritis \| 2 C0013502 \| hydatid cyst \| 1 C0221238 \| mesangial proliferative glomerulonephritis \| 1 C0005694 \| bladder outlet obstruction \| 1 C0017658 \| glomerulonephritis \| 1 C0002871 \| anemia \| 1 C0027726 \| nephrotic syndrome \| 1 C0024790 \| paroxysmal nocturnal hemoglobinuria \| 1 C0022658 \| kidney diseases \| 1 C0022661 \| end-stage renal disease \| 1 C0022658 \| renal disease \| 1 C0022658 \| nephropathy \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0011633 \| dermatomyositis \| 1 C0003460 \| anuria \| 1 C0020456 \| hyperglycemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) SOD2 \| 6648 \| CTD_human POMC \| 5443 \| CTD_human PPARA \| 5465 \| CTD_human FABP1 \| 2168 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:169) 6376 \| CX3CL1 \| DISEASES 3675 \| ITGA3 \| DISEASES 359 \| AQP2 \| DISEASES 8646 \| CHRD \| DISEASES 3162 \| HMOX1 \| DISEASES 4627 \| MYH9 \| DISEASES 3002 \| GZMB \| DISEASES 51285 \| RASL12 \| DISEASES 10404 \| CPQ \| DISEASES 5327 \| PLAT \| DISEASES 973 \| CD79A \| DISEASES 4818 \| NKG7 \| DISEASES 3082 \| HGF \| DISEASES 6804 \| STX1A \| DISEASES 5054 \| SERPINE1 \| DISEASES 7431 \| VIM \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 4254 \| KITLG \| DISEASES 3565 \| IL4 \| DISEASES 5624 \| PROC \| DISEASES 3217 \| HOXB7 \| DISEASES 4360 \| MRC1 \| DISEASES 6568 \| SLC17A1 \| DISEASES 718 \| C3 \| DISEASES 10047 \| CST8 \| DISEASES 6945 \| MLX \| DISEASES 968 \| CD68 \| DISEASES 4277 \| MICB \| DISEASES 2056 \| EPO \| DISEASES 10343 \| PKDREJ \| DISEASES 1401 \| CRP \| DISEASES 301 \| ANXA1 \| DISEASES 967 \| CD63 \| DISEASES 7024 \| TFCP2 \| DISEASES 3569 \| IL6 \| DISEASES 27348 \| TOR1B \| DISEASES 10068 \| IL18BP \| DISEASES 4069 \| LYZ \| DISEASES 3690 \| ITGB3 \| DISEASES 5465 \| PPARA \| DISEASES 23523 \| CABIN1 \| DISEASES 7299 \| TYR \| DISEASES 3553 \| IL1B \| DISEASES 4036 \| LRP2 \| DISEASES 84083 \| ZRANB3 \| DISEASES 25759 \| SHC2 \| DISEASES 3383 \| ICAM1 \| DISEASES 6550 \| SLC9A3 \| DISEASES 1950 \| EGF \| DISEASES 5286 \| PIK3C2A \| DISEASES 3263 \| HPX \| DISEASES 8128 \| ST8SIA2 \| DISEASES 81631 \| MAP1LC3B \| DISEASES 55520 \| ELAC1 \| DISEASES 5972 \| REN \| DISEASES 10280 \| SIGMAR1 \| DISEASES 3934 \| LCN2 \| DISEASES 3606 \| IL18 \| DISEASES 5805 \| PTS \| DISEASES 23576 \| DDAH1 \| DISEASES 10563 \| CXCL13 \| DISEASES 9530 \| BAG4 \| DISEASES 22808 \| MRAS \| DISEASES 1636 \| ACE \| DISEASES 27306 \| HPGDS \| DISEASES 248 \| ALPI \| DISEASES 2168 \| FABP1 \| DISEASES 152185 \| SPICE1 \| DISEASES 213 \| ALB \| DISEASES 327 \| APEH \| DISEASES 10935 \| PRDX3 \| DISEASES 79158 \| GNPTAB \| DISEASES 11318 \| GPR182 \| DISEASES 90678 \| LRSAM1 \| DISEASES 3479 \| IGF1 \| DISEASES 10736 \| SIX2 \| DISEASES 340024 \| SLC6A19 \| DISEASES 7369 \| UMOD \| DISEASES 2147 \| F2 \| DISEASES 285590 \| SH3PXD2B \| DISEASES 836 \| CASP3 \| DISEASES 358 \| AQP1 \| DISEASES 4327 \| MMP19 \| DISEASES 90637 \| ZFAND2A \| DISEASES 1909 \| EDNRA \| DISEASES 4233 \| MET \| DISEASES 637 \| BID \| DISEASES 10419 \| PRMT5 \| DISEASES 10229 \| COQ7 \| DISEASES 147138 \| TMC8 \| DISEASES 9622 \| KLK4 \| DISEASES 10250 \| SRRM1 \| DISEASES 5271 \| SERPINB8 \| DISEASES 6401 \| SELE \| DISEASES 9376 \| SLC22A8 \| DISEASES 64412 \| GZF1 \| DISEASES 2686 \| GGT7 \| DISEASES 4521 \| NUDT1 \| DISEASES 6187 \| RPS2 \| DISEASES 9536 \| PTGES \| DISEASES 259307 \| IL4I1 \| DISEASES 92399 \| MRRF \| DISEASES 26762 \| HAVCR1 \| DISEASES 728 \| C5AR1 \| DISEASES 23556 \| PIGN \| DISEASES 841 \| CASP8 \| DISEASES 4151 \| MB \| DISEASES 3135 \| HLA-G \| DISEASES 5599 \| MAPK8 \| DISEASES 10724 \| MGEA5 \| DISEASES 4283 \| CXCL9 \| DISEASES 23038 \| WDTC1 \| DISEASES 183 \| AGT \| DISEASES 142 \| PARP1 \| DISEASES 26002 \| MOXD1 \| DISEASES 1490 \| CTGF \| DISEASES 1810 \| DR1 \| DISEASES 959 \| CD40LG \| DISEASES 680 \| BRS3 \| DISEASES 2021 \| ENDOG \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 1896 \| EDA \| DISEASES 84930 \| MASTL \| DISEASES 100507436 \| MICA \| DISEASES 56243 \| KIAA1217 \| DISEASES 4878 \| NPPA \| DISEASES 6564 \| SLC15A1 \| DISEASES 7454 \| WAS \| DISEASES 6668 \| SP2 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 1910 \| EDNRB \| DISEASES 1906 \| EDN1 \| DISEASES 51334 \| PRR16 \| DISEASES 3559 \| IL2RA \| DISEASES 551 \| AVP \| DISEASES 3030 \| HADHA \| DISEASES 5268 \| SERPINB5 \| DISEASES 55022 \| PID1 \| DISEASES 2054 \| STX2 \| DISEASES 80196 \| RNF34 \| DISEASES 838 \| CASP5 \| DISEASES 162239 \| ZFP1 \| DISEASES 6696 \| SPP1 \| DISEASES 65010 \| SLC26A6 \| DISEASES 2919 \| CXCL1 \| DISEASES 655 \| BMP7 \| DISEASES 9170 \| LPAR2 \| DISEASES 255743 \| NPNT \| DISEASES 6916 \| TBXAS1 \| DISEASES 3112 \| HLA-DOB \| DISEASES 1029 \| CDKN2A \| DISEASES 5076 \| PAX2 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 7258 \| TSPY1 \| DISEASES 4152 \| MBD1 \| DISEASES 7148 \| TNXB \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 23543 \| RBFOX2 \| DISEASES 8842 \| PROM1 \| DISEASES 6565 \| SLC15A2 \| DISEASES 55922 \| NKRF \| DISEASES 567 \| B2M \| DISEASES 29931 \| LINC00312 \| DISEASES 100169750 \| PRINS \| DISEASES
Locus	(Waiting for update.)

Disease ID	1272
Disease	acute kidney tubular necrosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:27) HP:0000083 \| Renal insufficiency \| 21 HP:0001919 \| Acute renal failure \| 15 HP:0003201 \| Rhabdomyolysis \| 4 HP:0000123 \| Nephritis \| 3 HP:0002913 \| Myoglobinuria \| 2 HP:0001970 \| Interstitial nephritis \| 2 HP:0100806 \| Sepsis \| 2 HP:0100519 \| Anuria \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0002907 \| Microhematuria \| 1 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0003074 \| High blood glucose \| 1 HP:0000092 \| Tubular atrophy \| 1 HP:0000969 \| Dropsy \| 1 HP:0012574 \| Mesangial hypercellularity \| 1 HP:0000097 \| focal glomerulosclerosis \| 1 HP:0004743 \| Chronic tubulointerstitial nephritis \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0012579 \| Minimal change glomerulonephritis \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0001903 \| Anemia \| 1 HP:0011106 \| Depleted blood volume \| 1 HP:0000100 \| Nephrosis \| 1 HP:0000112 \| Nephropathy \| 1 HP:0001941 \| acidemia \| 1 HP:0000099 \| Glomerular nephritis \| 1

Disease ID	1272
Disease	acute kidney tubular necrosis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0035078 \| renal failure \| 20 C0022660 \| acute renal failure \| 9

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:34)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022672	acetaminophen	D000082	103-90-2	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	11881430
C0022672	acetylcysteine	D000111	616-91-1	kidney tubular necrosis, acute	MESH:D007683	therapeutic	17365906
C0022672	amikacin	D000583	37517-28-5	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	15199201
C0022672	caffeine	D002110	1958/8/2	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	10803761
C0022672	carbamazepine	D002220	298-46-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	8107947
C0022672	cefdinir	C056814	-	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	11300142
C0022672	cefmetazole	D015311	56796-20-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	3172294
C0022672	cefotiam	D015310	61622-34-2	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	6271094
C0022672	ceftazidime	D002442	78439-06-2	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	12818927
C0022672	ceftazidime	D002442	78439-06-2	kidney tubular necrosis, acute	MESH:D007683	therapeutic	19802993
C0022672	cephalexin	D002506	15686-71-2	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	15222673
C0022672	ciprofloxacin	D002939	85721-33-1	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	9531191
C0022672	cyclosporine	D016572	59865-13-3	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	1778857
C0022672	cyclosporine	D016572	59865-13-3	kidney tubular necrosis, acute	MESH:D007683	therapeutic	6351368
C0022672	diatrizoate	D003973	117-96-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	1743919
C0022672	cisplatin	D002945	15663-27-1	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	11231351
C0022672	diclofenac	D004008	15307-86-5	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	19473619
C0022672	fenoprofen	D005279	31879-05-7	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	6520381
C0022672	folic acid	D005492	59-30-3	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	12969123
C0022672	fomepizole	C010238	7554-65-6	kidney tubular necrosis, acute	MESH:D007683	therapeutic	20530232
C0022672	foscarnet	D017245	4428-95-9	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	2554731
C0022672	indomethacin	D007213	53-86-1	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	860058
C0022672	ketorolac	D020910	66635-83-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	9585304
C0022672	pamidronate	C019248	40391-99-9	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	14964460
C0022672	phenylpropanolamine	D010665	14838-15-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	7313755
C0022672	propylthiouracil	D011441	51-52-5	kidney tubular necrosis, acute	MESH:D007683	therapeutic	16354242
C0022672	rifampin	D012293	13292-46-1	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	7121659
C0022672	sirolimus	D020123	53123-88-9	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	12544890
C0022672	streptozocin	D013311	18883-66-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	15590127
C0022672	tacrolimus	D016559	109581-93-3	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	12544890
C0022672	tenofovir	D000068698	-	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	19473619
C0022672	thiopental	D013874	76-75-5	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	16116121
C0022672	tretinoin	D014212	302-79-4	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	9378467
C0022672	vancomycin	D014640	1404-90-6	kidney tubular necrosis, acute	MESH:D007683	marker/mechanism	11810128

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)