PedAM

Pediatric Disease Annotations & Medicines


	acne

Disease ID	681
Disease	acne
Definition	A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
Synonym	acne vulgaris acne vulgaris (disorder) acne vulgaris [disease/finding] acne, vulgaris common acne vulgaris - acne
DOID	DOID:6543
ICD10	ICD10CM:L70.0
UMLS	C0001144
MeSH	D000152
SNOMED-CT	SNOMEDCT_US_2016_09_01:88616000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:57) C0011570 \| depression \| 9 C0003467 \| anxiety \| 7 C0206081 \| hyperandrogenism \| 6 C0032460 \| polycystic ovary syndrome \| 4 C0001144 \| acne vulgaris \| 4 C0037274 \| skin disease \| 4 C0032460 \| polycystic ovary \| 3 C0016436 \| folliculitis \| 3 C0849777 \| cystic ovaries \| 2 C0263859 \| sapho syndrome \| 2 C0004936 \| mental disorders \| 2 C0032460 \| polycystic ovaries \| 2 C0031572 \| social phobia \| 2 C0015230 \| rash \| 2 C0037274 \| skin diseases \| 2 C0041696 \| major depression \| 2 C0011847 \| diabetes \| 2 C0004096 \| asthma \| 2 C0009324 \| ulcerative colitis \| 1 C0022735 \| klinefelter syndrome \| 1 C0034013 \| precocious puberty \| 1 C0039446 \| telangiectasia \| 1 C0151313 \| sensory neuropathy \| 1 C0152095 \| trisomy 13 \| 1 C0022353 \| neonatal jaundice \| 1 C0024236 \| lymphedema \| 1 C0011854 \| type 1 diabetes \| 1 C0022408 \| arthropathy \| 1 C0010346 \| crohn's disease \| 1 C0032460 \| polycystic ovarian syndrome \| 1 C0162836 \| hidradenitis suppurativa \| 1 C0037280 \| infestation \| 1 C0014544 \| epilepsy \| 1 C0006384 \| bundle branch block \| 1 C0004134 \| ataxia \| 1 C0272286 \| immune thrombocytopenia \| 1 C0003128 \| anovulation \| 1 C0018203 \| chronic granulomatous disease \| 1 C0948265 \| metabolic syndrome \| 1 C0409974 \| lupus erythematosus \| 1 C0376358 \| prostate cancer \| 1 C0035854 \| rosacea \| 1 C0009319 \| colitis \| 1 C0042373 \| vascular disease \| 1 C0002395 \| alzheimer's disease \| 1 C0456909 \| blindness \| 1 C0029443 \| osteomyelitis \| 1 C0028754 \| obesity \| 1 C0442874 \| neuropathy \| 1 C0037274 \| skin disorder \| 1 C0037274 \| skin disorders \| 1 C0011633 \| dermatomyositis \| 1 C0020538 \| hypertension \| 1 C0004943 \| behcet's syndrome \| 1 C0035304 \| retinal degeneration \| 1 C0949690 \| spondyloarthritis \| 1 C0024141 \| systemic lupus erythematosus \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) UBE2E1 \| 7324 \| GWASCAT ADORA2A-AS1 \| 646023 \| GWASCAT C11orf49 \| 79096 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 1586 \| CYP17A1 \| infer 367 \| AR \| infer 3552 \| IL1A \| infer 3557 \| IL1RN \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:149) 6793 \| STK10 \| DISEASES 28954 \| REM1 \| DISEASES 158 \| ADSL \| DISEASES 5411 \| PNN \| DISEASES 57761 \| TRIB3 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 4210 \| MEFV \| DISEASES 2222 \| FDFT1 \| DISEASES 2765 \| GML \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 6822 \| SULT2A1 \| DISEASES 55851 \| PSENEN \| DISEASES 8688 \| KRT37 \| DISEASES 4598 \| MVK \| DISEASES 4057 \| LTF \| DISEASES 374291 \| NDUFS7 \| DISEASES 3485 \| IGFBP2 \| DISEASES 335 \| APOA1 \| DISEASES 91754 \| NEK9 \| DISEASES 718 \| C3 \| DISEASES 3630 \| INS \| DISEASES 9119 \| KRT75 \| DISEASES 3866 \| KRT15 \| DISEASES 51124 \| IER3IP1 \| DISEASES 57498 \| KIDINS220 \| DISEASES 1643 \| DDB2 \| DISEASES 84950 \| PRPF38A \| DISEASES 8728 \| ADAM19 \| DISEASES 5959 \| RDH5 \| DISEASES 55332 \| DRAM1 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 6386 \| SDCBP \| DISEASES 4322 \| MMP13 \| DISEASES 16 \| AARS \| DISEASES 898 \| CCNE1 \| DISEASES 7077 \| TIMP2 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 10994 \| ILVBL \| DISEASES 10578 \| GNLY \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 5423 \| POLB \| DISEASES 3858 \| KRT10 \| DISEASES 207 \| AKT1 \| DISEASES 1393 \| CRHBP \| DISEASES 5531 \| PPP4C \| DISEASES 3606 \| IL18 \| DISEASES 26040 \| SETBP1 \| DISEASES 23643 \| LY96 \| DISEASES 5468 \| PPARG \| DISEASES 117159 \| DCD \| DISEASES 23385 \| NCSTN \| DISEASES 5798 \| PTPRN \| DISEASES 84818 \| IL17RC \| DISEASES 1672 \| DEFB1 \| DISEASES 84659 \| RNASE7 \| DISEASES 4714 \| NDUFB8 \| DISEASES 5346 \| PLIN1 \| DISEASES 51129 \| ANGPTL4 \| DISEASES 5617 \| PRL \| DISEASES 79663 \| HSPBAP1 \| DISEASES 3479 \| IGF1 \| DISEASES 1673 \| DEFB4A \| DISEASES 56246 \| MRAP \| DISEASES 624 \| BDKRB2 \| DISEASES 3872 \| KRT17 \| DISEASES 5467 \| PPARD \| DISEASES 3642 \| INSM1 \| DISEASES 2771 \| GNAI2 \| DISEASES 57085 \| AGTRAP \| DISEASES 9322 \| TRIP10 \| DISEASES 140596 \| DEFB104A \| DISEASES 414325 \| DEFB103A \| DISEASES 6863 \| TAC1 \| DISEASES 503618 \| DEFB104B \| DISEASES 4312 \| MMP1 \| DISEASES 55894 \| DEFB103B \| DISEASES 5663 \| PSEN1 \| DISEASES 8204 \| NRIP1 \| DISEASES 2242 \| FES \| DISEASES 8694 \| DGAT1 \| DISEASES 8912 \| CACNA1H \| DISEASES 199720 \| GGN \| DISEASES 114548 \| NLRP3 \| DISEASES 25818 \| KLK5 \| DISEASES 5017 \| OVOL1 \| DISEASES 4306 \| NR3C2 \| DISEASES 2770 \| GNAI1 \| DISEASES 3605 \| IL17A \| DISEASES 10493 \| VAT1 \| DISEASES 6720 \| SREBF1 \| DISEASES 57091 \| CASS4 \| DISEASES 2475 \| MTOR \| DISEASES 7096 \| TLR1 \| DISEASES 22796 \| COG2 \| DISEASES 343035 \| RD3 \| DISEASES 254428 \| SLC41A1 \| DISEASES 6278 \| S100A7 \| DISEASES 2312 \| FLG \| DISEASES 10500 \| SEMA6C \| DISEASES 51107 \| APH1A \| DISEASES 1081 \| CGA \| DISEASES 10285 \| SMNDC1 \| DISEASES 2316 \| FLNA \| DISEASES 2773 \| GNAI3 \| DISEASES 27329 \| ANGPTL3 \| DISEASES 94233 \| OPN4 \| DISEASES 4318 \| MMP9 \| DISEASES 1104 \| RCC1 \| DISEASES 7099 \| TLR4 \| DISEASES 367 \| AR \| DISEASES 434 \| ASIP \| DISEASES 3293 \| HSD17B3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 160897 \| GPR180 \| DISEASES 1114 \| CHGB \| DISEASES 2308 \| FOXO1 \| DISEASES 6462 \| SHBG \| DISEASES 10670 \| RRAGA \| DISEASES 3486 \| IGFBP3 \| DISEASES 10333 \| TLR6 \| DISEASES 51199 \| NIN \| DISEASES 10274 \| STAG1 \| DISEASES 5650 \| KLK7 \| DISEASES 838 \| CASP5 \| DISEASES 5627 \| PROS1 \| DISEASES 594857 \| NPS \| DISEASES 643418 \| LIPN \| DISEASES 387836 \| CLEC2A \| DISEASES 7124 \| TNF \| DISEASES 2821 \| GPI \| DISEASES 2263 \| FGFR2 \| DISEASES 2566 \| GABRG2 \| DISEASES 3586 \| IL10 \| DISEASES 54475 \| NLE1 \| DISEASES 100289462 \| DEFB4B \| DISEASES 2533 \| FYB \| DISEASES 55733 \| HHAT \| DISEASES 143686 \| SESN3 \| DISEASES 4157 \| MC1R \| DISEASES 9051 \| PSTPIP1 \| DISEASES 820 \| CAMP \| DISEASES 100129060 \| SEMA3F-AS1 \| DISEASES 9299 \| SNORD30 \| DISEASES
Locus	(Waiting for update.)

Disease ID	681
Disease	acne
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:49) HP:0000716 \| Depression \| 9 HP:0000739 \| Anxiety \| 7 HP:0100699 \| Scarring \| 6 HP:0000147 \| Sclerocystic ovaries \| 5 HP:0000858 \| Menstrual irregularity \| 4 HP:0000958 \| Xerosis \| 3 HP:0002099 \| Asthma \| 2 HP:0001007 \| Hirsutism \| 2 HP:0000138 \| Ovarian cyst \| 2 HP:0200039 \| Pustules \| 2 HP:0000822 \| Hypertension \| 1 HP:0001251 \| Ataxia \| 1 HP:0001009 \| Telangiectases \| 1 HP:0000662 \| Poor night vision \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0006579 \| Neonatal jaundice \| 1 HP:0000826 \| Precocious puberty \| 1 HP:0012411 \| Premature pubarche \| 1 HP:0012378 \| Fatigue \| 1 HP:0002664 \| Neoplasia \| 1 HP:0003040 \| Arthropathy \| 1 HP:0001262 \| Somnolence \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0000618 \| Blindness \| 1 HP:0002583 \| Colitis \| 1 HP:0001510 \| Growth deficiency \| 1 HP:0100825 \| Inflammation of the lips \| 1 HP:0000546 \| Retinal degeneration \| 1 HP:0000952 \| Yellow skin \| 1 HP:0001513 \| Obesity \| 1 HP:0002754 \| Bone infection \| 1 HP:0010562 \| Keloids \| 1 HP:0001004 \| Lymphatic obstruction \| 1 HP:0100518 \| Painful or difficult urination \| 1 HP:0200034 \| Papule \| 1 HP:0001973 \| Autoimmune thrombocytopenia \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0000876 \| Oligomenorrhea \| 1 HP:0009937 \| Facial hirsutism \| 1 HP:0000316 \| Increased distance between eye sockets \| 1 HP:0011710 \| Bundle-branch block \| 1 HP:0003077 \| Hyperlipidemia \| 1 HP:0040154 \| Hidradenitis suppurativa \| 1 HP:0010783 \| Erythema \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0000763 \| Sensory neuropathy \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0000855 \| Insulin resistance \| 1

Disease ID	681
Disease	acne
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:19)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061622	20556591	7124	TNF	umls:C0702166	BeFree	In this case-control study, the relationship between M196R (676 T-->G) variant in exon 6 of tumor necrosis factor receptor type 2 (TNFR2) gene and genetic susceptibility of acne vulgaris in Han Chinese was investigated.	0.001900093	2010	TNFRSF1B	1	12192898	T	G
rs1061622	20556591	7124	TNF	umls:C0001144	BeFree	In this case-control study, the relationship between M196R (676 T-->G) variant in exon 6 of tumor necrosis factor receptor type 2 (TNFR2) gene and genetic susceptibility of acne vulgaris in Han Chinese was investigated.	0.004267125	2010	TNFRSF1B	1	12192898	T	G
rs1061622	20556591	7133	TNFRSF1B	umls:C0702166	BeFree	TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study.	0.000542884	2010	TNFRSF1B	1	12192898	T	G
rs1061622	20861605	7133	TNFRSF1B	umls:C0001144	BeFree	The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.	0.000542884	2010	TNFRSF1B	1	12192898	T	G
rs1061622	20556591	7133	TNFRSF1B	umls:C0001144	BeFree	TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study.	0.000542884	2010	TNFRSF1B	1	12192898	T	G
rs1061622	20861605	7133	TNFRSF1B	umls:C0702166	BeFree	The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.	0.000542884	2010	TNFRSF1B	1	12192898	T	G
rs17651189	24927181	646023	ADORA2A-AS1	umls:C0001144	GWASCAT	Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.	0.12	2014	ADORA2A-AS1	22	24448915	T	C
rs1801282	24984871	5468	PPARG	umls:C0001144	BeFree	The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris.	0.000271442	2014	PPARG	3	12351626	C	G
rs1801282	24984871	5468	PPARG	umls:C0702166	BeFree	The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris.	0.000271442	2014	PPARG	3	12351626	C	G
rs1805192	24984871	5468	PPARG	umls:C0001144	BeFree	The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris.	0.000271442	2014	PPARG	3	12379739	C	G
rs1805192	24984871	5468	PPARG	umls:C0702166	BeFree	The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris.	0.000271442	2014	PPARG	3	12379739	C	G
rs28405582	24927181	7324	UBE2E1	umls:C0001144	GWASCAT	Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.	0.12	2014	UBE2E1	3	23863271	T	C
rs5743708	20861605	7133	TNFRSF1B	umls:C0702166	BeFree	The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.	0.000542884	2010	TLR2	4	153705165	G	A
rs5743708	20861605	7133	TNFRSF1B	umls:C0001144	BeFree	The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.	0.000542884	2010	TLR2	4	153705165	G	A
rs5743708	20861605	7124	TNF	umls:C0001144	BeFree	Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group.	0.004267125	2010	TLR2	4	153705165	G	A
rs5743708	20861605	7097	TLR2	umls:C0702166	BeFree	Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group.	0.000542884	2010	TLR2	4	153705165	G	A
rs5743708	20861605	7097	TLR2	umls:C0001144	BeFree	Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group.	0.003267234	2010	TLR2	4	153705165	G	A
rs5743708	20861605	7124	TNF	umls:C0702166	BeFree	Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group.	0.001900093	2010	TLR2	4	153705165	G	A
rs747650	24399259	79096	C11orf49	umls:C0001144	GWASCAT	Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.	0.12	2013	C11orf49;LOC105376663	11	47154454	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:162)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	11836811	rs140362679	G	A	rs140362679	24927181	6.87E-05	NA	3.79	[1.92-7.49]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs140362679-A	Research Support, Non-U.S. Gov't	G	C1orf167
1	19141142	rs72651812	C	G	rs72651812	24927181	1.88E-05	NA	1.2	[1.09-1.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs72651812-C	Research Support, Non-U.S. Gov't	C	NA
1	19671766	rs72651465	T	A	rs72651465	24927181	4.06E-04	NA	1.98	[1.23-3.19]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs72651465-A	Research Support, Non-U.S. Gov't	T	CAPZB
1	56198190	rs76831627	G	T	rs76831627	24927181	6.66E-05	NA	1.29	[1.14-1.46]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs76831627-T	Research Support, Non-U.S. Gov't	G	NA
1	70243630	rs75115510	C	T	rs75115510	24927181	2.79E-04	NA	1.31	[1.14-1.51]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs75115510-T	Research Support, Non-U.S. Gov't	C	LRRC7
1	117531813	rs3829881	T	C	rs3829881	24927181	1.05E-04	NA	1.14	[1.05-1.22]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs3829881-T	Research Support, Non-U.S. Gov't	G	PTGFRN
1	117550623	rs2764850	A	G	rs2764850	24927181	1.83E-04	NA	1.15	[1.06-1.23]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2764850-A	Research Support, Non-U.S. Gov't	C	CD101
1	169651044	rs7531806	G	A	rs7531806	24399259	1.00E-08	(fixed effect model)	1.22	[1.12-1.28]	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7531806-A	Research Support, Non-U.S. Gov't	G	NA
1	184619002	rs73046798	C	T	rs73046798	24927181	1.03E-04	NA	1.42	[1.13-1.79]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73046798-T	Research Support, Non-U.S. Gov't	C	NA
1	184624354	rs73046800	G	A	rs73046800	24927181	1.05E-04	NA	1.42	[1.13-1.79]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73046800-A	Research Support, Non-U.S. Gov't	G	NA
1	210386892	rs2494184	T	C	rs2494184	24399259	8.35E-04	(fixed effect model)	1.14	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2494184-G	Research Support, Non-U.S. Gov't	C	NA
1	218844906	rs1159268	G	A	rs1159268	24927181	4.00E-08	NA	1.17	[1.08-1.26]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1159268-A	Research Support, Non-U.S. Gov't	A	NA
1	220098929	rs138775009	C	G	rs138775009	24927181	1.97E-04	NA	1.82	[1.31-2.54]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs138775009-G	Research Support, Non-U.S. Gov't	C	SLC30A10
2	13951524	rs6432417	A	G	rs6432417	24927181	4.74E-04	NA	1.16	[1.08-1.25]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs6432417-G	Research Support, Non-U.S. Gov't	A	NA
2	20399764	rs4666374	A	T	rs4666374	24927181	1.21E-04	NA	1.2	[1.10-1.32]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs4666374-T	Research Support, Non-U.S. Gov't	A	NA
2	60500484	rs2110398	T	C	rs2110398	24927181	4.75E-06	NA	1.2	[1.11-1.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2110398-T	Research Support, Non-U.S. Gov't	T	NA
2	60514993	rs4671386	C	A	rs4671386	24927181	2.00E-06	NA	1.19	[1.11-1.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs4671386-C	Research Support, Non-U.S. Gov't	A	NA
2	70665662	rs187293906	C	T	rs187293906	24927181	5.00E-06	NA	3.27	[1.65-6.49]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs187293906-T	Research Support, Non-U.S. Gov't	C	NA
2	102576839	rs191222274	G	A	rs191222274	24927181	4.99E-05	NA	5.93	[1.73-20.37]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs191222274-A	Research Support, Non-U.S. Gov't	G	NA
2	204529949	rs3115961	G	A	rs3115961	24927181	3.72E-05	NA	1.19	[1.09-1.32]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs3115961-G	Research Support, Non-U.S. Gov't	A	NA
2	223946834	rs75419782	T	C	rs75419782	24927181	4.17E-05	NA	2.43	[1.46-4.07]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs75419782-C	Research Support, Non-U.S. Gov't	T	NA
3	1716268	rs6798827	G	A	rs6798827	24927181	8.51E-04	NA	1.23	[1.11-1.36]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs6798827-A	Research Support, Non-U.S. Gov't	A	NA
3	3577113	rs7652928	G	A	rs7652928	24114350	7.83E-06	GWAS stage only	0.81	[0.44-1.18] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7652928-A	Research Support, N.I.H., Extramural	G	NA
3	3583063	rs723168	T	G	rs723168	24114350	1.07E-05	GWAS stage only	0.78	[0.42-1.15] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs723168-G	Research Support, N.I.H., Extramural	A	NA
3	20717929	rs75430906	G	A	rs75430906	24927181	1.00E-07	NA	3.46	[1.51-7.96]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs75430906-A	Research Support, Non-U.S. Gov't	G	NA
3	23904762	rs28405582	T	C	rs28405582	24927181	1.00E-06	NA	11.67	[2.53-53.75]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs28405582-C	Research Support, Non-U.S. Gov't	T	UBE2E1
3	24370875	rs9812034	T	G	rs9812034	24114350	1.57E-05	GWAS stage only	0.75	[0.41-1.09] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9812034-G	Research Support, N.I.H., Extramural	G	THRB
3	45384683	rs146692665	G	T	rs146692665	24927181	3.00E-06	NA	2.17	[1.45-3.24]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs146692665-T	Research Support, Non-U.S. Gov't	G	NA
3	63449855	rs57891639	T	C	rs57891639	24927181	2.22E-04	NA	4.16	[1.81-9.60]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs57891639-C	Research Support, Non-U.S. Gov't	C	SYNPR
3	63449954	rs59460117	T	C	rs59460117	24927181	4.66E-05	NA	3.59	[1.74-7.43]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs59460117-C	Research Support, Non-U.S. Gov't	T	SYNPR
3	106777359	rs12493716	A	G	rs12493716	24927181	1.37E-04	NA	1.23	[1.11-1.36]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12493716-G	Research Support, Non-U.S. Gov't	G	NA
3	106778761	rs12494766	A	G	rs12494766	24927181	1.69E-04	NA	1.23	[1.11-1.36]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12494766-G	Research Support, Non-U.S. Gov't	A	NA
3	112854339	rs2700230	T	G	rs2700230	24927181	3.86E-05	NA	1.21	[1.12-1.32]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2700230-G	Research Support, Non-U.S. Gov't	G	NA
3	112855401	rs73223903	A	G	rs73223903	24927181	3.89E-05	NA	1.21	[1.12-1.32]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73223903-G	Research Support, Non-U.S. Gov't	A	NA
3	146601714	rs9816683	G	T	rs9816683	24114350	1.86E-05	GWAS stage only	1.21	[0.69-1.74] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9816683-T	Research Support, N.I.H., Extramural	G	NA
3	146618768	rs6792682	T	C	rs6792682	24114350	1.08E-05	GWAS stage only	2.05	[0.78-3.33] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs6792682-C	Research Support, N.I.H., Extramural	C	NA
3	170718937	rs73169713	C	T	rs73169713	24927181	2.46E-04	NA	1.59	[1.29-1.98]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73169713-T	Research Support, Non-U.S. Gov't	C	SLC2A2
3	176406924	rs1027185	G	A	rs1027185	24114350	1.51E-05	GWAS stage only	0.73	[0.39-1.06] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1027185-G	Research Support, N.I.H., Extramural	G	NA
3	189055932	rs142095888	A	G	rs142095888	24927181	2.33E-04	NA	14.85	[1.90-115.73]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs142095888-G	Research Support, Non-U.S. Gov't	A	NA
3	189356941	rs7636839	A	G	rs7636839	24399259	1.08E-04	(fixed effect model)	1.15	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7636839-G	Research Support, Non-U.S. Gov't	G	TP63
3	194667767	rs2082377	C	T	rs2082377	24114350	2.09E-05	GWAS stage only	0.86	[0.44-1.28] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2082377-T	Research Support, N.I.H., Extramural	C	NA
3	194668776	rs11927349	C	A	rs11927349	24114350	2.23E-05	GWAS stage only	0.85	[0.43-1.27] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11927349-A	Research Support, N.I.H., Extramural	A	NA
4	23249435	rs115036347	T	C	rs115036347	24927181	2.89E-04	NA	1.49	[1.15-1.93]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs115036347-C	Research Support, Non-U.S. Gov't	T	NA
4	87097973	rs1460762	G	A	rs1460762	24927181	1.07E-04	NA	1.47	[1.19-1.79]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1460762-G	Research Support, Non-U.S. Gov't	G	MAPK10
4	101986972	rs10022217	A	T	rs10022217	24114350	5.32E-06	GWAS stage only	1.35	[0.81-1.89] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10022217-T	Research Support, N.I.H., Extramural	A	PPP3CA
4	123787079	rs308388	G	A	rs308388	24927181	3.12E-05	NA	1.18	[1.09-1.27]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs308388-A	Research Support, Non-U.S. Gov't	T	FGF2
4	123788495	rs7694627	T	C	rs7694627	24927181	5.48E-05	NA	1.21	[1.10-1.34]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7694627-C	Research Support, Non-U.S. Gov't	T	FGF2
4	124173635	rs991183	G	A	rs991183	24927181	3.33E-05	NA	1.22	[1.11-1.34]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs991183-A	Research Support, Non-U.S. Gov't	C	SPATA5
4	130781670	rs2969004	C	A	rs2969004	24927181	1.19E-05	NA	1.15	[1.06-1.25]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2969004-A	Research Support, Non-U.S. Gov't	G	NA
4	141851355	rs13118519	C	T	rs13118519	24399259	8.21E-04	(fixed effect model)	1.12	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs13118519-G	Research Support, Non-U.S. Gov't	T	RNF150
4	159195032	rs72701704	T	C	rs72701704	24114350	1.89E-05	GWAS stage only	0.72	[0.39-1.06] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs72701704-A	Research Support, N.I.H., Extramural	C	LOC646890
4	181237230	rs12512821	T	C	rs12512821	24114350	8.22E-06	GWAS stage only	1.08	[0.55-1.61] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12512821-C	Research Support, N.I.H., Extramural	T	NA
4	181237984	rs17778403	G	T	rs17778403	24114350	8.25E-06	GWAS stage only	1.08	[0.55-1.61] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs17778403-T	Research Support, N.I.H., Extramural	G	NA
4	181908501	rs144528140	T	C	rs144528140	24927181	2.24E-05	NA	1.92	[1.25-2.93]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs144528140-C	Research Support, Non-U.S. Gov't	T	NA
4	187921499	rs7660345	A	T	rs7660345	24399259	3.00E-06	(fixed effect model)	1.19	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7660345-T	Research Support, Non-U.S. Gov't	T	NA
5	2697371	rs78383867	G	A	rs78383867	24927181	1.04E-04	NA	1.53	[1.20-1.97]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78383867-A	Research Support, Non-U.S. Gov't	G	NA
5	2707454	rs78804414	C	T	rs78804414	24927181	1.50E-05	NA	1.41	[1.19-1.69]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78804414-T	Research Support, Non-U.S. Gov't	C	NA
5	52560644	rs38055	A	G	rs38055	24927181	5.00E-09	NA	1.18	[1.09-1.27]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs38055-A	Research Support, Non-U.S. Gov't	C	NA
5	65390287	rs148508319	A	G	rs148508319	24927181	7.38E-05	NA	3.08	[1.47-6.45]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs148508319-G	Research Support, Non-U.S. Gov't	A	NA
5	95453623	rs73136503	A	G	rs73136503	24927181	6.07E-05	NA	13.03	[1.59-106.59]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73136503-G	Research Support, Non-U.S. Gov't	A	NA
5	152179283	rs78188806	C	A	rs78188806	24927181	9.23E-05	NA	2.57	[1.61-4.10]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78188806-A	Research Support, Non-U.S. Gov't	C	NA
5	156975016	rs6896064	T	G	rs6896064	24399259	1.55E-04	(fixed effect model)	1.22	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs6896064-C	Research Support, Non-U.S. Gov't	T	ADAM19
5	169624772	rs13153995	T	C	rs13153995	24927181	3.00E-06	NA	1.22	[1.11-1.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs13153995-C	Research Support, Non-U.S. Gov't	T	NA
6	2931354	rs318448	C	A	rs318448	24114350	1.74E-05	GWAS stage only	0.74	[0.4-1.08] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs318448-C	Research Support, N.I.H., Extramural	A	NA
6	2932455	rs318449	A	G	rs318449	24114350	1.75E-05	GWAS stage only	0.74	[0.4-1.08] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs318449-A	Research Support, N.I.H., Extramural	G	NA
6	16232556	rs114353847	A	C	rs114353847	24927181	1.06E-04	NA	22.85	[2.38-219.15]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs114353847-C	Research Support, Non-U.S. Gov't	A	NA
6	31896874	rs11752672	G	C	rs11752672	24927181	8.12E-05	NA	2.97	[1.79-4.93]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11752672-C	Research Support, Non-U.S. Gov't	G	C2
6	32041043	rs11751545	A	C	rs11751545	24927181	6.29E-05	NA	3.6	NA	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11751545-C	Research Support, Non-U.S. Gov't	A	TNXB
6	37278933	rs149709	T	C	rs149709	24927181	2.00E-06	NA	1.19	[1.08-1.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs149709-C	Research Support, Non-U.S. Gov't	A	TBC1D22B
6	37295630	rs195403	A	G	rs195403	24927181	2.17E-06	NA	1.21	[1.09-1.35]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs195403-G	Research Support, Non-U.S. Gov't	G	TBC1D22B
6	70185897	rs149826766	G	T	rs149826766	24927181	1.69E-04	NA	2.05	[1.48-2.82]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs149826766-T	Research Support, Non-U.S. Gov't	G	NA
6	89255077	rs9444628	G	A	rs9444628	24927181	8.79E-04	NA	1.28	[1.12-1.46]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9444628-A	Research Support, Non-U.S. Gov't	G	NA
6	107161532	rs2642465	G	A	rs2642465	24927181	8.52E-05	NA	1.21	[1.10-1.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2642465-A	Research Support, Non-U.S. Gov't	A	NA
6	134458872	rs7453135	T	A,G	rs7453135	24399259	5.37E-05	(fixed effect model)	1.49	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7453135-A	Research Support, Non-U.S. Gov't	G	NA
6	134461880	rs6569930	A	C,G,T	rs6569930	24399259	2.08E-04	(fixed effect model)	1.45	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs6569930-A	Research Support, Non-U.S. Gov't	C	NA
6	148467702	rs9377112	T	C	rs9377112	24114350	1.51E-05	GWAS stage only	0.79	[0.44-1.14] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9377112-C	Research Support, N.I.H., Extramural	T	NA
7	5278176	rs148445986	G	A,T	rs148445986	24927181	1.37E-05	NA	2.36	[1.44-3.89]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs148445986-A	Research Support, Non-U.S. Gov't	G	NA
7	7401954	rs7800159	T	G	rs7800159	24114350	2.22E-05	GWAS stage only	0.8	[0.44-1.16] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7800159-T	Research Support, N.I.H., Extramural	T	COL28A1
7	7402150	rs10952053	A	T	rs10952053	24114350	2.21E-05	GWAS stage only	0.8	[0.44-1.16] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10952053-A	Research Support, N.I.H., Extramural	A	COL28A1
7	127796040	rs73226626	C	T	rs73226626	24927181	5.85E-05	NA	1.19	[1.10-1.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73226626-T	Research Support, Non-U.S. Gov't	C	NA
8	437397	rs62484362	C	A	rs62484362	24927181	2.74E-04	NA	1.33	[1.10-1.61]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs62484362-C	Research Support, Non-U.S. Gov't	C	NA
8	8263629	rs11785930	T	C	rs11785930	24927181	4.50E-05	NA	1.25	[1.15-1.39]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11785930-T	Research Support, Non-U.S. Gov't	T	NA
8	8645725	rs2409088	G	C	rs2409088	24927181	1.34E-04	NA	1.18	[1.09-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2409088-C	Research Support, Non-U.S. Gov't	G	MFHAS1
8	9159895	rs330071	G	A	rs330071	24927181	9.00E-07	NA	1.23	[1.14-1.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs330071-G	Research Support, Non-U.S. Gov't	C	NA
8	9279553	rs13281098	C	A	rs13281098	24927181	2.38E-04	NA	1.19	[1.10-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs13281098-C	Research Support, Non-U.S. Gov't	C	NA
8	9279811	rs1458944	G	T	rs1458944	24927181	1.64E-04	NA	1.19	[1.09-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1458944-G	Research Support, Non-U.S. Gov't	T	NA
8	11425105	rs13280813	G	T	rs13280813	24927181	4.02E-04	NA	1.19	[1.10-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs13280813-G	Research Support, Non-U.S. Gov't	G	NA
8	11698747	rs1296028	A	G	rs1296028	24927181	1.26E-04	NA	1.19	[1.10-1.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1296028-A	Research Support, Non-U.S. Gov't	A	NA
8	11701933	rs4839	T	C	rs4839	24927181	5.08E-05	NA	1.18	[1.09-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs4839-T	Research Support, Non-U.S. Gov't	T	CTSB
8	53105573	rs78744452	C	G	rs78744452	24927181	3.68E-04	NA	1.67	[1.27-2.17]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78744452-C	Research Support, Non-U.S. Gov't	C	ST18
8	74234628	rs79520422	A	C	rs79520422	24927181	1.11E-04	NA	1.77	[1.25-2.50]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs79520422-C	Research Support, Non-U.S. Gov't	A	RDH10
8	101870990	rs2386492	G	T	rs2386492	24927181	8.99E-04	NA	1.28	[1.14-1.45]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2386492-G	Research Support, Non-U.S. Gov't	A	NA
8	101876999	rs17364251	T	C	rs17364251	24927181	7.62E-04	NA	1.28	[1.14-1.45]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs17364251-T	Research Support, Non-U.S. Gov't	T	NA
8	128676131	rs4133274	A	G	rs4133274	24114350	1.70E-06	GWAS stage only	1.39	[0.86-1.91] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs4133274-G	Research Support, N.I.H., Extramural	A	NA
8	128691212	rs13248513	T	C	rs13248513	24114350	2.02E-06	GWAS stage only	1.34	[0.83-1.86] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs13248513-C	Research Support, N.I.H., Extramural	T	NA
9	3280136	rs73642627	C	T	rs73642627	24927181	1.55E-04	NA	1.8	[1.31-2.48]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73642627-T	Research Support, Non-U.S. Gov't	C	RFX3
9	4695068	rs7874378	A	G	rs7874378	24927181	1.20E-04	NA	1.16	[1.07-1.27]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7874378-G	Research Support, Non-U.S. Gov't	A	CDC37L1
9	12573415	rs190806135	G	T	rs190806135	24927181	2.17E-05	NA	4.17	[1.96-8.88]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs190806135-T	Research Support, Non-U.S. Gov't	G	NA
9	31862948	rs10970564	T	C	rs10970564	24927181	7.58E-05	NA	1.23	[1.10-1.39]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10970564-T	Research Support, Non-U.S. Gov't	C	NA
9	75318935	rs186937202	A	G	rs186937202	24927181	7.52E-05	NA	3.63	[1.43-9.22]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs186937202-G	Research Support, Non-U.S. Gov't	A	TMC1
10	11396152	rs12245515	G	A	rs12245515	24927181	4.55E-04	NA	1.2	[1.10-1.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12245515-G	Research Support, Non-U.S. Gov't	G	NA
10	61961795	rs10994250	G	A	rs10994250	24927181	2.88E-05	NA	1.19	[1.09-1.31]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10994250-A	Research Support, Non-U.S. Gov't	A	ANK3
10	61997956	rs10821707	A	G	rs10821707	24927181	1.64E-05	NA	1.2	[1.09-1.32]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10821707-G	Research Support, Non-U.S. Gov't	G	ANK3
10	77004792	rs10824293	C	T	rs10824293	24927181	1.09E-04	NA	1.25	[1.11-1.41]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10824293-C	Research Support, Non-U.S. Gov't	C	NA
10	80702012	rs117450696	G	A	rs117450696	24927181	1.98E-04	NA	1.45	[1.19-1.78]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs117450696-A	Research Support, Non-U.S. Gov't	G	NA
10	90592544	rs11202868	T	G	rs11202868	24927181	1.43E-04	NA	23.1	[1.87-285.09]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11202868-G	Research Support, Non-U.S. Gov't	T	ANKRD22
10	104050840	rs79332175	A	C	rs79332175	24927181	1.90E-04	NA	3.75	[1.38-10.21]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs79332175-C	Research Support, Non-U.S. Gov't	A	GBF1
10	119289027	rs149745931	G	C	rs149745931	24927181	1.35E-04	NA	15.6	[1.43-169.91]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs149745931-C	Research Support, Non-U.S. Gov't	G	EMX2OS
11	8219178	rs146103307	A	G	rs146103307	24927181	2.85E-04	NA	4.49	[1.54-13.11]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs146103307-G	Research Support, Non-U.S. Gov't	A	NA
11	34502042	rs7949972	C	T	rs7949972	24399259	3.03E-04	(fixed effect model)	1.14	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7949972-A	Research Support, Non-U.S. Gov't	C	ELF5
11	47176005	rs747650	C	T	rs747650	24399259	4.00E-09	(fixed effect model)	1.24	[1.16-1.34]	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs747650-G	Research Support, Non-U.S. Gov't	G	C11orf49
11	47179829	rs1060573	A	G	rs1060573	24399259	1.28E-08	(fixed effect model)	1.23	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1060573-G	Research Support, Non-U.S. Gov't	T	C11orf49
11	64968864	rs149618074	C	T	rs149618074	24927181	1.27E-05	NA	3.03	NA	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs149618074-C	Research Support, Non-U.S. Gov't	C	CAPN1
11	65494260	rs478304	G	T	rs478304	24927181	3.00E-11	NA	1.2	[1.11-1.29]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs478304-T	Research Support, Non-U.S. Gov't	A	NA
11	65546857	rs610037	A	C	rs610037	24927181	4.04E-11	NA	1.2	[1.11-1.29]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs610037-C	Research Support, Non-U.S. Gov't	C	AP5B1
11	65562852	rs72922786	G	C	rs72922786	24927181	3.39E-08	NA	1.35	[1.19-1.54]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs72922786-G	Research Support, Non-U.S. Gov't	G	OVOL1
11	75096063	rs676703	C	T	rs676703	24114350	1.68E-05	GWAS stage only	0.74	[0.39-1.09] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs676703-C	Research Support, N.I.H., Extramural	A	NA
11	104249002	rs12365754	A	G	rs12365754	24114350	1.36E-05	GWAS stage only	0.89	[0.51-1.28] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12365754-G	Research Support, N.I.H., Extramural	A	NA
11	123976067	rs58908941	T	G	rs58908941	24927181	1.33E-04	NA	8.92	[2.08-38.33]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs58908941-G	Research Support, Non-U.S. Gov't	T	NA
12	26285545	rs7358598	G	A	rs7358598	24927181	1.45E-04	NA	1.41	[1.21-1.65]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs7358598-A	Research Support, Non-U.S. Gov't	A	NA
12	26285974	rs78579876	A	C	rs78579876	24927181	6.65E-05	NA	1.41	[1.20-1.65]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78579876-C	Research Support, Non-U.S. Gov't	A	NA
12	67134174	rs2127535	C	G	rs2127535	24927181	2.13E-04	NA	1.45	[1.20-1.75]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2127535-G	Research Support, Non-U.S. Gov't	G	NA
12	67135759	rs2870913	A	G	rs2870913	24927181	3.53E-05	NA	1.47	[1.22-1.77]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2870913-G	Research Support, Non-U.S. Gov't	G	NA
12	72762998	rs148340537	C	G	rs148340537	24927181	2.92E-04	NA	2.47	[1.53-3.99]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs148340537-G	Research Support, Non-U.S. Gov't	T	TRHDE
12	76931246	rs73385569	C	T	rs73385569	24927181	1.64E-04	NA	11.6	[2.30-58.47]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs73385569-T	Research Support, Non-U.S. Gov't	C	OSBPL8
12	108547387	rs181947843	G	A	rs181947843	24927181	5.00E-06	NA	2.17	[1.32-3.58]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs181947843-A	Research Support, Non-U.S. Gov't	G	WSCD2
13	98939102	rs9513393	A	G	rs9513393	24927181	3.76E-05	NA	1.44	[1.16-1.80]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9513393-G	Research Support, Non-U.S. Gov't	A	FARP1
14	33848109	rs1315148	A	G	rs1315148	24927181	2.39E-05	NA	1.18	[1.10-1.27]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1315148-G	Research Support, Non-U.S. Gov't	A	NPAS3
14	73253019	rs111724826	T	C	rs111724826	24927181	6.69E-05	NA	3.16	[1.76-5.68]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs111724826-C	Research Support, Non-U.S. Gov't	T	DPF3
14	73261871	rs60344050	G	A	rs60344050	24927181	1.45E-04	NA	2.92	[1.67-5.12]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs60344050-A	Research Support, Non-U.S. Gov't	G	DPF3
14	76818989	rs2360999	A	C	rs2360999	24114350	2.23E-05	GWAS stage only	0.78	[0.43-1.14] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2360999-C	Research Support, N.I.H., Extramural	A	NA
14	90044729	rs10142749	C	A	rs10142749	24927181	7.15E-05	NA	7.95	[1.70-37.30]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs10142749-A	Research Support, Non-U.S. Gov't	C	FOXN3
14	99812577	rs906933	C	A	rs906933	24927181	1.81E-04	NA	1.18	[1.10-1.28]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs906933-C	Research Support, Non-U.S. Gov't	A	NA
15	48604477	rs8030330	A	G	rs8030330	24927181	3.69E-05	NA	1.72	[1.32-2.27]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs8030330-A	Research Support, Non-U.S. Gov't	G	NA
15	51878548	rs184120294	A	G	rs184120294	24927181	9.63E-05	NA	2.32	[1.66-3.25]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs184120294-G	Research Support, Non-U.S. Gov't	A	DMXL2
15	51995459	rs182326997	T	C	rs182326997	24927181	1.58E-05	NA	2.53	[1.63-3.94]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs182326997-C	Research Support, Non-U.S. Gov't	T	SCG3
15	57793765	rs1994887	C	A	rs1994887	24114350	1.84E-05	GWAS stage only	0.96	[0.47-1.44] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs1994887-A	Research Support, N.I.H., Extramural	C	CGNL1
16	30353264	rs188305385	T	A	rs188305385	24927181	1.56E-04	NA	3.8	[1.83-7.87]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs188305385-A	Research Support, Non-U.S. Gov't	T	NA
16	30536916	rs61735343	T	C	rs61735343	24927181	5.17E-05	NA	5.14	[1.78-14.82]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs61735343-C	Research Support, Non-U.S. Gov't	T	ZNF768
16	79172681	rs11647886	G	T	rs11647886	24114350	4.05E-06	GWAS stage only	2.36	[0.86-3.86] unit decrease	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs11647886-T	Research Support, N.I.H., Extramural	G	WWOX
17	5788346	rs189869876	G	T	rs189869876	24927181	7.07E-05	NA	17.83	[1.80-176.37]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs189869876-T	Research Support, Non-U.S. Gov't	G	LOC339166
17	10528368	rs201597	A	G	rs201597	24927181	6.55E-04	NA	1.49	[1.21-1.83]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs201597-G	Research Support, Non-U.S. Gov't	C	NA
17	10553769	rs62060696	C	T	rs62060696	24927181	4.20E-05	NA	1.79	[1.37-2.38]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs62060696-C	Research Support, Non-U.S. Gov't	C	MYH3
17	27238075	rs2277665	G	A	rs2277665	24114350	1.07E-05	GWAS stage only	0.98	[0.56-1.4] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2277665-A	Research Support, N.I.H., Extramural	C	PHF12
17	27257478	rs4795476	G	C	rs4795476	24114350	1.27E-05	GWAS stage only	0.97	[0.55-1.39] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs4795476-C	Research Support, N.I.H., Extramural	G	PHF12
18	9991724	rs9945403	T	C	rs9945403	24114350	2.46E-05	GWAS stage only	0.76	[0.4-1.11] unit increase	81 European ancestry cases; 847 European ancestry controls	European(928)	ALL(928)	EUR(928)	ALL(928)	Acne (severe teenage)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs9945403-C	Research Support, N.I.H., Extramural	C	NA
18	54886093	rs77512994	T	C	rs77512994	24927181	1.51E-04	NA	7.54	[2.28-24.94]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs77512994-C	Research Support, Non-U.S. Gov't	C	NA
18	71454947	rs75366668	C	T	rs75366668	24927181	4.53E-04	NA	2.23	[1.46-3.42]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs75366668-T	Research Support, Non-U.S. Gov't	C	NA
19	8012094	rs12972972	C	T	rs12972972	24927181	4.00E-04	NA	1.18	[1.09-1.29]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs12972972-T	Research Support, Non-U.S. Gov't	C	NA
19	53381938	rs142045433	T	C	rs142045433	24927181	1.16E-05	NA	1.97	[1.34-2.89]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs142045433-C	Research Support, Non-U.S. Gov't	T	ZNF320
20	5282850	rs117106081	C	T	rs117106081	24399259	8.92E-04	(fixed effect model)	1.37	NA	1,031 Han Chinese ancestry cases; 1,031 Han Chinese ancestry controls	Han Chinese(2062)	ALL(2062)	ASN(2062)	ALL(2062)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs117106081-G	Research Support, Non-U.S. Gov't	C	PROKR2
20	19317729	rs150897529	G	A	rs150897529	24927181	1.30E-05	NA	1.49	[1.20-1.85]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs150897529-A	Research Support, Non-U.S. Gov't	G	SLC24A3
22	21353925	rs3747084	G	A,C,T	rs3747084	24927181	3.77E-04	NA	1.27	[1.14-1.41]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs3747084-G	Research Support, Non-U.S. Gov't	G	NA
22	21363505	rs2516542	C	T	rs2516542	24927181	1.89E-04	NA	1.28	[1.14-1.43]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs2516542-C	Research Support, Non-U.S. Gov't	C	NA
22	24788697	rs79612614	A	C	rs79612614	24927181	1.14E-06	NA	1.42	[1.22-1.65]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs79612614-C	Research Support, Non-U.S. Gov't	A	SPECC1L
22	24844883	rs17651189	T	C	rs17651189	24927181	6.00E-07	NA	1.44	[1.24-1.68]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs17651189-C	Research Support, Non-U.S. Gov't	T	C22orf45
22	24849753	rs80134322	C	T	rs80134322	24927181	1.37E-06	NA	1.42	[1.22-1.65]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs80134322-T	Research Support, Non-U.S. Gov't	C	C22orf45
22	24936096	rs117493866	G	A	rs117493866	24927181	5.97E-07	NA	1.44	[1.21-1.73]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs117493866-A	Research Support, Non-U.S. Gov't	G	NA
22	46647844	rs78023664	G	A	rs78023664	24927181	5.94E-04	NA	1.27	[1.13-1.44]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs78023664-A	Research Support, Non-U.S. Gov't	G	NA
22	50297888	rs3922872	T	C	rs3922872	24927181	1.88E-04	NA	1.31	[1.18-1.47]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs3922872-C	Research Support, Non-U.S. Gov't	T	ALG12
22	50345556	rs62231870	G	C	rs62231870	24927181	7.71E-06	NA	1.28	[1.16-1.42]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs62231870-C	Research Support, Non-U.S. Gov't	G	NA
22	50346042	rs56091001	C	T	rs56091001	24927181	4.00E-06	NA	1.28	[1.16-1.42]	1,893 European ancestry cases; 5,132 European ancestry controls	European(7025)	ALL(7025)	EUR(7025)	ALL(7025)	Acne (severe)	HPOID:0001061	Acne	DOID:6543	acne	NA	NA	NA	NA	Acne	rs56091001-T	Research Support, Non-U.S. Gov't	C	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:14)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0001144	adapalene	D000068816	-	acne vulgaris	MESH:D000152	therapeutic	12207595
C0001144	azelaic acid	C010038	-	acne vulgaris	MESH:D000152	therapeutic	17456913
C0001144	betamethasone	D001623	378-44-9	acne vulgaris	MESH:D000152	therapeutic	4241782
C0001144	dapsone	D003622	80-08-0	acne vulgaris	MESH:D000152	therapeutic	9330049
C0001144	doxycycline	D004318	564-25-0	acne vulgaris	MESH:D000152	therapeutic	12900822
C0001144	erythromycin	D004917	114-07-8	acne vulgaris	MESH:D000152	therapeutic	11809596
C0001144	etonogestrel	C044815	-	acne vulgaris	MESH:D000152	marker/mechanism	11861056
C0001144	gefitinib	C419708	184475-35-2	acne vulgaris	MESH:D000152	marker/mechanism	17166623
C0001144	levonorgestrel	D016912	797-63-7	acne vulgaris	MESH:D000152	marker/mechanism	11861056
C0001144	oxytetracycline	D010118	79-57-2	acne vulgaris	MESH:D000152	therapeutic	8671830
C0001144	spironolactone	D013148	1952/1/7	acne vulgaris	MESH:D000152	therapeutic	15752283
C0001144	tretinoin	D014212	302-79-4	acne vulgaris	MESH:D000152	therapeutic	161830
C0001144	vitamin a	D014801	11103-57-4	acne vulgaris	MESH:D000152	therapeutic	11824142
C0001144	vitamin e	D014810	1406-18-4	acne vulgaris	MESH:D000152	therapeutic	6455256

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)