PedAM

Pediatric Disease Annotations & Medicines


	acute kidney failure

Disease ID	666
Disease	acute kidney failure
Definition	clinical syndrome characterized by a sudden decrease in glomerular filtration rate, usually associated with oliguria and always associated with biochemical consequences of the reduction in glomerular filtration rate such as a rise in blood urea nitrogen (BUN) and serum creatinine concentrations.
Synonym	acute and unspecified renal failure acute failure kidney acute failure renal acute kidney failure nos acute kidney failure, unspecified acute kidney failures acute kidney injury acute renal failure acute renal failure (disorder) acute renal failure nos acute renal failure nos (disorder) acute renal failure syndrome acute renal failure syndrome (disorder) acute renal failure syndrome, nos acute renal failures acute renal insufficiency acute renal shutdown aki arf arf - acute renal failure failure acute renal failure kidney acute kidney failure acute kidney failure, acute kidney failure, acute [disease/finding] kidney failures, acute kidney, failure, acute renal failure acute renal failure, acute renal failures, acute renal shutdown acute syndrome acute renal failure
DOID	DOID:3021
ICD10	ICD10CM:N17.9
UMLS	C0022660
MeSH	D058186
SNOMED-CT	SNOMEDCT_US_2016_09_01:14669001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C0026764 \| multiple myeloma \| 2 C0042769 \| virus infection \| 1 C0034072 \| pulmonary heart disease \| 1 C0010346 \| crohn's disease \| 1 C0041341 \| tuberous sclerosis \| 1 C0000832 \| abruptio placenta \| 1 C0007134 \| renal carcinoma \| 1 C0019061 \| hemolytic uremic syndrome \| 1 C0002871 \| anemia \| 1 C0000832 \| abruptio placentae \| 1 C1145670 \| respiratory failure \| 1 C0038041 \| spotted fever \| 1 C0024225 \| lymphangitis \| 1 C0006060 \| mediterranean spotted fever \| 1 C0026764 \| myeloma \| 1 C0018799 \| heart disease \| 1 C0020538 \| hypertension \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 2056 \| EPO \| infer 5409 \| PNMT \| infer 1636 \| ACE \| infer 185 \| AGTR1 \| infer 1535 \| CYBA \| infer 3586 \| IL10 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:163) 6376 \| CX3CL1 \| DISEASES 1774 \| DNASE1L1 \| DISEASES 84957 \| RELT \| DISEASES 359 \| AQP2 \| DISEASES 8646 \| CHRD \| DISEASES 57026 \| PDXP \| DISEASES 3162 \| HMOX1 \| DISEASES 3002 \| GZMB \| DISEASES 51285 \| RASL12 \| DISEASES 973 \| CD79A \| DISEASES 4818 \| NKG7 \| DISEASES 3082 \| HGF \| DISEASES 6804 \| STX1A \| DISEASES 5054 \| SERPINE1 \| DISEASES 7431 \| VIM \| DISEASES 6347 \| CCL2 \| DISEASES 4254 \| KITLG \| DISEASES 4360 \| MRC1 \| DISEASES 9409 \| PEX16 \| DISEASES 847 \| CAT \| DISEASES 6568 \| SLC17A1 \| DISEASES 57187 \| THOC2 \| DISEASES 10047 \| CST8 \| DISEASES 6945 \| MLX \| DISEASES 968 \| CD68 \| DISEASES 3998 \| LMAN1 \| DISEASES 4277 \| MICB \| DISEASES 10343 \| PKDREJ \| DISEASES 1401 \| CRP \| DISEASES 8170 \| SLC14A2 \| DISEASES 967 \| CD63 \| DISEASES 3569 \| IL6 \| DISEASES 4069 \| LYZ \| DISEASES 3690 \| ITGB3 \| DISEASES 5465 \| PPARA \| DISEASES 23523 \| CABIN1 \| DISEASES 7299 \| TYR \| DISEASES 3553 \| IL1B \| DISEASES 4036 \| LRP2 \| DISEASES 84083 \| ZRANB3 \| DISEASES 25759 \| SHC2 \| DISEASES 54888 \| NSUN2 \| DISEASES 3383 \| ICAM1 \| DISEASES 6550 \| SLC9A3 \| DISEASES 1950 \| EGF \| DISEASES 51083 \| GAL \| DISEASES 5286 \| PIK3C2A \| DISEASES 3263 \| HPX \| DISEASES 56938 \| ARNTL2 \| DISEASES 51411 \| BIN2 \| DISEASES 8128 \| ST8SIA2 \| DISEASES 55520 \| ELAC1 \| DISEASES 5972 \| REN \| DISEASES 3934 \| LCN2 \| DISEASES 133 \| ADM \| DISEASES 3606 \| IL18 \| DISEASES 8526 \| DGKE \| DISEASES 9530 \| BAG4 \| DISEASES 22808 \| MRAS \| DISEASES 1636 \| ACE \| DISEASES 27306 \| HPGDS \| DISEASES 4880 \| NPPC \| DISEASES 2168 \| FABP1 \| DISEASES 213 \| ALB \| DISEASES 327 \| APEH \| DISEASES 4846 \| NOS3 \| DISEASES 552 \| AVPR1A \| DISEASES 79158 \| GNPTAB \| DISEASES 90678 \| LRSAM1 \| DISEASES 3479 \| IGF1 \| DISEASES 59350 \| RXFP1 \| DISEASES 10736 \| SIX2 \| DISEASES 340024 \| SLC6A19 \| DISEASES 3708 \| ITPR1 \| DISEASES 7369 \| UMOD \| DISEASES 2147 \| F2 \| DISEASES 134 \| ADORA1 \| DISEASES 285590 \| SH3PXD2B \| DISEASES 836 \| CASP3 \| DISEASES 358 \| AQP1 \| DISEASES 90637 \| ZFAND2A \| DISEASES 1909 \| EDNRA \| DISEASES 4233 \| MET \| DISEASES 196500 \| PIANP \| DISEASES 3321 \| IGSF3 \| DISEASES 10229 \| COQ7 \| DISEASES 147138 \| TMC8 \| DISEASES 9622 \| KLK4 \| DISEASES 10250 \| SRRM1 \| DISEASES 5271 \| SERPINB8 \| DISEASES 554 \| AVPR2 \| DISEASES 64412 \| GZF1 \| DISEASES 2686 \| GGT7 \| DISEASES 6187 \| RPS2 \| DISEASES 9536 \| PTGES \| DISEASES 92399 \| MRRF \| DISEASES 26762 \| HAVCR1 \| DISEASES 728 \| C5AR1 \| DISEASES 23556 \| PIGN \| DISEASES 4151 \| MB \| DISEASES 10724 \| MGEA5 \| DISEASES 23038 \| WDTC1 \| DISEASES 6905 \| TBCE \| DISEASES 8443 \| GNPAT \| DISEASES 183 \| AGT \| DISEASES 5743 \| PTGS2 \| DISEASES 8504 \| PEX3 \| DISEASES 26002 \| MOXD1 \| DISEASES 1490 \| CTGF \| DISEASES 959 \| CD40LG \| DISEASES 11093 \| ADAMTS13 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 1896 \| EDA \| DISEASES 3055 \| HCK \| DISEASES 84930 \| MASTL \| DISEASES 100507436 \| MICA \| DISEASES 56243 \| KIAA1217 \| DISEASES 4878 \| NPPA \| DISEASES 7454 \| WAS \| DISEASES 6668 \| SP2 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 1910 \| EDNRB \| DISEASES 116085 \| SLC22A12 \| DISEASES 1906 \| EDN1 \| DISEASES 51334 \| PRR16 \| DISEASES 25820 \| ARIH1 \| DISEASES 3559 \| IL2RA \| DISEASES 551 \| AVP \| DISEASES 3030 \| HADHA \| DISEASES 6019 \| RLN2 \| DISEASES 124220 \| ZG16B \| DISEASES 3875 \| KRT18 \| DISEASES 55022 \| PID1 \| DISEASES 2054 \| STX2 \| DISEASES 80196 \| RNF34 \| DISEASES 838 \| CASP5 \| DISEASES 162239 \| ZFP1 \| DISEASES 3426 \| CFI \| DISEASES 6696 \| SPP1 \| DISEASES 65010 \| SLC26A6 \| DISEASES 2919 \| CXCL1 \| DISEASES 655 \| BMP7 \| DISEASES 2641 \| GCG \| DISEASES 255743 \| NPNT \| DISEASES 6916 \| TBXAS1 \| DISEASES 1029 \| CDKN2A \| DISEASES 5076 \| PAX2 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 4152 \| MBD1 \| DISEASES 5830 \| PEX5 \| DISEASES 834 \| CASP1 \| DISEASES 3586 \| IL10 \| DISEASES 23543 \| RBFOX2 \| DISEASES 8842 \| PROM1 \| DISEASES 6565 \| SLC15A2 \| DISEASES 55922 \| NKRF \| DISEASES 8972 \| MGAM \| DISEASES 567 \| B2M \| DISEASES 29931 \| LINC00312 \| DISEASES 100169750 \| PRINS \| DISEASES
Locus	(Waiting for update.)

Disease ID	666
Disease	acute kidney failure
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0003201 \| Rhabdomyolysis \| 2 HP:0011675 \| Arrhythmias \| 2 HP:0006775 \| Multiple myeloma \| 2 HP:0000822 \| Hypertension \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0100845 \| Anaphylactic shock \| 1 HP:0003259 \| Increased serum creatinine \| 1 HP:0100806 \| Sepsis \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0001941 \| acidemia \| 1 HP:0011419 \| Abruptio placentae \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0001903 \| Anemia \| 1 HP:0005575 \| Hemolytic-uremic syndrome \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0001250 \| Seizures \| 1 HP:0002721 \| Immunodeficiency \| 1

Disease ID	666
Disease	acute kidney failure
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0002871 \| anemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121907892	17362586	116085	SLC22A12	umls:C0022660	BeFree	The patient had compound heterozygous mutations in the hURAT1 gene (R90H and W258X), but showed no clinical manifestations such as urolithiasis or exercise-induced acute renal failure.	0.001357209	2007	SLC22A12	11	64593747	G	A
rs121907896	17362586	116085	SLC22A12	umls:C0022660	BeFree	The patient had compound heterozygous mutations in the hURAT1 gene (R90H and W258X), but showed no clinical manifestations such as urolithiasis or exercise-induced acute renal failure.	0.001357209	2007	SLC22A12	11	64591825	G	A
rs281875304	16449289	11093	ADAMTS13	umls:C0022660	BeFree	Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure.	0.000542884	2006	ADAMTS13	9	133428649	C	A
rs4680	24167357	1312	COMT	umls:C0022660	BeFree	COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery.	0.002909916	2013	COMT;MIR4761	22	19963748	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:45)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	155194980	rs2049805	T	C	rs2049805	22797727	2.00E-12	NA	0.01	[0.0052-0.0092] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs2049805-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	27755825	rs4665987	G	A	rs4665987	22797727	8.80E-05	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	113978940	rs11123170	C	G	rs11123170	22797727	3.00E-10	NA	0.01	[0.0035-0.0067] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs11123170-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	170204800	rs2673172	G	T	rs2673172	22797727	8.10E-05	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
2	213132822	rs1021916	A	G	rs1021916	22797727	2.20E-05	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	66798950	rs13069000	C	G	rs13069000	22797727	1.00E-19	NA	0.01	[0.0073-0.0113] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs13069000-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	169150632	rs16853722	T	C	rs16853722	22797727	3.00E-14	NA	0.01	[0.0048-0.0080] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs16853722-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	171992912	rs10513699	G	T	rs10513699	22797727	7.60E-04	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
3	187713718	rs10937329	T	A	rs10937329	22797727	9.00E-30	NA	0.01	[0.0082-0.0118] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs10937329-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	9995182	rs3775948	G	C	rs3775948	22797727	2.00E-65	NA	0.18	[0.16-0.20] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	rs3775948-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	77412140	rs13146355	G	A	rs13146355	22797727	7.00E-11	NA	0.01	[0.0035-0.0067] ml/min/1.73m2 decrease	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs13146355-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	77412140	rs13146355	G	A	rs13146355	22797727	9.00E-12	NA	0	[0.0033-0.0061] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs13146355-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
4	88959922	rs2725220	G	C	rs2725220	22797727	4.00E-30	NA	0.14	[0.11-0.16] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	rs2725220-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	72432036	rs17663555	C	G	rs17663555	22797727	2.00E-06	NA	0	[0.0024-0.0056] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs17663555-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	176794191	rs12654812	G	A	rs12654812	22797727	2.00E-07	NA	0	[0.0022-0.0050] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs12654812-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
5	176794191	rs12654812	G	A	rs12654812	22797727	5.00E-07	NA	0	[0.0022-0.0050] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs12654812-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	25878361	rs566530	T	C	rs566530	22797727	4.90E-05	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	31440669	rs3828890	C	G	rs3828890	22797727	1.00E-09	NA	0.01	[0.0046-0.0092] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs3828890-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	31440669	rs3828890	C	G	rs3828890	22797727	3.00E-09	NA	0.01	[0.0046-0.0092] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs3828890-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	50786008	rs2206271	T	A	rs2206271	22797727	2.00E-07	NA	0.01	[0.0035-0.0075] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs2206271-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	101674290	rs2797369	C	T	rs2797369	22797727	1.00E-07	NA	0	[0.0026-0.0058] unit decrease	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs2797369-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	127436064	rs1936800	C	T	rs1936800	22797727	1.00E-11	NA	0.01	[0.0036-0.0068] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs1936800-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
6	154986664	rs9397738	G	A	rs9397738	22797727	5.00E-06	NA	0	[0.0021-0.0057] unit decrease	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs9397738-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	1273845	rs10275044	A	T	rs10275044	22797727	4.00E-09	NA	0.01	[0.0046-0.0093] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs10275044-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	1285195	rs10277115	A	T	rs10277115	22797727	1.00E-10	NA	0.01	[0.0036-0.0068] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs10277115-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	1285195	rs10277115	A	T	rs10277115	22797727	5.00E-11	NA	0.01	[0.0036-0.0068] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs10277115-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
7	7680697	rs17169194	A	C	rs17169194	22797727	1.40E-04	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
9	123473242	rs10984991	G	A	rs10984991	22797727	3.00E-04	NA	NA	NA	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	NA	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	30749090	rs963837	T	C	rs963837	22797727	1.00E-09	NA	0	[0.0025-0.0049] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs963837-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	30749090	rs963837	T	C	rs963837	22797727	3.00E-09	NA	0	[0.0025-0.0049] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs963837-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	30768678	rs10767873	C	T	rs10767873	22797727	5.00E-16	NA	0.01	[0.0052-0.0084] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs10767873-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
11	64464085	rs504915	T	A	rs504915	22797727	3.00E-63	NA	0.23	[0.20-0.25] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	rs504915-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	112241766	rs671	G	A	rs671	22797727	3.00E-10	NA	0	[0.0031-0.0059] mg/dl increase	42,257 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42257)	ALL(42257)	SAN,ASN(42257)	ALL(42257)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs671-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
12	112645401	rs2074356	G	A	rs2074356	22797727	2.00E-09	NA	0.01	[0.0042-0.0086] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs2074356-A	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	53907948	rs17730281	G	A	rs17730281	22797727	3.00E-11	NA	0.01	[0.0035-0.0067] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs17730281-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	53942928	rs17730436	T	C	rs17730436	22797727	1.00E-13	NA	0.01	[0.0036-0.0064] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs17730436-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
15	53942928	rs17730436	T	C	rs17730436	22797727	6.00E-13	NA	0.01	[0.0036-0.0064] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs17730436-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	20400839	rs11864909	C	T	rs11864909	22797727	1.00E-10	NA	0.01	[0.0036-0.0068] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs11864909-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	20400839	rs11864909	C	T	rs11864909	22797727	4.00E-10	NA	0.01	[0.0036-0.0068] mg/dl increase	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs11864909-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
16	79645989	rs889472	C	A	rs889472	22797727	1.00E-09	NA	0.07	[0.048-0.094] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (urea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004761	renal system measurement	Kidney disease	rs889472-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	59239221	rs11868441	A	G	rs11868441	22797727	2.00E-09	NA	0.01	[0.0039-0.0079] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs11868441-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	59456589	rs9895661	C	T	rs9895661	22797727	5.00E-11	NA	0.01	[0.0035-0.0067] ml/min/1.73m2 decrease	42,451 Japanese, Chinese, Malaysian, Indian ancestry individuals	Indian,Malaysian,Japanese,Chinese(42451)	ALL(42451)	SAN,ASN(42451)	ALL(42451)	Renal function-related traits (eGRFcrea)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs9895661-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
17	59456589	rs9895661	C	T	rs9895661	22797727	7.00E-11	NA	0	[0.0031-0.0059] mg/dl increase	21,417 Japanese and Chinese ancestry individuals	Japanese,Chinese(21417)	ALL(21417)	ASN(21417)	ALL(21417)	Renal function-related traits (sCR)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004742	renal system measurement	Kidney disease	rs9895661-C	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
18	43187130	rs7227483	A	G	rs7227483	22797727	7.00E-18	NA	0.01	[0.0063-0.0103] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs7227483-G	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't
20	57469073	rs6026584	T	C	rs6026584	22797727	9.00E-09	NA	0.01	[0.0034-0.0070] mg/dl increase	39,717 Japanese, Korean and Chinese ancestry individuals	Korean,Japanese,Chinese(39717)	ALL(39717)	ASN(39717)	ALL(39717)	Renal function-related traits (BUN)	HPOID:0000077	Abnormality of the kidney	DOID:557	kidney disease	D058186	Acute Kidney Injury	EFOID:0004741	renal system measurement	Kidney disease	rs6026584-T	Research Support, N.I.H., Extramural	Meta-Analysis	Research Support, Non-U.S. Gov't

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:148)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022660	acetaminophen	D000082	103-90-2	acute kidney injury	MESH:D058186	marker/mechanism	10454517
C0022660	acetylcysteine	D000111	616-91-1	acute kidney injury	MESH:D058186	marker/mechanism	19526394
C0022660	acetylcysteine	D000111	616-91-1	acute kidney injury	MESH:D058186	therapeutic	14624421
C0022660	allopurinol	D000493	315-30-0	acute kidney injury	MESH:D058186	marker/mechanism	19814645
C0022660	amifostine	D004999	20537-88-6	acute kidney injury	MESH:D058186	therapeutic	11977638
C0022660	amikacin	D000583	37517-28-5	acute kidney injury	MESH:D058186	marker/mechanism	1491509
C0022660	amiloride	D000584	2609-46-3	acute kidney injury	MESH:D058186	marker/mechanism	3861973
C0022660	aminocaproic acid	D015119	60-32-2	acute kidney injury	MESH:D058186	marker/mechanism	18805613
C0022660	aminosalicylic acid	D010131	65-49-6	acute kidney injury	MESH:D058186	marker/mechanism	1227221
C0022660	amitriptyline	D000639	50-48-6	acute kidney injury	MESH:D058186	marker/mechanism	6842224
C0022660	amlodipine	D017311	88150-42-9	acute kidney injury	MESH:D058186	therapeutic	11016776
C0022660	amoxapine	D000657	14028-44-5	acute kidney injury	MESH:D058186	marker/mechanism	4002015
C0022660	amphetamine	D000661	300-62-9	acute kidney injury	MESH:D058186	marker/mechanism	16161930
C0022660	ampicillin	D000667	69-53-4	acute kidney injury	MESH:D058186	marker/mechanism	14736991
C0022660	arsenic trioxide	C006632	1327-53-3	acute kidney injury	MESH:D058186	marker/mechanism	18463343
C0022660	atenolol	D001262	29122-68-7	acute kidney injury	MESH:D058186	marker/mechanism	9640485
C0022660	azithromycin	D017963	83905-01-5	acute kidney injury	MESH:D058186	marker/mechanism	11247598
C0022660	aztreonam	D001398	78110-38-0	acute kidney injury	MESH:D058186	marker/mechanism	2967033
C0022660	benazepril	C044946	86541-75-5	acute kidney injury	MESH:D058186	marker/mechanism	12243603
C0022660	bendamustine hydrochloride	D000069461	-	acute kidney injury	MESH:D058186	marker/mechanism	16313266
C0022660	bisoprolol	D017298	66722-44-9	acute kidney injury	MESH:D058186	marker/mechanism	15662077
C0022660	capreomycin	D002207	11003-38-6	acute kidney injury	MESH:D058186	marker/mechanism	5935897
C0022660	capsaicin	D002211	404-86-4	acute kidney injury	MESH:D058186	therapeutic	18460982
C0022660	carbamazepine	D002220	298-46-4	acute kidney injury	MESH:D058186	marker/mechanism	11346062
C0022660	carbenicillin	D002228	4697-36-3	acute kidney injury	MESH:D058186	marker/mechanism	7199128
C0022660	cefotaxime	D002439	63527-52-6	acute kidney injury	MESH:D058186	marker/mechanism	10803769
C0022660	ceftazidime	D002442	78439-06-2	acute kidney injury	MESH:D058186	marker/mechanism	17036408
C0022660	celecoxib	D000068579	-	acute kidney injury	MESH:D058186	marker/mechanism	11816257
C0022660	cephalexin	D002506	15686-71-2	acute kidney injury	MESH:D058186	marker/mechanism	4406795
C0022660	cerivastatin	C086276	-	acute kidney injury	MESH:D058186	marker/mechanism	11371708
C0022660	chlorambucil	D002699	305-03-3	acute kidney injury	MESH:D058186	marker/mechanism	19122478
C0022660	chloroquine	D002738	1954/5/7	acute kidney injury	MESH:D058186	marker/mechanism	15526909
C0022660	chlorpromazine	D002746	50-53-3	acute kidney injury	MESH:D058186	marker/mechanism	1485575
C0022660	cidofovir	C059262	113852-37-2	acute kidney injury	MESH:D058186	marker/mechanism	11773481
C0022660	cimetidine	D002927	51481-61-9	acute kidney injury	MESH:D058186	marker/mechanism	3817629
C0022660	ciprofloxacin	D002939	85721-33-1	acute kidney injury	MESH:D058186	marker/mechanism	10893604
C0022660	clozapine	D003024	5786-21-0	acute kidney injury	MESH:D058186	marker/mechanism	10513719
C0022660	colchicine	D003078	64-86-8	acute kidney injury	MESH:D058186	marker/mechanism	16495211
C0022660	creatine	D003401	57-00-1	acute kidney injury	MESH:D058186	marker/mechanism	12394880
C0022660	cyclophosphamide	D003520	50-18-0	acute kidney injury	MESH:D058186	marker/mechanism	10637075
C0022660	cyclophosphamide	D003520	50-18-0	acute kidney injury	MESH:D058186	therapeutic	11956877
C0022660	cyclosporine	D016572	59865-13-3	acute kidney injury	MESH:D058186	marker/mechanism	11271297
C0022660	cyclosporine	D016572	59865-13-3	acute kidney injury	MESH:D058186	therapeutic	21058009
C0022660	dapsone	D003622	80-08-0	acute kidney injury	MESH:D058186	marker/mechanism	15947852
C0022660	daptomycin	D017576	103060-53-3	acute kidney injury	MESH:D058186	marker/mechanism	16410267
C0022660	dronabinol	D013759	-	acute kidney injury	MESH:D058186	marker/mechanism	16161930
C0022660	pentostatin	D015649	53910-25-1	acute kidney injury	MESH:D058186	marker/mechanism	11219485
C0022660	diatrizoate	D003973	117-96-4	acute kidney injury	MESH:D058186	marker/mechanism	11016776
C0022660	cisplatin	D002945	15663-27-1	acute kidney injury	MESH:D058186	marker/mechanism	10454517
C0022660	cisplatin	D002945	15663-27-1	acute kidney injury	MESH:D058186	therapeutic	12180108
C0022660	diclofenac	D004008	15307-86-5	acute kidney injury	MESH:D058186	marker/mechanism	10444806
C0022660	digoxin	D004077	20830-75-5	acute kidney injury	MESH:D058186	marker/mechanism	12243603
C0022660	diltiazem	D004110	42399-41-7	acute kidney injury	MESH:D058186	marker/mechanism	12243603
C0022660	disopyramide	D004206	3737/9/5	acute kidney injury	MESH:D058186	marker/mechanism	6615089
C0022660	enalapril	D004656	75847-73-3	acute kidney injury	MESH:D058186	marker/mechanism	12698328
C0022660	enalapril	D004656	75847-73-3	acute kidney injury	MESH:D058186	therapeutic	14629192
C0022660	enflurane	D004737	13838-16-9	acute kidney injury	MESH:D058186	marker/mechanism	3476700
C0022660	ethambutol	D004977	74-55-5	acute kidney injury	MESH:D058186	marker/mechanism	15102986
C0022660	everolimus	D000068338	-	acute kidney injury	MESH:D058186	marker/mechanism	19135948
C0022660	fenoprofen	D005279	31879-05-7	acute kidney injury	MESH:D058186	marker/mechanism	6228839
C0022660	fluconazole	D015725	86386-73-4	acute kidney injury	MESH:D058186	marker/mechanism	18363177
C0022660	fluorouracil	D005472	51-21-8	acute kidney injury	MESH:D058186	marker/mechanism	15895229
C0022660	flutamide	D005485	13311-84-7	acute kidney injury	MESH:D058186	marker/mechanism	12180480
C0022660	folic acid	D005492	59-30-3	acute kidney injury	MESH:D058186	marker/mechanism	1068326
C0022660	leucovorin	D002955	1958/5/9	acute kidney injury	MESH:D058186	therapeutic	15984523
C0022660	foscarnet	D017245	4428-95-9	acute kidney injury	MESH:D058186	marker/mechanism	10231404
C0022660	foscarnet	D017245	4428-95-9	acute kidney injury	MESH:D058186	therapeutic	7802522
C0022660	gabapentin	C040029	60142-96-3	acute kidney injury	MESH:D058186	marker/mechanism	10919603
C0022660	gadodiamide	C064925	-	acute kidney injury	MESH:D058186	marker/mechanism	11287523
C0022660	ganciclovir	D015774	82410-32-0	acute kidney injury	MESH:D058186	therapeutic	7802522
C0022660	gemcitabine	C056507	103882-84-4	acute kidney injury	MESH:D058186	marker/mechanism	15895229
C0022660	glutathione	D005978	70-18-8	acute kidney injury	MESH:D058186	marker/mechanism	10729747
C0022660	haloperidol	D006220	52-86-8	acute kidney injury	MESH:D058186	marker/mechanism	6121542
C0022660	ibutilide	C067192	130350-52-6	acute kidney injury	MESH:D058186	marker/mechanism	9989724
C0022660	icatibant	C065679	130308-48-4	acute kidney injury	MESH:D058186	therapeutic	24975837
C0022660	ifosfamide	D007069	3778-73-2	acute kidney injury	MESH:D058186	marker/mechanism	15738605
C0022660	ifosfamide	D007069	3778-73-2	acute kidney injury	MESH:D058186	therapeutic	12180108
C0022660	imatinib mesylate	D000068877	-	acute kidney injury	MESH:D058186	marker/mechanism	16288076
C0022660	indinavir	D019469	150378-17-9	acute kidney injury	MESH:D058186	marker/mechanism	10421052
C0022660	indomethacin	D007213	53-86-1	acute kidney injury	MESH:D058186	marker/mechanism	15007713
C0022660	ketorolac	D020910	66635-83-4	acute kidney injury	MESH:D058186	marker/mechanism	12195419
C0022660	labetalol	D007741	36894-69-6	acute kidney injury	MESH:D058186	marker/mechanism	3094808
C0022660	lansoprazole	D064747	-	acute kidney injury	MESH:D058186	marker/mechanism	19814645
C0022660	linezolid	D000069349	-	acute kidney injury	MESH:D058186	marker/mechanism	18044266
C0022660	liposomal amphotericin b	C068538	-	acute kidney injury	MESH:D058186	marker/mechanism	11072358
C0022660	loratadine	D017336	79794-75-5	acute kidney injury	MESH:D058186	marker/mechanism	14558336
C0022660	lovastatin	D008148	75330-75-5	acute kidney injury	MESH:D058186	marker/mechanism	2253372
C0022660	melphalan	D008558	148-82-3	acute kidney injury	MESH:D058186	marker/mechanism	15696449
C0022660	metformin	D008687	657-24-9	acute kidney injury	MESH:D058186	marker/mechanism	11910877
C0022660	metformin	D008687	657-24-9	acute kidney injury	MESH:D058186	therapeutic	20164825
C0022660	methadone	D008691	76-99-3	acute kidney injury	MESH:D058186	marker/mechanism	1436354
C0022660	methotrexate	D008727	1959/5/2	acute kidney injury	MESH:D058186	marker/mechanism	10609804
C0022660	metoprolol	D008790	37350-58-6	acute kidney injury	MESH:D058186	marker/mechanism	12243603
C0022660	minoxidil	D008914	38304-91-5	acute kidney injury	MESH:D058186	marker/mechanism	387174
C0022660	mitomycin	D016685	1950/7/7	acute kidney injury	MESH:D058186	marker/mechanism	2508290
C0022660	mitoxantrone	D008942	65271-80-9	acute kidney injury	MESH:D058186	marker/mechanism	8832525
C0022660	mitoxantrone	D008942	65271-80-9	acute kidney injury	MESH:D058186	therapeutic	12180108
C0022660	morphine	D009020	57-27-2	acute kidney injury	MESH:D058186	marker/mechanism	10609351
C0022660	moxifloxacin	C104727	-	acute kidney injury	MESH:D058186	marker/mechanism	20731847
C0022660	nicotine	D009538	-	acute kidney injury	MESH:D058186	marker/mechanism	21511693
C0022660	nisoldipine	D015737	63675-72-9	acute kidney injury	MESH:D058186	therapeutic	2441191
C0022660	norepinephrine	D009638	51-41-2	acute kidney injury	MESH:D058186	marker/mechanism	1102487
C0022660	ofloxacin	D015242	82419-36-1	acute kidney injury	MESH:D058186	marker/mechanism	12196055
C0022660	omeprazole	D009853	73590-58-6	acute kidney injury	MESH:D058186	marker/mechanism	10566755
C0022660	oxytetracycline	D010118	79-57-2	acute kidney injury	MESH:D058186	marker/mechanism	5413699
C0022660	pantoprazole	C064276	102625-70-7	acute kidney injury	MESH:D058186	marker/mechanism	15372423
C0022660	peginterferon alfa-2a	C100416	-	acute kidney injury	MESH:D058186	marker/mechanism	15252182
C0022660	phenindione	D010630	1983/12/5	acute kidney injury	MESH:D058186	marker/mechanism	139882
C0022660	phenylephrine	D010656	59-42-7	acute kidney injury	MESH:D058186	marker/mechanism	13678392
C0022660	phenylpropanolamine	D010665	14838-15-4	acute kidney injury	MESH:D058186	marker/mechanism	7109141
C0022660	phenytoin	D010672	57-41-0	acute kidney injury	MESH:D058186	marker/mechanism	1036571
C0022660	piperacillin	D010878	61477-96-1	acute kidney injury	MESH:D058186	marker/mechanism	10830188
C0022660	piroxicam	D010894	36322-90-4	acute kidney injury	MESH:D058186	marker/mechanism	12185885
C0022660	pravastatin	D017035	81093-37-0	acute kidney injury	MESH:D058186	therapeutic	20368269
C0022660	propranolol	D011433	525-66-6	acute kidney injury	MESH:D058186	therapeutic	19945959
C0022660	propylthiouracil	D011441	51-52-5	acute kidney injury	MESH:D058186	marker/mechanism	11014318
C0022660	pyrimethamine	D011739	58-14-0	acute kidney injury	MESH:D058186	marker/mechanism	8773165
C0022660	quinine	D011803	130-95-0	acute kidney injury	MESH:D058186	marker/mechanism	12682720
C0022660	ribavirin	D012254	36791-04-5	acute kidney injury	MESH:D058186	marker/mechanism	15252182
C0022660	rifampin	D012293	13292-46-1	acute kidney injury	MESH:D058186	marker/mechanism	10493553
C0022660	ritonavir	D019438	-	acute kidney injury	MESH:D058186	marker/mechanism	10452668
C0022660	rofecoxib	C116926	-	acute kidney injury	MESH:D058186	marker/mechanism	14633764
C0022660	sirolimus	D020123	53123-88-9	acute kidney injury	MESH:D058186	marker/mechanism	16316336
C0022660	streptozocin	D013311	18883-66-4	acute kidney injury	MESH:D058186	marker/mechanism	6281169
C0022660	succinylcholine	D013390	306-40-1	acute kidney injury	MESH:D058186	marker/mechanism	3476700
C0022660	sulfadiazine	D013411	68-35-9	acute kidney injury	MESH:D058186	marker/mechanism	10395422
C0022660	sulfadiazine	D013411	68-35-9	acute kidney injury	MESH:D058186	therapeutic	8243240
C0022660	sulindac	D013467	38194-50-2	acute kidney injury	MESH:D058186	marker/mechanism	7897758
C0022660	sulpiride	D013469	15676-16-1	acute kidney injury	MESH:D058186	marker/mechanism	15735255
C0022660	tacrolimus	D016559	109581-93-3	acute kidney injury	MESH:D058186	marker/mechanism	10743694
C0022660	tenofovir	D000068698	-	acute kidney injury	MESH:D058186	marker/mechanism	12460055
C0022660	theophylline	D013806	58-55-9	acute kidney injury	MESH:D058186	marker/mechanism	10441997
C0022660	theophylline	D013806	58-55-9	acute kidney injury	MESH:D058186	therapeutic	1956491
C0022660	ticlopidine	D013988	55142-85-3	acute kidney injury	MESH:D058186	marker/mechanism	7771492
C0022660	tolmetin	D014046	26171-23-3	acute kidney injury	MESH:D058186	marker/mechanism	2773031
C0022660	tranexamic acid	D014148	1197-18-8	acute kidney injury	MESH:D058186	marker/mechanism	1961348
C0022660	tretinoin	D014212	302-79-4	acute kidney injury	MESH:D058186	marker/mechanism	10607690
C0022660	triamterene	D014223	396-01-0	acute kidney injury	MESH:D058186	marker/mechanism	3727353
C0022660	vancomycin	D014640	1404-90-6	acute kidney injury	MESH:D058186	marker/mechanism	11601669
C0022660	vincristine	D014750	-	acute kidney injury	MESH:D058186	marker/mechanism	10454517
C0022660	vindesine	D014751	53643-48-4	acute kidney injury	MESH:D058186	marker/mechanism	2170045
C0022660	vitamin a	D014801	11103-57-4	acute kidney injury	MESH:D058186	marker/mechanism	1248399
C0022660	cholecalciferol	D002762	67-97-0	acute kidney injury	MESH:D058186	marker/mechanism	19856155
C0022660	vitamin e	D014810	1406-18-4	acute kidney injury	MESH:D058186	marker/mechanism	9763232
C0022660	vitamin e	D014810	1406-18-4	acute kidney injury	MESH:D058186	therapeutic	3353995
C0022660	voriconazole	D065819	-	acute kidney injury	MESH:D058186	marker/mechanism	16410267
C0022660	zidovudine	D015215	30516-87-1	acute kidney injury	MESH:D058186	marker/mechanism	11214960
C0022660	zoledronic acid	C088658	-	acute kidney injury	MESH:D058186	marker/mechanism	17491196

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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