DNMIVD | DPP4

Summary
Symbol	DPP4
Name	dipeptidyl peptidase 4
Location	2q24.2
Locus Group	protein-coding gene
Entrez GeneID	1803
Aliases	DPPIV
External Links	Ensembl, HGNC, Uniprot

CpGs located in DPP4

Group: different genomic regions, including TSS1500, TSS200, 5'UTR, 1stExon and 3'UTR
         TSS200: region from -200 nt upstream to the transcription start site (TSS) itself
         TSS1500: sequence region from -200 to -1,500 nt upstream of the TSS
         1stExon: the first exon
         Body: gene body region

Relation To Island: CpG island, CpG island shores (2 kb regions upstream and downstream of the CpG islands) and shelves (2 kb regions upstream and downstream of the CpG island shores)
         CpG island (CGI): 200bp in length, GC percentage >50%, Observed/expected CpG ratio >60%
         Shore: Up to 2kb from CpG island, including N_shore (0-2 kb upstream from CGI) and S_shore (0-2 kb downstream from CGI)
         Shelf: 2-4 kb from CpG island, including N_shelf (2-4 kb upstream from CGI) and S_shelf (2-4 kb downstream from CGI)
         Open Sea: Isolated CpGs in the genome

Differentially methylated genes (promoter region).

Differentially Methylated Genes for DPP4 in pancancer

Definition of differentially methylated genes: |difference|>0.2 & indepedent Student's t-test adjusted p-value <= 0.05, Hypermethylation: beta difference > 0.2 & adjusted p-value<=0.05, Hypomethylation: beta difference < -0.2 & adjusted p-value<=0.05

Pearson and Spearman correlation between methylation of gene promoter and FPKM is calculated.

Methylation-Expression correlation for DPP4 in pancancer

Functional Epigenetic Modules (FEM) of protein-protein interactions (PPI) are calculated by FEM algorithm.

Functional Epigenetic Modules involving DPP4 in pancancer

FEM was generated by FEM algorithm

The statistic (stat(DNAm)) and P-value (P(DNAm)) of differential methylation,
the statistic (stat(mRNA)) and P-value (P(mRNA)) of differential expression and the overall statistic stat(Int)
are provided in the table.

Functional Epigenetic Modules (FEM) of Co-Occurrence and Mutual Exclusive (COME) network for genes are calculated by FEM algorithm, and COME is detected by DISCOVER (Discrete Independence Statistic Controlling for Observations with Varying Event Rates) algorithm.

Functional Epigenetic Modules involving DPP4 in pancancer

FEM was generated by FEM algorithm

Kaplan-Meier survival analysis.

Show records that are significant in pancancer

There are two different ways to divide samples into different groups.
(1) Using median DNA methylation beta values as threshold to divide samples into High and Low group.
(2) Using DNA methylation beta values of 0.3 and 0.7 as cutoff to divide samples into Low, Middle and High groups.

There are three different endpoint.
(1) OS: Overall Survival time.
(1) DFI: Disease-free Interval.
(1) PFI: Progression-free Interval.
P-value is calculated with Log rank test